Development of the Korea-Polyenvironmental Risk Score for Psychosis

Jeon Eun-Jin,Kang Shi-Hyun,Yan-Hong Piao,Kim Sung-Wan,Kim Jung-Jin,Lee Bong-Ju,Yu Je-Chun,Lee Kyu-Young,Won Seunghee,Lee Seung-Hwan,Kim Seung-Hyun,Kim Eui-Tae,Clara Tammy Kim,Dominic Oliver,Paolo Fusa 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.3

Objective Comprehensive understanding of polyenvironmental risk factors for the development of psychosis is important. Based on a review of related evidence, we developed the Korea Polyenvironmental Risk Score (K-PERS) for psychosis. We investigated whether the K-PERS can differentiate patients with schizophrenia spectrum disorders (SSDs) from healthy controls (HCs).Methods We reviewed existing tools for measuring polyenvironmental risk factors for psychosis, including the Maudsley Environmental Risk Score (ERS), polyenviromic risk score (PERS), and Psychosis Polyrisk Score (PPS). Using odds ratios and relative risks for Western studies and the “population proportion” (PP) of risk factors for Korean data, we developed the K-PERS, and compared the scores thereon between patients with SSDs and HCs. In addition, correlation was performed between the K-PERS and Positive and Negative Syndrome Scale (PANSS).Results We first constructed the “K-PERS-I,” comprising five factors based on the PPS, and then the “K-PERS-II” comprising six factors based on the ERS. The instruments accurately predicted participants’ status (case vs. control). In addition, the K-PERS-I and -II scores exhibited significant negative correlations with the negative symptom factor score of the PANSS.Conclusion The K-PERS is the first comprehensive tool developed based on PP data obtained from Korean studies that measures polyenvironmental risk factors for psychosis. Using pilot data, the K-PERS predicted patient status (SSD vs. HC). Further research is warranted to examine the relationship of K-PERS scores with clinical outcomes of psychosis and schizophrenia.

Mobile Computed Tomography : Three Year Clinical Experience in Korea

Jeon, Jin Sue,Lee, Sang Hyung,Son, Young-Je,Yang, Hee-Jin,Chung, Young Seob,Jung, Hee-Won The Korean Neurosurgical Society 2013 Journal of Korean neurosurgical society Vol.53 No.1

Objective : Obtaining real-time image is essential for neurosurgeons to minimize invasion of normal brain tissue and to prompt diagnosis of intracranial event. The aim of this study was to report our three-year experience with a mobile computed tomography (mCT) for intraoperative and bedside scanning. Methods : A total of 357 mCT (297 patients) scans from January 2009 to December 2011 in single institution were reviewed. After excluding postoperative routine follow-up, 202 mCT were included for analysis. Their medical records such as diagnosis, clinical application, impact on decision making, times, image quality and radiologic findings were assessed. Results : Two-hundred-two mCT scans were performed in the operation room (n=192, 95%) or intensive care unit (ICU) (n=10, 5%). Regarding intraoperative images, extent of resection of tumor (n=55, 27.2%), degree of hematoma removal (n=42, 20.8%), confirmation of catheter placement (n=91, 45.0%) and monitoring unexpected complications (n=4, 2.0%) were evaluated. A total of 14 additional procedures were introduced after confirmation of residual tumor (n=7, 50%), hematoma (n=2, 14.3%), malpositioned catheter (n=3, 21.4%) and newly developed intracranial events (n=2, 14.3%). Every image was obtained within 15 minutes and image quality was sufficient for interpretation. Conclusion : mCT is feasible for prompt intraoperative and ICU monitoring with enhanced diagnostic certainty, safety and efficiency.

Slowly Recovering Isolated Bilateral Abducens Nerve Palsy after Embolization of Ruptured Anterior Communicating Artery Aneurysm

Jeon, Jin Sue,Lee, Sang Hyung,Son, Young-Je,Chung, Young Seob The Korean Neurosurgical Society 2013 Journal of Korean neurosurgical society Vol.53 No.2

