요부수핵탈출증에서 Thermography의 진단적 가치

신현택,신승우,송재철,정석희,이종수,김성수,신현대 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

Objectives : Lumbar radiculopathy is a common disease in oriental rehabilitation medicine. It can be diagnosed by physical examination, plain X-ray, Myelography, CT, MRI, EMG etc. But those methods are not useful in observing the clinical procedure. Objectvie evaluating the clinical procedure is very important in treatment of lumbar radiculopathy. Mehthods : We studied the clinical efficacy of thermography in lumbar radiculopathy during conservative managements. We studied 36 patients with lumbar radiculopathy convinced by MRI. The had low back pain and radiating pain on one side. Thermography had taken before an after 4 weeks treatments, and compared with clinical procedure Results and conclusions : Thermography is not pertinent as a primary diagnostic method in lumbar radiculopathy, but useful in observing the clinical procedure. And it can be recommended as a objective evaluation for lumbar radiculopathy.

비만증 환자에서 한약제에 의한 체중 감소효과

Oh, Seung-Joon,Jeong, In-Kyung,Kim, Young-Seol,Choi, Young-Kil,Paeng, Jeong-Ryung,Bae, Jung-Hwan,Shin, Hyun-Dae 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Seung-Joon Oh, In-Kyung Jeong, Young-Seol Kim, Young-Kil Choi, Jeong-Ryung Paeng¹, Jung-Hwan Bae and Hyun-Dae Shin²Department of internal Medicine, College Medicine, Endocrine Research Institute¹. Department of Rehabilitation, College of Oriental Medicine², Seoul, korea. Bady Fat Reduction Effects of Red Ginseng Compound Preparation on the Patients with Obesity. Proceedings of International Symposium on East-West Medicine, Seoul. 244-254, 1999.-Obesity can be defined as a metabolic disease due to an increased state of fat tissues caused by an imbalance of calorie intake and use. Recently, in Korea by improvement and westernization of food intake, along with decrease in exercise activities, the prevalence of obesity has increased greatly. Our objectives were to study stability and effects of decrease in body fat by administering red ginseng compound preparation (known to have body fat decreasing effects in laboratory animals) to obesity patients on low calorie diets. Changes in weight and body fat were measured while carrying out calorie-restricted diets on patients for 4 weeks, then administering red ginseng compound preparation for another 4 weeks. The patients were 20 people whose BMI were 25kg/㎡ or over and whose percent body fat was also 30% or over when tested by bioelectrical conductivity. 1. Changes in weight were from 70.04kg(base line) to 67.43kg(after taking red ginseng compound preparation). 2. In similar sense, BMI decreased from 27.12kg/㎡(base line) to 26.56kg/㎡(after dieting), and further to 26.01kg/㎡ (after taking red ginseng compound preparation). The BMI seemed to decrease significantly compared to the baseline after the use of red ginseng compound. 3. Waist hip ratio was changed from 0.8858(base line) to 0.8728, but it was statistically insignificant. 4. The percent body fat was 35,16%(base line), 33.87%(after dieting), and 31.68%(after taking red ginseng compound preparation). 5. Complete blood cell count and blood chemisrty remained unaffected by the administration. 6. In concern to endocrinologic studies, T3 decreased from 118.7 to 98.2ng/dL, and T4 increased from 8.8 to 9.2㎕/ dL. Epinephrine showed a tendency to decreased from 0.27 to 0.25 ng/mL, and norepinephrine increased from 0.39 to 0.44ng/mL. 7. Leptin was not changed. 8. Some patients complained adverse effects; constipation(5 patients, may be due to diet therapy), fatigue (2 patients), pruritus(2 patients), flushing(s patients), dizziness(3 patients) and epigastric discomfort(2 patients). However their symptoms were mild, so medication did not stopped. In conclusion, loss of weight without significant side effects was observed during low calorie diet and red ginseng compound preparation administration. This is thought to be in relation to sympathetic nerve system rather than adrenal gland. Also, further long0term studies should be required, since the observed results were based on short-term changes in weight.

