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채일현(Ill Hyoun Chae),김명찬(Myoung Chan Kim),신세원(Se Won Shin),이성림(Seong Lim Lee),김인선(In Sun Kim),김인배(In Bae Kim),조봉춘(Bong Choon Jo),최인철(In Cheol Choi),박종각(Jong Gak Park) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.8
Holoprosencephaly is a rare malformation complex or development defect including different degrees of incomplete cleavages of the embryonic prosencephalon and varying degrees of the midface defects, resulting from the defect of prechordal mesoderm, migrating forward into the area anterior to the notochord during the third week of fetal development. Early antenatal diagnosis of holoprosencephaly is important to find out its severity, to predict its prognosis, and to determine proper management according to its prognosis and severity. The possibility of early antenatal diagnosis of holoprosencephaly by ultrasound has been suggested, but occasionally missed and rarely confirmed. We present one case of lobar holoprosencephaly, diagnosed postnatally and one case of alobar holoprosencephaly, diagnosed antenatally in our hospitals.