천연물 신약 특허 동향 분석

한유진,박선주,Han, Yoo-Jin,Park, Sunju 대한예방한의학회 2016 대한예방한의학회지 Vol.20 No.2

Objectives : This study aims to investigate the current situation of domestic patents in Korea on natural products and to provide directions for developing and applying herbal medicinal products by in-depth analyses. Methods : Combinations of words, such as "A61K" or "A61P", "herb" or "Korean medicinal herb" or "Korean medicine" or "traditional" or "natural" or "$botanic^*$" or "China", and "medicine" or "treatment" or "prevention" or "improvement", were used to search patents in the World Intellectual Property Service (WIPS) database. Three methods were applied to analyze natural products patents. First, the number of patent registrations was sorted by year. Second, the assignees were analyzed by count and country of origin. Finally, cluster map analysis was conducted to explore frequently emerging words in natural products and the relationship amongst those words to treat corresponding diseases/technologies. Results : Results showed that, first, the total number of patents had been increasing. Among the patents, 76.4% were registered by domestic institutes/companies, and 23.6% by foreign institutes/companies. Second, USA, Japan, and China possess a considerable number of Korean patents and, therefore, domestic institutes/companies can seek joint technological development opportunities with their counterparts from those countries in the future. Finally, a total of four clusters were identified by cluster map analysis. Each of the clusters includes natural products related to diseases involving skin, aging, and blood sugar, as well as adult diseases. Conclusions : In this study, natural products patents registered in the Korean Intellectual Property Office were analyzed. The analyses results showed the kinds of natural products that had been employed for the treatment of certain diseases. However, natural products included in existing patents were minimal given that 4,174 species of indigenous plants are found in Korea. Thus, Korean institutes/companies should utilize unexplored plants to develop more value-added drugs.

뇌전증 환자의 MEG 데이터에 대한 분류를 위한 인공신경망 적용 연구

한유진,김준식,김재희,Yujin Han,Junsik Kim,Jaehee Kim 한국통계학회 2024 응용통계연구 Vol.37 No.2

This study performed a multi-classification task to classify mesial temporal lobe epilepsy with left hippocampal sclerosis patients (left mTLE), mesial temporal lobe epilepsy with right hippocampal sclerosis (right mTLE), and healthy controls (HC) using magnetoencephalography (MEG) data. We applied various artificial neural networks and compared the results. As a result of modeling with convolutional neural networks (CNN), recurrent neural networks (RNN), and graph neural networks (GNN), the average k-fold accuracy was excellent in the order of CNN-based model, GNN-based model, and RNN-based model. The wall time was excellent in the order of RNN-based model, GNN-based model, and CNN-based model. The graph neural network, which shows good figures in accuracy, performance, and time, and has excellent scalability of network data, is the most suitable model for brain research in the future.

유망기술을 보는 여러 가지 관점

한유진,Han, Yu-Jin 한국발명진흥회 2007 發明特許 Vol.33 No.1

Carrageenan 유발염증에 대한 15Hz 전침의 효과에 대한 연구

한유진,이용태,장경전,Han, You-jin,Lee, Yong-tae,Jang, Kyung-jeon 대한침구의학회 2003 대한침구의학회지 Vol.20 No.3

Objective : The aim of this study is to investigate the anti-inflammatory effects of 15Hz electroacupuncture(EA) on carrageenan-injected rats. Inflammation was induced by an intraplantar injection of 1% carrageenan into the right hind paw. Methods : Bilateral EA stimulation with 15 Hz were delivered at those acupoints corresponding to Zusanli and Sanyinjiao in man via the needles for a total of 30 min duration in carrageenan-injected rats. Results: The developing edema was measured 30 minutes interval afer carrageenan injection and 15 Hz EA stimulation presented significant edema inhibition. Three hours after carrageenan injection, prostaglandin $E_2(PGE_2)$ and nitric oxide(NO) levels were measured. The 15Hz EA stimulation significantly inhibited $PGE_2$ and NO production in the right paw. The pro-inflammatory mRNA expression such as cyclooxygenases(COX)-2 and interleukin(IL)-$1{\beta}$ were slightly down-regulated by EA stimulation. The number of COX-2, IL-$1{\beta}$, tumor necrosis factor-${\alpha}$ immunoreactive cells were abundantly observed in paw edema. But these cells were decreased in nmber according to anti-edema effect of 15Hz EA. Conclusions: These results indicate that 15Hz EA stimulation have an alleviation action against carrageenan-induced edema and local inflammation.

