Right-to-Left Displacement of an Airgun Lead Bullet after Transorbital Entry into the Skull Complicated by Posttraumatic Epilepsy : A Case Report

Chao-bin Wang,Hui Wang,Jun-shuang Zhao,Ze-jun Wu,Hao-dong Liu,Chao-jia Wang,An-rong Li,Dawei Wang,Juntao Hu 대한신경외과학회 2023 Journal of Korean neurosurgical society Vol.66 No.5

Penetrating head injury is a serious open cranial injury. In civilians, it is often caused by non-missile, low velocity flying objects that penetrate the skull through a weak cranial structure, forming intracranial foreign bodies. The intracranial foreign body can be displaced due to its special quality, shape, and location. In this paper, we report a rare case of right-to-left displacement of an airgun lead bullet after transorbital entry into the skull complicated by posttraumatic epilepsy, as a reminder to colleagues that intracranial metal foreign bodies maybe displaced intraoperatively. In addition, we have found that the presence of intracranial metallic foreign bodies may be a factor for the posttraumatic epilepsy, and their timely removal appears to be beneficial for epilepsy control.

Regulatory Mechanisms of Annexin-Induced Chemotherapy Resistance in Cisplatin Resistant Lung Adenocarcinoma

Wang, Chao,Xiao, Qian,Li, Yu-Wen,Zhao, Chao,Jia, Na,Li, Rui-Li,Cao, Shan-Shan,Cui, Jia,Wang, Lu,Wu, Yin,Wen, Ai-Dong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

Adenocarcinoma of lung has high incidence and a poor prognosis, woith chemotherapy as the main therapeutic tool, most commonly with cisplatin. However, chemotherapy resistance develops in the majority of patients during clinic treatment. Mechanisms of resistance are complex and still unclear. Although annexin play important roles in various tumor resistance mechanisms, their actions in cisplatin-resistant lung adenocarcinoma remain unclear. Preliminary studies by our group found that in cisplatin-resistant lung cancer A549 cells and lung adenocarcinoma tissues, both mRNA and protein expression of annexins A1, A2 and A3 is increased. Using a library of annexin A1, A2 and A3 targeting combined molecules already established by ourselves we found that specific targeting decreased cisplatin-resistance. Taken together, the underlined effects of annexins A1, A2 and A3 on drug resistance and suggest molecular mechanisms in cisplatin-resistant A549 cells both in vivo and in vitro. Furthermore, the study points to improved research on occurrence and development of lung adenocarcinoma, with provision of effective targets and programmes for lung adenocarcinoma therapy in the clinic.

Combined Lowering Effects of Rosuvastatin and L. acidophilus on Cholesterol Levels in Rat

( Lijun Wang ),( Baihua Zhou ),( Xue Zhou ),( Yang Wang ),( Hongwei Wang ),( Shengying Jia ),( Zhipeng Zhang ),( Chao Chu ),( Jianjun Mu ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.3

Statins are a class of lipid-lowering drugs commonly used in the prevention of cardiovascular diseases. However, statin therapy presents many limitations, which have led to an increased interest in non-drug therapies, such as probiotics, to improve blood cholesterol levels. Indeed, probiotic strains such as Lactobacillus acidophilus have been found to improve blood lipid profiles, especially in reducing total cholesterol and LDL-C levels. In this study, we established a high-cholesterol rat model and studied the effect of Lactobacillus acidophilus administration alone or in combination with rosuvastatin. We were able to show that Lactobacillus exerts a cholesterol-lowering effect. Additionally, we observed that when administered together, rosuvastin and Lactobacillus exert a combined cholesterol-lowering effect. Altogether, our data advocate for the possibility of establishing probiotics as non-drug supplements for the treatment of hypercholesterolemia.

Dynamic characteristics analysis and experimental research on a new type planetary gear apparatus with small tooth number difference

Chao Huang,Jia-Xu Wang,Ke Xiao,Min Liu,Jun-Yang Li 대한기계학회 2013 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.27 No.5

Aimed at an internal mesh planetary gear with small tooth number difference (PGSTD) reducer, this paper proposes dynamic characteristics analysis. First, static finite element (FE) analysis is performed to check the structural strength with the stress distribution in the gear teeth. Second, by means of the dynamic contact FE method, the internal dynamic excitations of teeth mesh are obtained, including mesh stiffness excitation, transmission error excitation and mesh impact excitation. According to the established model for dynamic FE modal analysis, the natural frequencies and mode shapes of the planetary gear apparatus (PGA) are calculated, and its structural dynamic response and acceleration noise are researched with the comprehensive consideration of internal and external excitations. Finally, the noise and vibration testing on the PGA is carried out by utilizing the vibration test equipment. The results confirm that the predicted values are consistent with the experimental results.

