Distribution of Glutathione S-Transferase Omega Gene Polymorphism with Different Stages of HBV Infection Including Hepatocellular Carcinoma in the Egyptian Population

Shaban, Nadia Z,Salem, Halima H,Elsadany, Mohamed A,Ali, Bahy A,Hassona, Ehab M,Mogahed, Fayed AK Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4

Background: Infection with hepatitis B virus (HBV) is a major global public health problem, with a wide spectrum of clinical manifestations. Human cytosolic glutathione-S-transferases (GSTs) include several classes such as alpha (A), mu (M), pi (P), sigma (S), zeta (Z), omega (O) and theta (T). The present study aimed to investigate the role of GST omega genes (GSTO1 and GSTO2) in different groups of patients infected with HBV. Materials and Methods: HBV groups were classified according to clinical history, serological tests and histological analysis into normal carriers (N), acute (A), chronic (CH), cirrhosis (CI) and hepatocellular carcinoma (HCC) cases. The study focused on determination of the genotypes of GST omega genes (GSTO1 and GSTO2) and GST activity and liver function tests. Results: The results showed that GSTO1 (A/A) was decreased in N, A, CH, CI and HCC groups compared to the C-group, while, GSTO1 (C/A) and GSTO1(C/C) genotypes were increased significantly in N, A, CH, CI and HCC groups. GSTO2 (A/A) was decreased in all studied groups as compared to the C-group but GSTO2(A/G) and GSTO2(G/G) genotypes were increased significantly. In addition, GST activities, albumin and TP levels were decreased in all studied groups compared to the C-group, while the activities of transaminases were increased to differing degrees. Conclusions: The results indicate that GSTO genetic polymorphisms may be considered as biomarkers for determining and predicting the progression of HBV infection.

Murraya koenigii (L.) Sprengel seeds and pericarps in relation to their chemical profiles: new approach for multidrug resistant Acinetobacter baumannii ventilator-associated pneumonia

El-Shiekh Riham A.,Elshimy Rana,Mandour Asmaa A.,Kassem Hanaa A. H.,Khaleel Amal E.,Alseekh Saleh,Fernie Alisdair R.,Salem Mohamed A. 한국응용생명화학회 2024 Applied Biological Chemistry (Appl Biol Chem) Vol.67 No.-

Acinetobacter baumannii is without a doubt one of the most problematic bacteria causing hospital-acquired nosocomial infections in today’s healthcare system. To solve the high prevalence of multi-drug resistant (MDR) in A. baumannii, we investigated one of the medicinal plants traditionally used as antibacterial agent; namely Murraya koenigii (L.) Sprengel. The total methanolic extracts of seeds and pericarps were prepared and their anti-bacterial activity was assessed using the agar diffusion method and minimum inhibitory concentration (MIC) was then calculated as compared to tigecycline. Then, an in-vivo murine model was established which confirmed the promising activity of M. koenigii seeds in demonstrating anti-bacterial and anti-inflammatory actions. The histopathological study of lungs, scoring of pulmonary lesions, counting of bacterial loads after infection by multi-drug resistant A. baumannii all provided evidence to support these findings. LC–MS/MS profiling coupled to molecular networking and chemometrics detected the presence of carbazole alkaloids, and coumarins as dominate metabolites of the active seed extracts. Positively correlated metabolites to antibacterial potential were 6-(2ʹ,3ʹ-dihydroxy-3-methylbutyl)- 8-prenylumbelliferone, scopoline, and 5-methoxymurrayatin. An in-silico study was also performed on the crystal structure of MurF from A. baumannii (PDB ID: 4QF5), the studied structures of the mentioned extracts revealed good docking interaction at the active site suggestive of competition with the ATP ligand. These collective findings suggest that extracts of Murraya koenigii (L.) Sprengel seed is a novel prospective for the discovery of drug candidates against infections caused by MDR A. baumannii.

Effect of Chromium Chloride on the Mechanical and Dielectric Properties of EPDM Rubber

Salem, M.A.,Khaled, M.A.,Hussein, A.M.,Elway, E. The Polymer Society of Korea 2003 Macromolecular Research Vol.11 No.4

Measurements of Young's modulus, dielectric loss and a.c. conductivity have been carried out on EPDM rubber samples loaded with different concentrations of $CrCl_3$ (0,2,4 and 6 phr). The values of Young's modulus was found to be linearly dependent on the $CrCl_3$ content. Variation of the dielectric loss with temperature showed that $CrCl_3$ may act as plasticizer. However, at higher frequencies the dielectric loss was found to be independent of frequency and the rubber samples may behave as non-polar dielectric. Investigations of the a.c conductivity suggested that the conduction in these rubber samples can be described by small polaron tunneling. In addition, conductivity was found to increase with $CrCl_3$ content.

