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Nabil Chamroune,Florence Delange,Nathalie Caillault,Fabrice Morvan,Yongfeng Lu,Akira Kawasaki,Jean‑François Silvain 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.2
Aluminum (Al) matrix composite materials reinforced with graphite fakes (GF) and pitch-based carbon fbers (CF) werefabricated by solid–liquid phase sintering with a small amount of Aluminum–Silicon eutectic alloy (Al-12 wt%Si). Theamount of Al–Si is optimized for a carbon content of 50 vol% in order to achieve, in the plane of GF reinforcement, a higherthermal conductivity (TC) and a lower coefcient of thermal expansion (CTE) compared to identical composite material fabricated by conventional powder metallurgy route. Al/(GF+CF) composite materials were characterized by scanning electronmicroscopy (SEM), energy-dispersive X-ray microscopy and X-ray tomography in order to highlight the distribution of theAl–Si liquid phase and the formation of a carbon network in the aluminum matrix. A small amount of CF allows to controlthe through-plane CTE without afecting signifcantly the in-plane TC of the Al-C composites. The (GF+CF) mixture andthe solid–liquid phase sintering allow to achieve a TC of 410 W/m K (in-plane direction) and a CTE of 2.4×10−6/K (troughplane direction), which is, for example, applicable for lightweight heat sink material.
Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307
Albulescu, Lucian,Bigay, Joë,lle,Biswas, Bishyajit,Weber-Boyvat, Marion,Dorobantu, Cristina M.,Delang, Leen,van der Schaar, Hilde M.,Jung, Young-Sik,Neyts, Johan,Olkkonen, Vesa M.,van Kuppeveld, F Elsevier 2017 ANTIVIRAL RESEARCH Vol.140 No.-
<P>The genus Enterovirus (e.g. poliovirus, coxsackievirus, rhinovirus) of the Picornaviridae family of positive strand RNA viruses includes many important pathogens linked to a range of acute and chronic diseases for which no approved antiviral therapy is available. Targeting a step in the life cycle that is highly conserved provides an attractive strategy for developing broad-range inhibitors of enterovirus infection. A step that is currently explored as a target for the development of antivirals is the formation of replication organelles, which support replication of the viral genome. To build replication organelles, enteroviruses rewire cellular machinery and hijack lipid homeostasis pathways. For example, enteroviruses exploit the PI4KIIII beta-PI4P-OSBP pathway to direct cholesterol to replication organelles. Here, we uncover that TTP-8307, a known enterovirus replication inhibitor, acts through the PI4KIIII-PI4P-OSBP pathway by directly inhibiting OSBP activity. However, despite a shared mechanism of 1TP-8307 with established OSBP inhibitors (itraconazole and OSW-1), we identify a number of notable differences between these compounds. The antiviral activity of TTP-8307 extends to other viruses that require OSBP, namely the picornavirus encephalomyocarditis virus and the flavivirus hepatitis C virus. (C) 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license</P>