일본에 다녀와서… / 최성민

최성민 대한검도학회 2006 대학검도보 Vol.- No.22

Effects of Flavonoid Compounds on β-amyloid-peptide-induced Neuronal Death in Cultured Mouse Cortical Neurons

최성민,Kang-Ho Choi,박만석,Myeong-Kyu Kim,Ki-Hyun Cho,Jong-Keun Kim,Byeong C. Kim,Jane Chang,조연희 전남대학교 의과학연구소 2014 전남의대학술지 Vol.50 No.2

Excessive accumulation of β-amyloid peptide (Aβ) is one of the major mechanisms responsiblefor neuronal death in Alzheimer’s disease. Flavonoids, primarily antioxidants,are a group of polyphenolic compounds synthesized in plant cells. The presentstudy aimed to identify flavonoid compounds that could inhibit Aβ-induced neuronaldeath by examining the effects of various flavonoids on the neurotoxicity of Aβ fragment25-35 (Aβ25-35) in mouse cortical cultures. Aβ25-35 induced concentration- and exposure-time-dependent neuronal death. Neuronal death induced by 20 μM Aβ25-35 wassignificantly inhibited by treatment with either Trolox or ascorbic acid. Among 10 flavonoidcompounds tested [apigenin, baicalein, catechin, epicatechin, epigallocatechingallate (EGCG), kaempferol, luteolin, myricetin, quercetin, and rutin], all except apigeninshowed strong 1,1-diphenyl-2-pycrylhydrazyl (DPPH) scavenging activity undercell-free conditions. The flavonoid compounds except apigenin at a concentration of 30μM also significantly inhibited neuronal death induced by 20 μM Aβ25-35 at the end of24 hours of exposure. Epicatechin, EGCG, luteolin, and myricetin showed more potentand persistent neuroprotective action than did the other compounds. These resultsdemonstrated that oxidative stress was involved in Aβ-induced neuronal death, andantioxidative flavonoid compounds, especially epicatechin, EGCG, luteolin, and myricetin,could inhibit neuronal death. These findings suggest that these four compoundsmay be developed as neuroprotective agents against Alzheimer’s disease.

치과용 3D 프린팅 기술로 제작된 가공물의 정밀성 분석

최성민 대한치과기공학회 2018 대한치과기공학회지 Vol.40 No.4

Purpose: The development of the dental technology industry has digitized the dental process. Definition of Digitalization of Dental Implantation Digitalization is the process of model making and prosthodontic processing using 3D CAD and CAM. Currently, it is becoming popular due to the spread of various devices. However, precision evaluation at this stage is an important factor in precision-based dental procedures. Therefore, in this study, we want to analyze the precision of the processed body made with digital dental machine. Methods: The accuracy of digital dental pore devices was evaluated. Specimens were fabricated with 5 types of 3D printers. The external shape was measured with the prepared specimen. The surface roughness was measured. Results: As a result, precision was excellent in order of EP2 specimen, EP1 specimen, and EA2 specimen. The precision of EP3 specimen and EA1 specimen is not excellent. And the precision of the specimen processed with polymer 3D printer is excellent. The accuracy of LCPS type polymer 3D printers is considered to be excellent. Conclusion : 1. Observation of the shape The 3D printer for LCPS system and the 3D printer for SLM 40μm system were found to be precisely processed. 2. Surface roughness results The LCPS system polymer 3D printer has been shown to have a precise surface.

알레르기 질환의 치료로서의 CpG DNA

최성민 대한소아청소년과학회 2005 Clinical and Experimental Pediatrics (CEP) Vol.48 No.3

Atopy is a highly prevalent and serious health problem. The prevalence and severity of asthma and allergic diseases have increased over recent decades, particularly in industrialized nations. Early life infections may protect against the development of atopy and allergic diseases like asthma. The inverse relationship between the incidence of atopy and childhood infections has led to the ‘hygiene hypothesis’, which suggests that diminished exposure to childhood infections in modern society has led to decreased Th1-type responses. Th1 and Th2 responses are counter-regulatory. Reduced Th1 may lead to enhanced Th2-type inflammation, which is important in promoting asthma and allergic disease via up-regulation of IL-4, IL-5, and IL-13. It is now widely accepted that altered regulation of Th2 responses(and possibly the balance between Th1 and Th2 responses) is an important factor in the development of atopy. CpG DNA represent a novel class of drugs with substantial immunomodulatory properties. CpG DNA contain unmethylated motifs centered on the CpG dinucleotides, like bacterial DNA. These CpG DNA promote Th1 and regulatory type immune responses and suppress Th2 responses. In murine studies, CpG DNA are effective in prevention and treatment of asthma and allergic diseases. CpG DNA are just beginning to be tested in human asthma. While its precise mechanisms continue to be fully studied, CpG DNA offers considerable promise as a novel treatment for atopic inflammation. It may prove to be an important disease modifying therapy, or even curative therapeutic agent for asthma and allergic diseases.

