The Impact of Nanomaterials in Immune System

Jiyoung Jang,Dae-Hyoun Lim,In-Hong Choi 대한면역학회 2010 Immune Network Vol.10 No.3

The Impact of Nanomaterials in Immune System

Jang, Jiyoung,Lim, Dae-Hyoun,Choi, In-Hong The Korean Association of Immunobiologists 2010 Immune Network Vol.10 No.3

As a nanotechnology has been actively applied to the overall areas of scientific fields, it is necessary to understand the characteristic features, physical behaviors and the potential effects of exposure to nanomaterials and their toxicity. In this article we review the immunological influences induced by several nanomaterials and emphasize establishment of the animal models to estimate the impact of these nanomaterials on development of immunological diseases.

Environment-Sensitive Ectodomain Shedding of Epithin/PRSS14 Increases Metastatic Potential of Breast Cancer Cells by Producing CCL2

Jiyoung Jang,조은혜,Youngkyung Cho,Binderya Ganzorig,Ki Yeon Kim,Moon Gyo Kim,Chungho Kim 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.8

Epithin/PRSS14 is a membrane serine protease that plays a key role in tumor progression. The protease exists on the cell surface until its ectodomain shedding, which releases most of the extracellular domain. Previously, we showed that the remaining portion on the membrane undergoes intramembrane proteolysis, which results in the liberation of the intracellular domain and the intracellular domainmediated gene expression. In this study, we investigated how the intramembrane proteolysis for the nuclear function is initiated. We observed that ectodomain shedding of epithin/PRSS14 in mouse breast cancer 4T1 cells increased depending on environmental conditions and was positively correlated with invasiveness of the cells and their proinvasive cytokine production. We identified selenite as an environmental factor that can induce ectodomain shedding of the protease and increase C-C motif chemokine ligand 2 (CCL2) secretion in an epithin/PRSS14-dependent manner. Additionally, by demonstrating that the expression of the intracellular domain of epithin/PRSS14 is sufficient to induce CCL2 secretion, we established that epithin/PRSS14- dependent shedding and its subsequent intramembrane proteolysis are responsible for the metastatic conversion of 4T1 cells under these conditions. Consequently, we propose that epithin/PRSS14 can act as an environment-sensing receptor that promotes cancer metastasis by liberating the intracellular domain bearing transcriptional activity under conditions promoting ectodomain shedding.

Anti-diabetic effects of natural products an overview of therapeutic strategies

Jiyoung Park,Hyeung-Jin Jang,H.-J. Jang 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.1

Diabetes mellitus, a large part of metabolic disorder, is characterized by persistent hyperglycemia. The number of people suffering from diabetes is rapidly increasing worldwide, and the disease is often accompanied by severe complications such as heart disease, diabetic kidney failure, and retinal disease due to the high blood glucose levels over a long period of time. Comprehensive diabetic management is important, including efforts to lower the blood glucose level and body weight as well as to prevent insulin resistance. Although various prescriptions for diabetes have been used as therapeutic medicines, many researchers have long studied this disease in an effort to find new effective substances derived from natural products without side effects or toxicity. In the research on natural product, plants can have toxic or insufficient effects and unexplained outcomes, but the possibilities are unlimited. Here, we explain medicinal plants with anti- diabetic effects in a comprehensive manner, focusing on hormonal regulation and metabolic regulation, and describe active components and natural products based on the vast amount of research and on clinical trials. This review suggests that medicinal plants can used to treat diabetic mellitus through hormonal regulation and metabolic regulation as a therapeutic medication.

Toenail selenium levels and prevalence of dyslipidaemia among Korean adults

Jang, Jiyoung,Morris, J. Steven,Park, Kyong Cambridge University Press 2017 The British journal of nutrition Vol.118 No.6

<B>Abstract</B><P>Multiple studies have elucidated the antioxidant properties of Se, which are now well known among the nutrition and biomedical science communities. Recently, considerable interest has been focused on the possible association between Se exposure and risk of metabolic disease, such as lipid dysregulation; however, there is limited epidemiological data on this topic. The present study aimed to investigate associations between toenail Se levels and dyslipidaemia or individual lipid levels, and to examine the effect of dietary supplement use on these associations. We analysed baseline data from a cohort in the Yeungnam area, including 232 men and 269 women. Information on demographic, dietary and lifestyle characteristics was obtained through a self-reported questionnaire. Se levels in toenail specimens were measured using neutron activation analysis. Fasting blood lipid levels were measured during medical examinations. After adjusting for multiple confounding variables, we observed no association between toenail Se levels and dyslipidaemia or individual lipid profiles. However, the association was modified by dietary supplement use. Among the supplement users, higher toenail Se levels were associated with a higher prevalence of lipid dysregulation, whereas non-users exhibited a lower prevalence of lipid dysregulation. Associations between toenail Se levels, lipid levels and dyslipidaemia may be influenced by taking dietary supplements. Future large-scale, prospective cohort studies should be conducted to further evaluate the association between Se levels in the body and metabolic health effects in light of increasing rates of dietary supplement use.</P>

BLDC 모터의 비선형 마찰 모델 식별

장지영(Jiyoung Jang),허준서(Junseo Heo),좌동경(Dongkyoung Chwa) 대한전기학회 2021 대한전기학회 학술대회 논문집 Vol.2021 No.10

본 논문에서는 brushless direct current(BLDC) 모터의 정밀한 제어를 위해 비선형 마찰 모델인 Stribeck 모델을 이용하여 모터의 마찰력을 나타낸다. 비선형 마찰 모델을 포함하는 모터 운동 방정식의 파라미터를 Levenberg-Marquardt(LM) 알고리즘을 이용하여 식별한다. 본 논문에서는 실제 모터와 식별된 비선형 마찰 모델을 포함하는 시뮬레이션 모델이 얼마나 유사한지 검증하기 위해 실제 모터의 각속도 출력값과 시뮬레이션의 각속도 출력값을 비교한다.

