뇌경색후 우울증에서 Homocysteine, Vitamin B12 및 Folate 혈청 농도와 관계

문지수,김광수,유봉구,김종국,김민정 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.1

Background and purpose : Poststroke depression is common and linked to poor prognosis and higher mortality after stroke. Previous studies suggest that high level of serum homocysteine and low levels of vitamin B12 and folate may cause depression. However previous studies has showed large variation concerning the influencing factors of poststroke depression. The purpose of this study was to evaluated the factor that influencing the poststroke depression including serum levels of homocysteine, vitamin B12 and folate. Methods : Beck depression inventory (BDI) was obtained in 62 patients with cerebral infarction, and the patients were divided into non-depression group (BDI ≤ 13) and depression group (BDI ? 14) according to their BDI scores. Then, we compared serum homocysteine, vitamin B12, folate, age, sex, Barthel index, Scandinavian stroke scale, acute aphasia screening protocol, Korean version of mini-mental state examination and ischemic brain lesion between NDG and DG. And also calculate the correlations between serum homocysteine, vitamin B12 and folate with severity of poststroke depression. Results : The NDG were 41 patients (66.1%) and DG were 21 patients (33.9%). Serum homocysteine, vitamine B12 and folate were not different between the groups, and these levels were not correlated with the severity of BDI. The age, sex, BI, SSS, AASP, K-MMSE and location of ischemic stroke were not different between the groups. Conclusion : Frequency of poststroke depression were high in patients with acute ischemic stroke. In contrast with previous studies, poststroke depression was not influenced by the serum levels of homocysteine, vitamin B12 and folate. And poststroke depression was not influenced by age, sex, physical handicap after stroke, aphasia, cognitive function and location of ischemic stroke.

직렬통신과 Visual Basic을 이용한 Home Automation System

지준근,이광수 순천향대학교 부설 산업기술연구소 2002 순천향 산업기술연구소논문집 Vol.8 No.1

In this paper, hardware and control program for home automation system are developed. 9051 microcontroller is used in the hardware part. Multiple communication algorithm among plants is most important in the control program. Also image transfer method using USB port of IBM PC is used in this system. The DLL program needed for image transer is programmed by C++ and the entire control program is programmed by Visual Basic. Hardware part of the system is composed of multiple drivers according to each plant and some drivers have 8051 microcontroller for multiple communication. Data flow among plants is displayed on monitor of PC and transferred by serial communication with PC.

도시확장 분석을 위한 위성영상 토지이용 분류기준 설정에 관한 연구

김윤수,이광재,류지원,김정환 한국지리정보학회 2003 한국지리정보학회지 Vol.6 No.3

위성영상 자료는 도시의 물리적 확장을 분석하는데 있어 매우 유용하게 활용된다. 도시의 물리적 확장은 도시의 토지이용과 밀접하게 관련되어 있으며, 지속가능한 도시성장을 위해서는 토지이용을 중심으로 한 지속적인 성장관리가 필수적이다. 그러나 위성영상을 이용한 도시 토지이용의 분류는 우선 그 기준이 사용자의 관점에 따라 다르고 영상 해상도 등에 따라서도 그 기준이 달라질 수 있다. 따라서 도시 확장 분석을 위해서는 다중시기의 위성영상 및 항공사진을 이용하여 토지이용의 분류를 시행하고, 시기별 토지이용의 변화와 영상을 분석함으로써 확장의 형태와 패턴을 파악하여, 이를 기반으로 향후의 도사 확장을 예측할 수 있는 모델 개발이 가능해진다. 그러므로 본 연구에서는 도시 확장 예측 모델 개발의 전 단계로써 다양한 공간 해상도를 지닌 원격탐사 자료의 국내외 분류기준의 검토를 통해, 원격탐사 자료를 이용한 토지이용 분류기준을 도시확장 분석의 측면에서 설정하고자 한다. All the urban planning process require land use informations, which should be obtained after through intensive investigation and accurate analysis about the past and current situations and conditions of a city. Until now, the generation of land use informations form remotely sensed imagery has had many limitation because of its spatial resolution. It is now expected that the availability of high resolution satellite imagery whose spatial resolution less than 10m will reduce these limitations. For the purpose of urban growth monitoring we must first establish a urban land use classification nomenclature. In this study, we would like to establish a land use nomenclature for land use classification using remotely sensed data, especially using KOMPSAT EOC imagery.

