남성성기능장애 환자의 우울, 불안, 스트레스 지각 및 대응전략

정헌구,정상근,황익근,박종관 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.3

남성성기능장애 환자와 정상대조군을 비교한 우울, 불안, 스트레스 지각과 남성성기능 장애 환자의 스트레스 대응전략에서 다음과 같은 결과를 얻었다. 1) 남성성기능장애 환자에서 우울과 불안의 수준이 유의하게 더 높았다. 2) 남성성기능장애 환자에서 전반적 생활에서 느끼는 스트레스에 대한 지각이 유의하게 더 높았고 특히 일과 직업, 대인관계에서 스트레스를 더 많이 지각하고 있었으며 최근 1년간의 부정적 생활 사건의 빈도가 유의하게 더 높았다. 3) 남성성기능장애 환자의 대응전략으로는 지적추구, 재정립과 순응이 많았고 대부분이 취약성을 부정하는 경향을 보였다. 배우자가 없는 남성성기능장애 환자에 비해 배우자가 있는 남성성기능장애 환자자 적극적으로 대응하며 정서적 불안정성, 불안 및 두려움이 적었다. 남성성기능장애 환자의 가장 큰 지지원은 의사였다. Thirty-one male sexual dysfunctional patients were selected to investigate their depression, anxiety, stress perception, and coping strategy. Then were examined by Beck's Depression Inventory, State-Trait Anxiety Inventory, Symptom Checklist-90-Revised, Global Assessment of Recent Stress Scale an Coping Strategy. Twenty-seven healthy normal adults were selected as control group. The results were as follows: 1) Depression and anxiety scores were significantly higher in the patients. 2) Stress perception of usual life, especially work job and change in relationships, was significantly higher in the patients. Frequency of negative life events was significantly higher in the patients. 3) As coping strategy, intellectualisation, redefinition and compliance were most frequently used by the patients. Most of the patients showed tendency to deny their vulnerabilities. Patients who lived with spouse showed more active confrontation and less emotional turmoil, anxiety and fear than patients who lived without spouse.

Molecular Characterization of Small Heat Shock Protein(hsp20.8A) from the Silkworm, Bombyx mori

Hwang, Jae-Sam,Go, Hyun-Jeong,Goo, Tae-Won,Seong, Su-Il,Yun, Eun-Young,Ahn, Mi-Young,Kim, Seong-Ryul,Park, Kwan-Ho,Kim, Ik-Soo,Jeon, Jae-Pil,Kang, Seok-Woo Korean Society of Sericultural Science 2007 International Journal of Industrial Entomology Vol.15 No.1

To define the molecular mechanism of initiation and termination of diapause during the embryogenesis of silkworm, Bombyx mori, mRNA transcripts from diapausing eggs and diapause activated eggs were compared with differential expression using cDNA array. Among those clones, mRNA transcript from hsp20.8A, which was expressed at a high level in diapausing eggs that had been incubated at $25^{\circ}C$ for 30 days after oviposition, whereas, in the eggs exposed to $15^{\circ}C$ for 30 days, $5^{\circ}C$ for 60 days, the expression of mRNA decreased. On the other hand, the expression of mRNA during embryogenesis observed abundantly at 4 to 6 days after heat-HCl treatment and later at 9 to 10 days after just before hatching. This result was suggested for us that hsp20.8A was expressed in response to embryogenesis as well as physical stress.

자상으로 인한 우측상갑상선동맥 가성동맥류의 코일 색전

황대현,최형심,고은영,원형진,이재영,김현범,이인재,이관섭,이열,이일성,강익원,우영민,최창식,윤대원 대한혈관외과학회 2002 Vascular Specialist International Vol.18 No.1

A case of coil embolization in right superior thyroid artery pseudoaneurysm by stab wound is reported. A fifty-six-year old female, laceration and some bulging in right neck side. Aortic arch angiography, right common carotid angiography was done. Angiography shows 4×2 cm sized right thyroid artery pseudoaneurysm (FIg. 1) and (Fig. 2). We selected right superior thyroid artery by 3F micorofert (CooK, Bloomington, Ind.) and embolized by 2×4 mm (diameter), 2 cm (length) sized micro tornaido coil (CooK, Bloomington, Ind.). Post procedure right common carotid angiography was done. Angiography shows no visualized right thyroid artery pseudoaneurysm (Fig. 3).

