BCG 접종후의 결핵반응검사의 변화

김진경,김기홍,김행미,안두홍 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.1

신생아 시기에 BCG를 접종받은 영아를 대상으로 3±개월, 7-8개월 및 15-16개월에 Mantoux 검사를 시행하여 다음과 같은 결과를 얻었다. 3-4개월째 측정한 결절의 크기는 5.8±4.5㎜, 7-8개월째 7.9±4.9㎜,15-16개월째 6.7±4.9㎜로서 7-8개월째 의의있게 (p<0.55)증가되어 있었다. Mantoux 검사상 결절의 크기가 5㎜미만인 경우를 음성으로 간주하였을대 3-4개월째 38.5%, 7-8개월째 26.0% 및 15-16개월째 35.2%가 음성이었으며 15㎜이상의 강양성은 3-4개월째 1.9%, 7-8개월째 12%, 15-16개월째 7.5%를 차지하였다. 33례의 미숙아에 있어서 BCG 접종후 18개월 동안 5㎜ 이상의 반응을 보인 양전례는 63.6%인 21례로 이들 양전군과 비양전군 사이에는 출생시 제태연령, 체중 및 BCG 접종시기에 유의한 차이를 보이지 않았으며 만삭아의 양전율과 비교 하였을 때 의의있는 차이를 보이지 않았다. We conducted this study to evaluate the change of tuberculin reaction after neonatal BCG vaccination in Korea. Seventy-four infants were followed for 15-16 month after birth. BCG vaccination were given within 4 weeks after birht and 3 times of Mantoux test were performed at 3-4 months, 7-8 months and 15-16 month after birth. During the same period, Mantoux test were done on 238 cases of 3-4 months-old infants, 107 cases of 7-8 months-old infants and 85 cases of 15-16 months-old infants who were given BCG vaccination within 4 week after birth. We evaluated the results without distinction of these infants because there was no statistically significant difference between two groups. The size of induration was significantly increased at 7-8 months(7.9±4.9㎜) compare to the size at 3-4 months (5.8±4.5㎜) and 15-16months(6.7±4.9㎜) (P<0.05). But 38.5%, 26.8% andn 32.5% of infants were not converted ( < 5㎜) at 3-4months, 7-8 months and 15-16 months after birth respectively. Thirty-three preterm infants were followed for 18 months after birth. Twenty-one out of 33 (63.6%) were converted during this period. There was no difference of gestational age, birth weight, age on BCG vaccination between converters and nonconverters. There was no difference of conversion rate compatre to full term infants.

The Effects of Microeconomic Fundamentals on the Korean Financial Crisis

Kim,Sunghwan,Kim,Hong Kee,Kim,Jin San 한국산업경영학회 2010 한국산업경영학회 발표논문집 Vol.2010 No.1

In this study, we assess the effects of default risks and financial performance of firms on the overall risk of Korea around its financial crisis in the late 1990s and on their market values, using firm-level data from 1991 to 2007. We develop default prediction models and calculate Altman’s K scores to measure the overall risks and quality of firms respectively. Based on our own default prediction models, we have shown that the default risks of firms were extremely high before the crisis and drastically declined after the crisis. We have also found that the default risks of chaebol firms were much lower before and after the financial crisis and that their market values were much higher after the crisis, compared with those of non-chaebol firms. This implies that the Korean economy with high sovereign risks for a long time experienced the crisis due to weak firm-level fundamentals, regained its vitality due to significant improvements made by chaebol firms through the crisis and has become much stronger than before.

남북한 방송 언어의 운율 특성 비교연구 : 억양을 중심으로

김기호,홍종선,이용재 서울대학교 어학연구소 1996 語學硏究 Vol.32 No.3

This paper is to compare North and South Korean media languages acoustically and to describe its main prosodic characteristics. The result of the acoustic experiments shows that North and South Korean media languages share the same prosodic features. That is, in general report style, they both show ⅰ) the same basic accentual phrase (AP) pattern ((LH) LH) like Seoul dialect's and ⅱ) the same closing boundary tone, or L%. However, acoustically, they differ in the following aspects: in comparison with South Korean media language, the North Korean one tends to show ⅰ) more APs, ⅱ) wider pitch variation between the first and the second syllable of the AP, ⅲ) wider maximum pitch variation between the adjacent syllables, ⅳ) a more radical falling slope in that closing boundary tone, and, of more importance, it does not show clearly the downdrift phenomena ⅴ) between the intonational phrases as well as ⅵ) between the APs, which are the prosodic characteristics of South Korean dialects. On the other hand, in Kim Il-sung-related reports, the North Korean media language shows somewhat different prosodic features, i.e. in addition to the basic (LH)LH AP pattern, it shows another AP pattern, or LHL^0, similar to the Honam dialect (LHL) and it also shows a rather different closing boundary tone, or LHL%.

