Hyperghrelinemia Does Not Accelerate Gastric Emptying in Prader-Willi Syndrome Patients

Choe, Yon Ho,Jin, Dong-Kyu,Kim, Sang Eun,Song, Sang Yong,Paik, Kyung Hoon,Park, Hwa Young,Oh, Yoo Joung,Kim, An Hee,Kim, Jung Sim,Kim, Chi Wha,Chu, Su-Hyun,Kwon, Eun Kyung,Lee, Kyung Han The Endocrine Society 2005 The Journal of clinical endocrinology & metabolism Vol.90 No.6

Virologic Responses to Add-on Adefovir Dipivoxil Treatment Versus Entecavir Monotherapy in Children With Lamivudine-resistant Chronic Hepatitis B

Chu, MiAe,Cho, Seung Man,Choe, Byung-Ho,Cho, Min Hyun,Kwon, Soonhak,Lee, Won Kee by ESPGHAN and NASPGHAN 2012 Journal of pediatric gastroenterology and nutritio Vol.55 No.6

PURPOSE:: The aim of the study was to compare the virologic response to adefovir (ADV) add-on therapy with switching to entecavir (ETV) monotherapy in children and adolescents with chronic hepatitis B (CHB) who have developed lamivudine (LAM) resistance during LAM treatment. METHODS:: Twenty-seven consecutive patients with CHB who had developed LAM resistance during LAM treatment were included. Of these 27 patients, 8 patients were treated with the addition of ADV to ongoing LAM and 8 patients were treated by switching to ETV monotherapy and each of these 16 patients were compared with the 11 patients who were treated by switching to ADV alone, as a historical control. Therapeutic responses to treatment were evaluated at 12, 24, 36, and 48 weeks from the initiation of therapy by measuring the decrement of hepatitis B virus (HBV)-DNA titers. RESULTS:: The therapeutic period for HBV-DNA titer decrement (>2 log10 IU/mL) was significantly shorter in both the LAM+ADV group and the ETV group than in the ADV group (P = 0.008); however, there was no significant difference between the LAM+ADV group and the ETV group. The rate of virologic response, defined as decrement in HBV-DNA titer to undetectable levels at 24 weeks, was significantly higher in both the LAM+ADV group and the ETV group than in the ADV group (P = 0.029). CONCLUSIONS:: Both the LAM+ADV combination therapy and ETV monotherapy exhibited significantly more effective virologic responses compared to the ADV monotherapy in children and adolescents with LAM-resistant CHB, although there was no significant difference between the LAM+ADV group and the ETV group.

Near-ultraviolet light-emitting diodes with transparent conducting layer of gold-doped multi-layer graphene

Cho, Chu-Young,Choe, Minhyeok,Lee, Sang-Jun,Hong, Sang-Hyun,Lee, Takhee,Lim, Wantae,Kim, Sung-Tae,Park, Seong-Ju American Institute of Physics 2013 JOURNAL OF APPLIED PHYSICS - Vol.113 No.11

Longitudinal Association between Nonalcoholic Fatty Liver Disease and Cancer Risk

( Gi-ae Kim ),( Han Chu Lee ),( Jaewon Choe ),( Min Jung Lee ),( Hye-sook Chang ),( In Young Bae ),( Hong-kyu Kim ),( Jihyun An ),( Ju Hyun Shim ),( Kang Mo Kim ),( Young-suk Lim ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Little is known about the longitudinal association between nonalcoholic fatty liver disease (NAFLD) and cancer risk. This study investigated cancer incidence in NAFLD. Methods: This retrospective cohort study included subjects who underwent a heath checkup at a tertiary hospital from September 1, 2004 to December 31, 2005 and were then followed up for >1 year. NAFLD was diagnosed by ultrasonographic detection of hepatic steatosis in the absence of other known liver disease. Cancer risk was presented as a hazard ratio (HR) calculated in Cox proportional hazard regression model. Results: Of 25,947 subjects, 8,721 (33.6%) had NAFLD. During a total follow-up of 190,615 person-years (median 8.5 years), cancer incidence was higher in the NAFLD group than in the non-NAFLD group (677.8 vs. 511.5 per 100,000 person-years; HR 1.32; 95% confidence interval [CI], 1.17-1.49; p < 0.001). After adjusting for demographic and metabolic factors, the risks were significantly higher in the NAFLD group for hepatocellular carcinoma (HCC; HR, 16.73; 95% CI, 2.09-133.85; p = 0.008), colorectal cancer in males (HR 2.01; 95% CI, 1.10-3.68; p = 0.02), and breast cancer in females (HR 1.92; 95% CI, 1.15-3.20; p = 0.01). Subjects with high NAFLD fibrosis scores or high FIB-4 scores had a greater risk of all cancers and of HCC in particular. Conclusions: Patients with NAFLD had an increased risk of HCC, colorectal cancer in males, and breast cancer in females. Noninvasive fibrosis scores were shown to predict development of all cancers and HCC.

