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Shim, Hyun J.,Kim, Yu C.,Lee, Joo H.,Park, Kyung J.,Kwon, Jong W.,Kim, Won B.,Lee, Myung G. John Wiley Sons, Ltd. 2005 Biopharmaceutics & drug disposition Vol.26 No.4
<P>Species differences in the formation of DA-8164 after intravenous and/or oral administration of DA-8159 to mice, rats, rabbits, dogs and humans were investigated. After intravenous administration of DA-8159, the formation of DA-8164 decreased in the order mice, rats, rabbits and dogs; the AUC<SUB>DA-8164</SUB>/AUC<SUB>DA-8159</SUB> ratios were 0.479, 0.199, 0.0452 and close to 0 (DA-8164 was below the detection limit in dog plasma), respectively. After oral administration of DA-8159, the formation of DA-8164 was considerable in mice, rats and humans, but almost negligible in dogs; the AUC (or AUC<SUB>0–t</SUB>)<SUB>DA-8164</SUB>/AUC (or AUC<SUB>0–t</SUB>)<SUB>DA-8159</SUB> ratios were 2.99, 2.67, 1.39 and 0.0650, respectively. The above data suggested that the formation of DA-8164 was almost negligible after both intravenous and oral administration in dogs. The species differences for the formation of DA-8164 may be due to the involvement of different CYP isozymes for each species and/or a different amount or activity of CYP isozyme if the same CYP isozyme is involved for the formation of DA-8164 for all species. The AUC (or AUC<SUB>0–t</SUB>)<SUB>DA-8164</SUB>/AUC (or AUC<SUB>0–t</SUB>)<SUB>DA-8159</SUB> ratios after oral administration were greater than those after intravenous administration in mice, rats and dogs, and this could be due to considerable first-pass (gastric, intestinal and/or hepatic) effects in the species as proved in rats. Copyright © 2005 John Wiley & Sons, Ltd.</P>
Overweight and its association with aortic pressure wave reflection after exercise.
Shim, Chi Young,Yang, Woo-In,Park, Sungha,Kang, Min-Kyung,Ko, Young-Guk,Choi, Donghoon,Jang, Yangsoo,Chung, Namsik,Ha, Jong-Won Elsevier ; Elsevier Science Pub. Co 2011 American journal of hypertension Vol.24 No.10
<P>Obesity is associated with arterial stiffening, left ventricular (LV) hypertrophy, and diastolic dysfunction. However, there is no data regarding dynamic changes in arterial hemodynamics with exercise in overweight subjects. We hypothesized that overweight women would show a different exercise response in wave reflection compared with lean women.</P>
Evaluation of ion implantation for anti-thrombogenic coronary stent in vitro and in vivo
Shim, Jae-Won,Bae, In-Ho,Park, Dae Sung,Lim, Kyung-Seob,Lee, So-Youn,Jang, Eun-Jae,Park, Jun-Kyu,Kim, Ju Han,Jeong, Myung Ho Elsevier 2017 Journal of industrial and engineering chemistry Vol.54 No.-
<P><B>Abstract</B></P> <P>The aim of this study was to evaluate the effect of ion implantation on the surface of anti-thrombogenic coronary stent. Nitrogen (N) was implanted into the cobalt–chromium surface by using an ion source under a plasma environment to enhance its hardness and surface modification. The N ion dosage was 1×10<SUP>15</SUP> ions/cm<SUP>2</SUP>. All analysis results of the ion implanted stent were compared with those of bare metal stent. The N component and distribution were confirmed by auger electron spectroscopy. Microhardness was significantly increased after 40min of implantation (415.3±12.38 HV, 18.9±2.62%). The surface was altered to hydrophobic status through ion implantation (30.6±1.12% in contact angle increment). Platelet adhesion, and smooth muscle cell migration and proliferation were prevented in the ion implanted group (43.9%, 11.2%, and 45.1%, respectively). To verify the in vitro result, stents were implanted to rabbit iliac artery and isolated at 4 weeks post implantation. Then, the stents were subjected to histological analysis. No significant differences in injury score, internal elastic lamina, lumen area, and restenosis rate were found. However, the fibrin score was more significantly decreased in the ion beam-implanted group (2.5±0.15) than in the bare metal stent group (1.8±0.31, <I>n</I> =10, <I>p</I> <I><</I> 0.05). Taken together, ion beam implantation may be an efficient accessorial tool for preventing in-stent restenosis and in-stent thrombosis.</P>
Endoscopic Treatment of Hypothalamic Hamartomas
Shim, Kyu Won,Park, Eun Kyung,Kim, Dong-Seok The Korean Neurosurgical Society 2017 Journal of Korean neurosurgical society Vol.60 No.3
Hypothalamic hamartoma (HH) is a benign indolent lesion despite the presentation of refractory epilepsy. Behavioral disturbances and endocrine problems are additional critical symptoms that arise along with HHs. Due to its nature of generating epileptiform discharge and spreading to cortical region, various management strategies have been proposed and combined. Surgical approaches with open craniotomy or endoscopy, stereotactic approaches with radiosurgery and gamma knife surgery or radiofrequency thermos-coagulation, and laser ablation have been introduced. Topographical dimension and the surgeon's preference are key factors for treatment modalities. Endoscopic disconnection has been one of the most favorable options performed in treating HHs. Here we discuss presurgical evaluation, patient selection, surgical procedures, and complications.