비선형 마찰 모델을 고려한 BLDC 모터의 적분 슬라이딩 모드 제어

장지영(JiYoung Jang),허준서(Junseo Heo),좌동경(Dongkyoung Chwa) 대한전기학회 2022 전기학회논문지 Vol.71 No.1

This paper proposes an integral sliding mode control method for robust control of brushless direct current (BLDC) motor. In order to improve the control performance, the friction force of the motor is expressed using the Stribeck friction model, which is a nonlinear friction model that can accurately represent the friction force at low speed. The parameter values required to design the integral sliding mode controller are then obtained by identifying the parameters of the dynamic equations of the motor including the nonlinear friction model using the Levenberg-Marquardt (LM) algorithm. The performance of the proposed integral sliding mode control method for the BLDC motor is verified through both the simulation results and the actual motor speed control test results.

원청기업 매출의존도에 따른 하청기업의 이익유연화 현상

장지영(Jiyoung Jang),이준호(Joonho Lee),권선국(Sunkook Kwon) 한국산업경영학회 2012 경영연구 Vol.27 No.3

본 연구의 목적은 자동차 산업에 속해 있는 하청기업 중 주문자위탁생산방식(OEM)으로 원청 기업에 제품을 공급하는 기업을 대상으로 원청기업 매출의존도에 따른 하청기업 이익유연화 정도를 검증하고자 한다. 연구 목적을 달성하기 위해 자동차 산업과 관련된 기업의 감사보고서를 검토하여 원청기업에 OEM 방식으로 제품을 납품하는 94개사를 대상으로 원청기업에 대한 매출의존도가 이익유연화에 어떠한 영향을 미치는지를 실증 분석하였다. 분석 결과, 하청기업의 원청기업 매출의존도가 기업 마다 상당한 차이를 보이는 것으로 나타났다. OEM 방식으로 제품을 납품 하더라도 의존도가 낮은 집단과 높은 집단 간 이익유연화 정도는 상당한 차이가 있었다. 즉, 원청기업에 대한 매출의존도가 높은 기업은 낮은 기업에 비해 상대적으로 더 많이 이익을 유연화하는 것으로 나타났다. 원청기업에 대한 매출의존도가 높은 집단과 OEM 방식으로 제품을 납품하지 않은 집단을 이용한 추가분석에서도 동일한 결과가 나타났다. 그러나 원청기업에 대한 매출의존도가 낮은 집단과 OEM 방식으로 제품을 납품하지 않은 집단 간 이익유연화 정도는 차이가 없었다. 전반적으로 하청기업은 원청기업의 압력으로부터 자유로울 수 없는 상황이나, 하청기업의 교섭력은 원청기업에 대한 매출의존도에 따라 상이할 것이다. 이로 인하여 하청기업은 원청기업에 대한 매출의존도에 따라 이익을 유연화하려는 정도가 상이한 것으로 나타났다. 본 연구는 하청기업의 회계처리에 대한 연구로 일화적 증거에 대한 실증적 근거를 제시하였다는 데 큰 의의가 있다. The purpose of this research is to examine income smoothing of subcontractors according to sales dependence on prime companies. This research examined audit reports of 94 companies in the automotive industry. The results show that subcontractors’ sales dependency on prime companies appeared to have significant differences in the degree of income smoothing between low dependence group and high dependence group. In other words, companies with high sales dependency on prime companies showed to have relatively higher income smoothing than companies with low dependency. In additional analysis comparing high sales dependency group on prime companies to the group that did not supplied on OEM basis showed the same result. However, there was no difference in income smoothing between group that had low sales dependency to the prime companies and group that did not supply products in OEM basis. Generally, subcontractors are not free from the pressures of prime companies, since the bargaining power of subcontractors differs according to the sales dependency on prime companies. As a result, subcontractors appeared to have different level in income smoothing depending on the sales dependency to prime companies. This research shows empirical evidence that the relationship between prime companies and subcontractors on the income smoothing of subcontractors.

BLDC 모터의 비선형 마찰 모델 식별

장지영(Jiyoung Jang),허준서(Junseo Heo),좌동경(Dongkyoung Chwa) 대한전기학회 2021 정보 및 제어 심포지엄 논문집 Vol.2021 No.10

전방향 이동로봇의 적분 슬라이딩 모드 제어 기반 고장 허용 비주얼 서보잉

장지영(Jiyoung Jang),좌동경(Dongkyoung Chwa) 대한전기학회 2022 정보 및 제어 심포지엄 논문집 Vol.2022 No.10