Artificial Noise Assisted Secure Transmission for Distributed Antenna Systems

Wang, Hui-Ming,Wang, Chao,Ng, Derrick Wing Kwan,Lee, Moon Ho,Xiao, Jia Institute of Electrical and Electronics Engineers 2016 IEEE transactions on signal processing Vol.64 No.15

<P>This paper studies the artificial noise (AN) assisted secure transmission for a distributed antenna systems (DAS). To avoid a significant overhead caused by full legitimate channel state information (CSI) acquisition, tracking and collection in the central processor, we propose a distributed AN scheme utilizing the large-scale CSI of the legitimate receiver and eavesdropper. Our objective is to maximize the ergodic secrecy rate (ESR) via optimizing the power allocation between the confidential signal and AN for each remote antenna (RA) under the per-antenna power constraint. Specifically, exploiting random matrix theory, we first establish an analytical expression of the achievable ESR, which leads to a non-convex optimization problem with multiple non-convex constraints in the form of high-order fixed-point equations. To handle the intractable constraints, we recast it into a max-min optimization problem, and propose an iterative block coordinate descent (BCD) algorithm to provide a stationary solution. The BCD algorithm is composed of three subproblems, where the first two subproblems are convex with closed-form solutions, and the last one is a convex-concave game whose saddle-point is located by a tailored barrier algorithm. Simulation results validate the effectiveness of the proposed iterative algorithm and show that our scheme not only reduces the system overhead greatly but also maintains a good secrecy performance.</P>

Ultrasound Targeted Microbubble Destruction for Novel Dual Targeting of HSP72 and HSC70 in Prostate Cancer

Wang, Hang-Hui,Song, Yi-Xin,Bai, Min,Jin, Li-Fang,Gu, Ji-Ying,Su, Yi-Jin,Liu, Long,Jia, Chao,Du, Lian-Fang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3

The aim was to determine whether ultrasound targeted microbubble destruction (UTMD) promotes dual targeting of HSP72 and HSC70 for therapy of castration-resistant prostate cancer (CRPC), to improve the specific and efficient delivery of siRNA, to induce tumor cell specific apoptosis, and to find new therapeutic targets specific of CRPC.VCaP cells were transfected with siRNA oligonucleotides. HSP70, HSP90 and cleaved caspase-3 expression were determined by real-time quantitative polymerase chain reaction and Western blotting. Apoptosis and transfection efficiency were assessed by flow cytometry. Cell viability assays were used to evaluate safety. We found HSP72, HSC70 and HSP90 expression to be absent or weak in normal prostate epithelial cells (RWPE-1), but uniformly strong in prostate cancerous cells (VCaP). UTMD combined with dual targeting of HSP72 and HSC70 siRNA improve the efficiency of transfection, cell uptake of siRNA, downregulation of HSP70 and HSP90 expression in VCaP cells at the mRNA and protein level, and induction of extensive tumor-specific apoptosis. Cell counting kit-8 assays showed decreased cellular viability in the HSP72/HSC70-siRNA silenced group. These results suggest that the combination of UTMD with dual targeting HSP70 therapy for PCa may be most efficacious, providng a novel, reliable, non-invasive, safe targeted approach to improve the specific and efficient delivery of siRNA, and achieve maximal effects.

Soluble Expression and Purification of the Catalytic Domain of Human Vascular Endothelial Growth Factor Receptor 2 in Escherichia coli

( Jia Wei ),( Xiao Dan Cao ),( Sheng Min Zhou ),( Chao Chen ),( Hai Jun Yu ),( Yao Zhou ),( Ping Wang ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.8

Vascular endothelial growth factor (VEGF) plays a key role in angiogenesis through binding to its specific receptors, which mainly occurs to VEGF receptor 2 (VEGFR-2), a kinase insert domain-containing receptor. Therefore, the disruption of VEGFR-2 signaling provides a promising therapeutic approach for the treatment of cancer by inhibiting abnormal or tumorinduced angiogenesis. To explore this potential, we expressed the catalytic domain of VEGFR- 2 (VEGFR-2-CD) as a soluble active kinase in Escherichia coli. The recombinant protein was purified and the VEGFR-2-CD activity was investigated. The obtained VEGFR-2-CD showed autophosphorylation activity and phosphate transfer activity comparable to the commercial enzyme. Furthermore, the IC50 value of known VEGFR-2 inhibitor was determined using the purified VEGFR-2-CD. These results indicated a possibility for functional and economical VEGFR-2-CD expression in E. coli to use for inhibitor screening.

