A Case of Paracentric Inversion of Chromosome 18 (q21.1q22.1)

( Gh An ),( Kh Choi ),( My Kim ),( Jy Han ),( Hk Ahn ),( Jh Chung ),( Mh Kim ),( Sw Lee ),( Yj Han ),( Dw Kwak ),( Yh Chae ),( Sy Park ),( Hm Ryu ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-

We report on a case with a paracentric inversion of the long arm of chromosome 18: 46,XX,inv(18)(q21.1q22.1). A karyotype 46.XX.add(18) was found during antenatal diagnosis (amniocentesis) performed at local clinic because of advanced maternal age (38 years). And the pregnant woman visited our hospital at 18.4 weeks to confirm the result. We performed the amniocentesis and found the karyotype 46,XX,inv(18)(q21.1q22.1). The inversion was also found in the mother and the maternal grandmother of the fetus by chromosome studies from peripheral blood . The high resolution ultrasonography performed at 20.5 weeks showed normal findings. The diagnosis of paracentric inversion can be difficult and might be incorrect because of the variety of unpredictable unbalanced chromosome products that can result from a paracentric inversion. The vast majority of paracentric inversions are likely to be harmless. The risk of having an abnormal child for carriers of paracentric inversions is expected to be low. but sometimes by the variation of breakpoint or recombination process, various clinical phenotype can be seen : 18q- syndrome including: microcephaly, epicanthal folds, midface hypoplasia, and abnormally modeled ears, dermatoglyphic whorls on fingertips, clubfeet, hearing loss, and developmental delay. The mother is now ongoing pregnant state and the baby needs long term follow up after birth. This report underlines the importance of careful antenatal diagnosis and genetic counseling for parental and fetal paracentric inversion.

Ferreteria O'Higgins

GH+A 현대건축사 2012 월간 CONCEPT Vol.- No.158

Fabrication, Characterization and Investigating Properties of PVA Based Nanocomposite Films Reinforced with Mechano-chemically Synthesized CuO Nanoparticles

Gh. Dehghan Khalili,S. Alipour,M. R. Akbarpour,S. Moniri Javadhesari 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.8

In this study, copper oxide (CuO) nanoparticles were incorporate within polyvinyl alcohol (PVA) matrix and CuO–PVAnanocomposite film was fabricated by solution casting technique. In order to synthesize nanoparticles, a cost-competitive andfacile approach namely mechanochemical method was implemented. As nanoparticles precursors, pre-determined amountof CuSO4,NaCl, and NaOH were mixed. The mixture was ball-milled in zirconia medium for 10 h at ambient temperatureand rotational speed of 300 rpm. The XRD characterization analysis indicated CuO nanoparticles formation by ball milling. The CuO size was estimated to be in the ≈ 37 nm range. SEM images demonstrated the spherical morphology andlittle agglomeration for the nanoparticles. Furthermore, the bandgap energy of CuO was determined to be 1.84 eV. TheCuO content in the nanocomposite was set to be 2, 4, 8, and 10 wt%. Strong interaction between the PVA matrix and CuOnanofiller was confirmed by XRD and FT-IR investigations. Moreover, integration of CuO to the polymer matrix resultedin a decreased PVA crystallinity. The antibacterial behavior of PVA was increased by the addition of nanoparticles, and theCuO–PVA nanocomposite containing up to 4 wt% CuO had desirable antibacterial properties demonstrated against Escherichiacoli activity. CuO nanoparticles incorporating to PVA network led to reinforced mechanical and dielectric propertiesfor the nanocomposites. Besides, nanoparticles loading had direct impact on the intensified properties. Tensile strength wasenhanced from 85.8 (pure PVA) to 154.9 MPa (PVA-10 wt% CuO). The tensile modulus for neat PVA was 0.9 GPa andraised dramatically to 4.5 GPa for PVA-10 wt% CuO. Dielectric constant also improved more than three times at 1 kHzcomparing PVA and PVA-10 wt% CuO.

