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Song, Young Geun,Shim, Young-Seok,Kim, Sangtae,Han, Soo Deok,Moon, Hi Gyu,Noh, Myoung Sub,Lee, Kwangjae,Lee, Hae Ryong,Kim, Jin-Sang,Ju, Byeong-Kwon,Kang, Chong-Yun Elsevier Sequoia 2017 Sensors and actuators. B Chemical Vol.248 No.-
<P><B>Abstract</B></P> <P>We report the highly sensitive and selective downsized gas sensors for the IoT application. Sensing areas of Pt-interdigitated electrodes (IDEs) were varied to investigate the relation between sensing materials and electrodes. In<SUB>2</SUB>O<SUB>3</SUB> nanocolumns were deposited on the pre-patterned Pt IDEs using glancing angle deposition (GLAD). The effect of the interface resistance between electrodes and sensing materials, and the intergrain resistance between nanocolumns is analyzed by linear regression at different sensing area and incident angle of GLAD. In<SUB>2</SUB>O<SUB>3</SUB> (angle: 85°, sensing area: 0.3mm×0.3mm) nanocolumns with double Schottky barriers show the highest response and selectivity with fast response time of 10s to VOCs among the samples fabricated in this study. The analysis reveals that the intrinsic response of In<SUB>2</SUB>O<SUB>3</SUB> (angle: 85°, sensing area: 0.3mm×0.3mm) nanocolumns are dominantly affected by intergrain resistance, resulting in a high response. Our demonstration for the fundamental aspect of downsizing gas sensor makes an important contribution to the chemical sensor field with broad interest.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The sensing areas are varied to investigate the relation between sensing materials and electrodes. </LI> <LI> The effect of the interface resistance and the intergrain resistance are analyzed by linear regression. </LI> <LI> The performance of the downsizing gas sensor is greatly influenced by the interface resistance. </LI> </UL> </P>
백리향 오일 함유 유기농업자재의 보관온도에 따른 주성분 안정성 평가
류송희 ( Song-hee Ryu ),이지원 ( Jeewon Rhee ),윤효인 ( Hyoin Yoon ),최근형 ( Geun-hyoung Choi ),유혜진 ( Hyeijin Yu ),임성진 ( Sung-jin Lim ),이효섭 ( Hyo-sub Lee ),박상원 ( Sang-won Bark ) 한국환경농학회 2020 한국환경농학회 학술대회집 Vol.2020 No.-
백리향(Thymus vulgaris)은 꿀풀과 식물로 줄기와 잎에서 얻은 정유는 광범위한 살균효과가 있는 것으로 알려져 있다. 백리향의 이러한 특성으로 주로 서양종인 타임(Thyme) 정유가 병해충관리용 유기농업자재의 원료로 사용되고 있다. 타임에는 thymol과 carvacrol이 많이 함유되어 있으며 살균 활성이 높은 것으로 보고되어 있다. 친환경 농업에 대한 관심이 커지면서 이러한 식물 추출 물을 원료로 한 유기농업자재가 많이 사용되고 있으나 효능을 중심으로 한 유통기한이나 보관방법 에 대한 정보는 부족한 실정이다. 따라서 본 연구에서는 백리향 오일을 함유한 유기농업자재 중 주성분 thymol의 온도별 안정성을 평가하고자 하였다. 시중에 판매되는 백리향 오일 함유 유기농업자재 2개 제품을 대상으로 온도별(4℃, 25℃, 35℃, 45℃, 54℃)로 제품을 보관하며 주성분 thymol의 함량 변화를 조사하였다. 두 제품을 대상으로 분석한 결과, 주성분 thymol은 모든 온도에서 비교적 안정한 것으로 나타났다. 두 제품 모두 온도에 따른 안정성의 차이는 없었으며, 16주 까지 54℃의 학대조건(worst case)에서도 주성분이 안정하게 유지되어 해당 제품의 유효기간은 3년 이상으로 설정할 수 있을 것으로 판단된다.
Outcomes of Living and Deceased Donor Liver Transplant Recipients according to the MELD Score
( Jae Geun Lee ),( Juhan Lee ),( Jung Jun Lee ),( Seung Hwan Song ),( Jee Youn Lee ),( Su-kyung Kwon ),( Dong Jin Joo ),( Man Ki Ju ),( Gi Hong Choi ),( Jin Sub Choi ),( Soon Il Kim ),( Myoung Soo Kim 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Living donor liver transplantation (LDLT) has developed as an alternative to decease donor liver transplantation (DDLT) to overcome the critical shortage of deceased organ donations. However, the evidence supporting a LDLT for high model for end stage liver disease (MELD) score recipient is weak. We compared the outcomes of LDLT and DDLT according to MELD scores. Methods: The study included 498 adult patients who underwent liver transplantation between 2006 and 2014 at Severance Hospital. Patients with re-transplantation and fulminant liver failure were excluded from the study. Recipients were categorized according to their MELD score into low (MELD score ≤25) and high (MELD score >25) MELD group. Results: About 76.5% of patients are male and median age is 53. Major origin of liver cirrhosis is Hepatitis B virus and 50% of patients had HCC. There were no significant difference gender, donor gender, age, HBV, HCV, HCC and DM. However, age of donor, CTP score and MELD score in DDLT were significantly higher than LDLT. In both LDLT and DDLT groups, patients with high meld score show significantly lower graft survival than patients with low MELD score. (p =0.019 in LDLT and p=0.009 in DDLT) However, in both high and low meld group, there were no significant difference of survival between LDLT and DDLT. Non-HBV, HCC, High MED are risk factor for graft mortality in overall patients. However, HCV and high MELD are risk factor in patients without HCC. Conclusions: High MELD score is risk factor for Graft mortality in liver recipients regardless combined HCC. There was no significant difference between LDLT and DDLT, in patients with both high MELD and low MELD. When deceased donor organs are scare, LDLT with donor safety maybe good therapeutic option in patient with high MELD score.
