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Identification of CNVs and their association with the meat traits of Hanwoo
Chan Mi Bang,Khaliunaa Tseveen,Gwang Hyeon Lee,Gil Jong Seo,Hong Sik Kong The Korean Society of Animal Reproduction and Biot 2023 한국동물생명공학회지 Vol.38 No.3
Background: Copy number variation (CNV) can be identified using next-generation sequencing and microarray technologies, the research on the analysis of its association with meat traits in livestock breeding has significantly increased in recent years. Hanwoo is an inherent species raised in the Republic of Korea. It is now considered one of the most economically important species and a major food source mainly used for meat (Hanwoo beef). Methods: In this study, CNVs and the relationship between the obtained CNV regions (CNVRs) can be identified in the Hanwoo steer samples (n = 473) using Illumina Hanwoo SNP 50K bead chip and bioinformatic tools, which were used to locate the required data and meat traits were investigated. The PennCNV software was used for the identification of CNVs, followed by the use of the CNV Ruler software for locating the different CNVRs. Furthermore, bioinformatics analysis was performed. Results: We found a total of 2,575 autosomal CNVs (933 losses, 1,642 gains) and 416 CNVRs (289 gains, 111 losses, and 16 mixed), which were established with ranged in size from 2,183 bp to 983,333 bp and 10,004 bp to 381,836 bp, respectively. Upon analyzing the restriction of minor alleles frequency > 0.05 for meat traits association, 6 CNVRs in the carcass weight, 2 CNVRs in the marbling score, 3 CNVRs in the backfat thickness, and 2 CNVRs in the longissimus muscle area were related to the meat traits. In addition, we identified an overlap of 347 CNVRs. Moreover, 3 CNVRs were determined to have a gene that affects meat quality. Conclusions: Our results confirmed the relationship between Hanwoo CNVR and meat traits, and the possibility of overlapping candidate genes, annotations, and quantitative trait loci that results depended on to contribute to the greater understanding of CNVs in Hanwoo and its role in genetic variation among cattle livestock.
Infliximab으로 치료 받은 환자에서 발생한 결핵성 복막염과 동반된 Poncet`s Disease
박찬웅 ( Chan Woong Park ),김기방 ( Ki Bang Kim ),이민지 ( Min Ji Lee ),임미경 ( Mi Kyung Lim ),심승철 ( Seung Cheol Shim ),신동혁 ( Dong Hyuk Sheen ),박효 ( Hyo Park ),전석재 ( Seok Jae Zeon ) 대한류마티스학회 2011 대한류마티스학회지 Vol.18 No.1
Infliximab is a chimeric mouse/human monoclonal antibody against tumor necrosis factor-alpha (TNF-α) that is used worldwide to treat rheumatic disease. However, the reactivation of tuberculosis, including extrapulmonary menifestation, is a severe side effect of anti-TNF-α treatment. Mycobacterium tubercluosis causes two forms of joint involvement, TB arthritis and Poncet`s disease. Poncet`s disease is a rare aseptic form of arthritis, known as reactive arthritis in tuberculosis. We encountered a case of tuberculous peritonitis with Poncet`s disease in a 38-yearold man with a history of ankylosing spondylitis that was treated with infliximab. We report this case with a review of the literature.
Han, Mi Ah,Kim, Young-Woo,Choi, Il Ju,Oh, Myueng Guen,Kim, Chan Gyoo,Lee, Jong Yeul,Cho, Soo-Jeong,Eom, Bang Wool,Yoon, Hong Man,Ryu, Keun Won American Association for Cancer Research 2013 Cancer epidemiology, biomarkers & prevention Vol.22 No.10
<P><B>Background:</B> Smoking and drinking alcohol are major risk factors for cancer development, and we investigated their effects on gastric cancer prognosis following initial resection.</P><P><B>Methods:</B> Data from male patients with stage III–IV gastric adenocarcinoma who underwent surgery between 2001 and 2006 were retrospectively reviewed. Patients were followed up until 2011. Kaplan–Meier plots and Cox proportional hazards regressions were applied for survival rates.</P><P><B>Results:</B> Among 238 patients, 151 (63.4%) smoked and 146 (61.3%) drank alcohol. Current smokers had an increased risk of cancer recurrence or death from any cause [adjusted HR (aHR), 1.94; 95% confidence interval (CI), 1.18–3.21], cancer recurrence (aHR, 1.89; 95% CI, 1.12–3.21), and overall mortality (aHR, 2.14; 95% CI, 1.23–3.73) compared with never-smokers. Patients with a lifetime cigarette smoking of <40 and ≥40 pack-years had increased cancer recurrence or death from any cause (aHR, 1.72 and 2.43, respectively; 95% CI, 1.03–2.86 and 1.38–4.30, respectively), cancer recurrence (aHR, 1.63 and 2.61, respectively; 95% CI, 0.95–2.79 and 1.43–4.77, respectively), and overall mortality (aHR, 1.92 and 2.75, respectively; 95% CI, 1.09–3.38 and 1.47–5.12, respectively) compared with never-smokers. However, drinking alcohol was not associated with postsurgery survival.