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Hydantoin환의 가수분해반응 및 O-알킬화반응을 이용한 새로운 A1ky1 α-Anilinophenylacetate 유도체의 합성
박명숙,최희전,박해선,권순경 德成女子大學校 藥學硏究所 2002 藥學論文誌 Vol.13 No.1
For the development of new synthetic method for unnatural amino acid esters, alkyl α-anilinophenylacetates 4a-i were synthesized through base-catalyzed hydrolysis of 1,5-diphenylhydantoins 1a-b in methanol and O-alkylation of sodium α-anilinophenylacetate 3 with alkyl halides in DMF. Even though hydrolysis of hydantoin ring was undertaken under about 30-40℃ in methanol, the hydantoic acid sodium salt 2 was continuously converted to the sodium α-anilinophenylacetate 3. All synthetic process from hydantoin to alkyl α-anilinopheny lacetates could be carried out in one-pot without isolation of intermediates.
안경주 김철규 전해옥 김봉정 김혜숙 채명옥 윤현정 한달롱 김아린 청주대학교 보건의료과학연구소 2014 보건의료과학연구 Vol.3 No.1
Dynamics in the workplace and in society have contributed to the paradigm shift to outcome-based education. This study was performed to develop the curriculum based on assessment of existing program for the baccalaureate nursing program at Cheongju University. We used three steps-Analysis, Design, and Development-in ADDIE model for developing curriculum. The subjects were 18 graduate nurses, 41 nursing students, 38 parents, and 2 nursing team leaders for analysis of core competence. In conclusion, developing an outcome-based curriculum might be used to facilitate the students' development and evaluate the competence of the student during and on completion of the nursing baccalaureate program at Cheongju University.
Microsatellite Instability in Coloretal Cancer
Jeon, Hae Myung,Yoo, Seung Jin,Kim, Nam Il,Kim, Jeong Soo,Chang, Suk Kyun,Kim, Jae Sung CATHOLIC MEDICAL CENTER 1996 Bulletin of the Clinical Research Institute Vol.21 No.1
Microsatellites are short nucleotide repeat sequences present throughout the human genome. Alterations of microsatellites, comprising extra or missing copies of these sequences, have been termed microsatellite instability(genetic instability, replication errors, RER(+) phenotype). Spontaneous errors in DNA replication have been suggested to play a significant role in neo-plastic transformation and to explain the chromosomal alteration seen in cancer cell. We have studied six di , tri or tetranucleotide repeat loci, located on six different chromosomes by use of polymerase chain reaction amplification and denaturing polyacrylamide gel electrophoresis. We found that 9 of 46 (19.6%) sporadic colorectal cancers showed RER at two or several loci (RER(+)). Microsatellite instability was significantly associated with location of the tumor in the proximal colon (67%) and with poorly differentiated tumor phenotype(56%). These clinicopathological features in microsatellite instability of the colorectal cancer strongly similar to tumor from patients with HNPCC(Hereditary Non Polyposis Colorectal Cancer). These data in heritable HNPCC gene and microsatellite instability is closely associated to neoplastic transformation.
전혜정,박정희,신현준,최영칠,이상천,김명규,정규병 건국대학교 의과학연구소 1997 건국의과학학술지 Vol.7 No.-
We analyzed the image findings of bone scan and plain radiographs of 23 patients. The thirteen patients were traumatic rib fractures. Five patients were metastatic rib tumors. Five patients were rib caries. Differential diagnostic point were discussed by using bone scan images. Although 50 lesions were seen as increased uptake in the bone scan, only 30 lesions were found in the plain radiographs. In metastatic tumors, multiple lesions are scattered over the whole body. In fracture cases, the lesions are located one by one in orders, multiple increased uptake lesions are found in the same rib. In the caries cases, rib lesions were easily found by bone scan rather than plain radiographs. Increased uptake is also noted in the soft tissue abscess pocket adjacent to rib. Bone scan is very useful in the early detection of bone abnormality, even the etiology of bone lesion by analysis of images of bone scan.