Bilateral abducens nerve palsy related to ruptured aneurysm of the anterior communicating artery (ACoA) has only been reported in four patients. Three cases were treated by surgical clipping. No report has described the clinical course of the isolated bilateral abducens nerve palsy following ruptured ACoA aneurysm obliterated with coil. A 32-year-old man was transferred to our institution after three days of diplopia, dizziness and headache after the onset of a 5-minute generalized tonic-clonic seizure. Computed tomographic angiography revealed an aneurysm of the ACoA. Magnetic resonance imaging showed focal intraventricular hemorrhage without brain stem abnormalities including infarction or space-occupying lesion. Endovascular coil embolization was conducted to obliterate an aneurysmal sac followed by lumbar cerebrospinal fluid (CSF) drainage. Bilateral paresis of abducens nerve completely recovered 9 weeks after ictus. In conclusion, isolated bilateral abducens nerve palsy associated with ruptured ACoA aneurysm may be resolved successfully by coil embolization and lumbar CSF drainage without directly relieving cerebrospinal fluid pressure by opening Lillequist's membrane and prepontine cistern.

Identification of a prl-Like Gene of Entomopathongenic Fungus, Beauveria bassiana F-101 Isolated from Thecodiplosis japonensis

( Sang Chul Shin ),( Jong Yul Roh ),( Hee Jin Shim ),( Soon Kee Kim ),( Chul Su Kim ),( Il Kwon Park ),( Mun Jang Jeon ),( Yeon HO Je ) 한국잠사학회 2005 International Journal of Industrial Entomology Vol.10 No.2

Beauveria bassiana F-101, which has high toxicity toward Acantholyda parki as well as Thecodiplosis japonensis, was an isolate to develop an alternative control system against the major forest pests. Up to now, in B. bassiana, only one pr1 gene has been isolated and characterized. Therefore, we here reported the identification of a prl-like gene, which would be a factor of toxicity from B. bassiana F-101. The oligonucleotides for the amplification of the prl-like gene, were chosen based on the conserved regions of the subtilisin family enzymes, prl genes of B. bassiana and Metarhizium anisopliae, and proteinase K of Tritirachium album. The cloned PCR fragment had 1111bp including 52bp intron. The deduced Prl-like peptide showed a low identity with Prls of entomopathogenic fungi such as B. bassiana Prl (BbPrl) and M. anisopliae Prl (MaPrl) as well as the proteinase K of T. album (TaPrK). Instead, the deduced peptide had a substantially high amino acid sequence identity (>65%) with the serine proteases of Magnaporthe grisea (MgSPM1) and Podospora anserina (PaPspA). These results, therefore, appear to suggest that the putative Prl-like peptide of B. bassiana F-101 belongs to the subtilisin-like serine protease family and may be a novel gene.

Quantitative Analysis on Air-Dispensing Parameters for Manufacturing Dome Lenses of Chip-on-Board LED System

Jeon, Eun-Chae,Lee, Je-Ryung,Je, Tae-Jin,Choi, Doo-Sun,Ham, Young-Bog,Lee, Eung-Sug,Choi, Sang-Kyu,Kim, Hwi Korean Society for Precision Engineering 2014 International Journal of Precision Engineering and Vol.15 No.11

A COB(chip-on-board) LED(light emitting diode) system has advantages such as low cost and good heat dissipation. LED chips are bonded on PCB(printed circuit board) directly without packaging process in case of COB LED systems. Dome lenses made of polymeric resin are generally covered on the bonded LED chips by air dispensing for preventing mechanical damage and making white light. However, it is hard to control the shape of dome lenses precisely due to viscosity of the polymeric resin. We analyzed the relationship of the shape of dome lenses and experimental conditions of the air dispensing in this study. We introduced a new parameter, air pressure * dispensing time, whose physical meaning is impulse per unit area, and obtained much clear relationship of dispensing parameters and shape parameters of the dome lens. This relationship was similar to viscoelastic behavior. The aspect ratio (height over diameter) was increased as the new parameter increased, and was converged to a certain value. The maximum aspect ratio could be calculated by Young's equation of contact angle.