玄胡索의 이온參透療法을 通한 生體透過性에 關한 硏究

申鉉澤,申鉉大 慶熙大學校韓醫科大學韓醫學硏究所 1999 慶熙韓醫大論文集 Vol.22 No.1

Iontophoresis is the process whereby electrically charged drugs are transfered through skin via electrical potential which is nontraumatic and painless. It is possible to medicate electrically any surface tissue with drugs having a positive or negative charge. I am interested in applying herbal medicine to a new method of treatment in musculoskeletal inflammatory conditions instead of western medicine. It is necessary to study on the passage through skin of herbal medicine before application of iontophoresis clinically. Corydaline Standard and Corydalis Tubar Extract Solution were selected and studied. The results were following. 1. It was proved Corydaline Standard and Corydalis Tubar Extract Solution are absorbed through skin by intophoresis. 2. In the case of Corydaline Standard, the absorption increased more in impregnating on negative electrode, and there was statistical significance as compared with impregnating on positive electrode. 3. In the case of Corydalis Tubar Extract Solution, the absorption increased more in impregnating on positive electrode, and there was statistical significance as compared with impregnating on negative electrode. 4. In all group, there were no significant changes in the absorption during the experimental period.

외상성 주관절 구축의 수술적 치료

신현대,이원석 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

The eleven consecutive patients who had contracture of the elbow joint were treated by anterior capsulectomy and distraction arthroplasty without fascial interposition or anterior capsulectomy only. The ten elbows were post-traumatic contracture, and the one elbow was the ankylosis due to prolonged immoobilization after rain injury. Five patients were treated with distraction arthroplasty by modified Mayo Clinic Device and six patients underwent anterior capsulectomy under general or regional anesthesia. The mean preoperative arc of the total motion was 52 degrees(from 44 to 92 degrees of flexion). At follow-up examination, twelve to forty months postoperatively, of eleven patients, the mean arc of the total motion was 108 degrees (from 14 to 122 degrees of flexion). There were seven complications in seven of the eleven patients. Of these, the two were heterotopic ossification recurred in the posterior capsule of the elbow joint, so subsequently the ulnohumeral arthroplasty was performed at postoperative 8 months and 30 months later. The transient ulnar nerve injuries were occurred in two patients. The injured nerve dysfunction was resolved spontaneously. Two patients occured superficial wound infection. The pin site infection was occurred in one patient. The infection was subsided by dressing and antibiotics. Nine of the eleven patients who were followed for average 19 months satisfied with the results of the procedure because of the improved activity in carrying out daily life. No patients showed aggravation of pain. The three severely unstable elbow was improved from 3 points to 1 point on stability points. It was concluded that results of distraction arthroplasty and anterior capsulectomy could be gratifying and the range of motion of elbow was improved Significantly. But the technique is demanding and the rate of complications such as ulnar paresthesia or pin site infection is high especially distraction arthroplasty.

고혈압 환자에서 Leukoaraiosis 정도와 망막증과의 연관성 : 예비연구 Preliminary Results

신동익,한현정,서대희,이광훈 關東大學校 醫科大學 醫科學硏究所 2002 關東醫大學術誌 Vol.6 No.1

Changes in the cerebral white matter (leukoaraiosis;LA) are detected with increasing frequency by computed tomography (CT) and magnetic resonance imaging (MRI) in elderly patients with diabetes mellitus and hypertension. The purpose of this study is to determine whether the severity of retinopathy is correlated with degree of LA in patients with hypertension. Twenty-three consecutive patients with patients with hypertension admitted in the department of neurology were evaluated for degree of LA and severity of retinopathy. 8patients were 15female. The age distribution was between 52 and 85 years(mean 69.1years). The duration of hypertension was between 1 and 30 years(mean8.2 years). The degree of LA was correlated with severity of hypertensive retinopathy(p<0.05), especially in relatively young patient, short periods of disease, and female paitents(p<0.05). We can make a rough estimation of degree of LA with fundus examination without CT or MRI evaluations in hypertensive patients, especially in relatively young and female patients with short durations of disease. However, more broad study should be made for these value and relationship.

장골에 발생한 전이성 골종양의 수술적 치료

신현대,김영모 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

The sixteen patients who had had metastatic bone tumors in long bone were treated with operation from January 1994 to August 1996. We analyzed the cases in the aspects of age and sex distribution, primary origin site and metastatic site in long bone, Mirels scoring system and the duration of survival. The results were as follows ; 1. Six patients were male and 10 patients were female. The mean age of both group was 58.2 years old. female was 55 years and male was 63.5 years. Female was more younger than male. The peak incidence was in the 6th decade. 2. The main primary cancers were lung(31.25%) and breast(25%). 3. All sixteen patients had had eighteen pathologic fractures in long bone. Eight cases at the femur subtrochanter, five at the humerus shaft, two at the femur intertrochanter, two at the femur shaft and one at the tibia shaft. 4. To the Mirels scoring system, All cases scored above eight and no significant difference between fracture group and nonfracture group in X2-test. 5. Among the sixteen patients, twelve had been dead. One of them had been dead before operation with self-discharge, six patients survived less than six months, two patients survived from six to a year, two patients survived from a year to two years and one patient survived more than two years.