Effect of Chromium Chloride on the Mechanical and Dielectric Properties of EPDM Rubber

M.A.Salem,M.A.Khaled,A.M.Hussein,E.Elway 한국고분자학회 2003 Macromolecular Research Vol.11 No.5

Measurements of Young’s modulus, dielectric loss and a.c. conductivity have been carried out on EPDM rubber samples loaded with different concentrations of CrCl3 (0,2,4 and 6 phr). The values of Young’s modulus was found to be linearly dependent on the CrCl3 content. Variation of the dielectric loss with temperature showed that CrCl3 may act as plasticizer. However, at higher frequencies the dielectric loss was found to be independent of frequency and the rubber samples may behave as non-polar dielectric. Investigations of the a.c conductivity suggested that the conduction in these rubber samples can be described by small polaron tunneling. In addition, conductivity was found to increase with CrCl3 content.

Real-Time Implementation of On-Line Trained Neuro-Controller for a BLDC Motor

Salem, M.M.,Zahran, M.B.,Atia, Yousry,Zaki, A.M. The Korean Institute of Power Electronics 2003 JOURNAL OF POWER ELECTRONICS Vol.3 No.1

Implementation and experimental verification of a simple neuro-controller (SNC) as a speed controller for a brush less DC (BLDC) motor is presented. The SNC with one weight and a linear hard limit activation function is trained on-line using the back propagation algorithm. A modified error function is used to ensure good performance during the on-line training, which has been used without previous off-line training. The SNC has been implemented using a computer-interface card mounted on a PC. The driving system performance has been investigated by a number of experimental tests for a variety of input reference speed trajectories.

Eco-friendly Synthesis of New Polyfunctional Azo Dyes Using Shrimp Chitin as a Catalyst: Application on Polyester Fabrics and Their Biological Activities

Entesar A. Hassan,Hamada M. Mashaly,Zeinab M. Hashem,Salem E. Zayed,Ahmed M. Abo-Bakr 한국섬유공학회 2022 Fibers and polymers Vol.23 No.9

A series of varying and poly-functionalized heterocyclic compounds 3a-c, 4d-k, 6a,b, 8, 9, and 12 containing azofunction have been synthesized using 2-(1-(4-aminophenyl)ethylidene)malononitrile (1) and/or its diazonium salt as buildingblocks. In addition, new pyridazine derivatives 4a-c, 7a,b, and 13a-f were synthesized. Subsequent treating of the resultedazo dyes moieties with different reagents in conventional and green conditions using microwave irradiation and shrimp chitinas a green catalyst; homo- and hetero-molecules containing azo dyes were gathered. The obtained azo dyes were applied onfabrics at high temperatures and their properties such as washing fastness using standard soap (SDS) and rubbing fastness(wet and dry) under controlled conditions of pressure, speed, and moisture were studied. In addition, they were screened fortheir biological activities on two bacterial and two mycolic species. The synthesized products were characterized by theirelemental and spectral analyses such as IR, MS, 1H-NMR, and 13C-NMR spectra. The produced dyestuffs 3a-c, 4d, f, h, i, j,6a,b, 8, and 12 were dyed on polyester fabrics, and subsequently their dyeing properties and their light, washing, perspiration,rubbing, and sublimation fastness was determined and the dyed samples showed very good fastness levels to rubbing,washing, thermal fixation, good light, and possessed very good perspiration fastness.

