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- 저자 : Herd, Robert M. (검색결과 3 건)
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Jordan Au,Francis M. Hulme-Moir,Andrew Herd,Mathew A. Kozman 대한대장항문학회 2021 Annals of Coloproctolgy Vol.37 No.S
We report a case of a 66-year-old male who presented with a locally advanced primary mucinous adenocarcinoma arising from a fistula-in-ano. The presentation was typical for perianal sepsis and fistula-in-ano with anal pain and chronic discharge. Initial treatments with fistula debridement and seton were performed. Subsequent review of histology revealed underlying adenocarcinoma, while magnetic resonance imaging (MRI) showed local invasion into the prostate. The patient received neoadjuvant chemoradiotherapy followed by pelvic exenteration to maximize the chance of achieving cure. Features of this case are discussed together with its implications, including treatment guidelines and typical MRI findings.
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The 'Architect-friendliness' Of Six Building Performance Simulation Tools: A Comparative Study
Weytjens, Lieve,Attia, Shady,Verbeeck, Griet,De Herde, Andre Sustainable Building Research Center 2011 International journal of sustainable building tech Vol.2 No.3
Concerning net zero energy buildings, providing early design support for architects has never been more important. In this context, building performance simulation tools could be a strong supportive technique, when integrated early in the architectural design process. However, despite the available range of tools, most of them do not meet the architects' requirements. To identify this gap, this study compared the 'architect-friendliness' of six state-of-the-art simulation tools, to highlight the architects' requirements for these tools and to develop guidelines for researchers and tool developers. The examined tools included ECOTECT, IES/VE - Sketch-Up, Energy10, eQuest, HEED, and Design Builder. The analysis was based on an extensive list of criteria defining the user-friendliness of tools from an architect's point of view. The results show that no single tool is entirely adequate to assist the architect's decision-making process. One of the major limitations is the poor communication and visualization of the output results.
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Al-Husseini, Wijdan,Chen, Yizhou,Gondro, Cedric,Herd, Robert M.,Gibson, John P.,Arthur, Paul F. Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.10
MicroRNAs (miRNAs) are short non-coding RNAs that post-transcriptionally regulate expression of mRNAs in many biological pathways. Liver plays an important role in the feed efficiency of animals and high and low efficient cattle demonstrated different gene expression profiles by microarray. Here we report comprehensive miRNAs profiles by next-gen deep sequencing in Angus cattle divergently selected for residual feed intake (RFI) and identify miRNAs related to feed efficiency in beef cattle. Two microRNA libraries were constructed from pooled RNA extracted from livers of low and high RFI cattle, and sequenced by Illumina genome analyser. In total, 23,628,103 high quality short sequence reads were obtained and more than half of these reads were matched to the bovine genome (UMD 3.1). We identified 305 known bovine miRNAs. Bta-miR-143, bta-miR-30, bta-miR-122, bta-miR-378, and bta-let-7 were the top five most abundant miRNAs families expressed in liver, representing more than 63% of expressed miRNAs. We also identified 52 homologous miRNAs and 10 novel putative bovine-specific miRNAs, based on precursor sequence and the secondary structure and utilizing the miRBase (v. 21). We compared the miRNAs profile between high and low RFI animals and ranked the most differentially expressed bovine known miRNAs. Bovine miR-143 was the most abundant miRNA in the bovine liver and comprised 20% of total expressed mapped miRNAs. The most highly expressed miRNA in liver of mice and humans, miR-122, was the third most abundant in our cattle liver samples. We also identified 10 putative novel bovine-specific miRNA candidates. Differentially expressed miRNAs between high and low RFI cattle were identified with 18 miRNAs being up-regulated and 7 other miRNAs down-regulated in low RFI cattle. Our study has identified comprehensive miRNAs expressed in bovine liver. Some of the expressed miRNAs are novel in cattle. The differentially expressed miRNAs between high and low RFI give some insights into liver miRNAs regulating physiological pathways underlying variation in this measure of feed efficiency in bovines.
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