Infestation and Related Ecology of Chigger Mites on the Asian House Rat (Rattus tanezumi) in Yunnan Province, Southwest China

Fan Ding,Wen-Li Jiang,Xian-Guo Guo,Rong Fan,Cheng-Fu Zhao,Zhi-Wei Zhang,Ke-Yu Mao,Rong Xiang 대한기생충학열대의학회 2021 The Korean Journal of Parasitology Vol.59 No.4

TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway

Yu Hai-Fan,Zheng Lian-Wen,Yang Zhan-Qing,Wang Yu-Si,Wang Ting-Ting,Yue Zhan-Peng,Guo Bin 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

TAZ, as a crucial effector of Hippo pathway, is required for spermatogenesis and fertilization, but little is known regarding its physiological function in uterine decidualization. In this study, we showed that TAZ was localized in the decidua, where it promoted stromal cell proliferation followed by accelerated G1/S phase transition via Ccnd3 and Cdk4 and induced the expression or activity of stromal differentiation markers Prl8a2, Prl3c1 and ALP, indicating the importance of TAZ in decidualization. Knockdown of TAZ impeded HB-EGF induction of stromal cell proliferation and differentiation. Under oxidative stress, TAZ protected stromal differentiation against oxidative damage by reducing intracellular ROS and enhancing cellular antioxidant capacity dependent on the Nrf2/ARE/Foxo1 pathway. TAZ strengthened the transcriptional activity of Nrf2 which directly bound to the antioxidant response element (ARE) of Foxo1 promoter region. Additionally, silencing TAZ caused accumulation of intracellular ROS through heightening NOX activity whose blockade by APO reversed the disruption in stromal differentiation. Further analysis revealed that TAZ might restore mitochondrial function, as indicated by the increase in ATP level, mtDNA copy number and mitochondrial membrane potential with the reduction in mitochondrial superoxide. Additionally, TAZ modulated the activities of mitochondrial respiratory chain complexes I and III whose suppression by ROT and AA resulted in the inability of TAZ to defend against oxidative damage to stromal differentiation. Moreover, TAZ prevented stromal cell apoptosis by upregulating Bcl2 expression and inhibiting Casp3 activity and Bax expression. In summary, TAZ might mediate HB-EGF function in uterine decidualization through Ccnd3 and ameliorate oxidative damage to stromal cell differentiation via Nrf2/ARE/Foxo1 pathway.

Construction of Z-scheme W18O49/NiAl-LDH heterojunction with photothermal effect for photocatalytic reduction of CO2

Cheng Xia,Rui-Tang Guo,Zhen-rui Zhang,Chen-yuan Fan,Yu-zhe Liu,Yu-cheng Lin,Chu-fan Li,Wei-Guo Pan 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-

Recently, the photocatalytic CO2 reduction technology is an effective solution to remit the energy crisis. Inorder to improve the photocatalytic performance, Z-scheme W18O49/NiAl-LDH composite catalysts wereprepared by hydrothermal method. Fortunately, the prepared catalysts revealed excellent photocatalyticperformance under the simulated sunlight, and CO and CH4 could be detected in the reduction products. WO/LDH-0.5 catalyst possessed the optimal activity, with CO and CH4 yield of 37.09 and 8.01 lmol g-1h1separately, which were 7.9 and 3.6 times that of NiAl-LDH monomer. In addition, W18O49 endowedW18O49/NiAl-LDH catalysts with photothermal effect, which raised the surface temperature andfacilitated the catalytic reaction. Meanwhile, the Z-scheme heterojunction composed of flower-likeNiAl-LDH and urchin-like W18O49 accelerated the separation of photoexcited carriers and enhanced theredox ability. Through a series of characterizations and investigations, this work is promising to breaknew ground for the design of photocatalysts with photothermal effect.

