http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Herbert Y. Meltzer (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
Buspirone-induced Prolaction 분비와 5-HT<sub>1A</sub> 수용체: Pindolol 전처치 효과
이홍식(Hong Shick Lee),J. Frank Nash,Herbert Y. Meltzer 대한약리학회 1992 대한약리학잡지 Vol.28 No.1
Nonbenzodiazepine계 항불안제인 buspirone을 이용하여 건강한 8명의 남자를 대상으로 prolactin과 cortisol분비를 측정하였다. Buspirone는 DopaminE<sub>2</sub> 수용체 antagonist 성질 뿐 아니라 5-HT<sub>1A</sub> partial agonist 효과가 있는 것으로 보고되고 있다. Buspirone 30mg 경구투여시 혈청 prolactin 농도는 유의한 증가를 보였으나 혈청 cortisol 농도의 변화는 차이가 없었다. beta adrenoreceptor antagonist이면서 5-HT<sub>1A</sub> 수용체 antagonist로 알려진 pindolol (30mg)을 경구 투여한 결과 기초 혈청 prolactin이나 cortisol 농도는 유의한 차이가 없었다. Pinodlol을 전처치한 경우 buspirone-induced prolaction 분비의 유의한 억제효과는 없었다. 이상의 성적은 buspirone-induced prolactin 분비증가는 아마도 5-HT<sub>1A</sub> 수용체 활성과 관련되지 않음을 시사하는 것으로 사료된다. The effect of the nonbenzodiazepine anxiolytic, buspirone (Buspar<sup>R</sup>), a serotonin (5-HT)<sub>1A</sub> partial agonist, which also has dopamine (DA)<sub>2</sub> receptor antagonist properties, on prolactin and cortisol secretion was examined in eight normal male volunteers. The oral administration of buspirone (30 mg) significantly increased plasma prolactin concentrations but did not significantly increase plasma cortisol concentrations in this study. The oral administration of pindolol (30mg), a beta adrenoceptor antagonist which is also a 5-HT<sub>1A</sub> receptor antagonist, had no significant effect on basal prolactin or cortisol levels. Moreover, pretreatment with pindolol did not significantly inhibit the buspirone-induced increase in prolactin secretion. These preliminary data are suggestive that buspirone-induced prolactin secretion is not mediated via 5-HT<sub>1A</sub> receptor activation.
-
Lee, Hong-Shick,Nash, J. Frank,Meltzer, Herbert Y. The Korean Society of Pharmacology 1992 대한약리학잡지 Vol.28 No.1
Nonbenzodiazepine계 항불안제인 buspirone을 이용하여 건강한 8명의 남자를 대상으로 prolactin과 cortisol분비를 측정하였다. Buspirone는 $Dopamine_2$ 수용체 antagonist 성질 뿐 아니라 $5-HT_{1A}$ partial agonist 효과가 있는 것으로 보고되고 있다. Buspirone 30mg 경구투여시 혈청 prolactin 농도는 유의한 증가를 보였으나 혈청 cortisol 농도의 변화는 차이가 없었다. beta adrenoreceptor antagonist이면서 $5-HT_{1A}$ 수용체 antagonist로 알려진 pindolol (30mg)을 경구 투여한 결과 기초 혈청 prolactin이나 cortisol 농도는 유의한 차이가 없었다. Pinodlol을 전처치한 경우 buspirone-induced prolaction 분비의 유의한 억제효과는 없었다. 이상의 성적은 buspirone-induced prolactin 분비증가는 아마도 $5-HT_{1A}$ 수용체 활성과 관련되지 않음을 시사하는 것으로 사료된다. The effect of the nonbenzodiazepine anxiolytic, buspirone $(Buspar^R)$, a serotonin $(5-HT)_{1A}$ partial agonist, which also has dopamine $(DA)_2$ receptor antagonist properties, on prolactin and cortisol secretion was examined in eight normal male volunteers. The oral administration of buspirone (30 mg) significantly increased plasma prolactin concentrations but did not significantly increase plasma cortisol concentrations in this study. The oral administration of pindolol (30 mg), a beta adrenoceptor antagonist which is also a $5-HT_{1A}$ receptor antagonist, had no significant effect on basal prolactin or cortisol levels. Moreover, pretreatment with pindolol did not significantly inhibit the buspirone-induced increase in prolactin secretion. These preliminary data are suggestive that buspirone-induced prolactin secretion is not mediated via $5-HT_{1A}$ receptor activation.
-
Clozapine, but Not Haloperidol, Increases Hippocampal Dopamine and Acetylcholine Release
Young-Chul Chung,In-Seong Park,Zhu Li,Jin Dai,Herbert Y. Meltzer,Junji Ichikawa 대한정신약물학회 2003 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.1 No.1
Atypical antipsychotics (APDs) such as clozapine, but not the typical APD haloperidol, produce greater increases in dopamine and acetylcholine release in rat medial prefrontal cortex (mPFC), compared to the nucleus accumbens (NAC) or striatum (STR), a mechanism postulated to lead to improvements of negative symptoms and neurocognitive deficits in patients with schizophrenia. The present study determined whether typical and atypical APDs modulate dopamine and acetylcholine release in the ventral hippocampus (vHIP) as well as mPFC, both of which are important to neurocognitive functions in schizophrenia. Clozapine (3 and 10 mg/kg) produced comparable increases in dopamine release in the mPFC and vHIP. Clozapine (3 and 10 mg/kg) also increased acetylcholine release in both regions, without significant effect at 3 mg/kg in the mPFC. The perfusion of tetrodotoxin(1 μM) into the vHIP eliminated clozapine-induced dopamine and acetylcholine release in that region. Haloperidol (0.1, but not 1 mg/kg) only increased dopamine release in the mPFC, without an effect of all the doses on either release in either region. These results suggest that clozapine, but not haloperidol, increases dopamine and acetylcholine release in the vHIP as well as in the mPFC. This may further indicate that clozapine and perhaps related atypical APDs may differ from the typical APDs such as haloperidol in enhancing dopamine and acetylcholine transmission in the hippocampal-PFC pathway that may be responsible for neurocognitive deficits in schizophrenia.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