디메틸술폭시드용매 속에서 파라니트로벤젠아조레조르시놀의 폴라로그래피的 還元에 관한 硏究

최칠남,조기형,최주현,Chil Nam Choe,Ki Hyung Jo,Chu Hyun Choe 대한화학회 1986 대한화학회지 Vol.30 No.5

反陽性子性 溶媒인 dimethylsulfoxide中에서 p-nitrobenzeneazoresororcinol<4n-BAR>에 대하여 직류 폴라로그래피적 거동을 조사하였다. 0.05M $NaClO_4$의 DMSO溶媒中에서 4n-BAR은 1電子 2段階의 還元過程을 거쳐 hydrazo기를 포함하는 化合物로 還元된다. 還元反應의 中間 生成物은 比較的 反陽性子性 溶媒 속에서 安定하였다. 各 段階의 還元電流는 擴散支配的이었으며 一部 反應電流도 包含되었다. 酸을 添加함에 따라서 2個의 還元波가 하나로 合致되며 [acid]/[reductant]의 몰 (M)비가 M = 2인 條件에서 加電位(-E)에 대해 $log(i_d-i)(Mi_d/2-i)/i$/의 可逆性은 1電子 2段階 還元反應이고 非可逆的이었다. The direct current polarographic behavior of 4n-BAR in dimethylsulfoxide as an aprotic solvent have been investigated. The reduction of 4n-BAR in 0.05M sodium perchlorate solution proceeds along two one-electron steps to give the corresponding compound containing hydrazo groups, each reduction wave was considerably diffusion controlled and irreversible. By addition of acid HAc to 4n-BAR in DMSO solvent, the two reduction waves have coalesced into one in the condition M $\geq$ mole ratio, acid/reductant(M = 2), the slope of $log(i_d-i)(Mi_d/2-i)/i$/ vs. (-E) is irreversible along one-electron steps reduction waves.

연하장애가 있는 신경계 이상 환아에서 경피 내시경하 위루술 후 흡인성 폐렴의 빈도 감소

박효정(Hyo Jung Park),강지현(Ji Hyun Kang),김정미(Jung-mi Kim),추미애(Mi Ae Chu),최병호(Byung-Ho Choe),서혜은(Hye Eun Seo),권순학(Soonhak Kwon) 대한소아신경학회 2011 대한소아신경학회지 Vol.19 No.2

