증폭(蒸曝)에 의한 지황(地黃)의 성분 변화에 대한 고찰

정재우 ( Jae Woo Jung ),김한영 ( Han Young Kim ),류지효 ( Ji Hyo Lyu ),김정훈 ( Jung-hoon Kim ) 대한본초학회 2021 大韓本草學會誌 Vol.36 No.6

Objectives : ‘Steaming and drying’ is a traditional processing method that has been used to produce Suk-ji-hwang (熟地黃; Rehmanniae Radix Preparata) from Ji-hwang (地黃, the fresh root of Rehmannia glutinosa Liboschitz ex Steudel; Rehmanniae Radix). The steaming and drying process, which is proceeded in heating and moisturizing conditions, plays a crucial role in the change of therapeutic effect of Ji-hwang, presumably due to the modification of its chemical constituents. In this article, the chemical influence of the ‘Steaming and drying’ process was investigated for understanding the underlying mechanism of chemical modification of Ji-hwang. Methods : The articles regarding the modifications of chemical constituents of Ji-hwang during the ‘Steaming and drying’ process were collected and analyzed to investigate the influence of the processing to Ji-hwang. Results : The results indicated that iridoid glycosides were degraded to their aglycones and sugars, and such degradations occurred faster at a high pressure than at an atmospheric pressure during the process. The contents of catalpol, ajugol, and acteoside were decreased, while those of rehmannioside A and D were slightly increased during the repeated processing. The contents of oligosaccharides, namely sucrose, maltose, raffinose, and stachyose (except for manninotriose), were decreased, while those of monosaccharides, glucose and fructose, were increased by the repeated processing. Conclusions : These results demonstrate that the ‘Steaming and drying’ process influenced the chemical constituents of Ji-hwang and provide probable basis for the therapeutic modification of Suk-ji-hwang after the processing of Ji-hwang.

가감청영탕(加減淸營湯)에 효과를 보인 열성 아토피 피부염 환자 6례 증례 보고

서지혜,정창환,박선정,임소영,한수련,Seo, Ji-Hye,Jung, Chang?Hwan,Park, Seon-Jeong,Lim, So-Young,Han, Su-Ryun 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.3

Objective : The purpose of this study is to investigate the effect of Gagamchengyoung-tang($Ji\bar{a}ji\check{a}nq\bar{i}ngy\acute{i}ng-t\bar{a}ng$) for atopic dermatitis patients diagnosed as the febrile tendency. Method : This case study was done on 6 atopic patients with febrile tendency who have visited Korean Medicine Clinic from 2013.08.01. to 2014.04.30.. Gagamchengyoung-tang($Ji\bar{a}ji\check{a}nq\bar{i}ngy\acute{i}ng-t\bar{a}ng$) was prescribed to all 6 patients and evaluated the symptom change through photographs and questionnaire. Objective SCORAD Index(OSI) was used to evaluate the objective symptom and VAS was used to evaluate the subjective change. Results & Conclusion : The Objective SCORAD index and VAS were decreased in all patients. The average OSI reduction score was 26.3. Most symptoms of 6 patients were improved. Gagamchengyoung-tang ($Ji\bar{a}ji\check{a}nq\bar{i}ngy\acute{i}ng-t\bar{a}ng$) can be effective in patients who were diagnosed as febrile tendency.

영골(靈骨).강압혈(降壓穴) 자극(刺鍼)이 혈압(血壓)에 미치는 영향(影向)

임영남,심성용,한지완,고호연,박종형,한양희,전찬용,김동우,Yim, Young-Nam,Sim, Sung-Yong,Han, Ji-Wan,Ko, Ho-Yeon,Park, Chong-Hyeong,Han, Yang-Hee,Chun, Chan-Yong,Kim, Dong-Woo 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.2

Objective : The purpose of this study is to evaluate the clinical effect of the non-pharmacological anti-hypertension method, acupuncture, for hypertensive patients. Methods : 26 patients diagnosed with hypertension were each treated by one of three methods: an anti-hypertension drug(adalat soft capsule), venepuncture, and acupuncture. In cases of rising blood pressure, patients were treated by their one of the three methods, and blood pressure was measured at regular intervals. Result : As for the group of acupuncture treated patients on Young-gol(ling-gu) and Gang-ap-hyul(jiang-ya-xue), readings dropped 18.0mmHg in systolic blood pressure and 6.50mmHg in diastolic blood pressure. This was a greater effect than that seen in the venepuncture treated patients. Blood pressure checked one hour after acupuncture treatment showed a greater difference than blood pressure checked after thirty minutes. Conclusion : Safe reductions in blood pressure were observed through the non-pharmacological method of acupuncture on Young-gol(ling-gu) and Gang-ap-hyul(Jiang-ya-xue).

