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Urinary Trypsin Inhibitor ( UTI ) 의 일반약리작용
성연희(Yeon Hee Seong),조순옥(Sun Ok Jo),이선애(Seon Ae Lee),임화경(Hwa Kyung Lim),장춘곤(Choon Gon Jang),김학성(Hack Seang Kim),강종구(Jong Koo Kang) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.4
General pharmacological properties of urinary trypsin inhibitor (UTI) following intravenous administration of 1,000,000 units/㎏ were examined in terms of effects on central nervous system, cardiovascular system, respiratory system, gastrointestinal system in mice, rats and rabbits. Administration of UTI (1,000,000 units/㎏, iv) had no effect on central nervous system; no influences on pentobarbital sleeping time, spontaneous activity, normal body temperature, chemoshock produced by pentylenetetrazole solution, writhing syndromes induced by 0.6% acetic acid solution, and motor coordination of mice. The administration of UTI (1,000,000 units/㎏, iv) in rats had no effect on systolic blood pressure and pulse rate. UTI (500,000 units/㎏, iv) given to anesthetized rabbits showed no effect on respiratory rate. However, it showed significant elevation of respiratory rate at the concentration of 1,000,000 units/㎏. Gastric secretion of rat and intestinal motility of mice were not influenced by the dose of 1,000,000 units/㎏. In terms of autonomic nervous system, the material did not show direct effect and inhibitory or augmentative action of histamine- or acetylcholine-induced contraction at the concentration of 2,000 units/ml in the isolated ileum of guinea pig.
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이희수(Hee-Su, Lee),조순옥(Sun-Ok, Cho) 중앙대학교 한국인적자원개발전략연구소 2007 역량개발학습연구 Vol.2 No.1
우리나라의 전략적 인적자원개발에 대한 연구는 그 중요성과 국제적 동향에 비추어 아직은 그리 활성화되어 있지 못하다. 인적자원개발과 관련하여 NHRD, RHRD, GHRD, MHRD 등과 같은 다양한 신조어들이 난무하고 있지만, 정작 이러한 용어들의 공통분모로서 전략적 인적자원개발(SHRD)에 대한 논의는 보이지 않고 있다. 지금은 인적자원개발의 열정만큼이나 냉정한 전략적 인적자원개발을 논할 때이며, 인적자원개발기본법 개정에 따른 국가인적자원위원회와 인적자원정책본부 구성 및 운영이란 큰 그림을 그려야 할 현 시점에서 전략적 인적자원개발에 대한 논의는 더 없이 중요하다고 할 것이다. 전략적 인적자원개발은 새로운 패러다임 전환이기에 앞서 전략적 의미를 더한 인적자원개발의 진화일 수 있다. 따라서 전략적 인적자원개발에 대한 논의는 개념의 특성론적 접근을 넘어서 인적자원개발의 진화서 면에서 전략적 인적자원개발의 모델 동향에 대한 논의가 있어야 한다. 인적자원개발의 진화론적 성숙을 논하는 가운데 전략적 인적자원개발이 나와야 하며, 그러한 전략적 인적자원의 안목을 갖고서 우리의 인적자원개발정책을 진단해야 한다. 이 글에서는 이러한 문제의식과 목적을 토대로 전략적 인적자원개발과 관련한 몇가지 시사점을 제안하고자 하였다. Compared to its importance and international trends, studies on Korea's SHRD(Strategic Human Resources Development) are not being actively made yet. There are many neologisms related with HRD like NHRD, RHRD, GHRD and MHRD. However, discussions about SHRD, a common denominator of these neologisms, are not being made. It's time to discuss about calm SHRD as much as passionate SHRD. To discuss about SHRD is very important to us at this time when the National HR Committee and Office for HR Policies should be organized and operated according to the amendment of the basic HRD law. SHRD can be the development of HRD in which a strategic meaning is included, before it is the conversion into a new paradigm. Consequently, we should discuss about trends of SHRD models from an aspect of HRD's evolutionary history, beyond the trait approach to its concept. While the evolutionary maturity of HRD is being discussed, SHRD should be made. And we should diagnose our HRD policies with a view of such SHRD. This study aims to suggest some implications related with SHRD based on such a critical mind and objective.
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성연희(Yeon Hee Seong),강종구(Jong Koo Kang),안희열(Hee Yul Ahn),김선돈(Sun Don KIm),이선애(Sun Ae Lee),조순옥(Soon Ok Jo),유보림(Bo Rim Yoo),정영신(Young Shin Jung),홍은경(Eun Kyung Hong),한영복(Young Bok Han) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.4
General pharmacological properties of AG 60 (mixture of acriflavine and guanosine (1:1, w/w)), which has anticancer effect, following intramuscular administration were examined in terms of effects on central nervous system, gastrointestinal system, cardiovascular system, respiratory system and autonomic nervous system in mice, rats, guinea-pigs and rabbits. AG 60 at the dose of 15 mg/kg had no influences on pentobarbital sleeping time, spontaneous motor activity, chemoshock produced by pentylenetetrazole solution, writhing syndromes induced by 0.8% acetic acid solution, and motor coordination of mice. However, AG 60 at the dose of 7.5 and 15 mg/kg caused significant decrease of normal body temperature 1 and/or 2 h after the administration. No influence on body temperature was observed at 3.75 mg/kg in mice. Gastric secretion of rat and intestinal motility of mice were not influenced by the dose of 15 mg/kg. In terms of autonomic nervous system, AG 60 did not show direct effect and inhibitory or augmentative action of histamine- or acetylcholine-induced contractions at the concentration of 5 mg/L in the isolated ileum of guinea-pig. The administration of 15 mg/kg of AG 60 did not affect mean arterial blood pressure and heart rate in rat. AG 60 (15 mg/kg) given to anesthetized rabbits showed no effect on respiratory rate.
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