Ranitidine HCE정제이 함량균일성 및 용출성 평가

최인,정경애,조아라,박재영,문홍섭 한국병원약사회 1996 병원약사회지 Vol.13 No.1

Ranitidine is a histamine H₂-receptor antagonist. The drug competitively inhibits the action of histamine H₂ receptors of parietal cells, reducing gastric acid secretion under daytime and nocturnal basal conditions and also when stimulated by food, insulin, amino acid, histamine, or pentagastrin. Ranitidine is used for the short term treatment of endoscopically or radiographically confirmed active duodenal ulcers and Zollinger-Ellison syndrome etc. Drug effect is depend on bioavailability of preparations and also bioavailability is depend on dissolution rate and content uniformity. This study was attempted to evaluate bioavailability of commercial ranitidine HCI tablets. The dissolution test was conducted in artificial gastric juice and artificial intestinal juice using K.P 1 method with three ranitidine HCI preparations (A, B and C) which were pharmaceutically equivalent. The result as following:1) The dissolution rate in artificial gastric juice was higher in the order three different brands A>B>C 2) The dissolution rate in artificial intestinal juice was higher in the order three different brands A>B>C 3) Content uniformity of three different brands was better in such order as B>A>C 4) There was no relationship between dissolution rate and content uniformity

頭頸部 癌患者의 齒科的 處置

崔仁 고신대학교 의학부 1986 高神大學校 醫學部 論文集 Vol.2 No.1

Oral/dental care is an important consideration in all patients but is essential in patients undergoing anticancer therapy because the complications of oral cavity associated with head & neck cancer therapy are substantial. The systemic defensive mechanism of the patient is decreased due to anticancer therapy, especially by immunomyelosuppression. As a result of the decrease in defensive mechanism, a oral tissue may respond to mild irritation (example : an ill-fitting denture), and then becoming excessively inflammed. A greater than normal susceptivility to infection also result from the systemic defensive mechanisms being lowered. This result can curtail the effectiveness of the therapeutic action, delaying further scheduled treatment. The cancer therapy is chiefly performed with chemotherapy & radiotherapy and the complications of the chemotherapy are infection, mucositis, hemorrhage, and pain. On the other hand, the complications of radiotherapy including mucositis, xerostomia, loss of taste, loss of the elasticity of skin of neck, osteoradionecrosis, fibrosis of the temporomandibular joint, and radiation induced dental caries may follow. To avoid the above complications, the dentist must do an oral screening examination before cancer therapy (example : observing presence of dental calculus, broken teeth & faulty restorations, periodontal disease or prosthodontic appliance). Then, upon resolution of all complications, a prosthetic appliance may be fabricated. Thus, the period of hosptalization & treatment fee is minimized for a patient. In conclusion : the dental oncologist must strive to maintain a healthy oral/dental condition in the patient in cooperation with the chief medical doctor.