Prototype Development of Nursing Simulation Contents Using Virtual Reality Technology

Ji-Young Yeo,Jong-Il Park,Soo-Yeon Han 한국간호과학회 2021 한국간호과학회 학술대회 Vol.2021 No.10

Aim(s): This study was aimed to develop a prototype for nursing simulation contents based on Virtual reality (VR) technology. Method(s): This methodological study was conducted through literature review on previous studies, composition of prototype development participants (nursing expert, technical expert, and 3D modeler), expert advice, examination of content validity, prototype design and development. The research period was from October 2020 to April 2021. The final prototype was implemented based on Unreal Engine 4. Result(s): The overall operation stage of simulation was designed into four stages: orientation, pre-practice, simulation practice, and follow-up activities. The prototype contents were designed according to the Han’s principles of virtual reality simulation design and guideline (2019): 1) principle of matching authentic problems in reality, 2) principle of judgement that is suitable for VR technology, 3) principle of similarity to real environment, 4) principle of structural planning, 5) principle of implementing the professional approach, 6) principle of conceptualizing deployment of simulation activity, 7) principle of simple to complex process, 8) principle of virtual recognition, 9) principle of the same operation and selection as reality, 10) principle of providing information, 11) principle of promoting critical thinking, 12) principle of reflection on the whole simulation. By referring to Jeffries’s simulation design, six scenarios of hospitalized children with pneumonia were constructed and content validity was evaluated (CVI=0.99). Conclusion(s): To maximize the effect of virtual reality-based simulation in nursing education, VR contents should be developed through virtual reality-based simulation design that incorporates the characteristics of VR education and learning components of traditional simulation, rather than simply using VR devices as a training method for existing simulation scenarios. Follow-up study should be conducted to analyze the learner"s reaction and confirm the dynamics of the virtual reality contents in real setting.

동거형태에 따른 젊은 남자성인의 식행동과 건강관련 행동의 차이

박영숙,장지혜,임은희,한재라 순천향대학교 기초과학연구소 2001 순천향자연과학연구 논문집 Vol.7 No.2

A survey was performed to 250 male young men who were living alone and shared living with friends in Chungnam province. Their average age was 22.6 years old, height was 171.8 cm, weight was 65.6 kg and BMI was 22.2 Comparing the prevalence of drinking, smoking and exercise, there were significantly different between living alone subjects and shared-living ones. The main value toward eating/meals was for hungry soultion. And we found many significant differences by living with or without companion. When young men living without companions, they shouved to be more in regular mealtimes, no-skipped meals, breakfast eating, adequate food amounts, eating-outs, etc. and to be less in pleasant mealtimes, various foods, snacking and especially late snacks. The good food intake pattern were highly scored in the alone-living group than the shared-living group, whereas the bad food intake pattern were also highly scoued in the alone-living group than the other. The latter might be due to the more food exposures because of companions. These findings could conclude that dietary behaviors of the young living alone were evaluated as good enough.

고령자 남녀와 20대 남녀에 있어서 다양한 등속수축중 최대 모멘트의 비교

金智源(Ji-Won Kim),金相佑(Sang-Woo Kim),文基旭(Ki-Wook Moon),嚴光文(Gwang-Moon Eom),李泳揆(Young-Gyu Lee),南貞淑(Jung-Sook Nam),朴寬龍(Kwan-Yong Park),金耀翰(Yo-Han Kim),洪廷和(Jeong-Hwa Hong),朴炳奎(Bung-Kyu Park) 대한전기학회 2008 전기학회논문지 Vol.57 No.10

In this paper, we investigated the maximum ankle joint plantarflexion moment (MPM) of young and elderly subjects during various modes of isokinetic contractions with special interest in the elderly females who were reported to have higher fall rate than the elderly males. Subjects include the young subjects (14 males: 22.7±2.5yrs, 13 females: 20.5±1.3yrs) and the elderly subjects (17 males: 65.8±10.5yrs, 26 females: 71.4±5.2yrs). The MPM was normalized by each subject's body weight. The MPM of elderly females was the weakest among the groups, particularly, at the eccentric contractions. The male-to-female ratio of MPM was greater in the elderly than in the young and the young-to-elderly ratio of MPM was greater in female than in male, both during the eccentric contractions. The result suggests that the decreased muscle force per body weight, especially at the eccentric contraction, may be one reason for the more frequent fall of the elderly female than the elderly male.