加味薏苡仁湯의 消炎效果 및 成分에 關한 硏究

申鉉大,金性洙 慶熙大學校 1985 論文集 Vol.14 No.-

Kamieuiyeeintang is a combined herb medicine which is used to treat inflammatory illness in oriental medicine field. In order to make clear the anti-inflammatory effects on rats and to find the effective constituents of this herb medicine, author extracted the herbs with water and methanol.. The water extracted portion was administered through mouth to rats and the methanol extraction were used as the samples in HPLC injection to find out the anti-inflammatory constituent by comparing the standard oleanolic acid. The following results were obtained. 1. The extract of Kamieuiyeeintang (100 ㎎/㎏) showed high inhibitory percent of 35.40-47.12 on rat. The aspirin (400 ㎎/㎏) which was used as a control showed 10.42-16.68 of the inhibitory percent. 2. Among the nine herbs of this Kamieuiyeeintang Rheum coreanum Nakai showed the highest swelling percent of 80.60 on the rat hind paw and Taraxacum officinale Wigg was the lowest value of 21.85%. 3. On the HPLC chromatogram Rheum Coreanum Nakai has largest number of peaks and Trichosanthes kirilowii Regel had only 1 peak. 4. In comparing with the standard oleanoloic acid, Paterinia scabiosifolia Fischer showed same peak pattern and retention time with the oleanolic acid. 5. It did not make any relationship between of peak on the chromatogram and anti-inflammatory effect. According to the above results, it is concluded that Kamieuiyeeintang is recognized as a therapeutics for inflammatory diseases and contains the same constituent as oleanolic acid which is a standard therapeutics of inflammation.

생활폐기물을 이용한 세라믹스 판재 개발

신대용,임현태,최돈량 강원대학교 부설 석재복합신소재 제품연구센터 2002 석재연 논문집 Vol.7 No.-

생활하수처리장에서 발생하는 하수슬러지의 용융슬래그와 장석, 물유리 및 전분을 이용하여 세라믹스 다공판을 제조하였다. 슬래그의 주성분은 SiO_2와 Al_2O_3로서 점토와 유사한 성질을 갖고 있어 세라믹스의 대체원료로 사용이 가능하였다. 하수슬러지를 1,200℃에서 2시간 열처리하여 얻어진 용융물을 수증에 급랭시켜 1∼3mm 입경의 슬래그 분말을 제조하고 80∼95wt%의 슬래그, 5∼20wt%의 장석, 5∼15wt%의 물유리 및 2wt%의 전분을 혼합하여 1,100∼1,200℃에서 2시간 소성하여 시편을 제조하였다. 슬래그의 첨가량과 소성온도가 증가함에 따라 시편의 부피비중 및 압축강도는 증가하였으나, 기공률과 흡수율은 감소하였다. 1,030℃에서 2시간 소성한 No. 1, 4 및 7번 시편은 부피비중 1.52∼1.67, 기공률과 흡수율 23.3∼ 32.5% 및 14.1∼19.3%, 압축강도 81∼173kgf/㎠의 값을 나타내었다. 또한, 슬래그의 첨가량과 소성온도가 동등한 시편은 물유리의 첨가량이 증가함에 따라 부피비중과 압축강도가 증가하여 No.7, 8 및 9번 시편은 부피비중 1.52∼1.94, 압축강도 81∼385kgf/㎠의 값을 나타내었다. 시편의 중금속용출량은 미량으로서 매립지 침출수배출 허용기준치보다 낮게 측정되어 주위환경에 해가 없고 흡음특성이 양호하여 본 연구에서 제조한 세라믹스 다공판은 흡음판으로의 이용이 가능하였다. Utilization of sewage sludge from the sewage sludge treatment facilities and the municipal wastes became very important matter to be solve for the environmental protection and recycling of waste materials. The reusability of sewage sludge slag as a raw material in the manufacturing process of ceramics was highly expected because the chemical composition of slag was mostly SiO_2 and Al_2O_3 and its properties were very similar with clay. Sewage sludge slag was fabricated by sintering at 1,200℃ for 2 hours and it was crushed into powder with particle size of 1∼3mm by a rapid cooling treatment in water. Then, the mixture of 80∼95 wt% of slag, 5∼20 wt% of feldspar, 5∼15 wt% of water glass and 2 wt% of starch were heated at 1,000∼1,100℃ for 2 hours. The density and compressive strength of specimen increased with increasing the sintering temperature and the addition amount of slag, No. 1, 4 and 7, specimens were shown 1.52∼1.67 of bulk density, 23.3∼32.5% of porosity, 14.1∼19.3% of water absorption and 81∼173 kgf/㎠ of compressive strength. And, that of the specimen at the same sintering temperature and addition amount of slag increased with increasing the addition amount of water glass, No. 7, 8 and 9 specimens, bulk density was 1.52∼1.94 and the compressive strength was 81∼385kgf/㎠. An extraction test for specimen to detect the toxic materials, such as Cu, Cd, Cr, Pb and As, showed below the permitted standard of land-filling extractable heavy metal contents. Sound absorption coefficients of specimen had a good properties in No. 7 specimen, and can be used as a sound absorption plate.

