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호흡동조 정위체부방사선치료에서 Gated Cone-beam CT의 유용성 평가
홍성윤,이충환,박제완,송흥권,윤인하,Hong sung yun,Lee chung hwan,Park je wan,Song heung kwon,Yoon in ha 대한방사선치료학회 2022 대한방사선치료학회지 Vol.34 No.-
Purpose: Conventional CBCT(Cone-beam Computed-tomography) caused an error in the target volume due to organ movement in the area affected by respiratory movement. The purpose of this paper is to evaluate the usefulness of accuracy and time spent using the Gated CBCT function, which reduces errors when performing RGRT(respiratory gated radiation therapy), and to examine the appropriateness of phase. Materials and methods: To evaluate the usefulness of Gated CBCT, the QUASAR<sup>TM</sup> respiratory motion phantom was used in the Truebeam STx<sup>TM</sup>. Using lead marker inserts, Gated CBCT was scaned 5 times for every 20~80% phase, 30~70% phase, and 40~60% phase to measure the blurring length of the lead marker, and the distance the lead marker moves from the top phase to the end of the phase was measured 5 times. Using Cedar Solid Tumor Inserts, 4DCT was scanned for every phase, 20-80%, 30-70%, and 40-60%, and the target volume was contoured and the length was measured five times in the axial direction (S-I direction). Result: In Gated CBCT scaned using lead marker inserts, the axial moving distance of the lead marker on average was measured to be 4.46cm in the full phase, 3.11cm in the 20-80% phase, 1.94cm in the 30-70% phase, 0.90cm in the 40-60% phase. In Fluoroscopy, the axial moving distance of the lead marker on average was 4.38cm and the distance on average from the top phase to the beam off phase was 3.342cm in the 20-80% phase, 3.342cm in the 30-70% phase, and 0.84cm in the 40-60% phase. Comparing the results, the difference in the full phase was 0.08cm, the 20~80% phase was 0.23cm, the 30~70% phase was 0.10cm, and the 40~60% phase was 0.07cm. The axial lengths of ITV(Internal Target Volume) and PTV(Planning Target Volume) contoured by 4DCT taken using cedar solid tumor inserts were measured to be 6.40cm and 7.40cm in the full phase, 4.96cm and 5.96cm in the 20~80% phase, 4.42cm and 5.42cm in the 30~70% phase, and 2.95cm and 3.95cm in the 40~60% phase. In the Gated CBCT, the axial lengths on average was measured to be 6.35 cm in the full phase, 5.25 cm in the 20-80% phase, 4.04 cm in the 30-70% phase, and 3.08 cm in the 40-60% phase. Comparing the results, it was confirmed that the error was within ±8.5% of ITV Conclusion: Conventional CBCT had a problem that errors occurred due to organ movement in areas affected by respiratory movement, but through this study, obtained an image similar to the target volume of the setting phase using Gated CBCT and verified its usefulness. However, as the setting phase decreases, the scan time was increases. Therefore, considering the scan time and the error in setting phase, It is recommended to apply it to patients with respiratory coordinated stereotactic radiation therapy using a wide phase of 30-70% or more.
홍성윤 ( Sung Yun Hong ),장유진 ( Yujin Chang ),이준배 ( Jun Bae Lee ),박천호 ( Chun Ho Park ),박명삼 ( Myung Sam Park ) 대한화장품학회 2019 대한화장품학회지 Vol.45 No.1
본 연구는 세테아릴 알코올, 세틸 팔미테이트, 소르비탄 팔미테이트, 소르비탄 올리베이트, 세라마이드 등을 이용하여 제조한 액정에멀젼의 다층구조에 따른 강화된 계면막에 의해 제형의 안정성이 확보됨을 확인하였다. 편광 현미경을 통해 제형 내 몰타 크로스(maltese cross) 무늬를 확인하고, cryo-SEM을 이용하여 다층구조가 형성되었음을 확인하였다. 소각 X선 산란법(SAXS)을 이용하여 라멜라 구조 생성여부를 확인하였으며, 점도계를 이용하여 점도변화를 확인하고 정적 광 산란법(SLS)을 이용하여 입도 분포를 확인하여 액정에멀젼의 제형 안정성을 입증하였다. We introduce to prepare liquid crystalline emulsion composed of cetearyl alcohol, cetyl palmitate, sorbitan palmitate, sorbitan olivate, ceramide and so on which can enforce interface between oil-based particle and water phase. In terms of structural analysis, the stability of the liquid crystalline emulsion including ceramide, which is immisible ingredient, at high temperature was proved by polarized microscope, cryo-SEM, small-angle x-ray scattering, in addition to viscometer and static light scattering by physical analysis.