혐오자극과 모델링 및 언어적 지시가 발달지체 아동의 상동행동에 미치는 효과 : 사례연구

한현민,함소희,김윤선,지지영,홍희영 대진대학교 교육연구소 2000 교육연구 Vol.2 No.1

The experiment was undertaken to determine the combined effects of aversive, modeling, and verbal instruction on the self-stimulatory stereotyped benavior exhibited by a three-year two-month old with developmental delay, The behavioral interventions were consisted of lemon juice(aversive), behavioral rehearsal(moleling), verbal instruction(prompting), and defferential reinforcement of incompatible behavior (DRI), and continued over 73 sessions. The data gathered across multitreatments design (A-BCD-A-BD-DE) were visually analyzed. The results revealed that all the treatments reduced the occurrences of stereotyped behavior, the significant differences among any interventions were not found, and more importantly, the behavior effects were maintained.

A Study on the Time Series with a Structural Change : When the Timing of the Intervention is Unknown 개입시점이 알려져 있지 않을 때

한영지,권계화 서울여자대학교 자연과학연구소 1999 자연과학연구논문집 Vol.11 No.-

우리는 주변에서 구조가 갑자기 변하는 시계열을 많이 접할 수가 있다. 이러한 시계열 data들은 개입시점이 언제인지 알려져 있지 않은 것이 많다. 개입여부를 고려하지 않고 data 분석을 할 경우에는 분석에 오차가 생기고 잘못된 결과를 얻게 되는 경우가 있다. 따라서, 개입이 일어난 시점이 언제인지 찾는 연구가 많이 요구되어 왔다. 본 논문에서는 개입여부를 모를 때 개입시점 등을 찾아내는 방법을 제시하였고 시뮬레이션을 통해 유효성과 정확성을 확인하였다. 또한, 「한국의 자동차 판매량」이라는 실제 data를 우리가 제안한 방법에 적용시켜 어느 시점에서 개입이 있었는지 그런 개입들이 얼마나 한국의 자동차 시장에 영향을 미쳤는지에 대해 알아보았다.