Cholestyramine과 Polyvinylpyrrolidone에 對한 Bilirubin 吸着의 Photoenhancement에 關한 硏究

신대현,Henning, D.,St-pierre, L. E. 충남대학교 자연과학연구소 1983 忠南科學硏究誌 Vol.10 No.2

Shifts in the visible spectrum of aqueous bilirubin (BR) solutions resulting from the addition of soluble polyvinypyrrolidone (PVP) suggest specific interactions. Hence, isotherms were determined for the adsorption of BR from aqueous bilirubin solution onto solid, crosslinked PVP and onto cholestyramine (CA) at 0, 10, 20 and 25℃. Although the adsorption onto PVP reaches equilibrium more rapidly than onto CA, the latter adsorbent has a larger capacity of adsorption. Furthermore the isotherms for PVP are independent of temperature while those for CA show an increase in the amount of BR adsorbed with an increase in temperature. Totally internal hydrogen bonded ZZ form of bilirubin can be converted under photoirradiation with blue filtered light to three forms: EZ, ZE and EE, all of which gives greater accessibility to the polar functional groups. Accordingly, I have attempted to discern whether the photolized-bilirubin could be adsorbed more rapidly on the two adsorbents than do the ZZ form, particularly on CA which has slower equilibrium, but greater adsorption capacity. The rate of adsorption of photolized-bilirubin on CA is seen to be considerably faster than that of the ZZ form. Thus the adsorption equilibrium could be improved by pre-irradiation of aqueous bilirubin solution. It will be determined if this phenomenon may aid the phototherapy treatment of hyperbilirubinaemia cases.

유지 투석중인 만성 신부전환자에서 허혈성 심질환의진단 지표로서의 심장트로닌-I의 유용성

신병철,강대웅,정지용,류봉관,서영욱,김정인,김범윤,김현리,정종훈 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.1

Background : Coronary disease is highly prevalent in patient with end stage renal disease (ESRD) and account for much of their observed morbidity and mortality. Troponin-I consistently maintains a high sensitivity and specificity and is most sensitive marker for ischemic heart disease (IHD). Method : We examed 49 hernodialyzed patients (22 male, 27 female) without evidence of acute coronary syndrome (ACS) for 6 months. Biochemical markers were measured in serial predialysis blood samples. For analysis, we used two cardio-specific assays for troponin-T (cTnT) as well as for troponin-I (cTnI) and compared the results with CK-MB (reference value ≤ 4.0 ng/mL) concentration. Results : Myocardial ischemia was observed in 47% (23/49) of patients. cTnT level above 0.1 ng/mL. and cTnI level above 0.5 ng/mL, were observed in 22% (11/49) and 20% (10/49) of patients respectively. cTnI revealed significantly higher positive rate in patients with myocardial ischemia than the patients without myocardial ischemia (43 % vs 30%) (p<0.05). cTnT and CK-MB revealed no difference in positive rate between the patients with and without myocardial ischemia (cTnT : 30% vs 15% and CK-MB : 30% vs 19%). The sensitivity and specificity of cTnI to myocardial ischemia were higher than those of cTnT and CK-MB (sensitivity 43% vs 30% and 30%. specificity 100% vs 85% and 81%). Conclusion: Both cTnT and cTnI are useful in ruling out myocardial injury in chronic renal failure patients. But. cTnI is a more sensitivity and excellent specificity of ischemic heart disease than cTnT and CK-MB in hemodialyzed patients. In patients with ischemic heart disease, the presences of DM and advanced age were higher than those in patients without ischemic heart disease (p<0.05). Among the baseline characteristics old age, elevated LDH and diabeties were significant more frequent in the patients with elevation of cardiac troponin-I (p>0.5 ng/mL) than those with cardiac troponin-I (p<0.5 ng/mL), p=0.038, p=0.049, and p=0.045, respectively. Our results suggest that these cTnI is the potential diagnostic marker for the prediction of IHD in ESRD patients.