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( Jae Young Jang ),( Soung Won Jeong ),( Sung Ran Cheon1 ),( Sae Hwan Lee1 ),( Sang Gyune Kim ),( Young Koog Cheon ),( Young Seok Kim1 ),( Young Deok Cho1 ),( Hong Soo Kim ),( So Young Jin ),( Yun Soo 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3
Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA. In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C. (Korean J Hepatol 2011;17:206-212)
( Sung Min Kim ),( Ji Su Lee ),( Ji Youn Hong ),( Jin Hee Kim ),( Joo Ran Hong ),( Hye In Cheon ),( Min Seok Hur ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: Atopic keratoconjuctivitis (AKC) is an allergic ocular diasese which cause severe damage to cornea and vision loss. AKC is associated with atopic dermatitis (AD), so alteration of conjuctival microbiome may be associated with immunologic imbalance. Objectives: We analyzed floral communities of conjuctiva in patients with AKC, and compared those in healthy induviduals. Methods: 16S ribosomal ribonucleic acid (rRNA) gene sequencing and data processing were used to aquire library of compositional information of patients with AKC and healthy individuals. The microbial and mycobial communities of conjuctiva in AKC were charaterized by average taxonomic composition, relative abundance and diversity analysis. Results: In AKC patients, the conjuctival taxonomic composition is more diverse than those in healthy individuals. Beta diversity in patients with AKC was higher compared to healthy control group. Conclusion: Composition and diversity of microbial and mycobial communities in AKC patients were different from those of healthy individuals. Although the bacterial genus that cause AKC is not uncertain, alteration of conjuctival microbiome in AKC patients may have an effect on local immunologic dysfunction in AD. Our findings suggested dysbiosis in AKC patients can be associated with mucosal barrier dysfunction as same as in AD patients.
( Sang-jin Cheon ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Gun-wook Kim ),( Hoon-soo Kim ),( Byung-soo Kim ),( Moon-bum Kim ),( Hyun-chan 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Bart’s syndrome is a rare hereditary mechanobullous disorder, first described by Bart et al in 1966. It is characterized by clinical manifestations: aplasia cutis congenita (ACC) over the lower extremities, epidermolysis bullosa (EB), and nail abnormalities. Previous genetic study revealed glycine substitution mutation in type VII collagen gene (COL7A1) indicated that Bart’s syndrome is a clinical variant of dominant dystrophic EB. The patient was a 1-day-old male newborn who presented with well-demarcated absence of skin over both lower extremities and erosive patches with blisters on nostril, lip, and hand since birth. He was born by Cesarean section at the 37th weeks of gestation. There was no family history of genetic disorder. There was no systemic involvement such as pyloric atresia, renal abnormalities, or arthrogryposis. Histopathologic findings from blister on hand showed subepidermal blister formation, and electron microscopy showed separation of below lamina densa layer. We performed mutation analysis of 118 exons of COL7A1. These result disclosed two novel heterogenous frameshift mutations (c.3841_3843delGGTinsTGGGG in exon 31 and c.8109_81014delGGTGAG in exon 109). Therefore, he was diagnosed as Bart’s syndrome with recessive dystrophic EB. Herein, we report a very rare case of Bart' syndrome which is clinical variant of recessive dystrophic EB, and review genetic mutation in this syndrome.
Spontaneous intracerebral hemorrhage in a patient with severe psoriasis vulgaris
( Sang-jin Cheon ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Moon-bum Kim ),( Byung-soo 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Psoriasis is chronic immune-mediated inflammatory skin disorder of unknown etiology. Psoriasis was previously believed to affect only the skin, and in some patients, the joints. Recent evidence suggests that chronic psoriasis may lead to other comorbidities such as cardiovascular disease, obesity, and type 2 diabetes mellitus. However, the association between psoriasis and intracerebral hemorrhage (ICH) has rarely been reported. The patient was 43-years-old female with a history of severe chronic psoriasis vulgaris for 6 years refractory to conventional immunomodulatory treatments and phototherapy. She was unregularly followed-up and 2 month ago, she was treated with cyclosporine (2.5mg/kg), but the disease aggravated. Four days ago, abruptly, she started to notice weakness of right lower extremity and dysarthria. She denied any history of trauma. On magnetic resonance imaging study, bilateral ICH in basal ganglia was observed. She did not have any risk factors such as trauma, advanced age, and hypertension for ICH. Therefore, we suspected that severe chronic psoriasis vulgaris may have played an important role in occurrence of spontaneous ICH.