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Yoonhyeong Byun,Eun Jin Kim,Areum Lee,Young-Ah Suh,Hee Ju Sohn,Jung Min Lee,Jae Seung Kang,Yoo Jin Choi,Youngmin Han,Hongbeom Kim,Wooil Kwon,Jin-Young Jang 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.102 No.2
Purpose: Various hemostatic agents have been introduced in therapy as postoperative bleeding is a poor prognostic factor for postoperative outcomes. These products can be divided into those that directly promote the hemostatic cascade and those that physically form a barrier by absorbing blood. The latter, powder-type hemostatic agents have the advantages of being inexpensive and more absorbable with less foreign body reactions (FBRs) and are applicable to a relatively wide area. This study was conducted to verify the safety and efficacy of a newly invented polysaccharide product (OOZFIX, Theracion Biomedical), which improves blood absorption and hemostatic effects. Methods: Two separate animal experiments were performed. The first evaluated FBRs histologically at 3 days, 2 weeks, and 4 weeks, after implantation of OOZFIX in rats, and the second compared hemostatic performance of OOZFIX and Arista AH (Bard) in the porcine liver punch biopsy model. Results: We found minimal FBRs in the 3-day group and no reactions in both the 2-week and 4-week groups after implantation of hemostatic agents. The time to hemostasis of OOZFIX was not significantly different from that of Arista AH (median [interquartile range]: 9 [6–10] minutes vs. 8 [6–10] minutes, respectively; P = 0.522). When comparing the serial bleeding grade tendency, there was no statistical difference between OOZFIX and Arista AH (P = 0.656). Conclusion: OOZFIX caused a minimal FBR that disappeared within 2 weeks in vivo, and its hemostatic performance was comparable with that of an existing agent, Arista AH. Further clinical studies are required in the future.
건축디자인과정에서 스케치와 창조적 디자인 행위의 인지적 상호작용분석을 위한 기초연구
최현아,전한종 대한건축학회 2004 대한건축학회논문집 Vol.20 No.7
One of characteristics of the design process in the area of architectural design is the use of a number of different types of sketches. Designers place great emphasis on the sketch often because it is thought to be associated with innovation and creativity. Because of this emphasis researchers have also begun to focus on the sketch and its role of design. Especially emergent shapes through the sketches plays a significant role in the creative design. The first aim of this paper is to collect together and review the results closely related researches that have looked at the role of sketches in design process. The second aim of this paper is to review analogy and emergence that can be effective in facilitating creative design. At last the mutational emergent shapes are introduced.
Choi, Han Ah,Park, Ha Neul,Won, Sung Wook Academic Press 2017 Journal of Environmental Management Vol. No.
<P>In this study, a mixture of polyethylenimine (PEI) and polyvinyl chloride (PVC) was reacted at 80 degrees C for 6 h to synthesize crosslinked PEI/PVC polymer solution, which was injected to produce the PEI/PVC-crosslinked fiber (PEI/PVC-CF). PEI/PVC-CF was investigated as an adsorbent to remove and recover Pd(II) from acidic solutions. In order to examine the adsorption characteristics and usability of PEI/PVC-CF for Pd(II) recycling, several experiments such as isotherm, kinetics, desorption and reuse were conducted. The adsorption isotherms were fitted using the Langmuir and Freundlich models, respectively. The maximum adsorption capacity was estimated as 146.03 mg/g according to the Langmuir model. The kinetic experiments demonstrated that adsorbent reaches adsorption equilibrium within 60 min for initial Pd(II) concentrations of 25-100 mg/L. After adsorption, Pd(II) on PEI/PVC-CF was easily desorbed using acidified thiourea solution, and the desorption efficiency increased with the thiourea concentration. It was also demonstrated that PEI/PVC-CF can be used repeatedly for at least five cycles without reduction in adsorption capacity. (C) 2017 Elsevier Ltd. All rights reserved.</P>