Parameterized Modeling of Spatially Varying PSF for Lens Aberration and Defocus

Wang Chao,Chen Juan,Jia Hongguang,Shi Baosong,Zhu Ruifei,Wei Qun,Yu Linyao,Ge Mingda 한국광학회 2015 Current Optics and Photonics Vol.19 No.2

Image deblurring by a deconvolution method requires accurate knowledge of the blur kernel. Existingpoint spread function (PSF) models in the literature corresponding to lens aberrations and defocus are eitherparameterized and spatially invariant or spatially varying but discretely defined. In this paper, aparameterized model is developed and presented for a PSF which is spatially varying due to lens aberrationsand defocus in an imaging system. The model is established from the Seidel third-order aberrationcoefficient and the Hu moment. A skew normal Gauss model is selected for parameterized PSF geometrystructure. The accuracy of the model is demonstrated with simulations and measurements for a defocusedinfrared camera and a single spherical lens digital camera. Compared with optical software Code V, thevisual results of two optical systems validate our analysis and proposed method in size, shape and direction. Quantitative evaluation results reveal the excellent accuracy of the blur kernel model

Review on the Synthesis and Antioxidation of Cu Nanowires for Transparent Conductive Electrodes

Jia Feng Chao,Yong Qiang Meng,Jingbing Liu,Qian Qian Zhang,Hao Wang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.4

Transparent conducting films based on solution-synthesized copper nanowires (Cu NWs) are considered to be an attractive alternative to indium tin oxide (ITO) due to the relative abundance of Cu and the low cost of solution-phase NW coating processes. Moreover, transparent electrodes tend to be flexible. This makes Cu NWs more attractive because ITO is brittle and can not meet the requirements of flexibility. For Cu NWs, aspect ratio is an important property. Cu NWs can be directly prepared by chemical reduction with various reducing agents and suitable capping agents. In general, the selectivity of the capping agent is very important for the formation of one-dimensional nanostructures because it plays a major role in the thermodynamic regulations and growth kinetics that influence the geometry and morphology of the crystal facets. Therefore, different aspect ratios are formed. Conductivity is the most important property for transparent electrodes. Organic pickling, annealing and glare pulses have a certain improvement in conductivity. Meanwhile, it is also essential to increase the oxidation resistance of the transparent electrode. The reduction of graphene oxide (r-GO), the coating of metal and polymer improve the oxidation resistance of the transparent electrode to varying degrees. This paper reviews the effect of different capping agents on the aspect ratio of NWs, and the effects of different post-treatments on oxidation resistance and conductivity of transparent electrodes.

Alkyl-substituted carbazole/pyridine hybrid host materials for efficient solution-processable blue- and green-emitting phosphorescent OLEDs

Chao Tang,Jianmei Chen,Yuxin Li,Xinchao Liu,Lili Zhang,Fangfang Wang,Jia Hu,Xudong Cao,Tao Jiang 대한금속·재료학회 2021 ELECTRONIC MATERIALS LETTERS Vol.17 No.2

Three new pyridine-cored alkyl-substituted carbazole derivatives of 2,6-bis(2,7-dimethyl-9H-carbazol-9-yl)pyridine(2,7-MeCzPy), 2,6-bis(3,6-dimethyl-9H-carbazol-9-yl) pyridine (3,6-MeCzPy) and 2,6-bis(3,6-di-tert-butyl-9H-carbazol-9-yl)pyridine (3,6-tBuCzPy) were synthesized by means of connecting methyl or tert-butyl substituents on the3,6 or 2,7 positions of carbazole with pyridine ring as the core. The influence of different alkyl and linkages modeon the thermal, photophysical, electrochemical properties and devices electrolumiescent (EL) performances of thecompounds were comprehensively studied. In solution-processed blue or green phosphorescent organic light-emittingdiodes (PHOLEDs) with bis[2-(4,6-difluorophenyl)-pyridinato-N,C2] picolinate iridium(III) (FIrpic) or fac-tris(2-phenylpyridine)iridium (Ir(ppy)3) as phosphorescent dopants, EL performances follow the same sequence of 2,7-MeCzPy> 3,6-tBuCzPy > 3,6-MeCzPy, the trend is consistent with the value of triplet energies (ET). Devices hosted by2,7-MeCzPy achieving the best EL performance, exhibited maxima 13.6 cd A−1 and 7.0 lm W−1 for current efficiency(CE) and power efficiency (PE) in blue PHOLEDs, maxima 26.2 cd A−1 and 16.2 lm W−1 for CE and PE in greenPHOLEDs.