두개강내 악성 기형종 1예

천봉권,장희경,허만하 대한병리학회 1990 Journal of Pathology and Translational Medicine Vol.24 No.1

제 1 병기 비소세포폐암에서 cyclin E, p27, 및 pRb의 발현과 예후 : Cyclin E, p27, pRb의 발현과 예후

천봉권,조봉균,조성래 고신대학교 의학부 2003 高神大學校 醫學部 論文集 Vol.18 No.1

Background: Cyclin E and cyclin-dependent kinase inhibitor p27^kipl are two important regulators of the Gl-S transition modulating the activity of cyclin-dependent kinases and completing phosphorylation of pRb. Aberrations in the cell cycle control ar often observed in tumors and might even be mandatory in tumor development. Little is known about the expression and prognostic significance of cyclin E and p27 and relationship between the expression of cyclin E, p27, and pRb in non-small cell lung cancer(NSCLC). Materials and Methods: The expression of cyclin E, p27, and pRb in eighty-one cases of resected stage I NSCLC tissues and its relation to major clinico-pathological factors, including histology, differentiation, size of tumor, pleural extension and survival rate were investigated and analyzed. Immunohistochemical analysis with monoclonal antibodies specific for cyclin E, p27, pRb were performed by ABC method. Result: Expression rates of cyclin E, p27, and pRb in stage I NSCLC tissues were 29.6%, 28.4%, and 58.0% respectively. Cyclin E was expressed higher in cases of pleural extension(p=0.04), and p27 was expressed higher in tumor of less than 3㎝ in diameter(p=0.015), and pRb was expressed higher in cases of poorly differentiated tumor (p=0.049). The relationship between expression of cyclin E and pRb was not observed. The 5-years survival rate was lower in cases of positive expression of cyclin E than in cases of negative expression of cyclin E(44.4% vs 68.2%, p=0.015), and the 5-years survival rate was 72.2% in positive expression of p27 and 56.2% in negative expression of p27(p=0.09). The 5-years survival rate was higher in negative expression of cyclin E and positive expression of p27 than in cases of positive expression of cyclin E and negative expression of p27 (73.5% vs 36.3%, p=0.0029). In multivariate analysis, expression of cyclin E and p27 were an unfavorable prognostic factor(RR=3.578, p=0.006) and an favorable prognostic factor(RR=0.183, p=0.019) respectively. Conclusion : Cyclin E and p27 may play an important role for the biological behavior of stage I NSCLC, so that the expressions of cyclin E and/or p27 may be new prognostic markers.

Primary Lymphoma of the Common Bile Duct A Case Report

천봉권 고신대학교(의대) 고신대학교 의과대학 학술지 2004 고신대학교 의과대학 학술지 Vol.19 No.1

Primary gastrointestinal involvement of non-Hodgkin's lymphoma is frequently reported, but primary lymphoma of the common bile duct is extremely rare. Only fifteen cases have been recorded in the literature. In this paper, a 48-year-old male with obstructive jaundice and a primary lymphoma of the common bile duct is described. The cholangiogram disclosed stricture of the common bile duct. Pathological studies of the surgical specimen revealed that the wall of the common bile duct was transmurally infiltrated by non-Hodgkin's lymphoma of follicular cell type of B=cell lineage, with positivity for Bcl-2. Periductal and peripancreatic lymph nodes were replaced by metastatic lymphomatous involvement. The patient received postoperative chemotherapy according to the CHOP regimen. There is no evidence of lymphoma recurrence 3 months after the surgery. The analysis of the reported cases supports that a complete surgical resection of the lymphoma followed by chemotherapy has shown a promising result.

