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Inhibition of keratinocyte differentiation by cytosolic RNA sensor MDA5
( Changhyeon Kim ),( Dongkyun Hong ),( Mira Choi ),( Yullye Hwang ),( Jaekyung Lee ),( Young Lee ),( Youngjoon Seo ),( Changdeok Kim ),( Jeunghoon Lee ),( Sooil Kim ),( Youngho Lee ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Psoriasis is a chronic inflammatory skin disease. The etiology of psoriasis is not fully understood, but the genetic background is considered to be the most important factor. To date, many psoriasis-related genes have been discovered, but the role of many important genes has not been well understood. Objectives: The purpose of this study is to uncover possible roles of MDA5 in psoriasis. Methods: Expression of MDA5 was investigated using immunohistochemistry. Then, MDA5 was overexpressed in keratinocytes using a recombinant adenovirus. Results: As a result of immunohistochemical staining, the expression of MDA5 was significantly increased in the epidermis of psoriasis compared to normal skin. Similarly, the expression of MDA5 was increased in imiquimodinduced psoriasiform dermatitis model. In cultured keratinocytes, TLR3 agonist poly(I:C) induced expression of MDA5 at both mRNA and protein levels. When MDA5 was overexpressed using a recombinant adenovirus, poly(I:C)- induced cytokine expression was significantly increased. Finally, MDA5 overexpression significantly inhibited calcium-induced differentiation of keratinocytes. Conclusion: These results suggest that MDA5 increases in psoriasis and negatively regulates keratinocyte differentiation.
Design of Simulator for Cloud Computing Infrastructure and Service
Changhyeon Kim,Junsang Kim,Won Joo Lee 보안공학연구지원센터 2014 International Journal of Smart Home Vol.8 No.6
Cloud computing that provides computational resource, platform and software as services is operated in cluster that is comprised of hundreds or thousands of servers. Thus, cloud computing providers may use various policies such as complex resource provisioning, allocation, configuration, and so on, to efficiently manage huge resources. In this environment, it is difficult to customize circumstance and to test and evaluate a hypothesis independently. To overcome these limitations, we provide SimCloudIS: simulator for cloud computing infrastructure and service. The SimCloudIS provides cloud system components such as the datacenter, host, VM, application, network and scheduling polices that are extendable and managed in independent layers. The network component supports packet based network communication which is based on the real network model, thereby facilitating simulation of internet based services. For evaluation, SimCloudIS provides a monitor that observes the status of all components and records them. The usefulness of SimCloudIS is demonstrated by involving a case study for dynamic allocation and relocation of VMs in a cloud environment and analyzing the result.
Glutamine (Q)‐peptide screening for transglutaminase reaction using mRNA display
Lee, Jae‐,Hun,Song, Changhyeon,Kim, Do‐,Hyun,Park, Il‐,Hyang,Lee, Sun‐,Gu,Lee, Yoon‐,Sik,Kim, Byung‐,Gee Wiley Subscription Services, Inc., A Wiley Company 2013 Biotechnology and bioengineering Vol.110 No.2
<P><B>Abstract</B></P><P>Information on subsite specificity of the transglutaminase (TG) is important to design any specific peptides for TG's applications and inhibitor studies. Here, mRNA display was introduced for identifying the subsite specificity of TG from <I>Streptomyces mobaraensis</I> (STG). Functionally active peptides expressed from mRNA display library were differentially conjugated to hexa lysine (K<SUB>6</SUB>)—beads according to their relative activities for STG. The active peptide substrates for STG were enriched through six rounds of screening, and its corresponding cDNA/mRNA sequences were identified by DNA sequencing. The results showed that tripeptides such as LQQ and TQP do not show any activity for STG, but the minimum size of the peptide displaying STG activity is pentapeptide. One such predicted peptide sequence, that is, RLQQP (TQ1), showed higher reactivity (ca. 182% conjugation yield) to STG than that of the highly active sequence, that is, control‐Q (PQPQLPYPQPQLPY), well‐known previously for mammalian TG2. Furthermore, when recombinant DsRed was tagged with TQ1 sequence at its C‐terminal, DsRed‐TQ1 underwent efficient covalent‐immobilization onto alginate–gelatin bead by STG reaction, showing a Q‐peptide application as a useful tagging molecule. Biotechnol. Bioeng. 2013; 110: 353–362. © 2012 Wiley Periodicals, Inc.</P>
Lee, Kyuho Jason,Bong, Kyeongryeol,Kim, Changhyeon,Jang, Jaeeun,Lee, Kyoung-Rog,Lee, Jihee,Kim, Gyeonghoon,Yoo, Hoi-Jun IEEE 2017 IEEE journal of solid-state circuits Vol.52 No.1
<P>The advanced driver assistance system (ADAS) for adaptive cruise control and collision avoidance is strongly dependent upon the robust image recognition technology such as lane detection, vehicle/pedestrian detection, and traffic sign recognition. However, the conventional ADAS cannot realize more advanced collision evasion in real environments due to the absence of intelligent vehicle/pedestrian behavior analysis. Moreover, accurate distance estimation is essential in ADAS applications and semiglobal matching (SGM) is most widely adopted for high accuracy, but its system-on-chip (SoC) implementation is difficult due to the massive external memory bandwidth. In this paper, an ADAS SoC with behavior analysis with Artificial Intelligence functions and hardware implementation of SGM is proposed. The proposed SoC has dual-mode operations of highperformance operation for intelligent ADAS with real-time SGM in D-Mode (d-mode) and ultralow-power operation for black box system in parking-mode. It features: 1) task-level pipelined SGM processor to reduce external memory bandwidth by 85.8%; 2) region-of-interest generation processor to reduce 86.2% of computation; 3) mixed-mode intention prediction engine for dualmode intelligence; and 4) dynamic voltage and frequency scaling control to save 36.2% of power in d-mode. The proposed ADAS processor achieves 862 GOPS/W energy efficiency and 31.4GOPS/ mm(2) area efficiency, which are 1.53x and 1.75x improvements than the state of the art, with 30 frames/s throughput under 720p stereo inputs.</P>
Energy Consumption Analysis of Downward-Tethered Quadcopter
ChangHyeon Lee,Junwoo Jason Son,Hakjun Lee,Soohee Han 제어로봇시스템학회 2021 제어로봇시스템학회 국제학술대회 논문집 Vol.2021 No.10
This paper analyze the energy consumption of a new concept of tethered quadrotor system, downward tethered quadrotor (DTQ), to provide insight about using DTQ. DTQ is one of a tethered quadrotor system in which station is located above the flight level of the quadrotor. Thanks to its system layout, the tether can play an important role in energy efficient flight of the quadrotor by adjusting the tension properly. In order to extremize the advantage of DTQ, optimization problem for mechanical power consumption of DTQ in hovering states is formulated. The DTQ in this paper considers misalignment between tether link point on the quadrotor and center of mass (CoM) of the quadrotor to simulate real system. Numerical simulation illustrates efficiency of the proposed method.