신생아 가사의 신경학적 예후에 대한 혈중 효소들의 예측도

김기혁,김두산,홍성진,오명호,심재건 건국대학교 의과학연구소 1999 건국의과학학술지 Vol.9 No.-

Perinatal asphyxia is one of the most important factors contributing to neonatal morbidity and mortality. However, no clear-cut parameters exist which enable an early identification of neonates who are at risk to develop brain damage. We measured creatine kinase(CK), CK isoenzyme, AST, ALT, LDH in full term asphyxiated(n=35) and healthy(n=39) newborns at 6-10 hours after birth to establish the values of these enzymes in the retrospective diagnosis of asphyxia and if serum levels of these enzymes correlated with the abnormalities of neurosonography or auditory evoked potential. The asphyxiated newborns had significantly increased serum activities of CK-BB(93.5±160.8 IU/L) and CK-BB%(11.1±12.4%) compare to controls(39.2±37.2 IU/L, 3.9±3.4%). However, there were no significant differences in the enzyme activities between normal and abnormal groups of neurosonography or auditory evoked potential. It is concluded that elevated CK-BB and CK-BB% are reliable indicator of the neonatal asphyxia. But the predictive value of specific enzymes for the development of neurologic disorders is not clear. Prospective long-term follow up studies are necessary to evaluate the predictive value of enzyme activities for the neurologic outcome.

폐수슬러지를 혼입한 콘크리트의 재료특성 및 강도특성

홍기호,하상훈,김정규,어석홍 國立 昌原大學校 產業技術硏究院 2004 産技硏論文集 Vol.18 No.-

The purpose of this study is to investigate the material characteristics and strength properties of concrete mixed with wastewater sludge, and to evaluate the leaching of environmentally harmful heavy metals from the wastewater sludge itself and from hardened concrete mixed with wastewater sludge. For this purpose, a reference mix with W/C ratio of 0.45 was used and the replacement proportion of wastewater sludge was varied with ratios of 0, 30, 50, 70 and 100% by volume of coarse aggregate in the reference mix. The variations of compressive and splitting tensile strength, workability and unit weight of concrete were considered. Test results showed that the strengths and unit weight decreased with increase in proportion of wastewater sludge replaced, but workability increased. Leaching test results showed that there would be no environmentally harmful problem from using wastewater as substitutes of coarse aggregates in concrete.

쓰레기 소각재를 잔골재로 혼합한 콘크리트의 기초적 물성연구

홍기호,하상훈,김정규,어석홍 國立 昌原大學校 產業技術硏究院 2004 産技硏論文集 Vol.18 No.-

The purpose of this study is to investigate the material characteristics and strength properties of concrete mixed with waste incinerated bottom ash(BA), and to evaluate the leaching of environmentally harmful heavy metals from the bottom ash itself and from hardened concrete mixed with bottom ash. For this purpose, two reference mixed with W/C ratio of 0.45 and 0.55 were used, and the replacement proportion of BA was varied with ratios of 0, 30, 50, 70 and 100% by volume of fine aggregate in the reference mixes. The variation of compressive and splitting tensile strength, workability and unit weight of concrete were considered. Test results showed that the strengths, workability and unit weight decreased with increase in proportion of BA replaced. Leaching test results showed that there would be no environmentally harmful problem from using BA as substitutes of fine aggregates in concrete.

비정질(Fe_(1-x)Ni_x) 77_Si_10B_13 합금의 전기적 특성

김택기,임영언,손홍재 충남대학교 공업교육연구소 1982 論文集 Vol.5 No.2

The electrical resistivity in amorphous (Fe_(1-x)Ni_x)_77Si_10B_13(0≤x≤1, interval of x : 0.1) alloys prepared by a rapid quenching method has been investigated as a function of Ni-concentration and temperature to study the relations between the structure and the properties of amorphous materials. The thickness of each specimen was derived from the density measured by the Archimedian method. The electrical resistance of the specimen was measured by 4-probe technique in the temperature range of 300-1100°K in the vacuum of 2 × 10^-5 torr. Findings follow: 1) The electrical resistivity for amorphous state except x=0.8 and 0.9 at room temperature is 1.5∼2 times as large as that for crystallized state and the electrical resistivity for both states reaches a maximum at about x=0.5 however, the electrical resistivity for x=0.8 and 0. 9 shows anomalous characteristics; i) the electrical resistivity for crystallized state is larger than that for amorphous state ii) the electrical resistivity for both states is very large in comparison with other compositions. 2) TCR (Temperature Coefficient of Resistivity) for amorphous state rises with increasing Ni-concentration and passes through a maximum at about x=0.5. 3) The crystallization temperature decreases linearly with increasing Ni-concentration.