Effect of nepheline syenite on the colorant behavior of porcelain stoneware body

A. Salem,S.H. Jazayeri,E. Rastelli,G. Timellini 한양대학교 세라믹연구소 2009 Journal of Ceramic Processing Research Vol.10 No.5

The effects of nepheline syenite on the colorant behavior of porcelain stoneware tiles were assessed with special reference to the body composition. Potassium feldspar was replaced by nepheline syenite in a typical porcelain stoneware body by up to 15.6 wt.%. Technological parameters such as shrinkage, water absorption and porosity were measured. Phase composition and microstructural characteristics were determined to understand the role of nepheline syenite in the whiteness of a ceramic body. The results show that nepheline syenite had a significant effect on the sintering rate and influences remarkably the sintering behavior, increasing the shrinkage and decreasing total porosity. On the other hand there is a decrease in the amounts of mullite and quartz with addition of nepheline syenite. The bodies richer in nepheline syenite show larger amounts of albite and glassy phase. These bodies also present a higher whiteness with the same sintering conditions. The colorant characteristics appear to be directly related to the free albite crystals content. In conclusion nepheline syenite can be used in small amounts, 5 wt.%, to obtain an effective color development. The effects of nepheline syenite on the colorant behavior of porcelain stoneware tiles were assessed with special reference to the body composition. Potassium feldspar was replaced by nepheline syenite in a typical porcelain stoneware body by up to 15.6 wt.%. Technological parameters such as shrinkage, water absorption and porosity were measured. Phase composition and microstructural characteristics were determined to understand the role of nepheline syenite in the whiteness of a ceramic body. The results show that nepheline syenite had a significant effect on the sintering rate and influences remarkably the sintering behavior, increasing the shrinkage and decreasing total porosity. On the other hand there is a decrease in the amounts of mullite and quartz with addition of nepheline syenite. The bodies richer in nepheline syenite show larger amounts of albite and glassy phase. These bodies also present a higher whiteness with the same sintering conditions. The colorant characteristics appear to be directly related to the free albite crystals content. In conclusion nepheline syenite can be used in small amounts, 5 wt.%, to obtain an effective color development.

Coupled Heat and Mass Transfer in Darcy-Forchheimer Mixed Convection from a Vertical Flat Plate Embedded in a Fluid-Saturated Porous Medium under the Effects of Radiation and Viscous Dissipation

A. M. Salem 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.3

This paper investigates the influence of viscous dissipation and radiation on the problem of Darcy-Frochheimer mixed convection from a vertical flat plate embedded in a fluid-saturated porous medium with thermal and mass diffusion. The fluid considered is a gray medium, and the Rosseland approximation is used to describe the radiative heat flux in the energy equation. A similarity solution for the transformed governing equations is obtained, and those equations are been solved by employing a numerical shooting technique with a fourth-order Runge-Kutta integration scheme. Numerical computations are carried out for the non-dimensional physical parameters. The results are analyzed for the effect of different physical parameters, such as radiation, natural and forced convection, the Ecret number, the buoyancy ratio, and the inertia parameter, on the flow, the heat, and the mass- transfer characteristics. "***

Influence of palm oil fuel ash on behaviour of green high-performance fine-grained cement mortar

Sagr, Salem Giuma Ibrahim,Johari, M.A. Megat,Mijarsh, M.J.A. Techno-Press 2022 Advances in materials research Vol.11 No.2

In the recent years, the use of agricultural waste in green cement mortar and concrete production has attracted considerable attention because of potential saving in the large areas of landfills and potential enhancement on the performance of mortar. In this research, microparticles of palm oil fuel ash (POFA) obtained from a multistage thermal and mechanical treatment processes of raw POFA originating from palm oil mill was utilized as a pozzolanic material to produce high-performance cement mortar (HPCM). POFA was used as a partial replacement material to ordinary Portland cement (OPC) at replacement levels of 0, 5, 10, 15, 20, 25, 30, 35, 40% by volume. Sand with particle size smaller than 300 ㎛ was used to enhance the performance of the HPCM. The HPCM mixes were tested for workability, compressive strength, ultrasonic pulse velocity (UPV), porosity and absorption. The results portray that the incorporation of micro POFA in HPCMs led to a slight reduction in the compressive strength. At 40% replacement level, the compressive strength was 87.4 MPa at 28 days which is suitable for many high strength applications. Although adding POFA to the cement mixtures harmed the absorption and porosity, those properties were very low at 3.4% and 11.5% respectively at a 40% POFA replacement ratio and after 28 days of curing. The HPCM mixtures containing POFA exhibited greater increase in strength and UPV as well as greater reduction in absorption and porosity than the control OPC mortar from 7 to 28 days of curing age, as a result of the pozzolanic reaction of POFA. Micro POFA with finely graded sand resulted in a dense and high strength cement mortar due to the pozzolanic reaction and increased packing effect. Therefore, it is demonstrated that the POFA could be used with high replacement ratios as a pozzolanic material to produce HPCM.

Real-Time Implementation of On-Line Trained Neuro-Controller For a BLDC Motor

M.M.Salem,M.B.Zahran,Yousry Atia,A.M.Zaki 전력전자학회 2003 JOURNAL OF POWER ELECTRONICS Vol.3 No.1

Implementation and experimental verification of a simple neuro-controller (SNC) as a speed controller for a brush less DC (BLDC) motor is presented The SNC with one weight and a linear hard limit activation function is trained on-line using the back propagation algorithm. A modified error function is used to ensure good performance during the on-line training, which has been used without previous off-line training. The SNC has been Implemented using a computer-interface card mounted on a PC The driving system performance has been investigated by a number of experimental tests for a variety of input reference speed trajectories.<br/>