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패시브주택 에너지 절감목표 수준별 요소기술 통합구성에 관한 연구
김빛나(Kim Bich-na),윤종호(Yoon Jong-Ho),신우철(Shin U-Cheul),백남춘(Baek Nam-Choon) 한국태양에너지학회 2010 한국태양에너지학회 학술대회논문집 Vol.2010 No.11
It is essential to reduce energy consumption in Residential Buildings from 2012 because government strengthened the standard of annual total energy consumption by stages. So, this study analyzed energy saving rate of passive house by stages. it suggests the application of necessary technical elements to satisfy with the level in progressive energy performance objectives. The level of progressive energy saving rate of passive house is 30%, 40%, 50%. According to analyze the elemental heat, It can know that the heat loss from window per unit area loss is large. Passive technical elements is the insulation of wall and roof, highly efficient window system, reduction of infiltration. It is analyzed energy saving rate of base house by simulating with building energy analysis program. Consequently energy saving rate by the insulation of wall is the most largest. It is analyzed energy saving rate of base house by combining technical elements to apply base house. Energy saving proposal according to energy saving rate is calculated at 240 unit. Energy saving rate show from minimum 22.2% to maximum 51%. It selected the proposal of passive house of energy saving rate 30%, 40%, 50% based aim of this study from among these. Result is arrived that 30% saving proposal is 7 unit, 40% saving proposal is 8 unit and 50% saving proposal is 2 unit. It is expected to apply data of standard of annual total energy consumption from 2012 as this study suggests integrated application to compose technical elements of passive house by the level of energy saving.
Her, Young,Shin, Bich-Na,Lee, Yun Lyul,Park, Joon Ha,Kim, Dae Won,Kim, Ki Seob,Kim, Hyunjung,Song, Minah,Kim, Jong-Dai,Won, Moo-Ho,Ahn, Ji Hyeon MDPI 2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.20 No.6
<P>In recent years, the use of botanical agents to prevent skin damage from solar ultraviolet (UV) irradiation has received considerable attention. <I>Oenanthe javanica</I> is known to exert anti-inflammatory and antioxidant activities. This study investigated photoprotective properties of an <I>Oenanthe javanica</I> extract (OJE) against UVB-induced skin damage in ICR mice. The extent of skin damage was evaluated in three groups: control mice with no UVB, UVB-exposed mice treated with vehicle (saline), and UVB-exposed mice treated with 1% extract. Photoprotective properties were assessed in the dorsal skin using hematoxylin and eosin staining, Masson trichrome staining, immunohistochemical staining, quantitative real-time polymerase chain reaction, and western blotting to analyze the epidermal thickness, collagen expression, and mRNA and protein levels of type I collagen, type III collagen, and interstitial collagenases, including matrix metalloproteinase (MMP)-1 and MMP-3. In addition, tumor necrosis factor (TNF)-α and cyclooxygenase (COX)-2 protein levels were also assessed. In the UVB-exposed mice treated with extract, UV-induced epidermal damage was significantly ameliorated. In this group, productions of collagen types I and III were increased, and expressions of MMP-1 and MMP-3 were decreased. In addition, TNF-α and COX-2 expressions were reduced. Based on these findings, we conclude that OJE displays photoprotective effects against UVB-induced collagen disruption and inflammation and suggest that <I>Oenanthe javanica</I> can be used as a natural product for the treatment of photodamaged skin.</P>
Park, Joon Ha,Shin, Bich Na,Ahn, Ji Hyeon,Cho, Jeong Hwi,Lee, Tae-Kyeong,Lee, Jae-Chul,Jeon, Yong Hwan,Kang, Il Jun,Yoo, Ki-Yeon,Hwang, In Koo,Lee, Choong Hyun,Noh, Yoo Hun,Kim, Sung-Su,Won, Moo-Ho,Ki Medknow PublicationsMedia Pvt Ltd 2018 Chinese medical journal : CMJ Vol.131 No.6
<P><B>Background:</B></P><P><I>Glehnia littoralis</I> has been used for traditional Asian medicine, which has diverse therapeutic activities. However, studies regarding neurogenic effects of <I>G. littoralis</I> have not yet been considered. Therefore, in this study, we examined effects of <I>G. littoralis</I> extract on cell proliferation, neuroblast differentiation, and the maturation of newborn neurons in the hippocampus of adult mice.</P><P><B>Methods:</B></P><P>A total of 39 male ICR mice (12 weeks old) were randomly assigned to vehicle-treated and 100 and 200 mg/kg <I>G. littoralis</I> extract-treated groups (<I>n</I> = 13 in each group). Vehicle and <I>G. littoralis</I> extract were orally administrated for 28 days. To examine neurogenic effects of <I>G. littoralis</I> extract, we performed immunohistochemistry for 5-bromo-2-deoxyuridine (BrdU, an indicator for cell proliferation) and doublecortin (DCX, an immature neuronal marker) and double immunofluorescence staining for BrdU and neuronal nuclear antigen (NeuN, a mature neuronal marker). In addition, we examined expressional changes of brain-derived neurotrophic factor (BDNF) and its major receptor tropomyosin-related kinase B (TrkB) using Western blotting analysis.