GreenIoT Architecture for Internet of Things Applications

( Yi-wei Ma ),( Jiann-liang Chen ),( Yung-sheng Lee ),( Hsin-yi Chang ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.2

A power-saving mechanism for smartphone devices is developed by analyzing the features of data that are received from Internet of Things (IoT) sensors devices to optimize the data processing policies. In the proposed GreenIoT architecture for power-saving in IoT, the power saving and feedback mechanism are implemented in the IoT middleware. When the GreenIoT application in the power-saving IoT architecture is launched, IoT devices collect the sensor data and send them to the middleware. After the scanning module in the IoT middleware has received the data, the data are analyzed by a feature evaluation module and a threshold analysis module. Based on the analytical results, the policy decision module processes the data in the device or in the cloud computing environment. The feedback mechanism then records the power consumed and, based on the history of these records, dynamically adjusts the threshold value to increase accuracy. Two smart living applications, a biomedical application and a smart building application, are proposed. Comparisons of data processed in the cloud computing environment show that the power-saving mechanism with IoT architecture reduces the power consumed by these applications by 24% and 9.2%.

Long non-coding RNAs in Sus scrofa ileum under starvation stress

Wang Shu,Ma Yi Jia,Li Yong Shi,Ge Xu Sheng,Lu Chang,Cai Chunbo,Yang Yang,Zhao Yan,Liang Guo Ming,Guo Xiaohong,Cao Guoqing,Li Bugao,Gao Pengfei 아세아·태평양축산학회 2022 Animal Bioscience Vol.35 No.7

Objective: In this study, we aimed to identify long non-coding RNAs (lncRNAs) that play important roles in starvation stress, analyze their functions, and discover potential molecular targets to alleviate starvation stress to provide a theoretical reference for subsequent in-depth research. Methods: We generated a piglet starvation stress animal model. Nine Yorkshire weaned piglets were randomly divided into a long-term starvation stress group (starved for 72 h), short-term starvation stress group (starved for 48 h), and the control group. LncRNA libraries were constructed using high-throughput sequencing of piglet ileums. Results: We obtained 11,792 lncRNAs, among which, 2,500 lncRNAs were novel. In total, 509 differentially expressed (DE)lncRNAs were identified in this study. Target genes of DElncRNAs were predicted via cis and trans interactions, and functional and pathway analyses were performed. Gene ontology functions and Kyoto encyclopedia of genes and genomes analysis revealed that lncRNA-targeted genes mainly participated in metabolic pathways, cellular processes, immune system processes, digestive systems, and transport activities. To reveal the mechanism underlying starvation stress, the interaction network between lncRNAs and their targets was constructed based on 26 DElncRNAs and 72 DEmRNAs. We performed an interaction network analysis of 121 DElncRNA–DEmRNA pairs with a Pearson correlation coefficient greater than 0.99. Conclusion: We found that MSTRG.19894.13, MSTRG.16726.3, and MSTRG.12176.1 might play important roles in starvation stress. This study not only generated a library of enriched lncRNAs in piglets, but its outcomes also provide a strong foundation to screen key lncRNAs involved in starvation stress and a reference for subsequent in-depth research. Objective: In this study, we aimed to identify long non-coding RNAs (lncRNAs) that play important roles in starvation stress, analyze their functions, and discover potential molecular targets to alleviate starvation stress to provide a theoretical reference for subsequent in-depth research.Methods: We generated a piglet starvation stress animal model. Nine Yorkshire weaned piglets were randomly divided into a long-term starvation stress group (starved for 72 h), short-term starvation stress group (starved for 48 h), and the control group. LncRNA libraries were constructed using high-throughput sequencing of piglet ileums.Results: We obtained 11,792 lncRNAs, among which, 2,500 lncRNAs were novel. In total, 509 differentially expressed (DE)lncRNAs were identified in this study. Target genes of DElncRNAs were predicted via cis and trans interactions, and functional and pathway analyses were performed. Gene ontology functions and Kyoto encyclopedia of genes and genomes analysis revealed that lncRNA-targeted genes mainly participated in metabolic pathways, cellular processes, immune system processes, digestive systems, and transport activities. To reveal the mechanism underlying starvation stress, the interaction network between lncRNAs and their targets was constructed based on 26 DElncRNAs and 72 DEmRNAs. We performed an interaction network analysis of 121 DElncRNA–DEmRNA pairs with a Pearson correlation coefficient greater than 0.99.Conclusion: We found that MSTRG.19894.13, MSTRG.16726.3, and MSTRG.12176.1 might play important roles in starvation stress. This study not only generated a library of enriched lncRNAs in piglets, but its outcomes also provide a strong foundation to screen key lncRNAs involved in starvation stress and a reference for subsequent in-depth research.