Molecular Characterization of A Glycine and Proline-rich Antibacterial Protein from Larvae of A Beetle, Protaetia brevitarsis

Hwang, Jae-Sam,Kim, Seong-Ryul,Kang, Heui-Yun,Yun, Eun-Young,Ahn, Mi-Young,Park, Kwan-Ho,Jeon, Jae-Pil,Kim, Mi-Ae,Kim, Nam-Jung,Hwang, Seok-Jo,Kim, Ik-Soo Korean Society of Sericultural Science 2007 International Journal of Industrial Entomology Vol.15 No.1

A glycine and proline-rich antibacterial protein was cloned from larvae of a beetle, Protaetia brevitarsis. The DNAs encoded a deduced propeptide of 127 amino acid residues with predicted molecular weight of 14.0 kDa and PI of 7.89. Structural analysis of this protein indicated the presence of a recognition sequence for the cleavage site within the constitutive secretory pathway(Arg-Xaa-Lys/Arg-Arg), suggesting that mature portion(72 amino acid residues) is produced by cleavage of signal peptide and propeptide from 127 amino-acid-long precursor protein. Mature portion sequence of this protein showed 72% similarity to that of Oryctes rhinoceros Rhinocerosin and 91% to that of Holotrichia diomphalia holotricin 2. The mRNA expression was reached the highest level at 4 hrs after E. coli injection and then declined gradually.

Molecular Characterization of a Defensin-like Peptide from Larvae of a Beetle, Protaetia brevitarsis

Hwang, Jae-Sam,Kang, Bo-Ram,Kim, Seong-Ryul,Yun, Eun-Young,Park, Kwan-Ho,Jeon, Jae-Pil,Nam, Sung-Hee,Suh, Hwa-Jin,Hong, Mee-Yeon,Kim, Ik-Soo Korean Society of Sericultural Science 2008 International Journal of Industrial Entomology Vol.17 No.1

A cDNA encoding a defensin-like peptide (Protaetiamycine) from the larvae of a beetle, Protaetia brevitarsis was cloned. The DNAs encoded the deduced propeptide of 79 amino acid residues with the predicted molecular weight of 8.4 kDa and PI of 8.24. Overall amino acid sequence of this protein has 39% similarity to that of Rhodnius prolixus defensin, 43% similarity to that of Acalolepta luxuriosa defensin, and 72% similarity to that of Oryctes rhinoceros defensin, suggesting that this gene is an insect defensin. In an attempt to apply the anti-bacterial peptide to the development of therapeutic agents, a 12-mer peptide amidated at its C-terminus, ACAAHCLAIGRG-$NH_2$ (Ala55-Lys66-$NH_2$, 12Pbn) was synthesized. This peptide showed some antifungal activity against Candida albicans. To increase antifungal activity, six 9-mer peptides were synthesized by modifying amino acid sequences of 12Pbn fragment. Among these peptides, 9Pbm3-9Pbm6 exhibited strong activity compared with Cecropin B and mellitin.

Mountain ginseng extract exhibits anti-lung cancer activity by inhibiting the nuclear translocation of NF-관B.

