軟口蓋에 發生한 混合腫瘍의 1例

高敬煥 대한이비인후과학회 1970 대한이비인후과학회지 두경부외과학 Vol.13 No.4

活性슬럿지法에 의한 炭化水素 함유 廢水의 淨化

고정삼,김재하,강경수,고영환 濟州大學校工科大學附屬産業技術硏究所 1991 尖端技術硏究所論文集 Vol.2 No.-

Activated sludge process which has been widely applied to the treatment of waste-water was slightly modified to remove hydrocarbons from wastewater. The process of wastewater treatment consisted of two consecutive reactors. Cells of Acinetobacter calcoaceticus were first cultivated in synthetic wastewater containing 3%(W/V) of hydrocarbons. The resulting culture was then exposed to acclimatized active sludge. Hydrocarbon concentrations of the effluent from the process were 0.19-0.21%(W/V). The contents of suspended solid were reduced to 17-53 ㎎/l. The data imply that A.calcoaceticus can be used for the treatment of wastewater containing hydrocarbons.

활성슬럿지법에 의한 탄화수소 함유 폐수의 정화

고영환,강경수,김재하,고정삼 濟州大學校 工科大學 産業技術硏究所 1991 産業技術硏究報告 Vol.2 No.-

Activated sludge process which has been widely applied t o the treatment of waste-water was slightly modified to remove hydrocarbons from wastewater. The process of wastewater treatment consisted of two consecutive reactors. Cells of Acinetobacter calcoaceticus were first cultivated in synthetic wastewater containing 3% (W/V) of hydrocarbons. The resulting culture was then exposed to acclimatized active sludge. Hydrocarbon concentrations of the effluent from the process were 0.19-0.21% (W/V). The contents of suspended solid were reduced to 17-53 ㎎/l. The data imply that A. calcoaceticus can be used for the treatment of wastewater containing hydrocarbons.

문법과 담화

고경환(Koh, Kyung-Hwan) 미래영어영문학회 2007 영어영문학 Vol.12 No.1

SINGLE INJECTION OF PENTOBARBITAL INDUCES LONG-LASTING EFFECTS ON ANP SYNTHESIS AND GENE EXPRESSION IN THE RAT ATRIA

Seul, Kyung Hwan,Cho, Kyung woo,Kim, Suhn Hee,Hwang, Yun Ha,Park, Chung Ung,Koh, Gou Young 全北大學校 基礎科學硏究所 1994 基礎科學 Vol.16 No.-

To define the long-term effects of pentobarbital sodium on the plasma and atrial atrial natriuretic peptide (ANP) system, experiments were performed in female Sprague-Dawley rats. The plasma levels of immunoreactive (ir) ANP showed chronic as well as acute response to pentobarbital sodium administration. A single dose (30mg/kg, i.p.) of pentobarbital sodium resulted in s suppression in the plasma levels of irANP up to 1 week of administration. The suppressive effect on plasma irANP concentrations was dose-dependent. Right but not left atrial contents of irANP increased by an administration of pentobarbital sodium up to 4 weeks. ANP mRNA contents of the atria exposed to pentobarbital sodium began to increase after 2 days, reached to the peak after 2 weeks, and began to return to control values after 6 weeks. Surgical stress accentuated these patterns of plasma and atrial ANP responses to pentobarbital sodium treatment. The present data, therefore, suggest that even a single anesthetic dose of pentobarbital could elicit long-lasting profound changes in ANP system, i.e., changes in gene expression, synthesis and the secretion of ANP.

Nephron Heterogeneity of Renin Release in Rat Kidney Slices: Effects of L-Isoproterenol, Angiotensin II and TMB-8

Seul. Kyung-Hwan,Kim. Suhn-Hee,Koh. Gou-Young,Cho. Kyung-Woo 대한생리학회 1991 대한생리학회지 Vol.25 No.1