Identification of Entomopathogenic Fungus, Beauveria spp. F-101 Isolated from Thecodiplosis japonensis Using Internal Transcribed Spacer Sequence

( Sang Chul Shin ),( Jong Yul Roh ),( Chul Su Kim ),( Il Kwon Park ),( Mun Jang Jeon ),( Yeon Ho Je ) 한국잠사학회 2007 International Journal of Industrial Entomology Vol.8 No.1

For the development of the alternative control system against the major forest pests, Beauveria spp. F-101, isolated from a dead larva of Thecodiplosis japonensis, was selected because this isolate showed high pathogenicities against T. japonensis and Acantholyda parki. Beauveria spp. F-101 had irregular clustered conidiophores and conidia borne on a distinctive apical zigzag extension, and it showed typical characteristic of the genus, Beauveria in morphology. For molecular based-identification, the ribosomal ITS region of Beauveria spp. F-101 was amplified with ITS1 and ITS4 primers, and cloned into pGEM-T Easy vector. The amplified PCR product was 569 bp in size and completely sequenced. The similarities of the cloned ITS sequence were 99% and 97% to those of B. bassiana and B. brongniartii, respectively. In comparison to other species among the genus Beauveria, the ITS region of Beauveria spp. F-101 showed a similarity of 95% to B. amorpha, 95% to B. tenella, 89% to B. vermiconia and 69% to B. alba, respectively. In addition, in comparison to different genus, it had 95% similarities to Cordyceps militaris and 91% to Paecilomyces tenuipes. Accordingly, the current result suggests that Beauveria spp. F-101 was a variant of B. bassiana and it seems to be a new isolate considering sequence variation in ITS region.

Effects of occlusal load on the stress distribution of four cavity configurations of noncarious cervical lesions : A three-dimentional finite element analysis study

Jeon, Sang-Je,Park, Jeong-Kil,Kim, Hyeon-Cheol,Woo, Sung-Gwan,Kim, Kwang-Hoon,Son, Kwon,Hur, Bock 대한치과보존학회 2006 Restorative Dentistry & Endodontics Vol.31 No.5

본 연구의 목적은 네 가지 형태의 비우식성 치경부 병소에 과다한 교합하중을 가했을 때 각 와동에 나타나는 응력분포를 3차원적으로 조사하고자 하였다. 임상적으로 많이 관찰되는 다양한 형태의 병소 중 4가지 형태의 서로 다른 병소를 대표적으로 선택하여 발치된 상악 제2소구치에 3차원 유한요소 모형을 제작하였다. 형성된 모형에 협측교두와 설측교두에 500 N의 하중을 가한 후 치경부병소 첨부와 수직 절단면의 주 응력을 분석하여 다음과 같은 결과를 얻었다. 1. 서로 다른 네 가지 형태의 와동에서 응력분포 양상은 비슷했지만 응력의 크기가 서로 달랐다. 2. 최대치 응력은 근심협측 우각부에서 나타났으며, 또한 병소의 첨부에 응력의 집중을 보였다. 3. 하중 A에서는 주된 응력이 압축 응력이었고 하중 B에서는 주된 응력이 인장 응력이었다. 4. 이러한 하중 하에서 수복치료를 하지 않으면 와동의 크기는 점차 커지고 치아구조에는 유해하게 작용하리라 생각된다. The objective of this study was to investigate the effect of excessive occlusal loading on stress distribution on four type of cervical lesion, using a three dimensional finite element analysis (3D FEA). The extracted maxillary second premolar was scanned serially with Micro-CT. The 3D images were processed by 3D-DOCTOR. ANSYS was used to mesh and analyze 3D FE model. Four different lesion configurations representative of the various types observed clinically for teeth were studied. A static point load of 500N was applied to the buccal and lingual cusp (Load A and B). The principal stresses in lesion apex, and vertical sectioned margin of cervical wall were analyzed. The results were as follows 1. The patterns of stress distribution were similar but the magnitude was different in four types of lesion. 2. The peak stress was observed at mesial corner and also stresses concentrated at lesion apex. 3. The compressive stress under load A and the tensile stress under load B were dominant stress. 4. Under the load, lesion can be increased and harmful to tooth structure unless restored.

