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면역 분변잠혈검사에 영향을 미치는 대장암과 대장선종의 인자에 관한 연구
박두호(Doo Ho Park),이보인(Bo In Lee),최규용(Kyu Yong Choi),배상수(Sang Soo Bae),김병욱(Byung Wook Kim),최 황(Hwang Chol),박수헌(Soo Heon Park),채현석(Hyun Suk Chae),최명규(Myung Gyu Choi),정인식(In Sik Jung),이세영(Se Young Lee) 대한소화기학회 2001 대한소화기학회지 Vol.37 No.6
Background/Aims: Since immunological fecal occult blood test (iFOBT) was introduced in Korea, there has been no study on factors of colorectal cancer and adenoma which affect iFOBTs. Thus, we compared the sensitivity of the iFOBT according to differentiations and locations of colorectal cancers and sizes, histological types, degrees of dysplasia, numbers and locations of adenomas. Methods: Sixty patients with histologically confirmed colorectal cancer and 174 patients with colorectal adenoma who underwent colonoscopy, were included in this study. They underwent iFOBTs for their two consecutive specimens before clonoscopy examinations. Results: There was no significant difference in the sensitivity of the iFOBT according to the differentiation and the location of colorectal cancers (p=0.061 and p=0.399, respectively). The univariate analysis of colorectal adenomas showed that the positive rates of the iFOBT were increased as the size of adenoma was bigger, the degree of dysplasia was severer and the number of adenoma was larger (p=0.000, p=0.009 and p=0.015, respectively). However, in the multivariate analysis, only the size of adenoma was significant (p=0.000). Conclusions: The iFOBT is a useful screening method which is not influenced by the location and the differentiation of colorectal cancer, but its usefulness is limited in colorectal adenoma less than 1cm. (Korean J Gastroenterol 2001;37:428-435)