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- 저자 : Kisoo Kim (검색결과 193 건)
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MgO nano-facet embedded silver-based dielectric/metal/dielectric transparent electrode.
Kim, Sungjun,Yu, Hak Ki,Hong, Kihyon,Kim, Kisoo,Son, Jun Ho,Lee, Illhwan,Kim, Kyoung-Bo,Kim, Tae-Yeob,Lee, Jong-Lam Optical Society of America 2012 Optics express Vol.20 No.2
<P>We replace Indium Tin Oxide (ITO) with an MgO nano-facet Embedded WO(3)/Ag/WO(3)(WAW) multilayer for electrodes of high efficiency OLEDs. WAW shows higher values for transmittance (93%) and conductivity (1.310(5) S/cm) than those of ITO. Moreover, WAW shows higher transmittance (92.5%) than that of ITO (86.4%) in the blue region (<500 nm). However, due to the large difference in refractive indices (n) of glass (n=1.55) and WO(3) (n=1.95), the incident light has a small critical angle (52). Thus, the generated light is confined by the glass/WAW interface, resulting in low light outcoupling efficiency (~20%). This can be enhanced by using a nano-facet structured MgO (n=1.73) layer and a ZrO(2) (n=1.84) layer as a graded index layer. Using these optimized electrodes, ITO-free, OLEDs with various emission wavelengths have been produced. The luminance of OLEDs using MgO/ZrO(2)/WAW layers is enhanced by 24% compared to that of devices with ITO.</P>
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Han, Rafael T.,Kim, Young-Beom,Park, Eui-Ho,Kim, Jin Yong,Ryu, Changhyeon,Kim, Hye Y.,Lee, JaeHee,Pahk, Kisoo,Shanyu, Cui,Kim, Hyun,Back, Seung K.,Kim, Hee J.,Kim, Yang In,Na, Heung S. Frontiers Media S.A. 2018 Frontiers in molecular neuroscience Vol.11 No.-
<P>Isolation stress is a major risk factor for neuropsychiatric disorders such as depressive and anxiety disorders. However, the molecular mechanisms underlying isolation-induced neuropsychiatric disorders remain elusive. In the present study, we investigated the subcellular mechanisms by which long-term isolation elicits depression and anxiety-related behaviors in mice. First, we found that long-term isolation induced depression-related behaviors in the forced swimming test (FST) and the sucrose preference test, as well as anxiety-related behaviors in the elevated zero maze test (EZMT) and the open field test. Next, we showed that intracentral amygdala (CeA) injection of oxytocin (OXT), but not intracerebroventricular injection, attenuated isolation-induced depression and anxiety-related behaviors via oxytocin receptor (OXTR), not vasopressin-1a receptor (V1aR), in the FST and EZMT, respectively. Quantitative real-time polymerase chain reaction analysis revealed that after 5 weeks of isolation, mRNA transcription of OXTR in the CeA, but not that of V1aR, significantly decreased, whereas OXT and vasopressin mRNA transcription in the paraventricular nucleus of hypothalamus did not change significantly. Whole-cell patch clamping of acute brain slices demonstrated that the frequency of miniature inhibitory postsynaptic currents (mIPSCs) in CeA neurons, but not their amplitude, was lower in isolated mice than in group-housed mice. Notably, OXT treatment increased the mIPSC frequency in the CeA neurons, but to a lesser extent in the case of isolated mice than in that of group-housed mice via OXTR. Taken together, our findings suggest that long-term isolation down-regulates OXTR mRNA transcription and diminishes OXT-induced inhibitory synaptic transmission in the CeA and may contribute to the development of depression and anxiety-related behaviors in isolated mice through the enhancement of CeA activity.</P>
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Kim, Sungjun,Hong, Kihyon,Kim, Kisoo,Lee, Illhwan,Lee, Jong-Lam The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.5
<P>We investigated phase-controllable copper oxide (CuO<SUB><I>x</I></SUB>) as a hole injection layer for improving the electrical and optical properties of organic light emitting diodes (OLEDs). The phase of CuO<SUB><I>x</I></SUB> is changed from CuO to Cu<SUB>2</SUB>O by elevating the deposition rate during thermal evaporation, and a non-stoichiometric film mixing with two phases occurs in the intermediate condition. In non-stoichiometric films, unbonded oxygen atoms with a large density of gap states are induced near the Fermi level, acting as a hole transport path. Thus, holes can be more easily injected into the highest occupied molecular orbital states of α-NPD, lowering the hole injection barrier significantly. Films of non-stoichiometric CuO<SUB><I>x</I></SUB> are inserted at the interface of α-NPD with an Ag electrode, serving as the hole injection layer. Significantly improved current densities and luminance were achieved, reducing the operation voltage at 1 mA cm<SUP>−2</SUP> from 6.1 V to 3.2 V.</P> <P>Graphic Abstract</P><P>The effect of phase-controllable CuO<SUB><I>x</I></SUB> on formation of gap-states and hole injection efficiency of OLEDs is investigated. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1jm14218f'> </P>
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Electroporation for nanomedicine: a review
Kim, Kisoo,Lee, Won Gu The Royal Society of Chemistry 2017 Journal of Materials Chemistry B Vol.5 No.15
<P>Nanoparticles have shown great promise in the development of efficient drug delivery systems, early diagnosis, and high-resolution imaging of hard-to-find diseases, such as early-stage malignant cancer and very rare circulating tumor cells, for pharmaceutical and medical applications. Recently, nanoparticles have been used as intracellular carriers of nano-drugs into targeted cells to release a slowly diffusing drug in the vicinity of the target disease. Several methods such as chemical reagent-based uptake, mechanical bombardment, direct injection, and electroporation have been developed to deliver nanoparticles into cells in a controlled manner. Unlike other methods, electroporation has continued to have great success with respect to the uptake efficiency, post-viability of cells, and high-throughput yield rate for numerous cell applications in association with nanoparticles. In this review, we present recent advances in the delivery of nanoparticles as intracellular carriers by electroporation (NICE) and highlight the salient features of NICE delivery at a multiscale level. We furthermore discuss the current challenges and future perspectives of NICE delivery for clinical applications.</P>
