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( Hyo Sang Jo ),( Duk-soo Kim ),( Eun Hee Ahn ),( Dae Won Kim ),( Min Jea Shin ),( Su Bin Cho ),( Jung Hwan Park ),( Chi Hern Lee ),( Eun Ji Yeo ),( Yeon Joo Choi ),( Hyeon Ji Yeo ),( Christine Seok Y 생화학분자생물학회(구 한국생화학분자생물학회) 2016 BMB Reports Vol.49 No.11
Oxidative stress is closely associated with various diseases and is considered to be a major factor in ischemia. NAD(P)H: quinone oxidoreductase 1 (NQO1) protein is a known antioxidant protein that plays a protective role in various cells against oxidative stress. We therefore investigated the effects of cell permeable Tat-NQO1 protein on hippocampal HT-22 cells, and in an animal ischemia model. The Tat-NQO1 protein transduced into HT-22 cells, and significantly inhibited against hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced cell death and cellular toxicities. Tat-NQO1 protein inhibited the Akt and mitogen activated protein kinases (MAPK) activation as well as caspase-3 expression levels, in H<sub>2</sub>O<sub>2</sub> exposed HT-22 cells. Moreover, Tat-NQO1 protein transduced into the CA1 region of the hippocampus of the animal brain and drastically protected against ischemic injury. Our results indicate that Tat-NQO1 protein exerts protection against neuronal cell death induced by oxidative stress, suggesting that Tat-NQO1 protein may potentially provide a therapeutic agent for neuronal diseases. [BMB Reports 2016; 49(11): 617-622]
A brief review on relaxor ferroelectrics and selected issues in lead-free relaxors
Ahn, Chang Won,Hong, Chang-Hyo,Choi, Byung-Yul,Kim, Hwang-Pill,Han, Hyoung-Su,Hwang, Younghun,Jo, Wook,Wang, Ke,Li, Jing-Feng,Lee, Jae-Shin,Kim, Ill Won 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol. No.
<P>Relaxor ferroelectricity is one of the most widely investigated but the least understood material classes in the condensed matter physics. This is largely due to the lack of experimental tools that decisively confirm the existing theoretical models. In spite of the diversity in the models, they share the core idea that the observed features in relaxors are closely related to localized chemical heterogeneity. Given this, this review attempts to overview the existing models of importance chronologically, from the diffuse phase transition model to the random-field model and to show how the core idea has been reflected in them to better shape our insight into the nature of relaxor-related phenomena. Then, the discussion will be directed to how the models of a common consensus, developed with the so-called canonical relaxors such as Pb(Mg1/3Nb2/3)O-3 (PMN) and (Pb, La)(Zr, Ti)O-3 (PLZT), are compatible with phenomenological explanations for the recently identified relaxors such as (Bi1/2Na1/2)TiO3 (BNT)-based lead-free ferroelectrics. This review will be finalized with a discussion on the theoretical aspects of recently introduced 0-3 and 2-2 ferroelectric/relaxor composites as a practical tool for strain engineering.</P>
( Hyo Jun Ahn ),( Myeong Jun Song ),( Jeong Won Jang ),( Si Hyun Bae ),( Jong Young Choi ),( Seung Kew Yoon ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: We aimed to evaluate the efficacy and safety of Tenofovir disoproxil fumarate (TDF) based therapy in naive and treatment experienced chronic hepatitis B (CHB) patients for 96 weeks in Korean real life practice. Methods: 209 CHB patients who had prescription for TDF at Seoul and Daejeon St. Mary’s hospital were enrolled from December, 2012 to October, 2014. We compared the virological responses and renal safety of naive and treatment experienced patients Results: Overall complete virological response (CVR) showed 80.4% and 84.6% of patients at week 48 and 96, respectively. In subgroup analysis, CVR at week 96 were 88.4%, 75.0 %, 75.5%, and 83.3%, in the lamivudine-resistant (LAM-R) group, Adefovir-resistant (ADV-R) group, multidrug-resistant (MDR) group, and suboptimal response group, respectively. In a multivariate analysis, ADV-R, MDR, HBV DNA, and HBeAg were independent predictors for CVR. In renal safety, Diabetes mellitus (DM), cirrhosis, and initial low estimated glomerular filtration rate were independent factors affecting Cr elevation (≥ 0.5mg/dL). Moreover, we note that 2 patients with DM and cirrhosis have experienced TDF-related Fanconi syndrome. Conclusions: TDF-based therapy demonstrated sustained viral suppression and a favorable safety throughout 2 years. Compared to the naive group, the LAM-R and suboptimal response group showed comparable efficacy, while the ADV-R group and MDR group both showed a relatively low efficacy. Also, the ADV-R group and MDR group were significantly associated with a low CVR. Close monitoring of renal function may be recommended in CHB patients receiving TDF, especially with DM and cirrhosis
Hyo-Min Ahn,Chang-Yeol Oh,Won-Yong Sung,Jung-Hoon Ahn,Byoung-Kuk Lee 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6
In this paper, a design method of LCL and a generalized model with various types of passive damping circuits for the three-phase grid-connected inverter are proposed. Based on the generalized model, theoretical analysis is carried out to examine the performance of the designed LCL filter. The validity of the proposed filter model is verified by simulation and experimental results.
Hyo-Won Ahn,Kyu-Rhim Chung,Suk-Man Kang,Lu Lin,Gerald Nelson,Seong-Hun Kim 대한치과교정학회 2012 대한치과교정학회지 Vol.42 No.5
In the correction of dental Class III molar relationship in skeletal Class II patients, uprighting of the mandibular posterior segments without opening the mandible is an important treatment objective. In the case reported herein, a C-tube miniplate fixed to the lower labial symphysis and connected with a nickel-titanium reversecurved archwire provided effective uprighting of the lower molars, without the need of orthodontic appliances on the mandibular anteriors. Using this approach, an appropriate magnitude of force is exerted on the molars while avoiding any negative effect on the mandibular anteriors.
A new type of clear orthodontic retainer incorporating multi-layer hybrid materials
Hyo-Won Ahn,Kyung A Kim,Seong-Hun Kim 대한치과교정학회 2015 대한치과교정학회지 Vol.45 No.5
Clear thermoplastic retainers have been widely used in daily orthodontics; however, they have inherent limitations associated with thermoplastic polymer materials such as dimensional instability, low strength, and poor wear resistance. To solve these problems, we developed a new type of clear orthodontic retainer that incorporates multi-layer hybrid materials. It consists of three layers; an outer polyethylenterephthalate glycol modified (PETG) hard-type polymer, a middle thermoplastic polyurethane (TPU) soft-type polymer, and an inner reinforced resin core. The resin core improves wear resistance and mechanical strength, which prevent unwanted distortion of the bucco-palatal wall of the retainer. The TPU layer absorbs impact and the PETG layer has good formability, optical qualities, fatigue resistance, and dimensional stability, which contributes to increased support from the mandibular dentition, and helps maintain the archform. This new type of vacuum-formed retainer showed improved mechanical strength and rate of water absorption.