Concentrations and Distributions of 5 Metals in Groundwater Based on Geological Features in South Korea

Sang-Ho Jeon,Sunhwa Park,Da-Hee Song,Jong-yeon Hwang,Moon-su Kim,Hun-Je Jo,Deok-hyun Kim,Gyeong-Mi Lee,Ki-In Kim,Hye-Jin Kim,Tae-Seung Kim,Hyen-Mi Chung,Hyun-Koo Kim 한국토양비료학회 2017 한국토양비료학회지 Vol.50 No.5

To establish new metal groundwater standard, 5 metals such as aluminum, chromium, iron, manganese, and selenium were evaluated by Chemical Ranking Of groundWater pollutaNts (CROWN) including possibility of exposure, toxicity, interest factor, connection standard for other media, and data reliability. 430 groundwater samples in 2013 and 2014 were collected semiannually from 110 groundwater wells and they were analyzed for selenium, manganese, iron, chromium, and aluminum. For this study, 430 groundwater samples were categorized into 3 geological distribution features, such as igneous, metamorphic, and sedimentary rock region and geological background levels were divided by pre-selection methods. For the results, the average concentrations of aluminum, chromium, iron, manganese, and selenium in 430 groundwater samples were 0.0008 mg L<SUP>-1</SUP>, 0.0001 mg L<SUP>-1</SUP>, 0.174 mg L<SUP>-1</SUP>, 0.083 mg L<SUP>-1</SUP>, and 0.0004 mg L<SUP>-1</SUP><SUP></SUP>, respectively. In addition, among various geologies, average concentration of selenium was the highest in igneous rock region, average concentrations of chromium, manganese and aluminum were the greatest in sedimentary rock region, and average concentration of iron was the most high in metamorphic rock region. As a result of the geological background concentration with pre-selection method, background concentrations of selenium and aluminum in groundwater samples were the highest from sedimentary rock as 0.0010 mg L<SUP>-1</SUP> and 0.0029 mg L<SUP>-1</SUP> and background concentrations of manganese and iron in groundwater samples were the greatest from metamorphic rock as 0.460 mg L<SUP>-1</SUP> and 1.574 mg L<SUP>-1</SUP>, and no chromium background concentration in groundwater samples was found from all geology.

Long-term persistence of sequence type 89 methicillin-resistant Staphylococcus aureus isolated from cases of staphylococcal scalded skin syndrome in a Korean community

Jeon, Hyejin,Ma, Sang Hyuk,Jo, Hyun Jin,Woo, Min-Seok,An, Hyeonjun,Park, Hyungsik,Kwon, Choongeun,Kim, Youjeong,Lee, Je Chul Microbiology Society 2016 Journal of medical microbiology Vol.65 No.12

HIF1A overexpression using cell-penetrating DNA-binding protein induces angiogenesis in vitro and in vivo

Jeon, Mijeong,Shin, Yooseok,Jung, Jaeeun,Jung, Ui-Won,Lee, Jae-Hoon,Moon, Jae-Seung,Kim, Ilkoo,Shin, Jin-Su,Lee, Sang-Kyou,Song, Je Seon Springer-Verlag 2018 MOLECULAR AND CELLULAR BIOCHEMISTRY - Vol.437 No.1

<P>Hypoxia-inducible factor-1 alpha (HIF1A) is an important transcription factor for angiogenesis. Recent studies have used the protein transduction domain (PTD) to deliver genes, but the PTD has not been used to induce the expression of HIF1A. This study aimed at using a novel PTD (Hph-1-GAL4; ARVRRRGPRR) to overexpress the HIF1A and identify the effects on angiogenesis in vitro and in vivo. Overexpression of HIF1A was induced using Hph-1-GAL4 in human umbilical vein/vascular endothelium cells (HUVEC). The expression levels of genes were analyzed by the quantitative real-time polymerase chain reaction (qPCR) after 2 and 4 days, respectively. An in vitro tube formation was performed using Diff-Quik staining. HIF1A and Hph-1-GAL4 were injected subcutaneously into the ventral area of each 5-week-old mouse. All of the plugs were retrieved after 1 week, and the gene expression levels were evaluated by qPCR. Each Matrigel plug was evaluated using the hemoglobin assay and hematoxylin and eosin (HE) staining. The expression levels of HIF1A and HIF1A target genes were significantly higher in HIF1A-transfected HUVEC than in control HUVEC in vitro. In the in vivo Matrigel plug assay, the amount of hemoglobin was significantly higher in the HIF1A-treatment group than in the PBS-treatment group. Blood vessels were identified in the HIF1A-treatment group. The expression levels of HIF1A, vascular endothelial growth factor (Vegf), and Cd31 were significantly higher in the HIF1A-treatment group than in the PBS-treatment group. These findings suggest that using Hph-1-G4D to overexpress HIF1A might be useful for transferring genes and regenerating tissues.</P>