Hwang, Jeong Won,Oh, Jung Han,Yoo, Hwa-Seung,Lee, Yeon-Weol,Cho, Chong-Kwan,Kwon, Ki-Rok,Yoon, Jung-Ho,Park, Junsoo,Her, Song,Lee, Zee-Won,Jang, Ik-Soon,Choi, Jong-Soon Institute for Advanced Research in Asian Science a 2012 The American journal of Chinese medicine Vol.40 No.1

<P>Administration of mountain ginseng (MG) extract can restore advanced cancer to a normal state. To elucidate the mechanism by which MG extract prevents the progression of lung cancer, the processes of proliferation and death of lung cancer cells (A549) were examined after treatment with MG extract. Butanol-extracted MG (BX-MG) showed a high inhibitory effect (IC(50) = 2 mg/ml) by attenuating proliferation and inducing apoptosis in lung cancer cells. By HPLC-UV analysis of BX-MG, ginsenosides, Rb1 was identified as the most abundant ginsenoside, followed by Rg1, Re, Rc and Rb2. BX-MG induced caspase-3 dependent apoptosis by inhibiting NF-관B. In addition, BX-MG activated p53 and p21, resulting in the attenuated proliferation of A549 cells. Reduced activity of the NF-관B promoter and increased activity of the p53 promoter indicate that BX-MG regulates apoptosis at the level of transcription in lung cancer cells. Furthermore, BX-MG blocked the nuclear translocation of RelA and the associated reduction in surviving. These results suggest that BX-MG inhibits lung cancer cell growth by activating tumor suppressors and inhibiting nuclear translocation of NF-관B.</P>

운동유발성천식이 트레드밀운동 후 폐기능에 미치는 영향

황수관,김남익,이상협,최건식 대한스포츠의학회 1996 대한스포츠의학회지 Vol.14 No.1

In an effect to analyze various factors of pulmonary functions caused by the before and after treadmill exercise showing the decrease of some values such as FEV1.0sec value, PEF and FEF25%-75%, subjects were selected from a group consisting of 20 males and 22 female, ranging from the age group of 30 to 60, who has not been engaged in any physical exercise in their daily life and dignosed as Exercise-Induced Asthma patients. Major findings and conclusion are as follows : 1. After treadmill exercise, both male and female showed significant differences in FEV1.0sec(p<0.05) in analyzing the change of pulmonary functions caused by the decrease of FEV1.0sec value. The male showed significant differences in FVC and FEV0.5sec, while the females showed significant differences in PEF, compared with their before exercise. 2. After treadmill exercise, the male's PEF decrease significantly affected other values related to the pulmonary functions. Both male and females showed statistically significant differences in PEF and FEF2.5%(p<0.01), as well as in MVV(P<0.01). And the male showed significant decrease in FVC, FEV0.5sec whilest there were significant decrease in the female in FEF50%, FEF75%(p<0.05) and FEF25%-75%(p<0.01), compared with their before exercise. 3. As for the change of pulmonary function caused by the decrease of FEF25%-75% after treadmill exercise, both males and females showed significance differences in FEF25%, FEF50% and FEF25%-75%(p<0.01). The female showed a significant difference in PEF(p<0.05).

한국성인에서 체지방, 혈중지질 농도와 혈압간의 상관관계

황수관,김남익,최건식 대한스포츠의학회 1997 대한스포츠의학회지 Vol.15 No.2

To investigate blood pressure and body fat, cholesterol, triglyceride concentration and relationship of each other in Korea adults, total 382(men 188 and women 196) aged between 20-69 years were chosen as subjects. The results are summarized as follows. 1. Body fat was increase with diastolic blood pressure from 60-69mmHg group to 110-130mmHg group in men and women. Body fat in women was always more than in men all range of blood pressure. 2. Triglyceride concentration was significantly increases with blood pressure in men. In women, triglyceride concentration was significantly increase over 90mmHg regarded as hypertension. 3. Total cholesterol had no relationship to blood pressure, but total/HDL cholesterol ratio tended to increase with blood pressure. Both men and women, high density lipoprotein cholesterol was decrease and low density lipoprotein cholesterol was increase with blood pressure. 4. The factor which had the best relationship to blood pressure was body fat in men and triglyceride in women. The total/HDL cholesterol ratio had higher correlation coefficient than HDL or LDL single value. From the above results it is speculated that body fat and triglyceride, cholesterol concentration responsible for hypertension. Especially high blood pressure has relation to body fat in men and triglyceride in women. And body fat, blood triglyceride, cholesterol concentration are concerned with each other, but the relationship is not high.