신용정보법 제・개정에 따른 신용정보업의 변화 연구: 신용정보법 일부개정법률안(김병욱 의원 대표발의, 2018.11.15.)을 중심으로

최성민 국회입법조사처 2019 입법과 정책 Vol.11 No.3

This study analyzed the pattern of changes in the credit informationindustry following the enactment and amendment of Credit InformationAct. Especially, the revised bill of Credit Information Act(November 15,2018) has actively accommodated the global environmental change of thetransition to Data Economy and adopted overseas legislation cases ofdata regulation in accordance with domestic circumstances. When thisamendment is enacted, the scope of credit information business issegmented, new players in business enter the market, I expect majorchanges in the existing credit information industry. In addition, it isalso anticipated that different strategies among existing and newbusinesses will be implemented and the market size of the creditinformation industry will be expanded significantly as the sales of creditbureaus increase. However, refined policy supplement is highly necessaryto minimize side effects from rapid changes while watching the transitionand growth of credit information industry as data industry. 본 연구는 신용정보법 제・개정에 따른 신용정보업의 변화양상에 대해 분석하였다. 신용정보법은 1995년 제정 이후, 현재까지 총 35차례에 걸쳐 개정이 이루어졌는데 신용정보업은 이로 인한 규제강화 또는 완화에 따라 다양한 변화를 보여왔다. 특히 2018년 11월15일 김병욱 더불어민주당 의원이 대표발의한 신용정보법 개정안은 데이터 경제로의 전환이라는 전세계적인 환경 변화를 적극 수용하고, 해외 데이터 규제와 관련된 입법례를국내 실정에 맞게 도입한 법안이다. 이 개정안이 입법되면, 신용정보업의 업무범위 세분화, 신규 사업자의 시장 진입, 겸업・부수업무 확대에 따른 금융분야 데이터 산업의 성장등 기존 신용정보업의 큰 변화가 예상된다. 또한 기존 사업자와 시장에 새롭게 진입하려는 신규 사업자는 이번 개정안에 대응하기 위해 서로 다른 경영전략을 펼칠 것으로 예상되며 향후 신용정보회사들의 매출액이 크게 증가하면서 신용정보업의 시장규모도 확대될 것으로 보인다. 다만, 데이터 산업으로서의 신용정보업의 변화와 성장을 주시하면서변화에 따른 부작용을 최소화할 수 있는 세밀한 보완정책이 뒷받침되어야 할 것이다.

국내 제조 지베렐린 DF(GA_(3)+GA_(4+7))에 의한 배 '신고' 비대촉진

최성민,이정명 경희대학교 생명자원과학연구원 2004 硏究論文集 Vol.23 No.-

새로운 원료로 국내에서 조제된 시제품 DF(GA₃+GA_(4+7)의 과경도포처리는 배 '신고' 품종의 과실비대에 있어서 과실의 무게, 종경, 횡경의 증가를 보였으므로 기존의 완제품 수입물에 비하여 동등 또는 그 이상의 비대촉진 효과가 있는 것으로 판단되었다. 배 '신고'의 비대촉진효과는 처리 40일 후부터 나타나기 시작하였으며 최종조사일인 수확기의 과실에서는 무처리에 비하여 과실의 종경에서 16.3~20.6%, 평균과중에서 40~52%의 증가를 보여 확실한 배(신고) 비대촉진효과를 보였다. 기준량이나 배량처리에서도 약해는 전혀 발생하지 않았으나 처리부위 및 처리량을 준수하는 것이 가능할 수 도 있는 형태불량과 내지는 기형과 발생을 감소시킬 수 있는 것으로 판단되었다. The domestic formation of gibberellin mixture, DF(GA_(3)+GA(4+7)), was judged to have equivalent efficacy of fruit enlargement as compared to the imported products on the basis of fruit fresh weight and height and diameter of fruit. Significant enlargement effects could be noticed from 40 days after the DF(GA_(3)+GA(4+7)) paste treatment to the fruit stalk and 16.3-20.6% increases in fruit height and 40-52% increases in mean fruit weight were obtained as compared to the untreated fruits. No phytotoxicity was found with standard amount of paste application or with double dose treatment. However, precise application in terms of amount and position is recommended to reduce the possible occurrence of malformed pear fruit.

