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Han, Jeonghoon,Kim, Duck-Hyun,Kim, Hui-Su,Kim, Hee-Jin,Declerck, Steven A.J.,Hagiwara, Atsushi,Lee, Jae-Seong Elsevier 2018 Comparative biochemistry and physiology. Part D, G Vol.25 No.-
<P><B>Abstract</B></P> <P>While marine invertebrate cytochrome P450 (CYP) genes and their roles in detoxification mechanisms have been studied, little information is available regarding freshwater rotifer CYPs and their functions. Here, we used genomic sequences and RNA-seq databases to identify 31 <I>CYP</I> genes in the freshwater rotifer <I>Brachionus calyciflorus</I>. The 31 <I>Bc-CYP</I> genes with a few tandem duplications were clustered into CYP 2, 3, 4, mitochondrial, and 46 clans with two marine rotifers <I>Brachionus plicatilis</I> and <I>Brachionus koreanus</I>. To understand the molecular responses of these 31 <I>Bc-CYP</I> genes, we also examined their expression patterns in response to benzo[α]pyrene (B[α]P). Three <I>Bc-CYP</I> genes (<I>Bc-CYP3044B3</I>, <I>Bc-CYP3049B4</I>, <I>Bc-CYP3049B6</I>) were significantly upregulated (<I>P</I> <0.05) in response to B[α]P, suggesting that these <I>CYP</I> genes can be involved in detoxification in response to B[α]P exposure. These genes might be useful as biomarkers of B[α]P exposure in <I>B. calyciflorus</I>. Overall, our findings expand the repertoire of known CYPs and shed light on their potential roles in xenobiotic detoxification in rotifers.</P>