Report - 국가 R&D 특허의 ASEAN 주요국가 지원 방안

한유진,Han, Yu-Jin 한국발명진흥회 2011 發明特許 Vol.36 No.12

특허청 '11년 계획에 ASEAN+3(한 중 일)을 언급하였으나 구체적인 실행 계획은 미흡한 상태이다. ASEAN은 동남아시아 경제협의체로서 우리나라와 지리적 무역 측면에 있어서 매우 가까우며, 회원국 대부분이 과학기술을 개발할 수 있는 최소한의 인프라가 갖추어져 있고 정부의 의지도 뚜렷한 편이다. 주요 협력 대상국으로 말레이시아('08년 2,086건 등록) 필리핀('08년 838건 등록), 태국('08년 966건 등록)을 선정하였다.

특허 정보를 활용한 컨버전스 산업에서의 경쟁 관계 분석 : 텔레매틱스의 예

한유진 ( Yoo-jin¸ Han ) 한국지식재산연구원 2006 지식재산연구 Vol.1 No.2

Recently, technological convergence has been paid much attention to in various fields. However, it has not been easy for firms to analyze the competition structure due to the vague characteristics of a convergence industry. Therefore, in this research, by using patents, I explore how firms can frame strategies in the fields wherein strategists suffer difficulties in defining competitors. To this end, a firm-wise technology portfolio and inter-firm technology portfolio similarity map will be prepared. As an example for a convergence industry, telematics is selected and among the patents granted by respective governments, US patents are used. The sample is composed of 363 patents corresponding to 40 companies and 36 technological fields. It was found that two company pairs had the exact same technology portfolios and three companies possessed unique technology portfolios. According to the similarities between these portfolios, appropriate technology strategies were proposed. Although the example of telematics may not be perfectly matched to other industries, the exploration process above will be a useful step for shaping technology strategy in a high-tech convergence industry.

아동과 청소년의 우울성향 (憂鬱性向) 및 귀인양식과 (歸因樣式) 학업성취

한유진,유안진 ( Eu Gene Han,An Jin Yoo ) 대한가정학회 1994 Human Ecology Research(HER) Vol.32 No.3

부모의 정서 규제와 아동의 정서 표출 규칙 이해

한유진,유안진 ( Eu Gene Han,An Jin Yoo ) 대한가정학회 1998 Human Ecology Research(HER) Vol.36 No.11

씨내리 소재 설화(說話)에 나타난 부부 간 권력관계의 불균형과 폭력의 문제 -남편의 폭력적 명령에 대응하는 아내의 행위 방식을 중심으로-

한유진(韓裕珍) ( Han Yu-jin ) 한국어문교육연구회 2021 어문연구(語文硏究) Vol.49 No.1

본 연구는 『韓國口碑文學大系』에 수록된 씨내리 소재 설화 53편을 대상으로, 부부 간 불균형한 위계로 인해 발생한 아내 성폭력의 구조를 남편의 명령형과 이에 대응하는 아내의 행위 방식을 통해 탐색하였다. 이때 아내에게 전달되는 남편의 ‘씨내리 명령’형과 이에 대응하는 ‘아내의 행위’는 다양한 형태로 나타난다. 첫째, 남편의 명령이 ‘비밀 동침’과 ‘언표(言表)되지 않은’ 형태로 나타날 경우, 서사 내에서 아내의 ‘목소리는 거세’되어 있다. 서사 내 상실된 아내 목소리의 진의(眞意)는 ‘체념에 의한 침묵’이거나, 화자에 의해 의도적으로 누락된 남편에 의해 ‘묵살된 거부 의사’이다. 둘째, 남편이 아내에게 일방적 ‘씨내리 결정을 통보’할 경우 아내는 이와 같은 결정에 ‘순종’한다. 남편의 말에 대한 아내의 순종은 승낙을 하지 않을 시 놓일 ‘위협으로 인한 순응’이거나, 사회적 ‘성역할에 의거한 동의’이다. 셋째, 아내가 남편의 ‘씨내리 명령을 적극 수행’하는 경우는, 아내가 다른 남성과의 동침을 집요하게 요구한 남편의 강요에 씨내리 남성을 ‘유혹하여 동침’하거나, 남편의 계승 고민을 자신에게 ‘과도하게 투사’함으로써 직접 씨내리를 결정하고 씨내리남성과 동침한다. This study investigated husbands’ structure of assaulting their wives sexually due to unbalanced hierarchy between couples through their orders and their wives’ acts to respond to them targeting 53 tales that feature surrogate fathers collected in the Collection of Korean Oral Literature. At this moment, the husbands’ ‘orders of the surrogate fathers’ delivered to their wives and ‘their acts’ to respond to it are shown in many different forms. First, when the husband’s orders are shown in a form of ‘sleeping together secretly’ and ‘non-verbal behaviors’, their wives’ ‘voices were deleted’ in the Narratives. Real intention of wives’ voices lost in the narratives is ‘silence by resignation’ or ‘intention of refusal’ ignored by their husbands and deliberately omitted by narrators. Second, when husbands unilaterally notify their wives of decisions of surrogate fathers, they are ‘obedient’ to them. The wives’ obedience to their husbands’ words is ‘adaptation due to threats that they will be faced with unless they will not approve’ or ‘their consent based on sex roles.’ Third, when wives ‘actively carry out their husbands’ orders of surrogate fathers’, wives ‘sleep together with men of surrogate fathers by tempting them’ by pressure of their husbands who stubbornly demand sleeping with other men. Or wives directly decide and sleep with surrogate fathers by ‘excessively reflecting’ their husbands’ worries about succession in themselves.

