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RISS 인기검색어
- 검색키워드
- 저자 : Jenisha Barnabas, M. (검색결과 6 건)
- 무료
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Jenisha Barnabas, M.,Parambadath, S.,Ha, C.S. Korean Society of Industrial and Engineering Chemi 2017 Journal of industrial and engineering chemistry Vol.53 No.-
A layered double hydroxide-mesoporous silica core-shell nanostructure (LDHμSiO<SUB>2</SUB>) with perpendicularly-oriented mesochannels was synthesised using a surfactant-directing method and modified with amine functionality for drug delivery applications. Mg/Al-layered double hydroxide (Mg/Al-LDH) materials with a disc-like morphology were synthesised and then coated with mesoporous silica (Mg/Al-LDHμSiO<SUB>2</SUB>) via the functionalisation of (3-aminopropyl)triethoxysilane using a post-synthesis route (NH<SUB>2</SUB>-Mg/Al-LDHμSiO<SUB>2</SUB>). The materials were characterised using a range of techniques. The Mg/Al-LDHμSiO<SUB>2</SUB> and NH<SUB>2</SUB>-Mg/Al-LDHμSiO<SUB>2</SUB> materials possessed a spherical morphology and good porosity. Ibuprofen (IBU) and ciprofloxacin (CIPRO) were loaded into the pore channels of the NH<SUB>2</SUB>-Mg/Al-LDHμSiO<SUB>2</SUB> and the release properties were examined at pH 4.0 and 7.4. The delayed release property exhibited by NH<SUB>2</SUB>-Mg/Al-LDHμSiO<SUB>2</SUB> was attributed to the strong interactions of the drug molecules with the surface amino functionality and the charged LDH surface. The release profile from NH<SUB>2</SUB>-Mg/Al-LDHμSiO<SUB>2</SUB> was also compared with that of the Mg/Al-LDHμSiO<SUB>2</SUB> system under identical conditions. The porosity and functionalisation of the mesoporous silica shell and the surface charge density of the layered structure of Mg/Al-LDH are the major reasons for the controlled release of the cargo molecules. Moreover, the favourable delay in drug release from both materials at pH 4 was attributed to the higher level of ionisation and dissolution than at pH 7.4.
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Silver (I)- Schiff-base complex intercalated layered double hydroxide with antimicrobial activity
Barnabas, Mary Jenisha,Parambadath, Surendran,Nagappan, Saravanan,Chung, Ildoo,Ha, Chang-Sik Techno-Press 2021 Advances in nano research Vol.10 No.4
In this work, silver nitrate complexes of sulfanilamide-5-methyl-2-thiophene carboxaldehyde (SMTCA) ligand intercalated Zn/Al-layered double hydroxide [Ag-SMTCA-LDH] were synthesized for the potential application as an antimicrobial system. The SMTCA ligand was synthesized by reacting sulfanilamide and 5-methyl-2-thiophene carboxaldehyde in methanol and further complexation with silver nitrate metal ions [Ag-SMTCA]. The structural analyses of synthesized compounds confirmed an intercalation of Ag-SMTCA into Zn/Al-NO<sub>3</sub>-LDH by flake/restacking method. SMTCA, Ag-SMTCA and Ag-SMTCA-LDH were characterized by <sup>1</sup>H nuclear magnetic resonance (<sup>1</sup>H NMR) spectroscopy, Fourier-transform infrared (FTIR), ultraviolet-visible (UV-Vis) spectrophotometer, scanning electron microscopy (SEM) and transmission electron microscopy (TEM), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). It was found that Ag-SMTCA-LDH exhibited good antimicrobial activity against both gram-positive (Bacillus subtilis, [B. subtilis], Staphylococcus aures, [S. aureus]) and gram-negative (Escherichia coli, [E. coli], Pseudomonas aeruginosa [P. aeroginosa]) bacteria as well as excellent antioxidant activity.