APPLICATION OF FINITE ELEMENT METHOD IN SOLVING BOUNDARY CONTROL PROBLEM GOVERNED BY PARABOLIC VARIATIONAL INEQUALITIES WITH AN INFINITE NUMBER OF VARIABLES

Gh. E. Mostafa 경남대학교 수학교육과 2020 Nonlinear Functional Analysis and Applications Vol.25 No.4

In this paper, we introduce the finite element method and solve the boundary control problem governed by parabolic variational inequalities with an infinite number ofvariables by using this method.

The Chrysanthemum Garden

GH?NG KY?NG-SE,Richard Rutt(번역자) The Academy of Korean Studies 1977 Korea Journal Vol.17 No.1

Out of plane behavior of walls, using rigid block concepts

Gh.M, Mohammadi,F, Yasrebi Techno-Press 2010 Structural Engineering and Mechanics, An Int'l Jou Vol.34 No.3

Out of plane behaviors of walls and infills are investigated in this paper, using rigid block concepts. Walls and infills are sometimes separated from top beams because of in plane movement of the walls and crumbling mortar layers under the top beams. Therefore, sufficient strength should be supplied to hold them against out of plane forces. Such walls are studied here under some real and scaled earthquakes, regarding their out of plane behavior. Influences of some reinforcements, connecting the walls to frames or perpendicular walls, are also studied. It is shown that unreinforced walls of regular sizes (3 m high and 4.5 m long) are normally unstable in the earthquakes. However, performing some reinforced bars that connect them to adjacent elements- frames or perpendicular walls - stabilizes them. Eventually, it is concluded that supplying 3 reinforced bars at 1/4, 2/4 and 3/4 of the panel's height stabilizes the walls in the assumed earthquakes. In this regard, for 20 cm and 35 cm thick walls ${\Phi}$18mm and ${\Phi}$20mm bars are to be used, respectively. For walls with other configurations, the forces and required areas of the reinforcements can be determined by the developed method of this paper.

POSTERS / PW-073 : WATER PERMEABILITY OF RED BLOOD CELLS FROM SEVERAL MAMMALIAN SPECIES

(Gh . Benga),(H . Matei),(L . Frentescu),(A . Florea),(B . E . Chapman),(C . H . Callagher),(P . W . Kuchel) 한국생화학분자생물학회 (구 한국생화학회) 1999 6th IUBMB SEOUL CONFERENCE Vol.- No.-

Distribution of strength and stiffness in asymmetric wall type system buildings considering foundation flexibility

Gh.R. Atefatdoost,H. Shakib,B. JavidSharifi 국제구조공학회 2017 Structural Engineering and Mechanics, An Int'l Jou Vol.63 No.3

Architecture constraints in buildings may typically cause irregularities in the distribution of stiffness and mass and consequently causes non-compliance of centers of mass, stiffness and strength. Such buildings are known as asymmetric buildings the distribution of strength and stiffness is one of whose main challenges. This distribution is more complicated for concrete buildings with RC shear walls in which stiffness and strength are interdependent parameters. The flexibility under the foundation is another subject that can affect this distribution due to the variation of dynamic properties of the structure and its constituting elements. In this paper, it is attempted to achieve an appropriate distribution pattern by expressing the effects of foundation flexibility on the seismic demand of concrete shear walls and also evaluate the effects of this issue on strength and stiffness distribution among lateral force resistant elements. In order to understand the importance of flexibility in strength and stiffness distribution for an asymmetric building in different conditions of under-foundation flexibility, the assigned value to each of the walls is numerically calculated and eventually a procedure for strength and stiffness distribution dependencies on flexibility is provided.

자궁근종에 대한 암상병리적 관찰

최근해(GH Choi),김혜경(HK Kim),김영기(YK Kim),이교웅(KW Lee) 대한산부인과학회 1966 Obstetrics & Gynecology Science Vol.9 No.5