Lentivirus-mediated silencing of the PTC1 and PTC2 genes promotes recovery from spinal cord injury by activating the Hedgehog signaling pathway in a rat model

Ya-Dong Zhang,Zhong-Sheng Zhu,Dong Zhang,Zhen Zhang,Bin Ma,Shi-Chang Zhao,Feng Xue 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-

This study aimed to investigate the effect of Patched-1 (PTC1) and PTC2 silencing in a rat model, on Hedgehog (Hh) pathwaymediated recovery from spinal cord injury (SCI). An analytical emphasis on the relationship between the sonic hedgehog (Shh) pathway and nerve regeneration was explored. A total of 126 rats were divided into normal, sham, SCI, negative control (NC), PTC1-RNAi, PTC2-RNAi and PTC1/PTC2-RNAi groups. The Basso, Beattie and Bresnahan (BBB) scale was employed to assess hind limb motor function. Quantitative real-time polymerase chain reaction and western blotting were performed to examine the mRNA and protein levels of PTC1, PTC2, Shh, glioma-associated oncogene homolog 1 (Gli-1), Smo and Nestin. Tissue morphology was analyzed using immunohistochemistry, and immunofluorescent staining was conducted to detect neurofilament protein 200 (NF-200) and glial fibrillary acidic protein (GFAP). The PTC1/PTC2-RNAi group displayed higher BBB scores than the SCI and NC groups. Shh, Gli-1, Smo and Nestin expression levels were elevated in the PTC1/PTC2-RNAi group. PTC1 and PTC2 mRNA and protein expression was lower in the PTC1/PTC2-RNAi group than in the normal, sham and SCI groups. Among the seven groups, the PTC1/PTC2-RNAi group had the largest positive area of NF-200 staining, whereas the SCI group exhibited a larger GFAP-positive area than both the normal and the sham groups. The Shh pathway may provide new insights into therapeutic indications and regenerative recovery tools for the treatment of SCI. Activation of the Hh signaling pathway by silencing PTC1 and PTC2 may reduce inflammation and may ultimately promote SCI recovery.

青岛市中学生网络成瘾倾向的影响因素研究

陸潭晟(Lu, Tan Sheng),馬?(Ma, Yan),許昌德(Huh, Chang Deog) 영남대학교 중국연구센터 2015 중국과 중국학 Vol.- No.24

본 연구는 중국 중학생들의 인터넷 중독에 영향을 주는 다양한 요인을 검토하여 중학생들의 올바른 인터넷 사용태도를 확립시키는 데 목적을 둔다. 이를 위하여 본 연구의 조사대상은 중국 청도시에 소재하는 5개 중학교의 각 학년 학생 330명을 대상으로 설문조사를 실시하였으며, 회수된 총 310부 중 부적절한 자료를 제외한 300부를 분석자료로 활용하였다. 또한 분석모형에서 가족친밀도와 학교생활만족도를 독립변수로, 인터넷 기대를 매개변수로, 인터넷 중독을 종속변수로 설정하여 수집된 자료에 대해 빈도분석, t-test, 다변량분석과 다중회귀분석, 그리고 Sobel-test를 실시하였으며, 이를 토대로 한 연구결과는 다음과 같다. 첫째, 조사대상자의 인구사회학 특성 중 성별, 학년 및 성적은 인터넷 중독에 영향을 미쳤으며, 학년이 높을수록, 성적이 나쁠수록, 남학생이 여학생보다 인터넷 중독의 가능성을 더 높게 보였으며 이는 통계적으로 유의미한 것으로 나타났다. 둘째, 조사대상자의 인터넷 사용 특성 중 컴퓨터 설치장소(자기 방), 인터넷 이용 장소(PC방), 인터넷 이용 유형(채팅, 게임) 등은 인터넷 중독에 영향을 주는 것으로 나타났다. 셋째, 조사대상자의 가족친밀도가 인터넷 기대에 음의 영향을 미치는 반면에 학교생활만족도가 인터넷 기대에 영향을 미치지 않는 것을 확인되었다. 넷째, 가족친밀도, 학교생활만족도가 인터넷 중독에 음의 영향을 미치는 반면에 인터넷 기대가 인터넷 중독에 긍정적인 영향을 미치는 것으로 나타났다. 다섯째, 중국 중학생들의 가족친밀도와 인터넷 중독의 관계에서 인터넷 기대가 부분매개 역할을 하는 것을 확인할 수 있었다. 반면에 학교생활만족도와 인터넷 중독의 관계에서 인터넷 기대의 매개효과는 없는 것으로 나타났다. This study tried to understand what variables influence the juvenile internet addiction tendency. For this purpose, a survey questionnaire was distributed to 330 students from five middle schools located in Qingdao City, Shan-dong Province, China and 300 questionnaires were used for data analysis. The study used SPSS 21.0 to execute Frequency Analysis, t-test, MANOVA, Multiple Regression Analysis and Sobeltest, entering the juvenile internet addiction tendency as a dependent variable, family relationship intimacy and school life satisfaction as independent variables, while internet expectancy was entered as a mediating variables. The study found the following results. First, significant differences in the degree of internet addiction tendency were found among the participants depending on gender, grade level, and GPA. Secondly, there was statistically significant difference in the degree of internet addiction tendency depending on the places where the internet is installed and used. Thirdly, the lower the degree of family intimacy was related to the more serious the internet addiction tendency. In addition, the lower the school life satisfaction was closely related to the more serious the internet addiction tendency. Finally, Internet expectancy had an indirect effect on the relationship between family relationship and internet addiction tendency.