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Calibration of on-chip cell electroporation by a pseudo-volumetric uptake model
Kim, Kisoo,Lee, Won Gu Elsevier 2017 Micron Vol.99 No.-
<P>Most conventional methods for assessing uptake of exogenous molecules and nanomaterials into cells use the projected two-dimensional (2D) area of uptake intensity into individual cells. However, since most cells have a three-dimensional (3D) spherical shape, volumetric uptake cannot be quantified accurately using 2D area analysis. Here, we present a method for calibrating the electroporative uptake intensity of small molecules by using a novel predictable spherical volume (PSV) model, which is more accurate and quantitative than previous methods. As a proof-of-concept, we visualized the electroporative uptake of propidium iodide (PI) into mammalian cells in a single rectangular polydimethylsiloxane (PDMS) microfluidic channel, often used for direct observation of on-chip cell electroporation. Our PSV method yielded more accurate results than conventional methods and faithfully reflected volumetric changes in uptake intensity, even those due to microflow. We believe that this approach can be potentially beneficial for screening the electroporative uptake efficiency of cell-membrane impermeable nanodrugs, such as functional nanoparticles incorporated with a small drug capable of slowly diffusing inside cells.</P>
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Kisoo Park,Kyung Hyun Kim,Yangsoo Kim,Yongho Kim 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.10
We have performed quantum mechanical calculations to study the geometries and binding energies of biologically important, cyclic hydrogen-bonded complexes, such as formic acid + H_2O, formamidine + H_2O,formamide + H_2O, formic acid dimer, formamidine dimer, formamide dimer, formic acid + formamide, formic acid + formamidine, formamide + formamidine, and barrier heights for the double proton transfer in these complexes. Various ab initio, density functional theory, multilevel methods have been used. Geometries and energies depend very much on the level of theory. In particular, the transition state symmetry of the proton transfer in formamidine dimer varies greatly depending on the level of theory, so very high level of theory must be used to get any reasonable results.
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Kisoo Park,Yeontae Kim,Heemun Park,Yeonwoo Choi,Taewoo Kim 한국도로학회 2018 한국도로학회 학술대회 발표논문 초록집 Vol.2018 No.05
Recently, road cave-in and depression in urban area due to subsurface cavity are emerging as a social issue in Korea. These phenomena enable to cause not only damage to human lives and properties, but also an anxiety of the citizens. Furthermore, it is a problem that needs more fundamental solution to countermeasure. The objective of this study is to evaluate the stiffness characteristics of asphalt pavement with existence of subsurface cavity using Falling Weight Deflectometer (FWD) deflection and backcalculation analysis using GAPAVE program developed the KICT. The characteristics of FWD deflections are analysed for cavity and intact asphalt pavements. The stiffness reduction in the asphalt pavement due to subsurface cavity was evaluated as a result of this FWD test. The Seoul Metropolitan Government has conducted a Ground Penetrating Radar (GPR) test, coring, and image photographing in four different locations to determine the presence of the cavity and figure out the cavity depth and size underneath asphalt pavements. The cavity depths measured in this section range between 17cm to 51cm, and its lengths are at least 70cm to up to 310cm. It is found from this analysis that the deflections measured from cavity section are generally higher than intact section in same locations. As results of backcalculation analysis, it appears that the backcalculated moduli are generally decreasing with increase of cavity depth. After comparing with AC moduli obtained from intact and cavity section, it is observed that about 80% of moduli was reduced with existence of subsurface.
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Kim, Kisoo,Han, Dong Yeol,Chang, Kyuho,Lee, Won Gu Korean Society for Precision Engineering 2018 International Journal of Precision Engineering and Vol.19 No.3
In this study, we present a design methodology that enables the automation of cell culture using a fluidic bioreactor module in a uniform, massively parallel fashion. To demonstrate our proof-of-concept validation, we designed the channel lengths that can uniformly distribute the fluid from one inlet to two to the power of n outlets. In our experiments, the module was composed of four layers which can hold eight petri dishes on each layer. The channel outlets were connected to the petri dishes, respectively. Cells and media were distributed into each petri dish by compensating the channel lengths with different potential energy of each layer in a controlled manner. The results show that the module was well-designed for the parallel supply of medium in automatic cell culture. Overall, the process can be automated by controlling the on/off events temporally, such as injecting a new cell media and removing the waste.
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