목적 : 스스로 먹을 수 없는 사람의 경우 타인에 의해 음식물을 공급하는 방법은 비위관을 통하거나 위루관을 통한 방법이 있다. 이중 내시경을 통한 위루술 후에 호흡기 감염의 감소 등의 유익을 확인하고자 연하장애가 있는 신경계 환아들을 대상으로 본 연구를 시행하였다. 방법 : 경북대학교병원 소아청소년과에서 1999년 1월부터 2008년 12월까지 연하장애가 있는 신경계 이상환자 중 경피 내시경하 위루술을 시행 받고 시술 후 12개월 이상 경과 관찰된 26명을 대상으로 환자들의 특성을 조사하고 기저 질환별로 분류하였으며 시술 전후에 체중과 흡인성 폐렴으로 입원하게 되는 횟수를 비교하였다. 시술 전과 시술 후 6개월 및 시술 후 6-12개월을 기간으로 정하여 비교하였다. 결과 : 총 26명(남자 14)의 시술 당시 평균 나이는 6.4±4.7 (0.9-16.9)세였다. 절반 이상인 16명의 체중이 또래에서 3 백분위수 미만이었다. 기저질환으로는 뇌성마비가 16명, 후천적 뇌손상이 4명, 척수성 근위축증이 3명, 신경계 퇴행성 질환과 선천성 근위축증이 각각 2명과 1명 이었다. 시술 전과 시술 후 6개월 및 6-12개월에 체중에는 유의한 증가가 없었다. 시술 전의 흡인성 폐렴의 빈도는 전체환자에서 6개월 간 평균 2.2회 였고 시술 후 6개월 이내에는 평균 0.35회, 6에서 12개월 이내에는 평균 0.27회로 유의한 감소가 있었다(P =0.000). 결론 : 경피 내시경하 위루술은 연하곤란을 보이는 신경질환 환아에서 흡인성 폐렴의 빈도를 감소시킬 수 있는 유용한 시술로 생각한다. Purpose : Nasogastric tube or percutaneous endoscopic gastrostomy (PEG) tube can provide a means of feeding when oral intake is not adequate. This study aimed to evaluate the benefits of PEG such as reduced respiratory complications in neurodisabled children with dysphagia. Methods : Twenty-six neurodisabled patients with dysphagia were followed-up after PEG for at least 12 months from 1999 to 2008. Medical records including characteristics, body weight, frequency of aspiration pneumonia, and grade of gastroesophageal reflux (GER) were reviewed retrospectively between the time before and after PEG. The data collected before PEG was compared with those at 0-6 months and 6-12 months after PEG. Results : The 26 (male 14) enrolled patients had a mean age on PEG of 6.4±4.7 (0.9-16.9) years. The body weight percentile of 16 out of 26 patients was under the 3rd percentile. Underlying diseases were cerebral palsy (n=16), acquired braininjury (n=4), spinal muscular atrophy (n=3), neurodegenerative disease (n=2), and congenital muscular dystrophy (n=1). Body weight was not significantly different before and after PEG. The frequency of aspiration pneumonia was 2.2 times per 6 months before PEG, compared to 0.35 times (0-6 months) and 0.27 times (6-12 months) after PEG, which showed a significant difference (P =0.000). Conclusion : The frequency of aspiration pneumonia decreased significantly by PEG in neurodisabled children with dysphagia.

Effects of the histamine H1 receptor antagonist hydroxyzine on hERG K+ channels and cardiac action potential duration

Lee, Byung Hoon,Lee, Seung Ho,Chu, Daehyun,Hyun, Jin Won,Choe, Han,Choi, Bok Hee,Jo, Su-Hyun Springer Science and Business Media LLC 2011 Acta pharmacologica Sinica. Vol.32 No.9

<P>To investigate the effects of hydroxyzine on human ether-a-go-go-related gene (hERG) channels to determine the electrolphysiological basis for its proarrhythmic effects.</P>

Studies on the Photo-electrochemical Properties of Ti$O_{2-x}$ Thin Films

최규원,최주현,조기형,최용국,Q Won Choi,Chu Hyun Choe,Ki Hyung Chjo,Yong Kook Choi Korean Chemical Society 1985 대한화학회지 Vol.29 No.6

티타늄 금속판을 수증기 산화하여 만든 Ti$O_{2-x}$ 박막과 Ti$O_2$ 단결정을 알곤기체속에서 환원한 시료를 사용하여 이들의 광전기화학적 성질을 연구하였다. 1M NaOH전해질 용액에서 Ti$O_{2-x}$ 전극에 200~800nm 사이의 광을 조사하였을 때 자외부 영역에서는 320nm에서, 가시부 영역에서는 520nm, 620nm 그리고 740nm에서 전류의 peak가 나타났다. 이미 보고된 것과는 대조적으로 가시부 영역의 이들 peak는 grating monochromator의 2차선의 영향에 의하여 나타난 것임이 밝혀졌다. The thin films of Ti$O_{2-x}$, were prepared by vapor oxidation and Ti$O_2$ single crystal was reduced by heating in argon atmosphere. The photo-electrochemical properties of these samples were studied. When the photocurrent was scanned in 1M NaOH electrolyte solution, several peaks were observed in the vicinity of 320nm in the UV-region and in the vicinity of 520nm, 620nm, and 740nm in the visible-region. Contrary to the previous suppositions, those peaks were produced by the second-order lines from the grating monochromator.

