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LC-HRMS를 이용한 송사리 내 의약품 농축 및 생체변환 연구
차현전 ( Hyeonjeon Cha ),전준호 ( Junho Jeon ) 한국환경분석학회 2021 환경분석과 독성보건 Vol.24 No.2
Theoccurrenceofpharmaceuticalsintheaquaticenvironmenthasbeenincreasingsteadilyowingtotheincreasinguseofpharmaceuticalsinourdailylife.Thisresultsinincreasingchallengesofenvironmentalhealthriskaspharmaceuticalsinthesurfacewatercanbeaccumulatedandtransformedinaquaticorganisms.ThepurposeofthisstudywastopredictthebioconcentrationandbiotransformationofseveralpharmaceuticalsinJapanesemedaka(Oryziaslatipes)usinga96hexposuretest.BasedonaninvestigationofthemostfrequentlydetectedpharmaceuticalsinthesurfacewatersinSouthKorea,11targetcompoundswereselectedincludingatenolol,caffeine,carbamazepine,diclofenac,fluoxetine,irbesartan,losartan,mefenamicacid,metoprolol,naproxen,andvenlafaxine.Abioconcentrationfactorof1.9,31.3,and10.7wasexpectedinfishowingtotheaccumulationofcarbamazepine,fluoxetine,andmefenamicacid,respectively.Atotalof12biotransformationproducts(BTPs)weretentativelyidentifiedviaoxidation,hydroxylation,dealkylation,anddemethylationreactions.Insummary,itisexpectedthattheseBTPsrepresentedbymolecularstructuresderivedfromtheirparentcompoundscanbeutilizedtoevaluatethechangeintoxicityofBTPscomparedtothatoftheparentcompounds.