적색식용색소인 아마란스의 약동학 특성 및 위장관 투과도 연구

한유진(Youjin Han),구수현(Soo Hyeon Goo),남소정(So Jeong Nam),강윤주(Yun Ju Kang),권미화(Mihwa Kwon),송임숙(Im-Sook Song) 한국생명과학회 2017 생명과학회지 Vol.27 No.7

적색 아조류 타르색소인 아마란스는 인공식용색소로 식품, 화장품, 의약품에 광범위하게 사용되고 있음에도 불구하고, 경구로 복용하였을 때 위장관 흡수율이나 흡수특성에 대해 연구된 바가 없다. 본 연구의 목적은 아마란스의 정맥투여 또는 경구 투여 후 약동학 특성을 평가하고 diffusion chamber system을 이용하여 위장관 흡수율 및 투과도를 평가하고자 하였다. 정맥투여된 아마란스는 38.8분의 소실반감기로 빠르게 혈중에서 소실된다. 그러나 경구투여된 아마란스는 생체이용률도 55.6%로 높은 위장관 흡수율을 나타내며 408분까지 혈중농도가 증가하고 24시간까지 혈중에 남아있는 특성을 나타내었다. 이는 아마란스의 위장관 흡수가 오랫동안 지속적으로 일어나는 것을 의미한다. 이를 확인하기 위하여 소장의 흡수부위를 공장, 회장사부, 회장하부로 나누어 위장관 투과도를 평가하고 투과성이 잘 알려진 지표물질과 비교하였다. 연구결과 아마란스의 위장관투과성은 투과도가 매우 높은 caffeine의 1/3정도의 투과도를 보이고, 중등도의 투과도를 보이는 atenolol과 유사한 투과도를 나타내었으며 회장상부에서의 투과도가 가장 높았다. 결과를 종합하면, 아마란스는 경구투여된 뒤 지속적으로 흡수되며 흡수율도 50% 이상을 보이므로, 식품, 립케어 화장용품, 경구용 의약품에 아마란스 등의 색소가 포함될 경우에는 첨가량 등을 고려하여 신중하게 사용해야 할 것이다. Although amaranth, a red-colored tar dye, is usually used in foods, cosmetics, and pharmaceutics, its bioavailability and intestinal absorption have not previously been investigated. Therefore, the purpose of this study was to investigate the pharmacokinetics properties and intestinal permeability of amaranth in rats following the intravenous and oral administration of this dye. Amaranth rapidly disappeared from the plasma following the intravenous injection, with a half-life of 38.8 minutes. However, the plasma concentration of amaranth was increased to 400 minutes following the oral administration of amaranth, and the absorption time and bioavailability of amaranth were calculated to be 356 minutes and 55.6%, respectively. This suggests that once amaranth exists in the gut, this dye may be efficiently and effectively absorbed. Consistent with this result, the intestinal permeability of amaranth was comparable to atenolol, a marker compound of moderate permeability, and to one-third of caffeine’s intestinal permeability (a highly permeable compound). In conclusion, a significantly long absorption time and substantial intestinal absorption of amaranth was observed following the oral administration of amaranth at a dose of 300 mg/kg in rats, despite the rapid elimination of this dye from the plasma. These results may suggest the necessity of a careful and limited use of amaranth dye when it is added to food, lip-care cosmetics, and orally administered pharmaceutics.