The uterine myoma is most common tumor of the uterus, its incidence has been estimated that 1 out of 4 or 5 women over 35 years. Uterine myoma make their appearance during the reproductive era and tend to shrink after menopause. In the present clinico-pathological observation, we submitted for analysis of 252 cases of uterine myoma admitted to Gynecologic Department of The National Medical Center from the beginning of 1959 to the end of August 1964. Total number of laparotomies (excluded obstetric operation) during same period was 1,032 cases and among those cases 24.2% was performed upon women due to uterine myoma. We summarized the result as follows: 1) Age frequency of the patients when operation performed, the peak frequency period was 40~49(58%) and no cases encountered before the age of 20 years. The youngest age was 21 and the oldest was 66. 2) Majority of cases were corporeal myoma, 87.2%, whereas cervical myomas were 10.3% and mixed forms were 2.5%. 3) Intramural myomas were most common type of uterine myomas(36%), mixed forms were 22%, subserous myomas were 21.2% and submucous myomas were 20.8% as order. 4) The most common physical sign was palpable mass in the pelvic cavity, more than a half of those cases revealed 12~14 weeks pregnant size, while the largest one is frll term pregnant size. Pain in the pelvic region or lower abdomen was most frequent complaint (80.6%) and 78.4% of the patients complained uterine bleeding. In most instances of uterine bleeding associated with uterine myoma was mono-metrorrhagia(61.1%). Meno-metrorrhagia was more frequently seen in the mixed forms and submucous myomas. Pressure symptoms were not infrequently found in the myoma cases, more frequent in the mixed forms, and rarely seen in the submucous myomas. 5) Pregnancy was experienced in 76.3% of patients and average pregnancy rate was 2.9. Infertility was observed 57.2% of uterine myomy cases and among those cases primary infertility was 22.8% and secondary infertility was 34.4%. Infertility was more frequently seen in the subserous myomas and mixed forms. Spontaneous abortion has been experienced in 9.6% of total cases of uterine myoma during previous pregnancies, 3.3% of total number of pregnancies, and which was more often in submucous myomas. 6) If 베흐% hemoglobin was used as a tentative borderline for anemia, 44.6% of patients were anemic and among those cases 9.6% had severe anemia (less than 5gm.%). 7) The most common of all secondary changes of uterine myomas was hyaline degeneration, 19.8%, and sarcomatous degeneration was observed only 3 cases (1.2%), while no cases of fatty degeneration was seen. 8) Associated conditions were found in 67.1% of all patients and ovarian tumor was more often than PID. Adenomyosis associated with uterine myomas were seen in 13.1% of cases, whereas 1 case(0.4%) of endometriosis could be seen. 9) Total abdominal hysterectomy was the most common remedy for symptomatic uterine myomas, 63.2% and subtotal hysterectomy was performed in 21.4% of all cases. Mymectomy was performed in 14.3% for selected cases of child bearing age. Expectant treatment was done with effects in 1.6%, vaginal total hysterectomy was 0.8%, total hysterectomy with cesarean section and radical hysterectomy was performed in 0.4% respectively. 10) Postoperative complications were seen in 7.3%. The largest incidence of morbid cases were urinary tract infection, 3.7% and the ureter damage during operation accounted for the second greatest incidence.

주산기사망에 대한 임상적고찰

최근해(GH Choi),김서규(SK Kim),배평원(PW Bae) 대한산부인과학회 1974 Obstetrics & Gynecology Science Vol.17 No.2