질병의 낭만과 공포 -은유로서의 질병-

최성민 한국문학치료학회 2020 문학치료연구 Vol.54 No.-

This study aims at exploring the Korean society and literature using Illness as Metaphor and AIDS and Its Metaphor by Susan Sontag. In addition, it examines whether we can overcome the limitation of ‘metaphor of illness’ or not. According to Sontag, the metaphor of illness hides the essence of illness, interferes with the remedy and isolates the patients. She writes about notice at tuberculosis, cancer, and AIDS, saying that romance pertains to tuberculosis and fear pertains to cancer and AIDS as metaphors. In the Korean literature, tuberculosis is also portrayed through romance, whereas cancer and AIDS scare the public. Generally, when people do not know the cause of illness or cannot overcome, they utilize it as a metaphor or exaggerate it fearfully. In fact, illness is always unknown and frightening. Let us consider the case of MERS, is highly infectious disease that scares people greatly. During the infective stage, MERS led to a collapse of the national system. After the epidemic, MERS catalyzed the hate discourse between genders. However, illness should still be the object of metaphor in these more complicated times. We can utilize the ‘metaphor of illness’ again to critically consider the social perception of illness. 본 논문의 연구 목적은 수전 손택의 『은유로서의 질병』을 통하여 한국 사회와 한국 문학을 되짚어보는 것이다. 그것을 통해 우리가 ‘질병의 은유’를 벗어날 수 있는가의 문제를 검토하게 될 것이다. 수전 손택은 ‘질병의 은유’가 질병의 본질을 가리고 치료를 방해하며, 환자들을 오히려 외롭게 만든다고 보았다. 그녀가 특별히 주목한 것은 결핵과 암, 에이즈였다. 수전 손택에 따르면, 결핵은 낭만으로, 암과 에이즈는 공포의 은유가 덧씌워졌었다. 한국 문학에서도 결핵은 낭만으로 인식되곤 하였다. 암이나 전염병은 ‘공포’의 대상이 되곤 하였다. 질병이 질병 그 자체가 아니라 은유적으로 활용되는 것, 혹은 과장된 공포심의 유발로 연결되는 것은 질병에 대한 원인을 제대로 모르거나, 그것을 쉽게 극복할 수 없을 때 자연스럽게 나타나는 현상이다. 사실 질병은 기본적으로 낯선 것이다. 최근 유행했던 ‘메르스’의 경우를 생각해보자. 메르스는 질병 그 자체의 전염성이 높아서, 공포와 두려움이 컸던 것도 사실이다. 메르스 유행의 과정에서, 메르스는 국가 시스템의 붕괴를 드러냈고, 유행이 지나간 뒤에 남녀 성별간 혐오 담론을 확산시키는 촉매가 되기도 했다. 기본적으로, 질병의 은유를 극복해야 질병 자체에 다가갈 수 있다는 수전 손택의 입장에 동의한다. 그러나 더욱 복잡해진 현대 사회에서 질병은 여전히 은유의 대상일 수밖에 없는 측면이 있다. 사회의 질병, 혹은 사회가 질병을 바라보는 인식 자체를 비판적으로 고찰하기 위해, 우리는 다시 '질병의 은유'를 활용하게 된다.

복강경 원위부 췌장절제술 : 적응증 및 한계성

최성민,이상권,김응국 대한외과학회 2006 대한외과학회 학술대회 초록집 Vol.2006 No.11

A Case of Primary Tracheal Schwannoma

최성민,유지홍,이상배,김성한,김윤수 고신대학교(의대) 고신대학교 의과대학 학술지 2017 고신대학교 의과대학 학술지 Vol.32 No.2

Although benign nerve sheath tumors have been described, primary tracheal schwannomas are extremely rare. We report a case of primary tracheal schwannoma, a rare benign nerve sheath tumor in a 58-year-old man with atypical symptoms of chronic cough, sputum and dyspnea for 2 months. Chest computerized tomography showed a 1.7 cm polypoid lesion in posterior wall of mid trachea. The results of bronchoscopic biopsy and immuno-histo-chemical studies were consistent with schwannoma. A surgical treatment of tumor resection and tracheal reconstruction by end-to-end anastomosis was performed.

SAXS and SANS Studies of Hierarchical Self-Assembly of One-Dimensional Nanoparticles in Polymeric Systems

최성민 한국고분자학회 2011 한국고분자학회 학술대회 연구논문 초록집 Vol.2011 No.2