한국인의 갑상선 병변 : 560증례에 관한 통계적 고찰 A statistical study on 560 cases

천봉권,장희경,허방,허만하 高神大學 醫學部 1989 高神大學醫學部 論文集 Vol.5 No.2

제 1 병기 비소세포폐암에서 cyclin E, p27, 및 pRb의 발현과 예후<cyclin E, p27, pRb의 발현과 예후>

천봉권,조봉균,조성래 고신대학교(의대) 고신대학교 의과대학 학술지 2003 고신대학교 의과대학 학술지 Vol.18 No.1

Background: Cyclin E and cyclin-dependent kinase inhibitor p27kip1 are two important regulators of the G1-S transition modulating the activity of cyclin-dependent kinases and completing phosphorylation of pRb. Aberrations in the cell cycle control are often observed in tumors and might even be mandatory in tumor development. Little is known about the expression and prognostic significance of cyclin E and p27 and relationship between the expression of cyclin E, p27, and pRb in non-small cell lung cancer(NSCLC). Materials and Methods: The expression of cyclin E, p27, and pRb in eighty-one cases of resected stage I NSCLC tissues and its relation to major clinico-pathological factors, including histology, differentiation, size of tumor, pleural extension and survival rate were investigated and analyzed. Immunohistochemical analysis with monoclonal antibodies specific for cyclin E, p27, pRb were performed by ABC method. Result: Expression rates of cyclin E, p27, and pRb in stage I NSCLC tissues were 29.6%, 28.4%, and 58.0% respectively. Cyclin E was expressed higher in cases of pleural extension(p=0.04), and p27 was expressed higher in tumor of less than 3cm in diameter(p=0.015), and pRb was expressed higher in cases of poorly differentiated tumor (p=0.049). The relationship between expression of cyclin E and pRb was not observed. The 5-years survival rate was lower in cases of positive expression of cyclin E than in cases of negative expression of cyclin E(44.4% vs 68.2%, p=0.015), and the 5-years survival rate was 72.2% in positive expression of p27 and 56.2% in negative expression of p27(p=0.09). The 5-years survival rate was higher in negative expression of cyclin E and positive expression of p27 than in cases of positive expression of cyclin E and negative expression of p27 (73.5% vs 36.3%, p=0.0029). In multivariate analysis, expression of cyclin E and p27 were an unfavorable prognostic factor(RR=3.578, p=0.006) and an favorable prognostic factor(RR=0.183, p=0.019) respectively. Conclusion: Cyclin E and p27 may play an important role for the biological behavior of stage I NSCLC, so that the expressions of cyclin E and/or p27 may be new prognostic markers.

Simultaneous Occurrence of Primary Pulmonary Racemose Hemangioma and Multiple Sclerosing Hemangioma -A case report-

천봉권 고신대학교(의대) 고신대학교 의과대학 학술지 2006 고신대학교 의과대학 학술지 Vol.21 No.2

Primary racemose hemangioma of the bronchial artery is a rare cause of repeated hemoptysis, and multiple sclerosing hemangioma of the lung is a rare benign pulmonary neoplasm. A 25-year-old male with repeated hemoptysis for one month was admitted to our hospital. An endobronchial polypoid cyst-like mass with spontanous bleeding was detected on bronchoscopy and a very tiny pulmonary nodule in the same lobe was revealed on computed tomographic scan. The left upper lung was resected, and the simultaneous existence of racemose hemangioma of the bronchial artery shunting to pulmonary artery and multiple sclerosing hemangioma in the same side lung was histopathologically confirmed. In respect of pathogenetic assocation of both lesions the auther reviewed previous literautures and report this very rare case.

A Malignant Bronchial Oncocytoma -A case Report-

천봉권 고신대학교(의대) 고신대학교 의과대학 학술지 2006 고신대학교 의과대학 학술지 Vol.21 No.2

Primary malignant bronchial oncocytoma is a very rare pulmonary neoplasm. A 59-year-old male with a presumed oncocytic carcinoid was referred to this hospital. An endobronchial polypoid bossolated mass within left main distal bronchus was detected on bronchoscopy and on computed tomographic scan. The left lung was resected, and final pathologic diagnosis of malignant bronchial oncocytoma was confirmed. This neoplasm is composed predominantly of oncocytes with numerous mitochondria and lack of neurosecretory granules in transmission electron microscopy. In respect of pathologico-clinical difference between the malignant oncocytoma and oncocytic carcinoid, the author reviewed previous literatures and report this very rare case.

