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- 저자 : Jingwen Pan (검색결과 4 건)
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Wear Behavior of P/M High Nb Containing γ-TiAl Alloy in Different Environments
Jingwen Qiu,Zhengfan Fu,Bin Liu,Yong Liu,Jianhui Yan,Di Pan,Weidong Zhang 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.6
The wear behavior of Ti–45Al–7Nb–0.3W (at%) alloy prepared by powder metallurgy (P/M) has been investigated using pinon-disk wear tests at the room temperature. The dry sliding wear tests were performed against on a zirconia disk in differentenvironments, viz, argon, hydrogen in nitrogen mixture, air and oxygen. The worn surfaces of Ti–45Al–7Nb–0.3W pins andwear debris were examined by scanning electron microscope, X-ray diffractometer and X-ray photoelectron spectroscopy. It was found that the high Nb containing Ti–45Al–7Nb–0.3W alloy didn’t exhibit better wear resistance in the presence ofoxygen than commercial γ-TiAl (Ti–47Al–2Nb–2Cr–0.2W) alloy. The oxidation on the worn surface and spalling of oxidescaused by the mechanical force during sliding were the main reason for the high wear losses in the air and oxygen. Thezirconia disk underwent a phase transformation caused by the high contact temperature and stress during the sliding tests. The abrasive particles produced in the wear tests largely consisted of the zirconia particles in different environments, exceptin the pure oxygen. The hard zirconia debris was embedded into the friction layer on the worn surfaces of TiAl pins, whichprovided protection against wear to some extent. The main wear mechanisms of Ti–45Al–7Nb–0.3W alloy were abrasivewear of two-body and three-body, some delamination and plastic deformation.
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Optimization of long span portal frames using spatially distributed surrogates
Zhifang Zhang,Jingwen Pan,Jiyang Fu,Hemant Kumar Singh,Yong-Lin Pi,Jiurong Wu,Rui Rao 국제구조공학회 2017 Steel and Composite Structures, An International J Vol.24 No.2
This paper presents optimization of a long-span portal steel frame under dynamic wind loads using a surrogate-assisted evolutionary algorithm. Long-span portal steel frames are often used in low-rise industrial and commercial buildings. The structure needs be able to resist the wind loads, and at the same time it should be as light as possible in order to be cost-effective. In this work, numerical model of a portal steel frame is constructed using structural analysis program (SAP2000), with the web-heights at five locations of I-sections of the columns and rafters as the decision variables. In order to evaluate the performance of a given design under dynamic wind loading, the equivalent static wind load (ESWL) is obtained from a database of wind pressures measured in wind tunnel tests. A modified formulation of the problem compared to the one available in the literature is also presented, considering additional design constraints for practicality. Evolutionary algorithms (EA) are often used to solve such non-linear, black-box problems, but when each design evaluation is computationally expensive (e.g., in this case a SAP2000 simulation), the time taken for optimization using EAs becomes untenable. To overcome this challenge, we employ a surrogate-assisted evolutionary algorithm (SAEA) to expedite the convergence towards the optimum design. The presented SAEA uses multiple spatially distributed surrogate models to approximate the simulations more accurately in lieu of commonly used single global surrogate models. Through rigorous numerical experiments, improvements in results and time savings obtained using SAEA over EA are demonstrated.
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Qiaoqing Xu,Jin Wan,Tingshuang Pan,Jingwen Zhou,Kete Ai,Daiqin Yang 한국유전학회 2015 Genes & Genomics Vol.37 No.5
Interferon regulatory factors (IRFs) play a vital role in the innate and adaptive immune system. The Asian swamp eel (Monopterus albus) is one of the most economically important freshwater fishes in China. Immunological data on the species are scare. In the present study, the expression pattern of six types of interferon regulatory factor (IRF) was studied in the Asian swamp eel. Six IRFs except IRF4 were shown to be constitutively expressed in all tissues examined. Their transcription was significantly higher in lymphoid tissues, such as intestine, skin and spleen. Furthermore, IRF1 and IRF5 was also respectively expressed at a high level in the heart and brain. However, the transcript level of IRF4 was low even undetected in most tissues. After polyinosinic- polycytidylic acid (poly I:C) treatment, the transcript levels of IRF1 and IRF4 increased, while those of IRF5 and IRF7 decreased at some time points. However, IRF2 and IRF10 did not respond to the poly I:C challenge. In addition, infection with bacterial pathogen Aermonas hydrophila and an acanthocephalan could upregulate the IRFs’ expression. The results suggested that IRFs are related to the immune response to viral, bacterial and parasitic infection in Asian swamp eel, which will help to clarify the biological function of IRFs in the immune system.
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A self-assembly and stimuli-responsive fusion gelonin delivery system for tumor treatment
Quan Liu,Lu Zhang,Xiuru Ji,Meong Cheol Shin,Shuping Xie,Baoyan Pan,Fei Yu,Jingwen Zhao,Victor C. Yang 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.89 No.-
Ribosome-inactivating proteins (RIPs) are potent protein toxins for cancer therapy, and they have strongability to inhibit protein synthesis and induce cell death via inactivation of ribosomes in eukaryotic cells. However, the delivery of RIPs has been a challenging task due to their large molecular weight and lack oftargeting property. Low molecular weight protamine (LMWP), a transmembrane peptide, has beenproved to effectively promote transmembrane transportation, whereas the enzyme-activatable systemcan enhance the specificity by enhancing the tumor drug concentration through enzymatic reaction. Weherein constructed a self-assembly and stimuli-responsive fusion gelonin delivery system. Gelonin, atypical RIP protein, was assembled with nickel ferrite nanoparticles by self-assembling between hexa-histidine tag (His-tagged) and nickel ions. Both in vitro and in vivo results indicated that the magneticnanoparticle carriers and the applied linkers did not damage the pharmaceutical effect of gelonin, andthe whole drug delivery system showed good biocompatibility, sensitive selectivity, and significantlyenhanced cytotoxic activity. This in turn presented theranostic nanoparticles as efficient delivery vehiclefor clinical use.
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