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Mary Jenisha Barnabas,Surendran Parambadath,하창식 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.53 No.-
layered double hydroxide-mesoporous silica core–shell nanostructure (LDH@mSiO2) with perpendicularly- oriented mesochannels was synthesised using a surfactant-directing method and modified with amine functionality for drug delivery applications. Mg/Al-layered double hydroxide (Mg/Al-LDH) materials with a disc-like morphology were synthesised and then coated with mesoporous silica (Mg/Al- LDH@mSiO2) via the functionalisation of (3-aminopropyl)triethoxysilane using a post-synthesis route (NH2-Mg/Al-LDH@mSiO2). The materials were characterised using a range of techniques. The Mg/Al- LDH@mSiO2 and NH2-Mg/Al-LDH@mSiO2 materials possessed a spherical morphology and good porosity. Ibuprofen (IBU) and ciprofloxacin (CIPRO) were loaded into the pore channels of the NH2-Mg/ Al-LDH@mSiO2 and the release properties were examined at pH 4.0 and 7.4. The delayed release property exhibited by NH2-Mg/Al-LDH@mSiO2 was attributed to the strong interactions of the drug molecules with the surface amino functionality and the charged LDH surface. The release profile from NH2-Mg/Al- LDH@mSiO2 was also compared with that of the Mg/Al-LDH@mSiO2 system under identical conditions. The porosity and functionalisation of the mesoporous silica shell and the surface charge density of the layered structure of Mg/Al-LDH are the major reasons for the controlled release of the cargo molecules. Moreover, the favourable delay in drug release from both materials at pH 4 was attributed to the higher level of ionisation and dissolution than at pH 7.4.
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Parambadath, S.,Mathew, A.,Jenisha Barnabas, M.,Ha, C.S. Elsevier 2015 Microporous and mesoporous materials Vol.215 No.-
Secondary amine based organic/inorganic hybrid periodic mesoporous organosilica (PMO) materials were synthesised from a bridged silsesquioxane precursor, N,N'-bis[3-(triethoxysilyl)propyl] ethylenediamine (TESEN) and tetramethyl orthosilicate (TMOS) with various amounts of TESEN and TMOS. Cetyltrimethylammonium bromide (CTABr) was used as the structure directing agent under basic conditions. The pore opening of the material was modified with N-[3-(trimethoxysilyl)propyl]aniline (TMSPA) to impart a nanovalve property under acidic conditions when co-operating with the β-cyclodextrin (β-CD) molecule. The physico-chemical properties of N,N'-bis-(propyl)ethylenediamine-bridged PMO with 15% (w/w) organo-functionality (DA-PMO-15) and the corresponding nanovalve system (GA-PMO-15) were determined by a range of spectroscopic analyses. X-ray diffraction and transmission electron microscopy showed that the DA-PMO-15 and GA-PMO-15 materials possess mesocopically ordered, hexagonal symmetry and well-defined morphologies. <SUP>29</SUP>Si magic angle spinning nuclear magnetic resonance (MAS NMR) spectral analysis revealed the silicon environment of the final material. N<SUB>2</SUB> sorption experiments showed the material has large surface area (591 m<SUP>2</SUP> g<SUP>-1</SUP>), acceptable pore diameter (3.0 nm) and affordable pore volume (0.38 m<SUP>3</SUP> g<SUP>-1</SUP>) to accommodate the guest molecules inside the pore channels. Organic functionalization was determined successfully by Fourier transform infrared and <SUP>13</SUP>C cross-polarization magic angle spinning (CP-MAS) NMR spectroscopy. Acidic drugs, such as 5-fluorouracil and ibuprofen were chosen as the cargo and the release rate from the GA-PMO-15 nanovalve at pH 4 was delayed significantly due to the gate keepers and the interaction of drug molecules with the internally functionalised N,N'-bis-(propyl)ethylenediamine molecule.
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