Microstructure and Mechanical Properties of Thin-Multilayer Ti/Al Laminates Prepared by One-Step Explosive Bonding

Fan, M.,Yu, W.,Wang, W.,Guo, X.,Jin, K.,Miao, R.,Hou, W.,Kim, N.,Tao, J. Springer Science + Business Media 2017 JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE Vol.26 No.1

<P>Thin-multilayer Ti/Al laminates were prepared by one-step explosive bonding method to investigate the interface bonding and mechanical properties owing to their potential application in aerospace and auto industry. It was found that Ti/Al laminates prepared at the detonation velocity of 2100 m/s exhibited superior surface quality without any defects in comparison with other detonation velocities owing to the optimum explosive pressure and impact velocity. The interface morphologies and element distribution of Ti/Al laminates prepared at the detonation velocity of 2100 m/s were characterized by means of SEM and EDS. The results indicated that the linear and wavy bonding interface coexisted and element diffusion occurred in the interfacial zone. Furthermore, thin-multilayer Ti/Al laminates possessed high microhardness, excellent interlaminar shear and tensile properties.</P>

Association Between Nasal Colonization of Staphylococcus aureus and Eczema of Multiple Body Sites

Guo Yang,Dou Xia,Chen Xiao-Fan,Huang Cong,Zheng Ying-Jie,Yu Bo 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.5

Purpose: Staphylococcus aureus is the critical pathogenic bacterium of eczema. The relationship between nasal colonization by S. aureus and eczema has not been well studied. We aimed to evaluate the associations between nasal colonization by S. aureus and eczema of multiple body sites, including persistent and ever-reported eczema. We further examined the associations between eczema and different subtypes of S. aureus, that is, methicillin-resistant S. aureus (MRSA) and methicillin-sensitive S. aureus (MSSA). Methods: The real-world data from the US National Health and Nutrition Examination Survey were used. The associations were calculated using survey-weighted multinomial logistic regression models and further calculated in subgroups stratified by demographic factors. Results: In total, 2,941 adults were included. The prevalence rate of S. aureus nasal carriage was significantly higher in adults with persistent hand eczema (51.0%) than in those with ever-reported hand eczema (23.3%) and never eczema (26.9%). S. aureus nasal colonization was associated with an approximately two-fold increased risk of persistent hand eczema (odds ratios ranges in different models: 2.86–3.06) without significant heterogeneity in the association by demographic factors. No significant associations between S. aureus nasal colonization and persistent eczema of other body sites or ever-reported eczema of multiple body sites (including hands) were observed. Furthermore, similar significant association between nasal colonization of MSSA and persistent hand eczema was seen; the association was much stronger (odds ratios ranges in different models: 4.64–6.54) for MRSA, although with borderline significant. Conclusions: Nasal colonization of S. aureus was associated with increased risk of persistent hand eczema. Our findings imply that preventive measures targeting S. aureus for the anterior nares should be considered in preventing and treating eczema.

매드 - 창사 문화 공원_창사, 중국

Yu Kui,Li Guo Jin,Shen Jun,Florian Pucher,Yi Wen Zhen,Li Juan,Zhao Fan,Hao Yi,Yao Mengyao 현대건축사 2006 월간 CONCEPT Vol.- No.86

Attitude Optimization Control Method of Agile Optical Small Satellite for Nonparallel Ground Track Imaging

Guo-Wei Fan,Xue-Ying Lv,Ying Song,Huan-Yu Zhao,Liu Zhang 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.8

Nonparallel ground track imaging of optical remote sensing satellite is an efficient imaging mode which could realize one-time transit imaging of complex observation tasks due to its fast and flexible imaging capability, and has attracted more attentions in the earth observation field recently. In this paper, an off-line attitude trajectory planning and on-line moving horizon attitude tracking control scheme based on optimal control idea is designed to satisfy the imaging requirement of high-performance attitude control oriented to nonparallel ground track imaging. Considering the entire satellite attitude adjustment of the drift angle, based on the geometric relationship of sapce vectors and the coordinate transformation principle, the three-axis attitude calculation of the precise pointing of key feature targets in the interested ground curve strip is conducted. Taking the attitude orientation as the constraint, the pseudospectral method is used following the established agile satellite control model to design the optimal trajectory of the attitude manever and the feedforward control torque of actuator for nonparallel ground track imaging. A moving horizon tracking control law based on the nonlinear error control model is designed to realize the highprecision attitude tracking control. The feasibility and effectiveness of the proposed control scheme are illustrated by numerical and imaging simulations.