Studies on the Electrochemical Properties of $TiO_{2-x}$ Thin Films

최규원,최주현,조기형,최용국,Q Won Choi,Chu Hyun Choe,Ki Hyung Chjo,Yong Kook Choi Korean Chemical Society 1986 대한화학회지 Vol.30 No.1

공기산화와 수증기 산화법에 의하여 Ti$O_{2-x}$박막을 만들었고, 알곤 기체속에서 $TiO_2$단결정을 환원하였다. Ti$O_{2x}박막의 전극 특성은 환원된 단결정 rutile의 특성과 거의 같았다. 산소가 용해된 전해질용액에서 측정된 Ti$O_{2-x}$전극들의 전류-전압 곡선으로 부터 음극전류의 peak는 -0.8V ~ -1.0V에서 나타났으며, 영볼트 근처의 Ti$O_{2-x}$전극들의 음극전류는 공기로 포화된 용액에서 보다 질소로 포화된 용액에서 더 크게 나타났다. 시간에 따르는 전류 (i)의 변화는 $i_0e^{-kt}$식에 의존하였고 이때의 속도상수(k)는 $k_0{[H^+]}^nexp(A{\eta}+\frac{E_a}{RT})$로 나타낼 수 있었다. 여기서 활성화에너지 Ea는 0.035~0.145V의 과전압에서는 4.6~4.8kcal/mole, 0.2~0.5V의 과전압에서는 1.6kcal/mole이고, 위식중의 n과 A는 0.035~0.145V에서 0.1과, 5.4~5.6/V, 0.2~0.5V에서는 0.04와 1.3/V이었다. 산소의 환원반응은 전체적으로 비가역 반응임을 알았다. A titanium oxide thin films were prepared by air oxidation and vapour oxidation and a $TiO_2$ single crystal was reduced by heating in an argon atmosphere. All the electrode characteristics of the Ti$O_{2-x}$, thin films are not different from those of slightly reduced single crystal rutile. In cyclic voltammogram of oxygen containing electrolyte solution at Ti$O_{2-x}$ electrodes, cathodic peaks were observed at between -0.8V and -1.0V vs. SCE. The cathodic current near 0V vs. SCE in saturated solution with nitrogen was observed to be greater than in saturated solution with air. The chronoamperogram was represented by the equation of i = $i_0e^{-kt}$, when the rate constant k was represented by the equation of k =$k_0{[H^+]}^nexp(A{\eta}+E_a/RT)$ The values of activation energy $E_a $were found to be 4.6~4.8kcal/mole in overpotential range of 0.035∼0.145 V and 1.6kcal/mole in overpotential range of 0.2∼0.5V. The values of n and A were found to be 0. 1 and 5.4~5.6/V in range of 0.035~0.145V, and in range of 0.2~0.5V, to be 0.04 and 1.3/V, respectively. This can be interpreted as an totally irreversible reduction of oxygen.

TDx - FLM 을 이용한 태아의 폐성숙도 평가의 의의

임문환(Moon Whan Im),최원식(Won Sick Choe),황성욱(Sung Ook Hwang),황태율(Tae Yul Hwang),이정례(Jeong Rye Lee),박지현(Jee Hyun Park),노인화(In Hwa Noh),고승권(Seung Kwon Koh),이병익(Byoung Ick Lee),이우영(Woo Young Lee),홍윤철(Yun Chu 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11

N/A Objective : The TDX analyzer, an automated fluorescence polarimeter, has been utilized to assess surfactant content in amniotic fluid. Amniostat-FLM is an immunologic semiquantitative agglutination test for determining the presence of phosphatidylglycerol in human amniotic fluid at concentration indicative of fetal lung maturity. We evaluated the usefulness of the recently introduced TDx-FLM assay in determining fetal lung maturity. Methods : Seventy-three samples of amniotic fluid were analyzed. Among them, 18 samples were compared with Amniostat-FLM assay. Results : Surfactant/albumin ratio using TDx-FLM assay increased with longer gestational age. And the concordance rate between Amniostat-FLM assay and TDx-FLM assay was 66.9%. Conclusion : The TDx-FLM assay appears to be a useful test in the field of fetal lung maturity testing.