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RISS 인기검색어
- 검색키워드
- 저자 : Ari Hirvonen (검색결과 4 건)
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Methylenetetrahydrofolate reductase polymorphism, diet, and breast cancer in Korean women
이상아,강대희,Hisahide Nishio,이명진,김동현,한원식,유근영,안세현,조국진,Ari Hirvonen,노동영 생화학분자생물학회 2004 Experimental and molecular medicine Vol.36 No.2
To evaluate the interactive effect of methylenetetrahydrofolate reductase (MTHFR) genotype and dietary factors on the development of breast cancer, a hospital based case-control study was conducted in South Korean study population consisting of 189 histologically confirmed incident breast cancer cases and their 189 age-matched controls without present or previous history of cancer. A PCR-RFLP method was used for the genotyping of MTHFR (C677T) and statistical evaluations were performed by unconditional logistic regression analysis. Consumption of some dietary factors, such as green vegetables (OR = 0.3, 95% CI: 0.2-0.6), white vegetables (OR = 0.3, 95% CI: 0.1-0.7) mushrooms (OR = 0.4, 95% CI: 0.3-0.7), and meats (OR = 1.7, 95% CI: 1.1-2.8) significantly decreased or increased the risk of breast cancer. Although the breast cancer risk was 1.7-fold (95% CI: 0.8-3.2) increased in women with MTHFR TT genotype, the association was not statistically significant. Women with MTHFR TT genotype and low green vegetable intake increased 5.6-fold (95% CI: 1.2-26.3) risk of breast cancer compared to high green vegetable intake group containing MTHFR CC/CT genotype. However, the interaction was not significant (p for interaction = 0.96). Our findings suggest that MTHFR polymorphism did not influence individual susceptibility to breast cancer. However MTHFR (C667T) genotype and green vegetable intakes appeared to have the interactive effect in breast cancer development.
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Obesity and genetic polymorphism of ERCC2 and ERCC4 as modifiers of risk of breast cancer
이상아,이경무,박웅양,Bongcheol Kim,Jinwu Nam,Keun-Young Yoo,노동영,Sei-Hyun Ahn,Ari Hirvonen,강대희 생화학분자생물학회 2005 Experimental and molecular medicine Vol.37 No.2
To evaluate the relationship of genetic polymor-phisms of ERCC2 and ERCC4 genes, both in-volved in nucleotide excision repair (NER), and the risk of breast cancer, a hospital-based case-con-trol study was conducted in Korea. Histologically confirmed breast cancer cases (n = 574) and con-trols (n = 502) with no present or previous history of cancer were recruited from three teaching hos-pitals in Seoul during 1995-2001. Information on selected characteristics was collected by inter-viewed questionnaire. ERCC2 Asp 312 Asn (G >A) was genotyped by single-base extension assay and ERCC4 Ser 835 Ser (T >C) by dynamic allele-specific hybridization system. Although no signifi-cant association was observed between the gene-tic polymorphisms and the risk of breast cancer, women with both ERCC2 A allele- and ERCC4 Callele-containing genotypes showed a 2.6-fold risk (95% CI: 1.02-6.48) of breast cancer compared to women concurrently carrying the ERCC2 GG and ERCC4 TT genotypes. The breast cancer risk in-creased as the number of “at risk” genotypes increased with a borderline significance (P for trend = 0.07). Interactive effect was also observed between ERCC4 genotype and body mass idnex (BMI) for the breast cancer risk; the ERCC4 C allele containing genotypes posed a 1.7-fold (95% CI: 0.96-2.93) breast cancer risk in obese women (BMI >25 kg/m 2 ) with a borderline significance. Our finding suggests that the combined effect of ERCC2 Asp 312 Asn and ERCC4 Ser 835 Ser genotypes might be associated with breast cancer risk in Korean women.
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Genetic Polymorphism of Glutathione S-transferase P1 and Breast Cancer Risk
Kim, Sook-Un,Lee, Kyoung-Mu,Park, Sue-Kyung,Yoo, Keun-Young,Noh, Dong-Young,Choe, Kook-Jin,Ahn, Sei-Hyun,Hirvonen, Ari,Kang, Dae-Hee Korean Society for Biochemistry and Molecular Biol 2004 Journal of biochemistry and molecular biology Vol.37 No.5
To evaluate the potential association between the GSTP1 genotype and the development of breast cancer, a hospital based case-control study was conducted on Korean women. The study population consisted of 171 histologically confirmed incident breast cancer cases and 171 age-matched controls with no present or previous history of cancer. PCR-RFLP was used for the GSTP1 genotyping and statistical evaluations were performed using an unconditional logistic regression model. Postmenopausal women with the GSTP1 Val allele were found to have a reduced risk of breast cancer (OR = 0.3, 95% CI = 0.10 - 0.74). A significant interaction was observed between the GSTP1 genotype and alcohol consumption (p for interaction = 0.01); compared with never-drinking women with Ile/Ile genotype, ever-drinking women with the GSTP1 Val allele had almost a three-fold risk of breast cancer (OR = 2.9, 95% CI = 1.05-7.85), whereas never-drinking women with Val allele had half this risk (OR = 0.5, 95% CI = 0.27-0.93). Our findings suggest that the GSTP1 polymorphism influences individual susceptibility to breast cancer in the Korean women and this effect may be modified by alcohol consumption.
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Genetic Polymorphism of Glutathione S-transferase P1 and Breast Cancer Risk
( Sook Un Kim ),( Kyoung Mu Lee ),( Sue Kyung Park ),( Keun Young Yoo ),( Dong Young Noh ),( Kook Jin Choe ),( Sei Hyun Ahn ),( Ari Hirvonen ),( Dae Hee Kang ) 생화학분자생물학회 2004 BMB Reports Vol.37 No.5
To evaluate the potential association between the GSTP1 genotype and the development of breast cancer, a hospital based case-control study was conducted on Korean women. The study population consisted of 171 histologically confirmed incident breast cancer cases and 171 age-matched controls with no present or previous history of cancer. PCR-RFI,P was used for the GSTPI genotyping and statistical evaluations were performed using an unconditional logistic regression model. Postmenopausal women with the GSTPI Val allele were found to have a reduced risk of breast cancer (OR = 0.3, 95% CI = 0.10 -0.74). A significant interaction was observed between the GSTPI genotype and alcohol consumption (p for interaction = 0.01); compared with never-drinking women with Ile/Ile genotype, ever-drinking women with the GSTPI Val allele had almost a three-fold risk of breast cancer (OR = 2.9, 95% CI = 1.05 -7.85), whereas never-drinking women with Val allele had half this risk (OR = 0.5, 95% CI = 0.27 ? 0.93). Our findings suggest that the GSTPI polymorphism influences individual susceptibility to breast cancer in the Korean women and this effect may be modified by alcohol consumption.
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