Burkitt Lymphoma : Radiologic Imaging 방사선학적 소견
Jeon, Hae Jeong,Lee, Myung Sook,Kim, Sang Yoon 건국대학교 1993 學術誌 Vol.37 No.2
Burkitt 림파종은 1958년에 Burkitt이 처음 보고한 종양으로 미분화된 B-림파구에서 기원하는 악성종양이며 아프리카에서 호발하는 림파종과 그외 지역에서 호발하는 두 가지 종류가 있다. Burkitt 림파종은 일반 림파종과 비교하여 임상양상과 방사선학적 소견에 차이점이 많다. 또한 전산화단층촬영(CT)과 초음파검사(US)를 비롯한 방사선학적 검사는 종양의 진단외에도 종양의 크기와 범위, 수술유무의 적절성, 주위 장기로의 침범유무, 치료후의 경과판정 및 재발유무를 정확히 알 수 있는 장점이 있다. 저자들은 상행결장과 공장에서 발생한 Burkitt 림파종 2예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. African Burkitt lymphoma was initially described by Burkitt in 1958. This is malignant neoplasm which occurred in Africa, endemic area, but also in non-endemic area, derived from undifferentiated B-cell lymphocytes. Radiologic studies provide informations about tumor bulk, extent, adequacy of surgical debunking, compromise of adjacent vital organs, response to chemotherapy and evidence of recurrence. We reported two cases of non-endemic Burkitt lymphoma with review of literatures.
( Hae Jun Song ),( Chul Jong Park ),( Tae Yoon Kim ),( Yong Beom Choe ),( Seok-Jong Lee ),( Nack In Kim ),( Jae We Cho ),( Jie Hyun Jeon ),( Min Soo Jang ),( Jai Il Youn ),( Myung Hwa Kim ),( Joonsoo 대한피부과학회 2017 Annals of Dermatology Vol.29 No.4
Background: Psoriasis is an immune-mediated, chronic in-flammatory disease affecting multiple aspects of patients` lives. Its epidemiology varies regionally; however, nation-wide epidemiologic data on psoriasis depicting profile of Korean patients has not been available to date. Objective: To understand nationwide epidemiologic characteristics and clinical features of adult patients with psoriasis visited uni-versity hospitals in Korea. Methods: This multicenter, non-in-terventional, cross-sectional study recruited 1,278 adult pa-tients with psoriasis across 25 centers in Korea in 2013. Various clinical data including PASI, BSA, DLQI, SF-36 and PASE were collected. Results: A total of 1,260 patients com-pleted the study (male:female=1.47:1). The mean age was 47.0 years with a distribution mostly in the 50s (24.9%). Early onset (<40 years) of psoriasis accounted for 53.9% of patients. The mean disease duration was 109.2 months; mean body mass index was 23.9 kg/m2; and 12.7% of patients had a family history of psoriasis. Plaque and guttate types of psoriasis accounted for 85.8% and 8.4%, respectively. Patients with PASI ≥10 accounted for 24.9%; patients with body surface area ≥10 were 45.9%. Patients with DLQI ≥6 accounted for 78.8%. Between PASI <10 and PASI ≥10 groups, significant difference was noted in age at diagnosis, disease duration, blood pressure, waist cir-cumference of female, and treatment experiences with pho-totherapy, systemic agents, and biologics. Conclusion: This was the first nationwide epidemiologic study of patients with psoriasis in Korea and provides an overview of the epidemio-logic characteristics and clinical profiles of this patient population. (Ann Dermatol 29(4) 462∼470, 2017)
전혜정,박정희,신현준,최영칠,이상천,김명규,정규병 건국대학교 의과학연구소 1997 건국의과학학술지 Vol.7 No.-
Bone scintigraphy using technetium is a simple, safe and accurate method in the diagnosis of osteomyelitis. Bone scan can find the exact site of osteomyelitis and the needle aspiration and surgical drainage. Bone scan is the choice of diagnostic method for determining bone infection in children who are unable to communicate of in those whose signs have been modified by previous inadequate antibiotic therapy. We had the eleven patients whose symptoms are suspicious bone infection taken both technetium bone scan and plain radiographs from March 1996 to April 1997. We analyzed the images of bone scans and plain radiographs retrospectively and studied that how useful the bone scan is. Among eleven patients, the bone scan showed all positive finding of bone infection, but the plain radiographs revealed normal finding in six cases, soft tissue swelling in three cases, bone destruction in one case and periosteal reaction in one case. Conclusively, bone scan is very useful in localization of exact lesion and early detection of osteomyelitis.