전립선 기질세포의 증식과 COX-2 발현에 대한 프로게스테론의 영향

정수련,김성한,최이화,박지은,전은미,강영진,이광윤,최형철 영남대학교 의과대학 2006 Yeungnam University Journal of Medicine Vol.23 No.1

전립선비대증은 노인 남성에서 흔히 유발되는 질환이며, 노화가 진행될 수록 빈도가 높아지는 특징을 가진다. 이 질환의 원인은 전립선기질세표의 과도한 증식으로 유발된다고 알려져 있지만 그 자세한 기전에 대해서는 잘 알려져 있지 않다. 전립선비대증에서 progesterone 수용체 양성 세포가 다른 전립선 종양에 비해서 많고, progesterone은 testosterone에서 DHT로 전환되는 것을 감소시키는 역할을 가진다고 알려졋다. 또한 남성 전립선 평활근의 과증식에 의한 질환이므로 평활근 세포의 증식과 관련성이 있다고 보고된 COX-2의 전립선비대증에 대한 영향에 대한 연구가 필요하다. 전립선 기질세포에 progesterone을 3일간 투여하여 배양한 경우 기질세포 증식은 차이가 없었다. Progesterone을 단독 또는 DHT와 같이 투여한 기질세포에서 남성호르몬 수용체 mRNA 발현은 비처리군과 비교하여 유의한 차이가 없었다. 또한 progesterone과 DHT 동시 투여에 의한 COX-2 mRNA 발현에도 차이가 없었다. 그러나 progesterone에 의한 남성 호르몬 수용체와 COX-2 단백 발현에서는 대조군과 비교하여 유의하게 감소시켰다. 이상의 결과는 progesterone은 남성호르몬 수용체에 대해 전사 후 반응 (post-transcriptional response)에 효과를 나타내어 남성호르몬 수용체 발현을 감소시키는 작용은 가지며, COX-2 발현 억제효과를 나타내므로 전립선비대증의 치료에 이용될 수 있을 것으로 사료된다. Background: Benign prostatic hyperplasia (BPH) is the most common benign tumor in older men; the etiology of this disease remains poorly understood. Testosterone and dihydrotestosterone (DHT) both act as androgen via a single androgen receptor. Testosterone is converted to DHT by 5α-reductase in prostatic stromal cells. Progesterone has been reported to inhibit DHT conversion; howevwe, its effect on prostatic stromal cells remains to be elucidated. Materials and Methods: In this experiment, we investigated the effect of progesterone on androgen receptor expression induced by DHT. We also tested the effect of progesterone on cyclooxygenase-2 (COX-2) expression, as well as prostate stromal cell proliferation using the cell count kit-8. Results: Progesterone did not cause an increase of prostate stromal cell proliferation. The mRNA expression of the androgen receptor and COX-2 were not changed by progesterone; the expressions of androgen receptor and COX-2 proteins were decreased by progesterone in prostate stromal cells. Conclusion: These results suggest that in prostate stromal cells, progesterone decreases androgen receptor protein expression, which results in decrement of COX-2 protein expression. This effect might be mediated by post-transcriptional regulation.

회귀분석 결과의 비교 연구

柳志喆,金光洙 忠州大學校 1993 한국교통대학교 논문집 Vol.28 No.-

This study attempts to present the linear regression analysis that involves more than one regressor variable, because regression analysis is the most widely used as statistical technique for describing, predictiong and estimating the relationships between given data. The model of multiple linear regression may be solved directly by the two linear programming methods, i.e., to minimize the sum of the absolute deviation(MSD) and to minimize the maximum deviation(MMD). In addition, some results was compared to each techniques for accuracy and tested to the validity of statistical meaning.

로버스트 회귀모형화 및 최소자승법과 역전파 신경망과의 성능비교

柳志喆,金光洙 忠州大學校 1997 한국교통대학교 논문집 Vol.32 No.1

Recently, neural network models have been employed as an alternative to regression analysis for point estimation or function fitting in various fields projected in the operations research domain as an alternative to optimization techniques. Especially backpropagation neural network is currently the most widely applied network architecture. This popularity primarily reflects the ability of backpropagation networks to learn complicated multidimensional mapping. One way to look at this ability is that, in the words of Werbos backpropagation goes "Beyond Regression". In this study, through the computer simulation, the performance of the three major function fitting techniques is evaluated such as regression analysis(LSM), robust regression analysis(MSR) and backpropagation neural network model. For the simulation of robust regression analysis, the quantitative systems for business plus software was used. Backpropagation algorithm was developed using C++. The study conclusions show that at the point of performance MSR held the best result, because MSR performs best in the 3 cases among the tested 4 cases.