The Soils of the Upper Reach of the Heihe River Basin in Relation to Aeolian Dust

Fan Yang,Gan-Lin Zhang,De-Cheng Li,Yu-Guo Zhao,Jin-Ling Yang,Feng Liu 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

Ginsengenin derivatives synthesized from 20(R)-panaxotriol: Synthesis, characterization, and antitumor activity targeting HIF-1 pathway

Guo, Hong-Yan,Xing, Yue,Sun, Yu-Qiao,Liu, Can,Xu, Qian,Shang, Fan-Fan,Zhang, Run-Hui,Jin, Xue-Jun,Chen, Fener,Lee, Jung Joon,Kang, Dongzhou,Shen, Qing-Kun,Quan, Zhe-Shan The Korean Society of Ginseng 2022 Journal of Ginseng Research Vol.46 No.6

Background: Ginseng possesses antitumor effects, and ginsenosides are considered to be one of its main active chemical components. Ginsenosides can further be hydrolyzed to generate secondary saponins, and 20(R)-panaxotriol is an important sapogenin of ginsenosides. We aimed to synthesize a new ginsengenin derivative from 20(R)-panaxotriol and investigate its antitumor activity in vivo and in vitro. Methods: Here, 20(R)-panaxotriol was selected as a precursor and was modified into its derivatives. The new products were characterized by ¹H-NMR, ¹³C-NMR and HR-MS and evaluated by molecular docking, MTT, luciferase reporter assay, western blotting, immunofluorescent staining, colony formation assay, EdU labeling and immunofluorescence, apoptosis assay, cells migration assay, transwell assay and in vivo antitumor activity assay. Results: The derivative with the best antitumor activity was identified as 6,12-dihydroxy-4,4,8,10,14-pentamethyl-17-(2,6,6-trimethyltetrahydro-2H-pyran-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl(tert-butoxycarbonyl)glycinate (A11). The focus of this research was on the antitumor activity of the derivatives. The efficacy of the derivative A11 (IC₅₀ < 0.3 µM) was more than 100 times higher than that of 20(R)- panaxotriol (IC₅₀ > 30 µM). In addition, A11 inhibited the protein expression and nuclear accumulation of the hypoxia-inducible factor HIF-1α in HeLa cells under hypoxic conditions in a dose-dependent manner. Moreover, A11 dose-dependently inhibited the proliferation, migration, and invasion of HeLa cells, while promoting their apoptosis. Notably, the inhibition by A11 was more significant than that by 20(R)-panaxotriol (p < 0.01) in vivo. Conclusion: To our knowledge, this is the first study to report the production of derivative A11 from 20(R)-panaxotriol and its superior antitumor activity compared to its precursor. Moreover, derivative A11 can be used to further study and develop novel antitumor drugs.

Sulfakinin inhibits activity of digestive enzymes in the brown planthopper, Nilaparvata lugens

Guo Di,Zhang Su,Zhang Yi-Jie,Ma Jun-Yu,Gao Cong-Fen,Wu Shun-Fan 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.4

In animals, feeding can regulate release of digestive enzymes. Digestive enzymes are produced and released in response to specific ratios of nutrients, so the quality and quantity of food ingested are important factors in the secretion and activity of digestive enzymes. In general, the enzyme activity and secretion in the fed insects are relatively higher than that in the unfed insects. Neuropeptides and peptide hormones are important regulators of enzyme activity. In several insects, the neuropeptide sulfakinin (SK) is known to be a regulator of feeding and digestion similar to cholecystokinin in mammals. However, the roles of diet and SK in regulation of activity of digestive enzymes in the important pest insect, the brown planthopper (Nilaparvata lugens), are unknown. In this study, we identified six genes encoding different digestive enzymes and cloned three of these. We found that enzymatic activity and transcriptional levels of digestive enzymatic activity genes were upregulated by refeeding animals for 5 h after 24 h starvation. Furthermore, injection of N. lugens SK reduces digestive enzyme activity and leads to a downregulation of digestive enzyme gene transcripts. This study provides new views into the action of diet and SK in regulation of digestive enzymes in (hemimetabolous) insects. Taken together with the roles of SK in inducing satiety, our data strongly suggest that SK signaling is important in regulation of food ingestion and processing.