The Correlation between Thyrotropin and Dyslipidemia in a Population-based Study

Li Lu,Beibei Wang,Zhongyan Shan,Fengwei Jiang,Xiaochun Teng,Yanyan Chen,Yaxin Lai,Jiani Wang,Haibo Xue,Sen Wang,Chenyan Li,He Liu,Ningna Li,Jiashu Yu,Liangfeng Shi,Xin Hou,Qian Xing,Xue Bai,Weiping Te 대한의학회 2011 Journal of Korean medical science Vol.26 No.2

This study investigated the relationship between serum thyrotrophin levels and dyslipidemia in subclinical hypothyroid and euthyroid subjects. A total of 110 subjects with subclinical hypothyroidism and 1,240 euthyroid subjects enrolled in this study. Patients with subclinical hypothyroidism had significantly lower high density lipoprotein cholesterol (HDL-C) levels than those who were euthyroid. The lipid profiles were each categorized and mean thyrotrophin levels were higher in subjects in the dyslipidemia subclasses than subjects in the normal subclasses. Thyrotrophin was positively associated with serum triglyceride and negatively associated with serum HDL-C in women. Thyrotrophin was also positively associated with total cholesterol (TC) in the overweight population along with TC and LDL-C in overweight women. In the euthyroid population, thyrotrophin was positively associated with TC in the overweight population. In conclusion, serum thyrotrophin was correlated with dyslipidemia in subclinical hypothyroid and euthyroid subjects; the correlation was independent of insulin sensitivity.

Antibiofilm activity of polyethylene glycol-quercetin nanoparticles-loaded gelatin-N,O-carboxymethyl chitosan composite nanogels against Staphylococcus epidermidis

Wanhe Luo,Yongtao Jiang,Jinhuan Liu,Beibei Sun,Xiuge Gao,Samah Attia Algharib,Dawei Guo,Jie Wei,Yurong Wei The Korean Society of Veterinary Science 2024 Journal of Veterinary Science Vol.25 No.2

Background: Biofilms, such as those from Staphylococcus epidermidis, are generally insensitive to traditional antimicrobial agents, making it difficult to inhibit their formation. Although quercetin has excellent antibiofilm effects, its clinical applications are limited by the lack of sustained and targeted release at the site of S. epidermidis infection. Objectives: Polyethylene glycol-quercetin nanoparticles (PQ-NPs)-loaded gelatin-N,O-carboxymethyl chitosan (N,O-CMCS) composite nanogels were prepared and assessed for the on-demand release potential for reducing S. epidermidis biofilm formation. Methods: The formation mechanism, physicochemical characterization, and antibiofilm activity of PQ-nanogels against S. epidermidis were studied. Results: Physicochemical characterization confirmed that PQ-nanogels had been prepared by the electrostatic interactions between gelatin and N,O-CMCS with sodium tripolyphosphate. The PQ-nanogels exhibited obvious pH and gelatinase-responsive to achieve on-demand release in the micro-environment (pH 5.5 and gelatinase) of S. epidermidis. In addition, PQ-nanogels had excellent antibiofilm activity, and the potential antibiofilm mechanism may enhance its antibiofilm activity by reducing its relative biofilm formation, surface hydrophobicity, exopolysaccharides production, and eDNA production. Conclusions: This study will guide the development of the dual responsiveness (pH and gelatinase) of nanogels to achieve on-demand release for reducing S. epidermidis biofilm formation.

Knock-down of OsLOX by RNA interference leads to improved seed viability in rice

Suyang Bai,Niqing He,Lu Zhou,Beibei Shen,Wei Wu,Xi Liu,Ling Jiang,Jianmin Wan 한국식물학회 2015 Journal of Plant Biology Vol.58 No.5

Previous work found that lipoxygenases were key enzymes in lipid peroxidation, which causes grain deterioration during storage. In order to obtain better seed viability in rice, 10 marker-free knock-down lines were obtained in the progeny of endogenous OsLOX knock-down mutations caused by the RNAi technology. After artificial accelerated aging, there were four types of knock-down lines with higher seed viability than wild type (receptor parent). OsLOX3 knock-down line NPF1 was of special interest. In a series of experiments, including Southern blots, analysis of OsLOX3 expression, and enzymatic activity, NPF1 had better seed viability than wild-type. We also investigated the main agronomic characters of both knock-down lines and non-transgenetic wild type families. Knock-down lines were identified with generally excellent agronomic characteristics similar to the wild-type.