생태환경을 이용한 정신지체아동의 읽기능력 향상프로그램 개발의 연구

김남순,홍기훈 조선대학교 학생지도연구소 2003 生活指導硏究 Vol.22 No.1

소아에서 발생한 골수이형성 증후군 2례

홍성진,윤석중,김성우,조형구,오명호,김기혁,이인성 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-

Myelodysplastic syndrome(MDS) is a group of acquired conditions characterized by progressive bone marrow failure associated with normocellular or hypercellular bone marrow that cannot be attributed to nutritional deficiency, chronic infection, or other chronic systemic illness, and cannot be reversed by the successful treatment of those conditions. Whereas the cases of secondary MDS occur at all ages, primary MDS is essentially a disease of elderly, though no age group is exempt and predomonant in men. The MDS is fundamentally clonal disorders at the level of the haemopoietic totipotent stem cell. Clinically, they are characterized by varing degrees of peripheral cytopenia(s) with morphological and functional abnormalities of blood elements. We have experienced two unrelated pediatric cases, who showed pancytopenia on admission and the characteristic marrow findings of MDS. The first case, a 12 months-old girl, showed increased reticulin with abnormal localization of immature precursor cells(ALIP) in her bone marrow, in addition to dysplastic features such as bi-and multi-nucleation of late normoblasts and internuclear bridging. She also showed 22% of blasts in her bone marrow cells thus classified in the category of RAEB-t after FAB classification. Also found were a chromosomal abnormality namely 46 XX t(14q21q), which was an unusual one. Her family brought her home and, 4 month later, she deceased. The second case, a 12 year-old boy, showed pancytopenia with Pseudo-Pelger-Huet anomaly in neutrophils but no blasts in the peripheral blood. Bone marrow of this case also showed the picture of dyserythropoiesis with binuclearity, internuclear bridging, nuclear fragments, multinuclearity of late normoblasts, in addition to megaloblastoid change in the normoblasts and increased mitosis in granulocytic series. No chromosomal abnormality was found. Classified as RA after FAB classification of MDS. Showed good response to conservative management for anemia for more than one year.

인삼이 말초신경 장애성 통증에 미치는 영향과 그 기전에 관한 연구

홍기완,김광진 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

The aim of the present study was to investigate the antinociceptive effects of ginseng extracts on neuropathic pain evoked by peripheral nerve injury in rats, according to the method of Bennett and Xie. Chronic constrictive nerve injury to sciatic evoked markedly allodynia, which was determined by withdrawal time and ratio to the innocuous mechanical, chemical and cold stimuli (5oC) applied to the hind paw. Total saponons of ginseng extract(100mg/kg) inhibited allodynia to the stimuli applied but higher dose of saponins had no effect. Among the saponin extract, protopanaxadiol saponins(PT) was found to be the effective component for the antinociceptive action of ginseng extracts on neuropathic pain. On the other hand the prototopanaxatriol saponins (PD) had no effect on neuropathic pain. MK-801(1.6mg/kg) and IA-966(0.1mM/kg) enhanced the antinociceptive effect of PT on chemical and cold allodynia. MK-801 and HA-966 enhanced, transiently, the effect of PT on chemical and cold allodynia. Apomorphine(4mg/kg) inhibited all the mechanical, chemical, and cold allodynias in the neuropathic animal that was reversed by the first day of PT administration, but returned to the inhibited state on the second day of PT administration. Serotonin(60mg/kg) enhanced transiently the antinociceptive effect of PT on allodynia to mechanical and chemical stimuli, but showed prolonged effect on the allodynia to cold stimuli. PT enhanced transiently the antinociceptive effects of the TEA(10mM) on allodynia to mechanical and chemical stimuli, but the enhanced effect on cold allodynia was maintained. From these results it is concluded that total saponin extracts of ginseng has antinociceptive effects on the allodynia to mechanical, chemical and cold stimuli in the neuropathic pain animal, and among the ginseng extract PT is the effective component, and that the mechanism of the antinociceptive effects of PT is not simple.