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RISS 인기검색어
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- 저자 : 홍순억 ( Soon-uk Hong ) (검색결과 2 건)
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Release Characteristics of Terbutaline Sulfate Sustained-Release Beads In Vitro
김기만,김영일,홍순억,Kim, Ki Man,Kim, Young Il,Hong, Soon Uk Korean College Of Clinical Pharmacy 1991 한국임상약학회지 Vol.1 No.1
The sustained-release beads containing terbutaline sulfate (TBS) were prepared by rotogranulation method. The drug was dusted on the non-pareil seeds in a CF-granulator. The sustained-release beads were obtained by coating the active beads with ethylcellulose or $Eudragits^{(R)}$, using in any case the same granulator employed for active beads preparation. The release characteristics of sustained-release beads were examined in vitro by rotating basket method applied to $Bricanyl^{(R)}$ durules which is a sustained-release TBS matrix tablet. The release of terbutaline from the beads in vitro was first-order, and the release rate was dependent on both the coat weight ratio and membrane hydrophilicity. Both surfaces of the beads before and after dissolution were smooth. The drug release pattern from the beads could be thought the diffusion through the polymer membrane. The release rate and the surface of the beads stored for 3 years at room temperature were the same with those of the initial beads.
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강은혜 ( Eunhye Kang ),최유신 ( Yoo-shin Choi ),오형철 ( Hyoung-chul Oh ),도재혁 ( Jae Hyuk Do ),홍순억 ( Soon-uk Hong ),이승은 ( Seung Eun Lee ) 대한췌장담도학회 2022 대한췌담도학회지 Vol.27 No.1
췌장 선방세포암은 췌장암 중 1% 미만을 차지하는 매우 드문 암으로, 수술 전 영상 검사상 췌장관세포암, 췌장 고형성가유두상 종양, 신경내분비 종양 등과 감별이 어려운 경우가 많다. 현재까지 명확하게 정립된 치료법은 없으며, 조기 진단 및 종양의 완전 절제만이 생존율 향상을 가져온다고 보고되고 있다. 그러나 췌장 관세포암에 비하여 종양 절제 후 비교적 좋은 예후를 보여준다. 본 증례와 같이 비교적 젊은 남자 환자가 낭성 부분을 포함한 크기가 큰 고형성 췌장 종양을 주소로 내원하였을 경우 췌장 선방세포암을 염두에 두고 적극적인 수술 치료를 고려해야 할 것이다. Pancreatic acinar cell carcinoma (ACC) is a rare neoplasm accounting less than 1% of malignant pancreatic tumors. A 47-year-old male patient visited the emergency room with epigastric pain. Computed tomography or magnetic resonance imaging revealed a 4.7-cm heterogeneously enhanced solid and cystic mass with internal necrosis located in the head of the pancreas. Radiological diagnosis was borderline malignancy such as neuroendocrine tumor or solid pseudopapillary neoplasm. Two months later, the necrotic mass in the pancreas head had grown up to 11 cm, compressing the duodenum, superior mesenteric vein, and proximal transverse colon. Pylorus preserving pancreatoduodenectomy with segmental resection of transverse colon was performed. Histopathological examination revealed that the tumor was pancreatic ACC. The patient recovered without any complication and was doing well without recurrence for 12 months after surgery. Korean J Pancreas Biliary Tract 2022;27(1):54-59
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