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RISS 인기검색어
- 검색키워드
- 저자 : Ackerman Jerome L. (검색결과 3 건)
- 무료
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Abdala-Junior Reinaldo,No-Cortes Juliana,Arita Emiko Saito,Ackerman Jerome L.,da Silva Renan Lúcio Berbel,Kim Jun Ho,Cortes Arthur Rodriguez Gonzalez 대한영상치의학회 2021 Imaging Science in Dentistry Vol.51 No.4
Purpose: The aim of this in vitro study was to assess the role of bandwidth on the area of magnetic resonance imaging (MRI) artifacts caused by orthodontic appliances composed of different alloys, using different pulse sequences in 1.5 T and 3.0 T magnetic fields. Materials and Methods: Different phantoms containing orthodontic brackets (ceramic, ceramic bracket with a stainless-steel slot, and stainless steel) were immersed in agar gel and imaged in 1.5 T and 3.0 T MRI scanners. Pairs of gradient-echo (GE), spin-echo (SE), and ultrashort echo time (UTE) pulse sequences were used differing in bandwidth only. The area of artifacts from orthodontic devices was automatically estimated from pixel value thresholds within a region of interest (ROI). Mean values for similar pulse sequences differing in bandwidth were compared at 1.5 T and 3.0 T using analysis of variance. Results: The comparison of groups revealed a significant inverse association between bandwidth values and artifact areas of the stainless-steel bracket and the self-ligating ceramic bracket with a stainless-steel slot (P<0.05). The areas of artifacts from the ceramic bracket were the smallest, but were not reduced significantly in pulse sequences with higher bandwidth values (P<0.05). Significant differences were also observed between 1.5 T and 3.0 T MRI using SE and UTE, but not using GE 2-dimensional or 3-dimensional pulse sequences. Conclusion: Higher receiver bandwidth might be indicated to prevent artifacts from orthodontic appliances in 1.5 T and 3.0 T MRI using SE and UTE pulse sequences.
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Easterhoff, David,Moody, M. Anthony,Fera, Daniela,Cheng, Hao,Ackerman, Margaret,Wiehe, Kevin,Saunders, Kevin O.,Pollara, Justin,Vandergrift, Nathan,Parks, Rob,Kim, Jerome,Michael, Nelson L.,O’Connell, Public Library of Science 2017 PLoS pathogens Vol.13 No.2
<▼1><P>The canary pox vector and gp120 vaccine (ALVAC-HIV and AIDSVAX B/E gp120) in the RV144 HIV-1 vaccine trial conferred an estimated 31% vaccine efficacy. Although the vaccine Env AE.A244 gp120 is antigenic for the unmutated common ancestor of V1V2 broadly neutralizing antibody (bnAbs), no plasma bnAb activity was induced. The RV305 (NCT01435135) HIV-1 clinical trial was a placebo-controlled randomized double-blinded study that assessed the safety and efficacy of vaccine boosting on B cell repertoires. HIV-1-uninfected RV144 vaccine recipients were reimmunized 6–8 years later with AIDSVAX B/E gp120 alone, ALVAC-HIV alone, or a combination of ALVAC-HIV and AIDSVAX B/E gp120 in the RV305 trial. Env-specific post-RV144 and RV305 boost memory B cell V<SUB>H</SUB> mutation frequencies increased from 2.9% post-RV144 to 6.7% post-RV305. The vaccine was well tolerated with no adverse events reports. While post-boost plasma did not have bnAb activity, the vaccine boosts expanded a pool of envelope CD4 binding site (bs)-reactive memory B cells with long third heavy chain complementarity determining regions (HCDR3) whose germline precursors and affinity matured B cell clonal lineage members neutralized the HIV-1 CRF01 AE tier 2 (difficult to neutralize) primary isolate, CNE8. Electron microscopy of two of these antibodies bound with near-native gp140 trimers showed that they recognized an open conformation of the Env trimer. Although late boosting of RV144 vaccinees expanded a novel pool of neutralizing B cell clonal lineages, we hypothesize that boosts with stably closed trimers would be necessary to elicit antibodies with greater breadth of tier 2 HIV-1 strains.</P><P><B>Trial Registration:</B> ClinicalTrials.gov NCT01435135</P></▼1><▼2><P><B>Author summary</B></P><P>Developing a successful HIV-1 vaccine remains a high global health priority. Several HIV-1 vaccine trials have been performed with only the RV144 vaccine trial showing vaccine efficacy, albeit modest. No broadly neutralizing antibody activity was identified in RV144 and inducing sterilizing immunity against a complex pathogen like HIV-1 remains a major challenge. Here we characterize the B cell responses after RV144 vaccine-recipients received two additional boosts severals years after the conclusion of the RV144 vaccine trial. Delayed and repetitive boosting of RV144 vaccine-recipients was capable of increasing somatic hypermutation of the Env-reactive antibodies and expanding subdominant pools of neutralizing B cell clonal lineages. These data are pertinent to HIV-1 vaccine-regimen design.</P></▼2>
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Abdala-Junior, Reinaldo,No-Cortes, Juliana,Arita, Emiko Saito,Ackerman, Jerome L.,da Silva, Renan Lucio Berbel,Kim, Jun Ho,Cortes, Arthur Rodriguez Gonzalez Korean Academy of Oral and Maxillofacial Radiology 2021 Imaging Science in Dentistry Vol.51 No.-
Purpose: The aim of this in vitro study was to assess the role of bandwidth on the area of magnetic resonance imaging (MRI) artifacts caused by orthodontic appliances composed of different alloys, using different pulse sequences in 1.5 T and 3.0 T magnetic fields. Materials and Methods: Different phantoms containing orthodontic brackets (ceramic, ceramic bracket with a stainless-steel slot, and stainless steel) were immersed in agar gel and imaged in 1.5 T and 3.0 T MRI scanners. Pairs of gradient-echo (GE), spin-echo (SE), and ultrashort echo time (UTE) pulse sequences were used differing in bandwidth only. The area of artifacts from orthodontic devices was automatically estimated from pixel value thresholds within a region of interest (ROI). Mean values for similar pulse sequences differing in bandwidth were compared at 1.5 T and 3.0 T using analysis of variance. Results: The comparison of groups revealed a significant inverse association between bandwidth values and artifact areas of the stainless-steel bracket and the self-ligating ceramic bracket with a stainless-steel slot(P<0.05). The areas of artifacts from the ceramic bracket were the smallest, but were not reduced significantly in pulse sequences with higher bandwidth values(P<0.05). Significant differences were also observed between 1.5 T and 3.0 T MRI using SE and UTE, but not using GE 2-dimensional or 3-dimensional pulse sequences. Conclusion: Higher receiver bandwidth might be indicated to prevent artifacts from orthodontic appliances in 1.5 T and 3.0 T MRI using SE and UTE pulse sequences.
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