In order to determine possible relationships between the renin-angiotensin system and nephron heterogeneity, we compared the response of renin release and the angiotensin-converting enzyme (ACE) activity from different areas of the rat kidney. We used the renal cortical slices from the capsular surface to the juxtamedullary junction. Slices from outer one-third of the cortex were designated as outer cortical slices (OC), middle one-third as midcortical slices (MC), and inner one-third as inner cortical slices (IC). The renal renin content markedly decreased from OC and MC to IC. The basal lenin release was higher in OC than in MC or IC. On the contrary the percent change of renin release in response to L-isoproterenol was significantly higher in MC than in OC or IC. By TMB-8, the renin release in MC by 231±21% was higher than OC by 171±19% or IC by 162±19. Angiotensin II suppressed renin release in OC and MC by 68±2, 71±4% respectively, but only 40±7% in IC. The ACE activity was higher in IC than in OC, MC, medulla and papilla. The present data indicate that renin content and basal lenin release gradulally decreased from outer (OC) to inner (IC) cortex. The renin release in response to beta-adrenergic agonist, L-isoproterenol and intracellular calcium antagonist, TMB-8 were higher in MC than in OC and IC, but angiotensin II suppressed renin release less in IC than in OC and MC. It is suggested that juxtaglomerular cells of outer, mid-and inner cortices show a difference in renin release response to the stimuli.

진행성 바터팽대부 선암종에서 카페시타빈과 옥살리플라틴 병합요법의 효과

이정환 ( Jung Hwan Lee ),김경희 ( Kyung Hee Kim ),우상명 ( Sang Myung Woo ),박상재 ( Sang-jae Park ),한성식 ( Sung-sik Han ),홍은경 ( Eun Kyung Hong ),고영환 ( Young Hwan Koh ),이주희 ( Ju Hee Lee ),이우진 ( Woo Jin Lee ) 대한췌담도학회 2017 대한췌담도학회지 Vol.22 No.3

배경/목적: 바터팽대부에서 발생하는 선암종은 드문 질환으로 항암화학요법에 대한 연구가 부족하다. 본 연구에서 진행성 바터팽대부 선암종 환자에서 XELOX 병합요법의 효능 및 안전성을 분석하고자 한다. 방법: 2006년 10월부터 2014년 1월까지 국립암센터에서 XELOX 병합요법으로 치료한 바터팽대부 선암종 환자 28명을 대상으로 후향적으로 분석하였다. 모든 환자는 진단 당시 전이성 또는 재발한 바터팽대부 선암종 환자이었다. XELOX 병합요법은 외래에서 3주마다 다음과 같은 프로토콜에 따라 투여되었다. 치료 시작 1-14일에 하루 2회 카페시타빈 750mg/m²를 경구 투여하고, 1일에 옥살리플라틴 130 mg/m²을 정맥 주사하였다. 결과: 24.6개월(범위 4.8-78개월)의 중앙 추적관찰 기간에서 중앙 무진행 생존 기간은 4.8개월(범위 0.7-18.0개월)이었고, 중앙 생존 기간은 11.9개월(범위 2.0-26.1개월)이었다. 1명의 환자(4%)가 완전 관해를 얻었고, 5명의 환자(18%)는 부분 관해를 보였다. 무진행 생존 기간와 전체 생존 기간에서 항암화학요법 반응 여부에 따른 차이는 없었다. 환자에서 가장 흔한 3등급의 이상 반응은 메스꺼움과 구토였다(10.7%). 치료와 관련된 사망은 관찰되지 않았다. 결론: XELOX 요법은 전이 혹은 재발 바터팽대부 선암종에서 비교적 낮은 독성의 발현과 중등도 효과를 보이는 치료법이다. Background/Aim: Adenocarcinoma arising from the ampulla of Vater is a rare disease and has limited data regarding outcome of palliative chemotherapy. We investigated the efficacy and safety of capecitabine plus oxaliplatin (XELOX) in patients with advanced ampullary adenocarcinoma. Methods: From October 2006 to January 2014, we retrospectively analyzed 28 patients with advanced ampullary adenocarcinoma treated by XELOX regimen at single institution. All the patients had histologically confirmed stage IV or recurrent ampullary adenocarcinoma. XELOX was administered in outpatient clinic every 3 weeks according to the following protocol: oral administration of capecitabine 750 mg/m² twice a day on days 1-14 and intravenous injection of oxaliplatin 130 mg/m² on day 1. Results: With follow-up of median 24.6 months (range 4.0-78.0 months), median progression-free survival (PFS) was 4.8 months (range 0.7-26.1 months), and median overall survival (OS) was 11.9 months (range 2.0-36.0 months). One patient (4%) achieved complete response and 5 patients (18%) showed partial response. There were no significant differences for PFS and OS according to response by chemotherapy. The most common grade 3 adverse events in patients were nausea and vomiting (10.7%). There was no treatment-related mortality. Conclusions: XELOX regimen is well tolerated and show moderate activity against advanced ampullary adenocarcinoma.