우울 증상을 수반한 만성 정신분열병 입원환자에서의 Paroxetine 효과 : 이중맹검 위약대조 연구

한평주,백영석,오상우,전현태,김지영 대한신경정신의학회 2000 신경정신의학 Vol.39 No.4

연구목적: 우울 증상이 있는 만성 정신분열병 환자를 대상으로 항정신병약물과 항우울제인 paroxetine 20mg을 병합 투여하여 우울 증상, 양성 증상, 음성 증상 및 일반적인 정신병리의 호전 여부를 밝히고자 하였다. 방법: DSM-IV 기준상 정신분열병으로 진단된 입원환자 중 우울 증상이 있는 49명을 대상으로 parox-etine과 위약을 이중맹검을 대조한 전향적 임상 연구로서 Hamilton Rating Scale for Depression (HRSD), Brief Psychiatric Rating Scale(BPRS), Positive and Negative Syndrome Scale (PANSS), Extrapyramidal Symptom Rating Scale(ESRS), UKU side effect rating scale(UKU), Clinical Global Impression(CGI)을 기저선과 1주, 2주, 4주, 6주의 시점에서 다섯 번 반복 측정하여 비교 검토하였다. 결과: 36명의 환자가 6주간의 실험을 마쳤다. Paroxetine군과 위약군을 비교해볼 때 HRSD 총점은 양군에서 의미있게 감소되어(p<.01) 우울 증상이 호전되었으나, 두 군간에 통계적으로 의미있는 차이는 없었다. 시간경과에 따라 항우울 효과는 paroxetine 군에서는 2주, 위약군에서는 4주 후부터 관찰되었다. 그리고 paroxetine군과 위약군 모두 PANSS 총점(p<.01)과 CGI 점수(p<.05)가 감소되어 전반적인 정신병리의 감소와 전체적인 임상적 호전을 보였으나, 두 군에서 양성 증상, 음성 증상, 일반적인 정신병리 그리고 약물 부작용은 유의미한 차이가 없었다. Paroxetine군에서 반응군고 비반응군으로 나누어 비교했을 때, 반응군이 비반응군보다 HRSD의 총점(p<.01)과 우울한 기분, 자살, 정신적 불안, 죄채감의 세부 항목에서 유의한 호전을 보였고(p</01),일과 활동, 초기 불면증, 건강염려증의 세부 항목이 호전되어(p<.05) 현저한 우울 증상의 호전을 보였다. 또한 반응군이 비반응군보다 BPRS 총점(p</01)과 PANSS의 일반적인 정신병리 점수(p<.05)가 낮게 나와, 일반 정신병리의 호전을 보였다. 결론: Paroxetine군과 위약군 모두에서 우울 증상의 감소가 있었지만, paroxetine군에서 항우울 효과가 빠르게 나타났다. 두 군간에 양성 증상, 음성 증상, 일반적인 정신병리와 부작용에 대한 차이는 없었다. Paroxetine군에서 반응군은 비반응군보다 우을 증상과 일반적인 정신병리에서 유의한 호전을 보였다. 즉 우울한 기분, 자살, 정신적 불안, 죄책감, 일과 활동, 초기 불면증, 건강염려증이 심한 정신분열병 환자에게 우울 증상을 회복시키는데 paroxetine 20mg의 병용 투여가 효과가 있었다. Objectives: This double-blind placebo-controlled study was conducted to demonstrate the improvement of depressive, positive and negative symptoms, and general psychopatholgy in depressed chronic schizophrenic inpatients with adjunctive paroxetine 20mg therapy in the morning. Methods: Forty nine chronic schizophrenic inpatients with depressive symptoms were randomly received adjunctive paroxetine of placebo for 6 week study period. Therapeutic effect and side dffects were evaluated by means of the Hamiltom Rating Scale for Depression(HRSD),The Brief Psychiatric Rating Scale(BPRS), the Positive and Negative Syndrome Scale(PANSS), the Extrapyramidal Symptom Rating Scale(ESRS), the UKU side effect rating scale(UKU), and the Clinical Global Impression(CGI) at baseline, first, second, forth, and sixth week of treatment in a controlled double-blind design. Results: 18 patients completed six weeks of paroxetine therapy, and 18 patients placebo therapy. 1) Comparison between paroxetine and placebo groups: (1) HRSD total scores in both groups were significantly decreased(p<.01) but there was no statistically significant difference between 2 groups. This study showed that significant effect in paroxetine group appeared at 2nd week of treatment(p<.01), while in placebo group at 4th week of treatment(p<.01). (2) PANSS, BPRS< CGI, ESRS, and UKU : In both groups, PANSS total scores and CGI scores were significantly decreased respectively(p<.01, p<.05) and thus indicated th im-provement of global psychopathology and entire effects. There were no significant differences between 2 groups in positive, negative symptoms, general psychopathology, and drug side effects. 2) Comparison between responding and nonresponding groups in paroxetine adjunctive therapy : (1) Compared with nonresponding group, responding group had significant decrease in HRSD total score(p<.01), in HRSD subitems such as depressed mood, suicide, psychic anxiety, and feelings of guilt(p<.01), and in other subitems such as work and activity, early insomnia, and hypochondriasis(p<.05). (2) Compared with nonresponding group, responding group had significantly decrease in BPRS total score(p<.01) and in general subscale of PANSS(p<.05). Conclusion: The results suggest that both paroxetine and placebo groups were improved in depressive symptoms, but paroxetine group had more rapid improvement than placebo group. There were no significant differences in positive symptoms, negative symptoms, general psychopathology, and drug side effects between two groups. Compared with nonresponding group in paroxetine adjunctive therapy, responding group had significant improvement in depressive symptoms and general psychopathology.