( Jae Geun Lee ),( Juhan Lee ),( Jung Jun Lee ),( Seung Hwan Song ),( Man Ki Ju ),( Gi Hong Choi ),( Myoung Soo Kim ),( Jin Sub Choi ),( Soon Il Kim ),( Dong Jin Joo ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Acute cellular rejection after liver transplantation (LT) can be treated with steroid pulse therapy, but there is no ideal treatment for steroid-resistant acute rejection (SRAR). We aimed to determine the feasibility and potential complications of rabbit anti-thymocyte globulin (rATG) application to treat SRAR in liver transplant recipients. Methods: We retrospectively reviewed medical records of 429 recipients who underwent LT at Severance Hospital between January 2010 and March 2015. We compared clinical features and graft survival between patients with steroid-sensitive acute rejection (SSAR; n=23) and SRAR (n=11). We also analyzed complications and changes in laboratory findings after 2.5 mg/kg rATG treatment in patients with SRAR for 6-10 days. Results: There were no significant differences in gender, age, Model for End-stage Liver Disease score, Child-Turcotte-Pugh score, or original liver diseases between patients with SSAR and SRAR, although deceased donors were more frequently associated with the SRAR group (P=0.004). All SRAR patients responded positively to rATG treatment; after treatment, the patients’ median AST levels decreased from 138 to 63 IU/L, and their median ALT levels dropped from 327 to 70 IU/L 1 day after rATG treatment (P=0.022 and 0.017, respectively). Median AST, ALT, and total bilirubin levels significantly decreased 1 month post-treatment (P=0.038, 0.004, and 0.041, respectively). Median survival after LT was 23 months, and median survival after rATG was 22 months in patients with SRAR. Adverse effects included hepatitis C virus (HCV) reactivation, fungemia, and cytomegalovirus (CMV) infection. Nine SRAR patients survived with healthy liver function, one died from a traffic accident during follow- up, and one died from graft-versus-host disease and fungemia. Conclusions: Administration of rATG is an effective therapeutic option for SRAR with acceptable complications in liver transplant recipients. However, occurrence of HCV reactivation and CMV infection in LT patients should be monitored after rATG treatment in these patients.
( Jae Geun Lee ),( Juhan Lee ),( Jung Jun Lee ),( Seung Hwan Song ),( Jee Youn Lee ),( Su-kyung Kwon ),( Myoung Soo Kim ),( Man Ki Ju ),( Gi Hong Choi ),( Sub Choi ),( Soon Il Kim ),( Dong Jin Joo ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: To reduce the HBV reinfection after liver transplantation, anti- hepatitis B immunoglobulin (HBIG) alone or combination with antiviral nucleotide analogues are usually used regimen. However, antiviral nucleotide analogues have nephrotoxicity, which is a critical issue because renal dysfunction frequently happens after liver transplantation. Methods: Medical records of 171 liver recipients with HBV who underwent liver transplantation between Sep. 2005 and Dec. 2012 were retrospectively reviewed. The difference of renal function of HBIG mono-therapy group (HBIG) and HBIG combined with Entecavir group (HBIG+ETV) were analyzed. Results: There was no significant difference in age, gender, body mass index, intraoperative blood loss, and MELD score between the two groups. But the patients who had preoperative ascites, mean preoperative AST level, preoperative GFR level, and the applying event of CRRT was significantly different between the groups. The decrease of eGFR between preoperative and 1 year after transplantation was 31.5±27.2 mL/min/1.73m2 (p<0.001), in HBIG group and 40.0±45.9 mL/min/1.73m2 (p<0.001) in HBIG+ETV group. Also, the eGFR decrease between preoperative and 4-year after transplantation was 24.5±29.9 mL/min/1.73m2 (p<0.001) in HBIG group and 38.9±56.8 mL/min/1.73m2 (p<0.001) in HBIG+ETV group. Conclusions: There was no difference of recurrence rate of HBV. However, HBIG+ETV combination regimen showed more declination of eGFR in long-term period after liver transplantation than HBIG alone.