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RISS 인기검색어
- 검색키워드
- 저자 : Daniel R. Scoles (검색결과 2 건)
- 무료
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- 유료
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DNA Microarray Analysis of Immediate Response to EGF Treatment in Rat Schwannoma Cells
오민규,Daniel R. Scoles,Stefan-M. Pulst 한국생물공학회 2005 Biotechnology and Bioprocess Engineering Vol.10 No.5
Epidermal growth factor (EGF) activates many intracellular effector molecules, which subsequently in-fluence the expression levels of many genes involved in cell growth, apoptosis and signal transduction, etc. In this study, the early response of gene expressions due to EGF treatment was monitored using oligonucleotide DNA microarrays in rat schwannoma cell lines. An immunoblotting experiment showed the successful activation of EGF receptors and an effector protein, STAT5, due to EGF treatment. The microarray study showed that 35 genes were significantly induced and 2 were repressed within 60 min after the treatment. The list of induced genes included early growth response 1, suppressor of cytokine signaling 3, c-fos, interferon regulatory factor 1 and early growth response 2, etc. According to the microarray data, six of these were induced by more than 10-fold, and showed at least two different induc-tion patterns, indicating complicated regulatory mechanisms in the EGF signal transduction.
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DNA Microarray Analysis of Immediate Response to EGF Treatment in Rat Schwannoma Cells
OH, Min-Kyu,Scoles, Daniel R.,Pulst, Stefan-M. The Korean Society for Biotechnology and Bioengine 2005 Biotechnology and Bioprocess Engineering Vol.10 No.5
Epidermal growth factor (EGF) activates many intracellular effector molecules, which subsequently influence the expression levels of many genes involved in cell growth, apoptosis and signal transduction, etc. In this study, the early response of gene expressions due to EGF treatment was monitored using oligonucleotide DNA microarrays in rat schwannoma cell lines. An immunoblotting experiment showed the successful activation of EGF receptors and an effector protein, STAT5, due to EGF treatment. The microarray study showed that 35 genes were significantly induced and 2 were repressed within 60 min after the treatment. The list of induced genes included early growth response 1, suppressor of cytokine signaling 3, c-fos, interferon regulatory factor 1 and early growth response 2, etc. According to the microarray data, six of these were induced by more than 10-fold, and showed at least two different induction patterns, indicating complicated regulatory mechanisms in the EGF signal transduction.
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