Acinetobacter calcoaceticus에 의한 유지와 탄화수소의 분해

고정삼,고영환,김권수,양상호,강경수 한국산업미생물학회 1992 한국미생물·생명공학회지 Vol.20 No.4

유지와 탄화수소를 탄소원으로 하여 Acinetobacter calcoaceticus를 배양하여 탄소원의 분해와 균체의 생육정도를 측정하고 활성오니법을 이용한 폐수정화에 이 균주의 이용가능성을 검토하였다. 실험에 사용된 모든 유지와 탄화수소가 분해되었다. 삼각플라스크에 의한 진탕배양의 경우 분해율은 어유가 26%로 식물성 유지의 40∼54%에 비하여 분해율이 낮게 나타났다. 포화지방산은 어유 중에는 약 55%, 식물성유지 중에는 6∼12% 각각 함유되어 있었다. Hexadecane의 분해율은 약 60%로 식물성유지에 비하여 높게 나타났다. 탄소원의 분해에 따라 균체량의 증가가 관찰되었고, jar fermentor 배양에 의하면 모든 탄소원이 80% 이상 분해되었고 균체수율도 1.00% 내외로 개선되었다. 배양조건에 따라 탄소원의 분해율에 영향을 받는다고 볼 수 있으며, 이는 초기 기질농도가 기질 분해율에 영향을 준 결과에서도 증명되었다. 유지 또는 탄화수소를 3% 함유한 인공폐수를 A. calcoaceticus로 우선 분해시키고, 그 분해산물을 활성오니법에 의하여 정화를 시도한 결과 탄소원의 농도는 0.06% 이하로, 부유물질농도는 53㎎/㎖ 이하로 각각 저하되어 이 균주를 폐수정화에 이용할 수 있음을 시사하였다. A bacterial strain Acinetobacter calcoaceticus was examined for its ability to degrade fats, oils and hydrocarbons, and tested for the possibility of application in wastewater treatment. All fats and oils tested were degraded by the strain. About 60% of hexadecane, 26% of fish oil, and 40∼54% of vegetable oils were consumed respectively in shaking-flask culture. Saturated fatty acid compositions were about 55% in fish oil and 6∼12% in vegetable oils. Increases in cell mass were accompanied with decreases in the concentrations of carbon sources. When jar fermentor in place of shaking-flask was used as a culturing vessel, above 80% of all carbon sources was consumed and yield of cell mass was improved to nearly 1.00. Synthetic wastewaters containing 3% of fat, oil, or hydrocarbon as a sole carbon source were treated sequentially with A. calcoaceticus first and then exposed to activated sludge. The concentrations of carbon sources were decreased below 0.06% through the process, and the concentrations of suspended solids were lower than 53 ㎎/㎖. The data imply the potential use of A. calcoaceticus in wastewater treatment.

實驗的 肝吸?症 家兎에 對한 Niclofolan 誘導體의 治療效果 및 毒性

高敬煥,金鍾石 慶北大學校 醫科大學 1976 慶北醫大雜誌 Vol.17 No.1

Amphiphilic polymer electrolytes consisting of PVC-g-POEM comb-like copolymer and LiCF₃SO₃

Koh, Joo Hwan,Lee, Kyung Ju,Seo, Jin Ah,Kim, Jong Hak Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of polymer science. Part B, Polymer physic Vol.47 No.15

<P>An amphiphilic comb-like copolymer consisting of a poly(vinyl chloride) (PVC) backbone and poly((oxyethylene)<SUB>9</SUB> methacrylate) (POEM) side chains, PVC-graft-POEM was synthesized via atom transfer radical polymerization. This comb copolymer was complexed with LiCF<SUB>3</SUB>SO<SUB>3</SUB> to form a solid polymer electrolyte. FTIR and FT-Raman spectroscopy indicate that lithium salts are dissolved in the ion conducting POEM domains of microphase-separated graft copolymer up to 10 wt % of salt concentration. Microphase-separated structure of the materials and the selective interaction of lithium ions with POEM domains were revealed by transmission electron microscopy, wide angle X-ray scattering, and differential scanning calorimetry. The maximum ionic conductivity of 4.4 × 10<SUP>−5</SUP> S/cm at room temperature was achieved at 10 wt % of salt concentration, above which salts are present as less mobile species such as ion pairs and higher order ionic aggregates, as characterized by FT-Raman spectroscopy. © 2009 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 47: 1443–1451, 2009</P>