http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Chenhui Ding (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
The nonlinear galloping of iced transmission conductor under uniform and turbulence wind
Zhonghua Liu,Chenhui Ding,Jian Qin,Ying Lei 국제구조공학회 2020 Structural Engineering and Mechanics, An Int'l Jou Vol.75 No.4
The analytical approach for stability and response of iced conductor under uniform wind or turbulent wind is presented in this study. A nonlinear dynamic model is established to describe the motion of iced conductor galloping. In the case of uniform wind, the stability condition is derived by analyzing the eigenvalue associated with linearized matrix; The first order and second order approximation of galloping amplitude are obtained using multi-scale method. However, real wind has random characteristics essentially. To accurately evaluate the performance of the galloping iced conductor, turbulence wind should be described by random processes. In the case of turbulence wind, the Lyapunov exponent is conducted to judge the stability condition; The probability density of displacement is obtained by using the path integral method to predict galloping amplitude. An example is proposed to verify the effectiveness of the previous methods. It is shown that the fluctuating component of wind has little influence on the stability of iced conductor, but it can increase galloping amplitude. The analytical results on stability and response are also verified by numerical time stepping method.
-
Next‑Generation Sequencing‑Based Preimplantation Genetic Testing for De Novo NF1 Mutations
DongJia Chen,Xiaoting Shen,Yan Xu,Bing Cai,Chenhui Ding,Yiping Zhong,Yanwen Xu,Canquan Zhou 한국바이오칩학회 2021 BioChip Journal Vol.15 No.1
Neurofibroma type 1 (NFI) is an autosomal dominant genetic disease associated with cancer and cognitive dysfunction. The 50% de novo mutation rate and numerous mutation types of the NF1 gene pose challenges to preimplantation genetic testing (PGT) for NFI. In 2020, a couple was subjected to next-generation sequencing (NGS)-based PGT at our center. Both husband and wife carried de novo NF1 mutations. Biopsied trophectoderm samples underwent whole-genome amplification using multiple displacement amplification. NGS was conducted to detect NF1 mutations as well as 105 closely linked single-nucleotide polymorphisms (SNPs) flanking NF1. Since no affected family member was available, the affected embryos identified by NF1-targeted sequencing were assigned as probands, based on which a haplotype analysis was constructed with informative SNP sites. Sanger sequencing was administrated for verification. Aneuploidy screening through NGS was performed in the same PGT cycle. Finally, among the nine biopsied blastocysts, two unaffected and euploid blastocysts were obtained in the couple, and one of the blastocysts was transferred in a frozen–thawed embryo transfer (FET) cycle. The outcome of FET is under observation. This study is the first to apply NGS-based PGT for NFI. In cases of sporadic NFI cases without affected family members, NGS-SNP can perform haploid analysis in an accurate manner by assigning the affected embryos as probands.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
