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- 저자 : 지현준 ( Hyun Jun Jee ) (검색결과 5 건)
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지현준(Hyun Jun Jee),정화경(Hwa Kyung Jung),조수용(Soo Yong Chough),박용균(Yong Kyun Park),서호석(Ho Suk Saw),오민정(Min Jeong Oh),허준용(Jun Young Hur) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.10
Clear cell carcinoma of the endometrium is a relatively rare malignancy that is considered to be one of the most aggressive types of endometrial carcinoma. It is an infrequent variant sharing a common Mullerian origin, accounting for 1 to 5 percent of all endometrial cancers. Histologically, these tumors consists of hobnail cells which have translucent or slightly eosinophilic cytoplasm and protrude to lumen of gland. These tumors occur predominantly in postmenopausal women and carry a relatively unfavorable prognosis comparing with other histologic types of endometrial cancer. We experienced a case of clear cell carcinoma of endometrium in a 81-year old women and this case is presented with a brief review of the literaturs.
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지현준(Hyun Jun Jee),정화경(Hwa Kyung Jung),조수용(Soo Yong Chough),박용균(Yong Kyun Park),서호석(Ho Suk Saw),오민정(Min Jeong Oh),허준용(Jun Young Hur) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.10
목적 : 우리나라 성인 여성의 월경양상과 월경과다 시 쉽게 이용할 수 있는 진단방법, 월경 과다에 대한 인식정도에 대하여 알아보고자 하였다. 대상 및 방법 : 초등학교 여교사 77명을 대상으로 정기 신체검사시 설문지를 통해 월경양상과 월경과다에 대한 인식정도를 조사하였고 그림표를 사용하여 월경지수를 계산하고 신체검사시 시행한 혈색소량을 조사 하였다. 월경지수와 혈색소량을 Spearman correlation test를 시행하여 상관관계를 알아보았다. 결과 : 조사 대상 여성들의 월경주기는 29.8일 (SD±5.1), 월경기간은 평균 5.6일 (SD±1.3)이었고, 월경지수는 평균 170 (SD±89.2)으로 12에서 411의 분포를 보였고, 혈색소량은 평균 12.3 g/dL 이었다. 월경지수와 혈색소량 간에는 통계적으로 유의하게 선형관계를 보였다 (r=-0.29, p=0.01). 혈색소량이 12 g/dL 이하로 빈혈이 있는 여성은 20명 (26%) 중 17명 (85%)과 월경지수가 200 이상으로 월경과다인 여성 26명 (34%) 중 25명 (96%)이 본인의 생리가 정상이라고 생각하고 있었다. 결론 : 월경과다나 이로 빈혈이 있는 여성들 중 많은 경우에서 심각성을 느끼지 못하고 있으므로 보다 간편하고 정확하게 여성 스스로가 월경과다를 의심하고 병원을 찾을 수 있게 하는 방법이 필요하고 그림표를 이용하여 스스로 작성하는 월경일지가 이를 위한 유용한 방법이 될 수 있다. Objective : This study was designed to evaluate the patterns of menstruation including menorrhagia using menstrual index, to find out correlations between patient`s own judgement and actual patterns of menstruation in Korean women, and to develop the menstrual diary using menstrual index as a screening of menstrual disorders. Methods : Seventy-seven women teachers of elementary school undergoing routine health screening test were asked to complete a pictorial blood loss assessment chart and a set of interview sheets regarding menstrual history and their subjective judgement on their amount of menstruation. Spearman correlation test was used to assess the correlation between menstrual index which was obtained from pictorial chart and serum hemoglobin concentration. Results : The mean menstrual intervals were 29.8 days (SD±5.1), the mean menstrual duration was 5.6 days (SD±1.3), the mean value of menstrual index was 170.3 (SD±89.2) which varied from 12 to 411, the mean serum hemoglobin concentration was 12.3 g/dL. Significant correlation was found between the serum hemoglobin concentration and the menstrual index (r=-0.29, p=0.01). Seventeen of 20 women who had anemia (serum hemoglobin concentration below 12.0 g/dL) and 25 of 26 women who had menorrhagia (menstrual index above 200) considered her menstruation as `normal`. Conclusion : Many women who have anemia due to menorrhagia are not aware of the serious consequences of menorrhagia. Writing a ‘menstrual diary` using menstrual index would be easier and more practical method in predicting menorrhagia.
