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천화분 약침액의 A549 폐암 세포주에서 apoptosis 유발효과
최태연 ( Tae Yeon Choi ),이성원 ( Sung Won Lee ),류연희 ( Yeon Hee Ryu ),반효정 ( Hyo Jeong Ban ),서근영 ( Geun Young Seo ),김재효 ( Jae Hyo Kim ),안성훈 ( Seong Hun Ahn ),손인철 ( In Chul Sohn ) 경락경혈학회 2010 Korean Journal of Acupuncture Vol.27 No.4
Objectives: In order to confirm the anti-cancer effect of Trichosanthes kirilowii pharmacopuncture fluid, this study was proceeded. Methods: A549 lung cancer cells were cultured to be treated by Trichosanthes kirilowii pharmacopuncture fluid as dose dependent manner for 72 hours. And then the cell viability, nucleus fragmentaion, p21 and p53 protein expression, Bcl-2 and Bax protein expression, procaspase-3 PARP protein expression. Results: 1. Trichosanthes kirilowii pharmacopuncture fluid decrease A549 cell viability as dose dependent manner. 2. Trichosanthes kirilowii pharmacopuncture fluid induced the nucleus fragmentation in A549 lung cancer cells as dose dependent manner. 3. Trichosanthes kirilowii pharmacopuncture fluid increase the p21 and p53 protein expression. 4. Trichosanthes kirilowii pharmacopuncture fluid decrease the Bcl-2 protein expression but cannot affect the Bax protein expression. 5. Trichosanthes kirilowii pharmacopuncture fluid increase the activation of caspase-3 and PARP protein. Conclusions: As the above results, it was conclused the Trichosanthes kirilowii pharmacopuncture fluid had the anti-cancer effects to induce apoptosis.