An in vitro Actinidia Bioassay to Evaluate the Resistance to Pseudomonas syringae pv. actinidiae

Faming Wang,Jiewei Li,Kaiyu Ye,Pingping Liu,Hongjuan Gong,Qiaosheng Jiang,Beibei Qi,Quanhui Mo 한국식물병리학회 2019 Plant Pathology Journal Vol.35 No.4

Pseudomonas syringae pv. actinidiae (Psa) is by far the most important pathogen of kiwifruit. Sustainable expansion of the kiwifruit industry requires the use of Psa-tolerant or resistant genotypes for the breeding of tolerant cultivars. However, the resistance of most existing kiwifruit cultivars and wild genotypes is poorly understood, and suitable evaluation methods of Psa resistance in Actinidia have not been established. A unique in vitro method to evaluate Psa resistance has been developed with 18 selected Actinidia genotypes. The assay involved debarking and measuring the lesions of cane pieces inoculated with the bacterium in combination with the observation of symptoms such as callus formation, sprouting of buds, and the extent to which Psa invaded xylem. Relative Psa resistance or tolerance was divided into four categories. The division results were consistent with field observations. This is the first report of an in vitro assay capable of large-scale screening of Psa-resistance in Actinidia germplasm with high accuracy and reproducibility. The assay would considerably facilitate the breeding of Psa-resistant cultivars and provide a valuable reference and inspiration for the resistance evaluation of other plants to different pathogens.

Microstructure Evolution and Mechanical Properties of Ultra-Fine Grain AlCrFe2Ni2Wx High-Entropy Alloys

Shougang Duan,Yufeng Yang,Yong Dong,Yu Wang,Beibei Jiang,Chuanqiang Li,Zhengrong Zhang 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.6

Ultra-fine grain AlCrFe2Ni2Wx(x = 0.1, 0.2, 0.3, 0.4) alloys were designed and prepared by vacuum arc melting, and correspondingmicrostructural evolution and mechanical properties were investigated. All of the alloys show a mixed structurewith FCC + BCC (B2) + TCP phases. The addition of W element has a significant effect on the formation mechanism of themorphology, which promotes the transition from FCC phase to μ phase and inhibits the spinodal decomposition of BCCphase. With the increase of W content, more μ phase precipitates from the FCC phase and grain boundaries. After the dissolutionof W element into matrix, the formed oversaturated solid solution and precipitated μ phase have the effect of solidsolution strengthening and second phase strengthening, respectively. The yield strength and Vickers hardness increasesfrom 765 to 1319.6 MPa and HV 332.2 to HV 461.8, respectively. The addition of W element enhances the strength of thealloys but reduced ductility. The AlCrFe2Ni2W0.1alloy exhibits outstanding comprehensive mechanical properties, with itsfracture strength reaching 2726.5 MPa and a considerable compressive strain of 43.3%, which implies promising potentialengineering application.

An in vitro Actinidia Bioassay to Evaluate the Resistance to Pseudomonas syringae pv. actinidiae

Wang, Faming,Li, Jiewei,Ye, Kaiyu,Liu, Pingping,Gong, Hongjuan,Jiang, Qiaosheng,Qi, Beibei,Mo, Quanhui The Korean Society of Plant Pathology 2019 Plant Pathology Journal Vol.35 No.4

Pseudomonas syringae pv. actinidiae (Psa) is by far the most important pathogen of kiwifruit. Sustainable expansion of the kiwifruit industry requires the use of Psa-tolerant or resistant genotypes for the breeding of tolerant cultivars. However, the resistance of most existing kiwifruit cultivars and wild genotypes is poorly understood, and suitable evaluation methods of Psa resistance in Actinidia have not been established. A unique in vitro method to evaluate Psa resistance has been developed with 18 selected Actinidia genotypes. The assay involved debarking and measuring the lesions of cane pieces inoculated with the bacterium in combination with the observation of symptoms such as callus formation, sprouting of buds, and the extent to which Psa invaded xylem. Relative Psa resistance or tolerance was divided into four categories. The division results were consistent with field observations. This is the first report of an in vitro assay capable of large-scale screening of Psa-resistance in Actinidia germplasm with high accuracy and reproducibility. The assay would considerably facilitate the breeding of Psa-resistant cultivars and provide a valuable reference and inspiration for the resistance evaluation of other plants to different pathogens.