한국산 어류에 기생하는 Nothobomolochus ( Poecilostomatoida , Bomolochidae ) 속 2 종
최상덕,홍성윤,서해립 ( Sang Duk Choi,Sung Yun Hong,Hae Lip Suh ) 한국수산과학회 1994 한국수산과학회지 Vol.27 No.6
Two species of the parasitic copepod were recovered from two Korean fishes, Lateolabrax japonicus (Cuvier and Valenciennes) and Pampus argenteus (Euphrasen) taken from Yosu Bay Korea. The present paper contains redescription of two species of Nothobomolochus of Bomolochidae. Both species, N lateolabracis (Yamaguti and Yamasu) and N. triceros (Basset-Smith), are newly recorded from the Korean water. N. lateolabracis and N. triceros were found on the L. japonicus and P. argenteus, respectively.
최상덕,서해립,홍성윤,Choi Sang-Duk,Suh Hae-Lip,Hong Sung-Yun 한국양식학회 1996 韓國養殖學會誌 Vol.9 No.2
Two species of the copepod parasite were observed from two marine fishes in Korea. A siphonostomatoid copepod Neobrachiella incurva (Shiino, 1956) (Lernaeopodidae) and a cyclopoid copepod Peniculus ostraciontis Yamaguti 1939 (Lernaeidae) were found on the gills of Halichoeres poecilopterus and the fins of Sebastes schlegeli, respectively. The most distinct features of N. incurva are bipartite of maxillule, 2 ventro-posterior processes and conical genital process. P. ostraciontis is very distinguishable in the body shape, antenna, and fused trunk. Both species of copepods are newly observed from the Korean waters.
화장품의 전기적 특성 분석을 위한 문지름 모사 시험 장치 개발
황희윤(Hui Yun Hwang),한수호(Soo Ho Han),이준배(Jun Bae Lee),홍성윤(Sung Yun Hong) 대한기계학회 2018 大韓機械學會論文集A Vol.42 No.11
최근 미세전류가 피부 개선 및 화장품의 유효성분 흡수력 향상에 도움이 된다는 보고와 함께 다양한 형태의 미용 장치가 개발되었다. 별도 장치 사용의 번거로움을 해결하기 위하여 전기 발생 화장품이 제안되었으나, 화장품 사용 중 발생하는 전기의 정량적 평가 기법이 개발되지 않은 실정이다. 본 연구에서는 레오미터와 d31 미터에 기반하여 화장품에 전단력을 가하면서 전기적 신호를 측정할 수 있는 문지름 모사 시험기를 개발하고, 이를 이용하여 화장품의 전기적 특성을 평가하였다. 화장품으로부터 발생한 전기적 신호는 전단력에 의해 화장품에 전단 변형이 발생할 때만 관찰되었으며, 화장품 성분의 함유량이 변하게 되면 전기적 특성도 변함을 확인하였다. 이로부터 개발된 문지름 모사 시험기는 화장품의 전기적 특성을 정량화할 수 있으며, 전기발생 화장품의 성분 최적화에 활용될 수 있다고 판단된다. Recently, various products related with beauty care were developed since microcurrents could improve the skin and boost the absorption of active constituents. Electrical cosmetics were suggested for solving inconveniences of the beauty care products, but no standard test method was established for the assessment of electrical characteristics of cosmetics quantitatively. In this study, we developed the rubbing type testing machine for measuring electrical signals from cosmetics under shear loadings based on a cone-plate rheometer and d31 meter. We compared the electrical characteristics of cosmetics with developed testing machine. We found that there were big changes of electric charge signals of cosmetics when the shear loadings were applied and electrical characteristics of cosmetics were changed as the content of one constituent was changed. From experiments, we can conclude that developed testing machine can quantify the electrical characteristics of cosmetics and be used for optimizing constituent contents of cosmetics.