1) 1968년 1월 1일부터 1972년 12월 말일까지 만 5년간 본원 산과병동에서 분만한 총 7,007 명의 산모로부터 출산된 7,102명의 출산아 중 주산기사망은 278명으로 주산기사망률은 생존 아출산 1,000명에 대하여 39.7에 해당하였다. 2) 주산기사망률은 초산부군에 비하여 2∼5회 경산부군에서 높았고 6회 이상의 다산부군에 서 가장 높았다. 반면 신생아사망률은 2∼5회 경산부군에서, 사망률은 초산부군에서 가장 낮 았고 6회 이상의 다산부군에서는 양자 공히 가장 높았다. 3) 다태임신에서 단태임신에 비하여 주산기사망률이 높았다. 4) 주산기사망의 49.3%가 조산아이었고 50.7%가 성숙아였다. 출산시 체중이 많을수록 주산 기사망률은 감소되었고, 4,000g 이상 군에서는 성숙아군에 비하여 그 사망률이 다소 증가되 었다. 5) 주산기사망 274명 중 65.7%는 산전관호를 받지 않았던 산모로부터, 34.3%는 산전관호를 받았던 산모로부터 출산된 예였다. 6) 태위에 따른 주산기사망률은 둔위분만례에서 172.2로 두위에 비하여 약 6배 높았고 횡위 에서는 564.1로 가장 높았다. 신생아사망은 둔위분만에서 많았고 사산률은 횡위에서 많았다. 7) 분만방법은 총 7,102명에 대하여 자연분만이 72.7%로 가장 많았고, 흡인분만 12.6%, 제와 절개술 8.5%, 인공개조둔위분만 4.5%, 겸자분만 148.9 등의 순이었다. 8) 신생아사망의 시기는 88.3%에서 24시간 이내에 발생하였고 주산기사망의 71.9%가 사산 이었다. 9) 주산기사망의 원인은 저산소증, 임신 중 고혈압증, 이상태위, 선천성기형, 감염 등의 순이 었고 저산소증은 주산기사망예의 29.6%에서 사인으로 간주되었으며 이에 대한 최대 원인은 정상위태반조기박리였다. 임신 중 고혈압증의 빈도는 전 분만예에 대한 24.1%였고 자간증에 서 주산기사망률은 자간전증에 비하여 2.4배 높았다. 그리고 주산기사망 274예 중 임신 중 고혈압증이 원인이라고 생각된 예는 15.7%에 해당하였다. The perinatal mortality has always attracted great interest and this wide interest has been readily explained by the complexity of the biological problems as well as certain definite factors connected with the perinatal period. The present clinical observation of the perinatal mortality at the Obstetric Ward of the National Medical Center, Seoul, during the years of 1968 to 1972, was based upon an obstetrical analysis of all deliveries during this 5 years. During this period there was a total of 6,913 single births with 93 twins and one triplet. Total number of births, therefore, were 7,102 and of these 6,905 were live births. Two hundred and seventy four perinatal deaths occurred throughout the above period. Perinatal mortality comprised all the dead infants with a birth weight above 1,000 gm who had died either before, during labor or in the first 7 days after birth. The results of clinical analysis were summarized as follows : 1. The perinatal mortality rate was 39.7 per 1,000 live births. For the last 2 years the perinatal mortality rate rose about 10 per 1,000 live births mainly due to increase of the neonatal death rate in prematures while the stillbirth rate remained stationary. The early nionatal death rate was 11.2. 2. The perinatal mortality rate was higher in 2 to 5 parity group than in primiparous group and highst in 6 or more. The nionatal death rate was the lowest in 2 to 5 parity group and the highst in 6 or more. 3. The perinatal mortality rate among pleural births were higher than single births. 4. One hundred thirty five babies (49.3%) among 274 perinatal deaths weighted between 1,000∼2,499 g and 139 babies (50.7%) weighed more than 2,500g. There was an inverse relationship between birth weight and mortality rate. 5. Perinatal deaths were more frequent in mothers who had not recieves prenatal care than in mothers who recieved it, even one or more times. 6. The perinatal mortality rate in breech presentation was higher than in cephalic and highst in transverse presentation. In breech presentation the fetuses were more often subject to birth traumas as compaired with ceplalic presentation and the risk of prolapse of the umbilical cord was increased in transverse presentation. Therefore the neonatal death was more frequent breech and the stillbirth rate was highst in transverse presentation. 7. The mode of deliveries were consisted of 72.7% of spontaneous delivery, 12.6% of vacuum extraction, 8.5% of cesarean section, 4.5% of assisted breech delivery, 0.7% of forceps delivery and 1% of moscellaneous modes. The perinatal mortality rate was lowest in the spontaneous delivery group (24.9) and was gradually increased by orders of vacuum extraction 37.6, cesarean section 61.9, assisted breech delivery 77.7 and forceps delivery 148.9. 8. The majority of neonatal deaths occurred within 24 hours after birth (88.3%) and the majority of perinatal deaths occurred during ante or intrapartum (71.9%). 9. The most common cause of perinatal deaths was related to hypoxia (29.6%) of which the most common contributing factor was abruptio placentae. Hypertensive disorders in pregnancy was present in 24.1% of all deliveries with a perinatal mortality rate of 25.5. About half of perinatal deaths were associated with prematurity.