</P><P><B>Results:</B></P><P>Treatment with 200 mg/kg, not 100 mg/kg, significantly increased number of BrdU-immunoreactive (<SUP>+</SUP>) and DCX<SUP>+</SUP> cells (48.0 ± 3.1 and 72.0 ± 3.8 cells/section, respectively) in the subgranular zone (SGZ) of the dentate gyrus (DG) and BrdU<SUP>+</SUP>/NeuN<SUP>+</SUP> cells (17.0 ± 1.5 cells/section) in the granule cell layer as well as in the SGZ. In addition, protein levels of BDNF and TrkB (about 232% and 244% of the vehicle-treated group, respectively) were significantly increased in the DG of the mice treated with 200 mg/kg of <I>G. littoralis</I> extract.</P><P><B>Conclusion:</B></P><P><I>G. littoralis</I> extract promots cell proliferation, neuroblast differentiation, and neuronal maturation in the hippocampal DG, and neurogenic effects might be closely related to increases of BDNF and TrkB proteins by <I>G. littoralis</I> extract treatment.</P>
Jiang, Zheng Er,Shin, Bich-Na,Kim, In-Hye,Lee, Hyun-Joo,Yong, Jun-Hwan,Lee, Min-Jae,Won, Moo-Ho,Lee, Yun-Lyul The Korean Society of Pharmacology 2011 The Korean Journal of Physiology & Pharmacology Vol.15 No.5
It has been rereported that axons which display 5-hydroxytryptamine (5-HT) immunoreactivity are abundant in the pancreas and the majority of serotonergic axons terminate within intrapancreatic ganglia, islet and acini. This histological result strongly suggests that intrapancreatic serotonergic nerves could affect to the pancreatic endocrine and exocrine secretion. Thus, this study was aimed to investigate whether intrapancreatic serotonergic nerves could affect pancreatic exocrine secretion and an action mechanism of the intrapancreatic serotonergic nerves. The rats were anesthetized with a single injection of urethane. The median line and the abdominal aorta was carefully dissected and cannulated with PE-50 tubing just above the celiac artery, and then tightly ligated just below the superior mesenteric artery. The pancreatic duct was also cannulated with Tygon microbore tubing. With the addition of serotonin, pancreatic volume flow and amylase output were significantly inhibited electrical field stimulation (EFS). On the other hand, pancreatic volume flow and amylase output were significantly elevated in EFS with the addition of spiperone. EFS application, however, pancreatic volume flow and amylase output had no significant change in cholecystokinin (CCK) alone when serotonin was applied under a 5.6 mM glucose background. Pancreatic volume flow and amylase output under 18 mM glucose background were significantly elevated in CCK plus serotonin than in CCK alone. These data suggest that intrapancreatic serotonergic nerves play an inhibitory role in pancreatic exocrine secretion and an important role in the insulin action or release.
Ahn, Ji Hyeon,Shin, Myoung Cheol,Park, Joon Ha,Kim, In Hye,Cho, Jeong-Hwi,Lee, Tae-Kyeong,Lee, Jae-Chul,Chen, Bai Hui,Shin, Bich Na,Tae, Hyun-Jin,Park, Jinseu,Choi, Soo Young,Lee, Yun Lyul,Kim, Dae Wo SPANDIDOS PUBLICATIONS 2017 MOLECULAR MEDICINE REPORTS Vol.15 No.6
<P>Therapeutic exercise is an integral component of the rehabilitation of patients who have suffered a stroke. The objective of the present study was to use immunohistochemistry to investigate the effects of post-ischemic exercise on neuronal damage or death and gliosis in the aged gerbil hippocampus following transient cerebral ischemia. Aged gerbils (male; age, 22–24 months) underwent ischemia and were subjected to treadmill exercise for 1 or 4 weeks. Neuronal death was detected in the stratum pyramidale of the hippocampal CA1 region and in the polymorphic layer of the dentate gyrus using cresyl violet and Fluoro-Jade B histofluorescence staining. No significant difference in neuronal death was identified following 1 or 4 weeks of post-ischemic treadmill exercise. However, post-ischemic treadmill exercise affected gliosis (the activation of astrocytes and microglia). Glial fibrillary acidic protein-immunoreactive astrocytes and ionized calcium binding adaptor molecule 1-immunoreactive microglia were activated in the CA1 and polymorphic layer of the dentate gyrus of the group without treadmill exercise. Conversely, 4 weeks of treadmill exercise significantly alleviated ischemia-induced astrocyte and microglial activation; however, 1 week of treadmill exercise did not alleviate gliosis. These findings suggest that long-term post-ischemic treadmill exercise following transient cerebral ischemia does not influence neuronal protection; however, it may effectively alleviate transient cerebral ischemia-induced astrocyte and microglial activation in the aged hippocampus.</P>