</P><P><B>Conclusions:</B> Cigarette-smoking history at the time of diagnosis, but not drinking history, is associated with cancer recurrence and poor survival after surgery in male patients with stage III–IV gastric cancer.</P><P><B>Impact:</B> These findings encourage physicians to advise patients with gastric cancer to stop smoking to obtain a general health benefit and likely improvement in the gastric cancer course. <I>Cancer Epidemiol Biomarkers Prev; 22(10); 1805–12. ©2013 AACR</I>.</P>
한국인에서의 악성 흑생종에 대한 임상 및 병리 조직학적 연구 - 대한피부과학회 피부병리연구분과위원회 공동연구 -
이미우 ( Mi-Woo Lee ),고재경 ( Jai-Kyoung Koh ),권경술 ( Kyung-Sool Kwon ),김낙인 ( Nack-In Kim ),김상원 ( Sang-Won Kim ),김수남 ( Soo-Nam Kim ),김방순 ( Bang-Soon Kim ),김유찬 ( You-Chan Kim ),김종민 ( Jong-Min Kim ),명기범 ( Ki- 대한피부과학회 2003 대한피부과학회지 Vol.41 No.1
Backgorund ; Malignant melanoma in Korean has been increasing as in other countries, but there is no nationwide survey of malignant melanoma in Korea. Objective : The aim of this study was to document the clinical and histopathological features of cutaneo
한국인에서의 피부 림프종의 임상 및 병리조직학적 연구 - 대한피부과학회 피부병리연구분과위원회 공동연구 -
이미우 ( Mi-Woo Lee ),고재경 ( Jai-Kyoung Koh ),권경술 ( Kyung-Sool Kwon ),김낙인 ( Nack-In Kim ),김상원 ( Sang-Won Kim ),김수남 ( Soo-Nam Kim ),김방순 ( Bang-Soon Kim ),김유찬 ( You-Chan Kim ),김종민 ( Jong-Min Kim ),명기범 ( Ki- 대한피부과학회 2003 대한피부과학회지 Vol.41 No.1
Background: The relative frequency and clinicopathologic characteristics of lymphomas vary according to geography and race. Data on the features of cutaneous lymphoma in Korea are limited. Objective . The aim of this study was to document the relative occ
( Seung Hyun Bang ),( Seung Mi Lee ),( Chan-wook Park ),( Joong Shin Park ),( Jong Kwan Jun ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: Induction of labor (IOL) is the most common procedures in obstetrics, and twin pregnancy is reported to be the risk factor for failed induction. The patients need to be counselled before induction, but there were not enough data regarding success rate of IOL in twin, especially in nulliparous women. The purpose of this study was to examine the success rate of vaginal delivery after IOL in term nulliparous women with twin pregnancy. Methods: In this retrospective cohort study, 806 nulliparous women with twin pregnancy were delivered at term after IOL between 2005 and 2018. A successful induction was defined as vaginal delivery after IOL, and a failed induction was defined as cesarean delivery. Clinical characteristics were compared according to the success or failure of induction. Results: Among the study population, 78% (628/806) women were successfully delivered vaginally. Women with successful induction had lower maternal age, higher maternal height, earlier gestational age at delivery, and lower summated birthweight of both twin. Logistic regression analysis showed that maternal age, height and summated birthweight of both twin were significant associated factors with successful IOL. Conclusion: In term nulliparous women with twin pregnancy, IOL resulted in 78 % of success rate. This can be used in counselling before induction of labor in twin pregnant women.
Jeong Yun-Mi,Choi Yeong-Gon,Kim Dong-Seok,Park Seo-Hyoung,Yoon Jin-A,Kwon Sun-Bang,Park Eun-Sang,Park Kyoung-Chan The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.11
In this study, we evaluated the cytoprotective effects of antioxidative substances in hydrogen peroxide ($H_{2}O_{2}$) treated Mel-Ab melanocytes. Tested substances include selenium, quercetin, green tea (GT) extract, and several vitamins (ascorbic acid, Trolox, and folic acid). Of these, both quercetin and GT extract were found to have strong cytoprotective effects on $H_{2}O_{2}$induced cell death. We also examined additive effects, but no combination of two of any of the above substances was found to act synergistically against oxidative damage in Mel-Ab cells. Nevertheless, a multi-combination of GT extract, quercetin, and folic acid appeared to prevent cellular damage in a synergistic manner, which suggests that combinations of antioxidants may be of importance, and that co-treatment with antioxidants offers a possible means of treating vitiligo, which is known to be related to melanocyte oxidative stress.