노근리와 이리역의 차이

최인 열린전북 2000 열린전북 Vol.11 No.-

혈액투석환자의 우울, 자아존중감, 가족지지가 절망감에 미치는 영향

최인,한숙정 사단법인 인문사회과학기술융합학회 2015 예술인문사회융합멀티미디어논문지 Vol.5 No.4

The study is to examine the effects of depression, self-esteem and family support to hopelessness of patients taking hemodialysis. The Subjects were 147 patients who were taking hemodialysis three times a week in a hospital and clinic which is located in B city in Gyonggi-do. Data collection was performed from the 1st to 10th in September, 2014. Subjects’ average age was 52.4, male patients were 54.%, high school graduates were 48.3%, 57.1% had a religion, 85.7% had no jobs, 74.1% were economically difficult, most of them were taking hemodialysis three times a week. From the study, having a religion(β= .109), depression(β= .338), self-esteem(β= -.567), family support(β= -.137) were shown to affect the degree of hopelessness significantly, and adj R2 were 57.5. Findings suggest that intervention aiming at decrease of depression, nurturing of self-esteem, and improvement of family support are expected to lead to the decrease of hopelessness of patients taking hemodialysis. 본 연구는 혈액투석 중인 만성신부전환자의 우울, 자아존중감, 가족지지가 절망감에 미치는 영향을 규명하고자, 경기도 B시 소재 병원 및 의원에서 3회/주 혈액투석을 받고 있는 환자 147명을 대상으로 2014년 9월1일부터 10일까지 설문조사를 실시하였다. 대상자의 평균연령은 52,4세, 남성 54%, 고졸 48%, 종교가 있는 사람이 57.1%, 직업 없는 사람 85.7%, 경제상태 어려운 사람 74.1%, 투석횟수 3회/주 96.6%이었다. 종교(β= .109), 우울(β= .338), 자아존중감(β= -.567), 가족지지(β= -.137)는 절망감에 유의한 영향을 주는 것으로 나타났으며, 57.5%(adj R2)의 설명력을 나타내었다. 따라서 혈액투석환자의 우울감소, 자아존중감 증진 및 가족지지 향상을 통해 절망감을 감소시킬 수 있는 간호중재프로그램이 개발되어야할 필요가 있겠다.

Improving empirical size of the KPSS test of stationarity

최인 한국계량경제학회 2009 계량경제학보 Vol.20 No.1

This note proposes a new testing procedure that can alleviate the size prob-Lem associated with semiparametric tests of stationarity. The note is focused on The test by Kwiatkowski, Phillips, Schmidt and Shin (1992) considering its pop-ularity in the literature. The testing procedure of this note employs sample-split and the Bonferroni test. The sample is split into two parts, one corresponding to the odd index and the other to the even index, and the KPSS test is applied to each subsample. The two KPSS tests are then combined using the Bonfer-roni principle. Simulation results demonstrate that this procedure significantly reduces the size distortion of the KPSS test.

방광질루의 임상적 고찰

최인,김동한 大韓泌尿器科學會 1983 Korean Journal of Urology Vol.24 No.3

장애인도 새 도시에서 살 권리가 있다

최인 열린전북 2003 열린전북 Vol.2003 No.8

요도손상에 관한 임상적 고찰

최인,김동한 大韓泌尿器科學會 1983 Korean Journal of Urology Vol.24 No.2

頭頸部 癌患者의 齒科的 處置

崔仁 高神大學 醫學部 1986 高神大學醫學部 論文集 Vol.2 No.1

Dental Care of Head & Neck Cancer Patients

최인 고신대학교(의대) 고신대학교 의과대학 학술지 1986 고신대학교 의과대학 학술지 Vol.2 No.1

Oral/dental care is an important consideration in all patients but is essential in patients undergoing anticancer therapy because the complications of oral cavity associated with head & neck cancer therapy are substantial. The systemic defensive mechanism of the patient is decreased due to anticancer therapy, especially by immunomyelosuppression. As a result of the decrease in defensive mechanism, a oral tissue may respond to mild irritation (example : an ill-fitting denture), and then becoming excessively inflammed. A greater than normal susceptivillity to infection also result from the systemic defensive mechanisms bein lowered. This result can curtail the effectiveness of the therapeutic action, delaying further scheduled treatment. The cancer therapy is chiefly performed with chemotherapy & radiotherapy and the complications of the chemotherapy are infection, mucositis, hemorrhage, and pain. On the other hand, the complications of radiotherapy including mucositis, xerostomia, loss of taste, loss of the elasticity of skin of neck, osteoradionecrosis, fibrosis of the temporomandibular joint, and radiation induced dental caries may follow. To avoid the above complications, the dentist must do an oral screening examination before cancer therapy (example : observing presence of dental calculus, broken teeth & faulty restorations, periodontal disease or prosthodontic appliance). Then, upen resolution of all complications, a prosthetic appliance may be fabricated. Thus, the period of hospitalization & treatment fee is minimized for a patient. In conclusion : the dental oncologist must strive to maintain a healthy oral/dental condition in the patient in cooperation with the chief medical doctor.