β-Sitosterol treatment attenuates cognitive deficits and prevents amyloid plaque deposition in amyloid protein precursor/ presenilin 1 mice

Jian-Ya Ye,Li Li,Qing-Mao Hao,Yong Qin,Chang-Sheng Ma 대한생리학회-대한약리학회 2020 The Korean Journal of Physiology & Pharmacology Vol.24 No.1

Alzheimer’s disease (AD) is the most common neurodegenerative disorder causing dementia worldwide, and is mainly characterized by aggregated β-amyloid (Aβ). Increasing evidence has shown that plant extracts have the potential to delay AD development. The plant sterol β-Sitosterol has a potential role in inhibiting the production of platelet Aβ, suggesting that it may be useful for AD prevention. In the present study, we aimed to investigate the effect and mechanism of β-Sitosterol on deficits in learning and memory in amyloid protein precursor/presenilin 1 (APP/PS1) double transgenic mice. APP/PS1 mice were treated with β-Sitosterol for four weeks, from the age of seven months. Brain Aβ metabolism was evaluated using ELISA and Western blotting. We found that β-Sitosterol treatment can improve spatial learning and recognition memory ability, and reduce plaque load in APP/PS1 mice. β-Sitosterol treatment helped reverse dendritic spine loss in APP/PS1 mice and reversed the decreased hippocampal neuron miniature excitatory postsynaptic current frequency. Our research helps to explain and support the neuroprotective effect of β-Sitosterol, which may offer a novel pharmaceutical agent for the treatment of AD. Taken together, these findings suggest that β-Sitosterol ameliorates memory and learning impairment in APP/PS1 mice and possibly decreases Aβ deposition.

Phase II Study of Preoperative Intra-Arterial Epirubicin, Etoposide, and Oxaliplatin Combined with Oral S-1 Chemotherapy for the Treatment of Borrmann Type 4 Gastric Cancer

Xiang, Xiao-song,Su, Yu,Li, Guo-li,Ma, Long,Zhou, Chang-sheng,Ma, Ru-feng The Korean Gastric Cancer Association 2020 Journal of gastric cancer Vol.20 No.4

Purpose: A phase II study was conducted to evaluate the safety and efficacy of preoperative, intra-arterial perfusion of epirubicin, etoposide, and oxaliplatin combined with oral chemotherapy S-1 (SEEOX) for the treatment of type 4 gastric cancer. Materials and Methods: A single-center, single-arm phase II trial was conducted on 36 patients with histologically proven type 4 gastric cancer without distant peritoneal or organ metastasis. Patients received 3, 21-day courses of SEEOX preoperative chemotherapy. The primary endpoint was overall survival (OS) and the secondary outcomes assessed were chemotherapeutic response, radical resection rate, pathological regression, toxicities, postoperative morbidity, and mortality. Results: All patients were at an advanced stage of cancer (stage III or IV) and completed the entire course of treatment. Based on changes in tumor volume and peritoneal metastasis, the objective response rate was 55.6% (20/36; 95% confidence interval [CI], 38.5%-72.6%) and the disease control rate was 69.4% (25/36; 95% CI, 53.6%-85.3%). The radical resection rate was 75% (27/36; 95% CI, 60.1%-89.9%) and the proportion of R0 resections was 66.7% (21/36; 95% CI, 50.5%-82.8%). The pathological response rate was 33.3%, of which 13.9% showed complete pathological regression. The median survival was 27.1 months (95% CI, 22.24-31.97 months), and the 2-year OS was 48.5% (95% CI, 30.86%-66.1%). Conclusions: Preoperative SEEOX is a safe and effective treatment for type 4 gastric cancer. Based on these preliminary data, a phase III study will be conducted to confirm the superiority of this regimen over standard treatment.