각관 추진 굴착시 궤도노반의 침하경향 실험분석

정관동(Kwan-Dong Jung),엄기영(Ki-Young Eum),최찬용(Chan-Yong Choi),조수익(Su-Ik Jo),황인환(Hwan-In Hwang) 한국철도학회 2010 한국철도학회 학술발표대회논문집 Vol.2010 No.7

The method in a bid to make better use of limited urban space amidst increasingly expanding urban area have been attempted in various ways. Efficient using underground space is one of the examples. The pipe roof and excavation for underground crossing implemented in this study was the part of evaluation of such attempt. However, the pipe roof method for underground crossing may cause the ground surface to be uplifted or settled down, having effect on structure above the ground. Thus in this study, a laboratory model test designed to evaluate the effect on surface during implementing pipe roof and excavation was carried out. The ground displacement during pipe roof advancing and excavation is usually occurred in a radial shape but as the study focused on trackbed, the evaluation included ground settlement only. Thus, appropriately-scaled model was selected considering domestic geological characteristics and operation characteristics of traditional and high-speed rail trains and the qualitative evaluation of displacement was carried out with a certain ground loss depending on excavation after categorizing trackbed settlement pattern depending on depth of top soil.

Computed Tomography Angiography Images of Coronary Artery Stenosis Provide a Better Prediction of Risk Than Traditional Risk Factors in Asymptomatic Individuals With Type 2 Diabetes: A Long-term Study of Clinical Outcomes

Lee, Kwan Yong,Hwang, Byung-Hee,Kim, Tae-Hoon,Kim, Chan Jun,Kim, Jin-Jin,Choo, Eun-Ho,Choi, Ik Jun,Choi, Young,Park, Ha-Wook,Koh, Yoon-Seok,Kim, Pum-Joon,Lee, Jong Min,Kim, Mi-Jeong,Jeon, Doo Soo,Cho, American Diabetes Association 2017 Diabetes Care Vol. No.

<P>OBJECTIVEWe investigated the efficacy of coronary computed tomography angiography (CCTA) in predicting the long-term risks in asymptomatic patients with type 2 diabetes and compared it with traditional risk factors.RESEARCH DESIGN AND METHODSWe analyzed 933 patients with asymptomatic type 2 diabetes who underwent CCTA. Stenosis was considered obstructive (50%) in each coronary artery segment using CCTA. The extent and severity scores for coronary artery disease (CAD) were evaluated. The primary end point was major adverse cardiovascular events (MACE), including all-cause mortality, nonfatal myocardial infarction, and late coronary revascularization during a mean follow-up period of 5.5 2.1 years.RESULTSNinety-four patients with MACE exhibited obstructive CAD with a greater extent and higher severity scores (P < 0.001 for all). After adjusting for confounding risk factors, obstructive CAD remained an independent predictor of MACE (hazard ratio 3.11 [95% CI 2.00-4.86]; P < 0.001]). The performance of a risk prediction model based on C-statistics was significantly improved (C-index 0.788 [95% CI 0.747-0.829]; P = 0.0349) upon the addition of a finding of obstructive CAD using CCTA to traditional risk factors, including age, male, hypertension, hyperlipidemia, smoking, estimated glomerular filtration rate, and HbA(1c). Both integrated discrimination improvement (IDI) and net reclassification improvement (NRI) analyses further supported this finding (IDI 0.046 [95% CI 0.020-0.072], P < 0.001, and NRI 0.55 [95% CI 0.343-0.757], P < 0.001). In contrast, the risk prediction power of the coronary artery calcium score remained unimproved (C-index 0.740, P = 0.547).CONCLUSIONSBased on our data, the addition of CCTA-detected obstructive CAD to models that include traditional risk factors improves the predictions of MACE in asymptomatic patients with type 2 diabetes.</P>