석탄계 입상활성탄을 이용한 수용액으로부터 염기성 염료의 제거
최한아(Han Ah Choi),박하늘(Ha Neul Park),문혜원(Hye Woon Moon),김은빈(Eun Bin Kim),장연우(Yeon Woo Jang),원성욱(Sung Wook Won) 한국청정기술학회 2017 청정기술 Vol.23 No.2
본 연구에서는 석탄계 입상활성탄을 이용하여 수용액으로부터 염기성 염료 Basic Blue 3 (BB3)의 흡착에 대해 조사하였다. 모든 실험은 회분공정에서 수행하였고, 활성탄의 투입량, 접촉시간, 초기농도 및 온도와 같은 흡착변수들에 대해 평가하였다. 활성탄의 투입량이 증가할수록 BB3 제거율도 증가하였으며, 활성탄 0.2 g 이상에서 초기농도 50 mg L<SUP>-1</SUP>의 BB3가 100%제거되었다. 또한, 흡착평형에 도달하는 시간은 염료의 초기농도에 의존적이었다. Langmuir 모델에 따르면, 석탄계 입상활성탄의 최대흡착량은 25, 35, 45 ℃에서 66.45, 84.97, 87.19 mg g<SUP>-1</SUP>으로 산출되었다. 그리고 Gibbs 자유에너지 변화량, 엔탈피변화량, 엔트로피 변화량과 같은 열역학적 변수들에 대해 평가하였다. This research studied the adsorption of basic dye, Basic Blue 3 (BB3) by using coal-based granular activated carbon (C-GAC) from aqueous solution. All experiments were performed in batch processes, and adsorption parameters such as C-GAC dosage, contact time, initial dye concentration and temperature were evaluated. The removal efficiency of BB3 was increased with increasing the C-GAC dosage and 100% of initial concentration, 50 mg L<SUP>-1</SUP> was removed above 0.2 g of C-GAC. Also, the time to reach equilibrium depended on the initial dye concentration. According to the Langmuir model, the maximum uptakes of C-GAC were calculated to be 66.45, 84.97 and 87.19 mg g<SUP>-1</SUP> at 25, 35 and 45 ℃, respectively. In addition, thermodynamic parameters such as Gibbs free energy change, enthalpy change and entropy change were investigated.
Diagnostic model for pancreatic cancer using a multi-biomarker panel
Yoo Jin Choi,Woongchang Yoon,Areum Lee,Youngmin Han,Yoonhyeong Byun,Jae Seung Kang,Hongbeom Kim,Wooil Kwon,Young-Ah Suh,Yongkang Kim,Seungyeoun Lee,Junghyun Namkung,Sangjo Han,Yonghwan Choi,Jin Seok H 대한외과학회 2021 Annals of Surgical Treatment and Research(ASRT) Vol.100 No.3
Purpose: Diagnostic biomarkers of pancreatic ductal adenocarcinoma (PDAC) have been used for early detection to reduce its dismal survival rate. However, clinically feasible biomarkers are still rare. Therefore, in this study, we developed an automated multi-marker enzyme-linked immunosorbent assay (ELISA) kit using 3 biomarkers (leucine-rich alpha-2-glycoprotein [LRG1], transthyretin [TTR], and CA 19-9) that were previously discovered and proposed a diagnostic model for PDAC based on this kit for clinical usage. Methods: Individual LRG1, TTR, and CA 19-9 panels were combined into a single automated ELISA panel and tested on 728 plasma samples, including PDAC (n = 381) and normal samples (n = 347). The consistency between individual panels of 3 biomarkers and the automated multi-panel ELISA kit were accessed by correlation. The diagnostic model was developed using logistic regression according to the automated ELISA kit to predict the risk of pancreatic cancer (high-, intermediate-, and low-risk groups). Results: The Pearson correlation coefficient of predicted values between the triple-marker automated ELISA panel and the former individual ELISA was 0.865. The proposed model provided reliable prediction results with a positive predictive value of 92.05%, negative predictive value of 90.69%, specificity of 90.69%, and sensitivity of 92.05%, which all simultaneously exceed 90% cutoff value. Conclusion: This diagnostic model based on the triple ELISA kit showed better diagnostic performance than previous markers for PDAC. In the future, it needs external validation to be used in the clinic.