시행 전 정보의 제시빈도가 기술습득에 미치는 영향

한지영,김기웅 한국학교체육학회 2003 한국학교 체육학회지 Vol.13 No.2

본 연구는 사전정보가 운동학습에 영향을 미친다는 선행연구를 바탕으로 골프퍼팅에서 일직선 스트로크 기술을 학습하는데 사전정보 중 지각적 선행훈련이 학습에 도움을 주는가를 살펴보고, 사전정보를 다양한 빈도로 제시하여 과제정보의 제시빈도가 기술습득에 미치는 영향을 살펴봄으로서 사전정보가 가이던스 가설에 영향을 받는가를 알아보고자 한 것이다. 이를 위해 24명의 오른손잡이 여대생(평균연령 23세)을 실험조건에 따라 각각 8명씩 3개의 집단(시행 전 정보제시 100%, 50%, 0% 집단)에 무선배정하였다. 실험은 5회 시행을 1분단으로 하여 8개 분단(총 40회)의 습득시행을 수행하는 것으로 설계하였다. 따라서 실험은 3(집단) ?8(분단) 반복측정 요인설계(3? FD with repeated-measures on block)하에서 이루어 졌다. 습득시행을 한 후, 약 24시간 후 2분단(총 10회)의 파지검사를 실시하였다. 실험을 통해 얻어진 점수는 이차원 과제(2D(dimension) task)의 정확성을 평가하기 위한 평균반경 오차(mean radial error: MRE)와 수행의 일관성을 측정하기 위한 이원변량 가변오차(bivariate variable error: BVE) 점수로 환산하여 분석하였다. 그 결과 평균반경오차와 이원변량 가변오차에서 통계적으로 유의한 차이가 나오지 않았으나 기술통계치에서 100% 집단이 다른 두 집단보다 좋은 결과를 보여주므로 가이던스 가설(guidance hypothesis)이 사전정보에는 영향을 미치지 않는다는 것을 보여주었다. 그러나 50% 제시집단은 오히려 0% 제시집단 보다 더 큰 오차점수를 보여주었다. 이것은 골프퍼팅이 이차원적인 과제이기는 하지만 본 연구는 퍼팅의 중요요소인 방향성(direction)과 힘의 크기(amplitude of force) 중 방향성만을 제시하였으므로 보다 분별력 있는 분석이 필요하며 시행 전 과제정보의 효과에 대한 일관된 연구가 부족하므로 지각적 선행연습을 포함한 모든 분야에서 다양한 연구가 요구되어진다. This study was intended to examine influence of perceptual pretraining, among pre-practice information, on learning straight stroke techniques in golf putting; and to examine the influence of differing frequencies of task information on the acquisition of golf putting techniques. On the basis of the results of previous studies that pre-practice information exerts a significant influence on motor learning. For this study, 24 right-handed female university students aged 23 in average were randomly and equably allocated to three different experimental groups; i.e. 1) 100% pre-practice information presentation group, second group 50%, and the third by 0%. The experiments was designed as follows: Acquisition trial blocks were to be performed for 8 blocks, with each block consisting of 5 trials (i. e. a total of 40 trials). Accordingly, the experiment was in a involving 3 (groups) ?8 (blocks) factorial design with repeated-measures on the second factor. Twenty four hours (i. e. one day) after the completion of the acquisition trial block, a retention test was conducted for 2 blocks (a total of 10 tests). The score points calculated from the experiments were converted into 1) mean radial error (MRE), i. e. a gauge to evaluate accuracy of two-dimensional tasks, and 2) bivariate variable error (BVE). i. e. a gauge to assess consistency of performance. As a result of the analysis, no significant difference was found between the MRE and BVE, However, in terms of descriptive statistical data, the group with 100% presentation of pre-practice information posted better results when compared to the two other groups, which is incongruous with the guidance hypothesis in case of pre-practice information. According to the guidance hypothesis, it is expected that high frequency group should not show better learning effect as compared to lower frequency group. However, the group with 50% presentation of pre-practice information showed larger errors when compared to the group with 0% presentation of pre-practice information. The findings of this study manifests a need for an analysis with higher discernability as the study proposed a direction only rather than proposing a combination of a direction and amplitude of force, which serve as major factors of golf putting, although golf putting is 2 dimensional task. The lack of consistent research results on effects of pre-practice task information, to date is interpreted to indicate a necessity of exploring multi-faceted studies in all the relevant areas including perceptual pretraining