다발성 말초신경병증으로 발현한 Churg-Strauss 증후군 1예

이지현,김종국,유봉구,김민정,김광수 KOSIN UNIVERSITY COLLEGE OF MEDICINE 2006 高神大學校 醫學部 論文集 Vol.21 No.1

Churg-Strauss syndrome (CSS) is defined by eosinophil-rich and granulomatous inflammation of the respiratory tract and necrotizing vasculitis affecting small to medium-sized vessels, associated with asthma and eosinophilia. It is strongly associated with antineutrophil cytoplasmic antibodies, especially the anti-myeloperoxidase type (p-antineutrophil cytoplasmic antibodies) are most often found in CSS. Neurologic involvement is common and may develops early in patients with CSS, usually manifestings as peripheral neuropathy especially mononeuritis multiplex. We report a 58-year-old woman of Churg-Strauss syndrome presented with distal asymmetric polyneuroapthy, which has been reported rarely.

食欌山의 高等菌類相

방지영,신광수 대전대학교 이과대학 기초과학연구소 1997 自然科學 Vol.- No.-

국내 자연생태조사의 일환으로 1997년부터 8월까지 식장산을 대상으로 하여 고등균류의 분포상을 조사하였다. 채집, 동정된 고등균류는 담자균류가 6목 18과 33속 52종이었고, 자낭균류가 3목3과 6속8종으로 도합 9목21과 39속60종이었다. 우점종은 덧부치버섯(A. lycoperdoides)과 먼지버섯(A. hygrometricus)으로 조사대상 전 지역에 걸쳐 높은 빈도로 채집되었다. 또한, 국내에서 처음 발견된 미기록종은 4종이 채집되었는데 각각 바늘국수버섯(C. acuta), 에매미눈꽃동충하초(I. sinclairii), 박뉘나방유충동충하초(C. hepiallidicola), 하늘소유충동충하초(C. nakawawai)로 동정되었다. The flora of higher fungi in Mt. Shkjmg was investigated during the penod of July to August 1997. The fleshy fungi growing in the area were collected and identified into 9 order;, 21 families, 39 genera, and 60 species including 52 species of Basidiomycota and 8 species of Ascomycota. Asterophora lycoperdoides and Astraeus hygrometricus were commonly found throughout the survey area. Four species, Clavaria acuta, Isaria sinclairii, Cordyceps hepididicola, and Cordyceps nakawawai were recognized as unrecorded species to Korea.

아케이드형 재래시장의 동계 실내환경 실태조사 연구

서혜수,김광호,김태연,노지웅,김병선 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

The arcades have been introduced for improving the environment of conventional markets, but thermal discomfort, poor IAQ and fire safety problems were occurred in same arcades because designers do not have proper design guideline for the arcades. The purpose of this study was to compare with two arcades on indoor environment and find design elements that cause for built environment problems. To find the design elements which influence on the environment of the arcade, the field measurements in the arcades were conducted, including temperature, humidity, air velocity, CO/CO2, etc. The indoor environment of the arcade was greatly influenced by the volume of arcade and the ventilation opening.

한국판 MMSE를 이용한 간질 환자의 인지기능 평가

민지원,유봉구,김광수,유경무 고신대학교 의학부 2003 高神大學校 醫學部 論文集 Vol.18 No.1

Background & Purpose : Patients with complex partial seizure have impaired cognitive performance. The aim of this study was to evaluate the cognitive function of patients with epilepsy using Korean version of Mini-Mental State Examination (K-MMSE). Methods : We measured the K-MMSE in 23 patients with complex partial seizure and 22 normal controls. Frequency matching was done about age, sex and residence between the two groups. The evaluation of cognitive function was assessed with K-MMSE. Results : Compared with controls, patients with epilepsy showed significantly lower in total score of K-MMSE and attention-calculation item(P=0.008, P=0.014). There were no differences in the score of other items of K-MMSE between the two groups. Conclusions : These results showed that epileptic patients have impaired cognitive function, especially in attention-calculation performance.