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- 저자 : Fang Yanpeng (검색결과 2 건)
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Seismic stability limit analysis of unsaturated soil slopes reinforced by frame beam anchor plates
Anping Huang,Yanpeng Zhu,Shuaihua Ye,Long Wang,Junguo Peng,Guangwen Fang 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.9
The frame beam anchor plate (FBAP) reinforced slope has been popularized and applied in some fill slope projects. Nevertheless, the existing design method ignores the influence of earthquake action and the suction effect of unsaturated soils. The stability of unsaturated soil slopes reinforced with FBAPs under an earthquake is analyzed based on the upper bound theorem of limit analysis and pseudo-dynamic method to solve the above problems. The influence of the suction effect on the effective weight and strength of unsaturated soils under one-dimensional steady seepage conditions was considered in the derivation of the energy balance equation. A simplified method based on the volume integral of the rotating body is used to calculate the external work rate. Two possible failure modes of anchorage structures are considered when solving internal energy dissipation. Results show that the influence of suction and seepage conditions on slope stability decreases with the increasing soil pore size distribution parameter n and saturated hydraulic conductivity ks. Also, the stability of the slopes is significantly improved with the increase of total rows of anchor plates. Likewise, the stability of slopes decreases with the increase in the horizontal seismic coefficient kh and amplification coefficient fa.
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Huang Xueyan,Chen Fei,Ma Yeshuo,Zheng Fan,Fang Yanpeng,Feng Bin,Huang Shuai,Zeng Hongliang,Zeng Wenbin 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Macroautophagy is an essential cellular self-protection mechanism, and defective autophagy has been considered to contribute to a variety of diseases. During the process, cytoplasmic components are transported via autophagosomes to acidic lysosomes for metabolism and recycling, which represents application niches for lysosome-targeted fluorescent probes. Additionally, in view of the complexity of the autophagy pathway, it entails more stringent requirements for probes suitable for monitoring autophagy. Meanwhile, aggregation-induced emission (AIE) fluorescent probes have been impressively demonstrated in the biomedical field, which bring fascinating possibilities to the autophagy visualization.We reported a generalizable de novo design of a novel pH-sensitive AIE probe ASMP-AP tailored to lysosome targeting for the interpretation of autophagy. Firstly, the theoretical calculation was carried out followed by the investigation of optical properties. Then, the performance of ASMP-AP in visualizing autophagy was corroborated by starvation or drugs treatments. Furthermore, the capability of ASMP-AP to monitor autophagy was demonstrated in ex vivo liver tissue and zebrafish in vivo.ASMP-AP displays a large stokes shift, great cell permeability and good biocompatibility. More importantly, ASMP-AP enables a good linear response to pH, which derives from the fact that its aggregation state can be manipulated by the acidity. It was successfully applied for imaging autophagy in living cells and was proved capable of monitoring mitophagy. Moreover, this novel molecular tool was validated by ex vivo visualization of activated autophagy in drug-induced liver injury model. Interestingly, it provided a meaningful pharmacological insight that the melanin inhibitor 1-phenyl-2-thiourea (PTU)-induced autophagy was clearly presented in wild-type zebrafish.ASMP-AP offers a simple yet effective tool for studying lysosome and autophagy. This is the first instance to visualize autophagy in zebrafish using a small-molecule probe with AIE characters, accurate lysosome targeting and simultaneous pH sensitivity. Ultimately, this novel fluorescent system has great potential for in vivo translation to fuel autophagy research.
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