삼중블록 고분자 계면활성제의 재유화 억제 기능을 이용한 지속내수성 O/W 에멀젼형 자외선 차단용 화장품 개발
이지현 ( Ji Hyun Lee ),홍성윤 ( Sung Yun Hong ),이진용 ( Jin Yong Lee ),안소연 ( So Youn An ),이효진 ( Hyo Jin Lee ),김성용 ( Sung Yong Kim ),이준배 ( Jun Bae Lee ),김진웅 ( Jin Woong Kim ),신경희 ( Kyounghee Shin ) 대한화장품학회 2019 대한화장품학회지 Vol.45 No.2
본 연구는 poly(ethylene glycol)-poly(ε-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG) 삼중블록 고분자 계면활성제를 이용하여 제조된 우수한 사용감과 선택적인 클렌징 효과를 갖는 수중유(O/W) 에멀젼 타입의 내수성 자외선 차단 제형에 관한 것이다. 수영, 등산 등 다양한 야외 레저 활동이 많아짐에 따라 내수성 자외선 차단제의 수요가 증가하고 있다. 내수성 자외선 차단제는 물이나 땀에 지워지지 않아야하기 때문에 대부분 유중수(W/O) 에멀젼 제형으로 만들어진다. 하지만, W/O 에멀젼 제형은 오일리한 사용감과 클렌징이 어렵다는 단점이 있다. 이에 비해 O/W 에멀젼 제형은 사용감이 우수하고, 클렌징도 용이하지만, 물과의 재유화가 쉽기 때문에 내수성 특성을 갖는 것이 매우 어렵다. 본 연구에서는 이러한 문제를 해결하기 위해 O/W 에멀젼 제형의 HLB 값(~ 10)을 가지면서도 상대적으로 높은 계면장력을 가짐으로써 재유화에 강한 삼중블록 고분자 계면활성제를 도입하였고, 이를 통해 O/W 에멀젼형 지속내수성 자외선 차단제를 개발하였다. 본 연구를 통해 개발된 자외선 차단제는 우수한 사용감과 지속내수성, 그리고 폼 클렌저와의 선택적인 클렌징 효과를 보여준다. 향후 사용감이 다양화된 새로운 O/W 에멀젼형 자외선 차단제 제품 개발에 도움이 될 것으로 기대된다. This study reports water-resistant oil-in-water (O/W) emulsion-based sunscreening formulations prepared using a poly(ethylene glycol)-poly(ε-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG) triblock polymeric surfactant. As a result of a variety of outdoor recreational activities such as swimming and hiking, consumer needs for development of advanced water-resistant sunscreen formulations are increasing. Water-resistant sunscreens are mostly based on water-in-oil (W/O) emulsions, because they should not be wiped off by water or sweat. However, the W/O emulsion formulations have a disadvantage in that the feeling of use is oily and difficult to remove. On the other hand, the O/W emulsion formulations are excellent in achieving the better skin feel as well as the easier removal. However, it is difficult to provide the O/W emulsion formulations with the water-repelling performance, since re-emulsification likely occurs upon getting touch with water. To solve this problem, this study proposes a O/W emulsion-based sunscreen formulation, a triblock polymeric surfactant having relatively high interfacial tension HLB value (~ 10). This allows the sunscreen formulations to exhibit the improved water repellence function by preventing their re-emulsification. The sunscreen formation system prepared in this study would be useful for diversification of functional sunscreen products, taking advantages of its excellent emulsion stability, UV protection performance, long lasting water-resistant function and selective cleansing effect with only foam cleanser.