Metachronous Squamous Cell Carcinoma of Renal Pelvis in Patient with Colonic Cancer Twenty Years after Surgery

천봉권,류현열 고신대학교(의대) 고신대학교 의과대학 학술지 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Squamous cell carcinoma of the kidney is a very rare neoplasm. Some synchronous or metachronous cancer in multiple organs has been sporadically reported, but metachronous squamous cell carcinoma of the renal pelvis and calyces in the patient who had been suffered from colectomy for the colonic cancer has not been reported in the literatures. The authors report a case of metachronous squamous cell carcinoma in the renal pelvis and calyces occuring 20 years after treatment for colonic carcinoma

한국인의 갑상선 병변 : 560증례에 관한 통계적 고찰 A statistical study on 560 cases

천봉권,장희경,허방,허만하 고신대학교 의학부 1989 高神大學校 醫學部 論文集 Vol.5 No.2

A total of 560 cases of surgically resected thyroid specimens from the pathology files of Department of Pathology, Kosin Medical Center, during the period of 18 years from 1971 to 1988, was pathologically reevaluated. These thyroid lesions consisted of thyroiditis, goiter, adenoma, thyroid malignancy, and other miscellaneous diseases. Histopathological classifications of all thyroid lesions were based on Volpe's classification for thyroiditis, Robbins' for goiter, Rosai's for adenoma, and Meissner's for thyroid malignancy. This study was performed to elucidate the relative frequency of the thyroid diseases on the basis of morphological alterations and to compare the results with the previous studies in Korea and other counturies. Also pathological observations were performed with special reference to the lymphocytic reaction in connection with the thryoid malignancy and the formation of calcific bodies in association with papillary neoplasms. The 560 cases were classified pathologically into 29 acute and chronic thyroiditis(5.2%), 160 goiter(28.5%), 177 adenoma(31.6%), and 187 thyroid malignancy(33.4%). Hashimoto's thyroiditis was the commonest thyroiditis(17 cases), representing 58.7% of all thyroiditis. Nontoxic goiter occupied 93.8% of all the goiter, and nontoxic nodular goiter represented 91.2% of all the goiter. Adenomas consisted of 171 follicular type(86.6%), 3 Hurthle cell adenoma, and 3 atypical adenoma. Histopathologically, 114 papillary carcinoma represented 77.0% of all the thyroid malignancy. All the carcinoma in teenagers(6 cases) showed papillary growth. No relationship between the types of thyroid carcinoma and the frequency of lymphocytic infiltration was seen. Of 144 papillary carcinoma, 30 cases showed calcification in the neoplastic tissue. The relatively higher proportion of thyroid maligancy in this report, compared with the previous reports in Korea and other counturies, is probably related to the nature of this medical institute.

Primary Lymphoma of the Common Bile Duct A Case Report

Chun, Bong-Kwon 고신대학교 의학부 2004 高神大學校 醫學部 論文集 Vol.19 No.1

림프절외 림프종은 주로 위장관이나 두경부에 발생하며, 총담관의 원발성 림프종의 보고는 매우 드물다. 지금까지 문헌에는 15 증례만이 보고되어 있다. 48세 남자 환자가 급성 폐쇄성 황달을 주소로 내원하였으며, 담관 촬영술에서 총담관의 협착이 관찰되었다. 병리학적으로 총담관의 벽은 전층이 B-세포 계통의 비호지킨성 여보성 림프종에 이환되어 있었고, 담관주위 및 췌장 주위 림프절도 전이성 림프종에 대치되어 있었다. 환자는 CHOP 요법에 따라 술후 항암치료를 받았다. 술후 약 3개월동안 림프종 재발의 증거는 관찰되지 않았다. 본 증례를 포함하여 보고된 증례를 분석한 결과 간외담관의 림프종의 완전한 절제 및 뒤이은 항암요법이 좋은 예후와 연관이 있다고 생각된다. Primary gastrointestinal involvement of non-Hodgkin's lymphoma is frequently, but primary lymphoma of the common bile is extremely rare. Only fifteen cases have been recorded in the literature. In this paper a 48-year-old male with obstructive jaundice and a primary lymphoma of the common bile duct is described. The cholangiogram disclosed stricture of the common bile duct. Pathological studies of the surgical specimen revealed that the wall of the common bile duct was transmurally infiltrated by non-Hodgkin's lymphoma of follicular cell type of B-cell lineage, with positivity for Bcl-2. Periductal and peripancreatic lymph nodes were replaced by metastatic lymphomatous involvement. the patient received postoperative chemotherapy according to the CHOP regiment. There is no evidence of lymphoma recurrence 3 months after the surgery. The analysis of the reported cases supports that a complete surgical resection of the lymphoma followed by chemotherapy has shown a promising result.