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부인과 악성종양 환자에서 복합 항암화학요법에 따른 세포독성에 대한 Amifostine 의 임상효과에 관한 연구
이린화(Lynn Hwa Lee),지현준(Hyun Jun Jee),정화경(Hwa Kyung Jung),정유아(Yu A Jung),신정호(Jung Ho Shin),오희숙(Hee Suk Oh),박용균(Yong Kyun Park),허준용(Jun Young Hur),조수용(Soo Yong Chough),서호석(Ho Suk Saw) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11
N/A Objective : Amifostine (Ethyol(R)), an organic thiophosphate, has shown the ability to protect normal, but not neoplastic, tissues from the damaging effects of chemotherapy and radiotherapy in various kinds of cancers. This study was designed to determine ifostine could reduce the serious hematologic and nephrologic toxicities associated with cisplatin based combination chemotherapy in gynecologic cancer patients. Patients and Methods : Forty patients who received cisplatin-based combination chemotherapy were randomized into two groups. They received chemotherapy with or without pretreatment of amifostine before each course. The occurrence of hematologic and renal toxicities were evaluated. Stastical analysis was done by independent t-test and Chi-square test. Results : Hematologic toxicity was evaluated with nadir count of neutrophil and platelet. The nadir count of neutrophil was 2034.2±1199.20/μl in group with pretreatment using amifostine vs 1070.85±472.66/μl in control group (p<0.01). Platelet count was not statistically different. (p<0.16) Grade 3 neutropenia was observed in nine (45%) patients in pretreatment group vs four (20%) patients with control group (p<0.09). Grade 4 neutropenia occurred in one patient only in control group. Renal toxicity was evaluated by serum creatinine and creatinine clearance. Protracted serum creatinine elevation was not significant in both groups. (p<0.14) Reduction of creatinine clearance was less in patients with pretreatment (p<0.01). There were no significant side reactions in subjects using amifostine. Conclusion : Pretreatment with amifostine reduces the neutropenia and nephrotoxicity associated with cisplatin-based combination chemotherapy with gynecologic cancer patients.
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양막 및 탈락막 유래 중간엽 줄기세포의 분리 및 특성 규명
윤영선 ( Young Sun Yoon ),정현철 ( Hyun Chul Jeong ),황종하 ( Jong Ha Hwang ),지현준 ( Hyun Jun Jee ),석예선 ( Oye Sun Seok ),조정윤 ( Jung Youn Jo ),김윤정 ( Yun Joung Kim ),이재관 ( Jae Kwan Lee ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.11
목적: 사람의 양막과 탈락막으로부터 각각 중간엽 줄기세포를 분리하고 줄기세포의 특성을 규명하고자 하였다. 방법: 정상 경질식분만을 하거나 혹은 제왕절개술을 시행받은 산모로부터 사람태반 (임신 주수, 30~42주)을 얻었다. 기계적인 방법으로 양막과 탈락막에서 세포를 분리한 후 각각 배양하였다. 세포배양액을 제거하고 세척, 분리, 침전과정을 거친 세포를 직접 또는 간접 측정법을 이용하여 면역표현형을 조사하고, 지방세포, 골모세포, 근육모세포 및 신경모세포로의 분화능을 시험하고, 세포증식 능력을 평가하였다. 결과: 123개의 사람태반 중 각각 123개의 양막과 탈락막에서 단핵의 방추상의 균일한 세포양상을 보이는 중간엽 줄기세포를 분리하였다. 중간엽 줄기세포의 면역표현형을 분석한 결과 공통적으로 CD29, CD34, CD44, CD73, CD90 항원을 발현하고 CD31, CD45, HLA-DR 항원은 발현되지 않았다. 양막에서 유래한 세포에서만 CD105항원이 발현하였다. 세포증식 능력은 비슷하였다. 중간엽 줄기세포를 성장배양액과 분화배양액을 이용하여 지방세포, 골모세포, 근육모세포, 신경모세포로 분화함을 확인하였다. 결론: 사람의 양막과 탈락막은 중간엽 줄기세포를 추출 분리가 용이하고, 분리한 세포의 증식력이 높으며, 특정 조직으로 분화를 유도할 수 있어 향후 태반은 중간엽 줄기세포의 주요한 원천이 될 것이다. Objectives: The purpose of this study is to isolate a population of multipotent cells from human amnion and decidua, respectively. Methods: Human placentas (gestational age, 30~42 weeks) were obtained after vaginal or cesarean deliveries. Amnions and deciduas were divided mechanically. The collected cells from the amnion and decidua were cultured. Cultured cells were immunophenotypically characterized. The adipogenic, osteogenic and neurogenic differentiation capacities were tested, and their growth kinetics were analyzed. Results: We successfully isolated MSCs from both the amnion and decidua. The phenotype of MSCs cultured from different fetal and maternal parts of the placenta was comparable. The growth kinetics of MSCs derived from amnions and deciduas were similar. Isolated MSCs were differentiated into various cell lines such as adipogenic, osteogenic, myogenic and neurogenic cells. Conclusions: The human amnion and decidua could be an excellent source of MSC because they are easily obtainable after delivery and showed a higher expansion capacity than that of MSCs from adult bone marrow.
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