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Development of Vascularized Outer Blood-retinal-barrier Model via 3D Cell Printing
J. Kim(김종민),J. S. Kong(공정식),J. Y. Won(원재연),D-.W. Cho(조동우) Korean Society for Precision Engineering 2021 한국정밀공학회 학술발표대회 논문집 Vol.2021 No.11월
The outer blood-retinal-barrier (oBRB) is formed by tight junction of retinal pigment epithelium (RPE) and controls the molecular transportation between choroid and retina. Moreover, the RPE plays a multifunctional role in ocular system, including clearance, visual and maintenance functions. Due to their crucial role, the loss of this epithelium causes a wide range of the disease related to retinal degeneration such as age-related macular degeneration. Unfortunately, currently, there is no cure for most of these diseases since there is no suitable testing platform. To overcome this limitation, we developed the 3D printed vascularized oBRB model. For this objective, we developed Bruch’s membrane derived bioink (BM-ECM), containing natural extracellular matrix (ECM). Using BM-ECM and 3D printing technology, the Bruch’s membrane mimetic substrate (BMMS) was developed to recapitulate the structural and ECM micro environment for RPE. Then, HUVEC and RPE cells were printed in both side of BMMS to from vascularized oBRB and confirmed their superiorities.
HA(Hydroxyapatite) 나노 입자를 이용한 bone scaffold의 개발
김종영(J. Y. Kim),이승재(S. -J. Lee),이진우(J. W. Lee),김신윤(Shin-yoon. Kim),조동우(D. -W. Cho) 한국정밀공학회 2006 한국정밀공학회 학술발표대회 논문집 Vol.2006 No.5월
A novel approach to the manufacture of biocompatible ceramic scaffold for tissue engineering using micro-stereolithography system is introduced. Micro-stereolithography is a newly proposed technology that enables to make a 3D micro structure. The 3D micro structures made by this technology can have accurate and complex shape within a few micron error. Therefore, the application based on this technology can vary greatly in nano-bio fields. Recently, tissue-engineering techniques have been regarded as alternative candidate to treat patients with serious bone defects. So many techniques to design and fabricate 3D scaffolds have been developed. But the imperfection of scaffold such as random pore size and porosity causes a limitation in developing optimum scaffold. So scaffold development with controllable pore size and fully interconnected shape have been needed for a more progress in tissue engineering. In this paper, bone scaffold was developed by applying the micro-stereolithography to the mold technology. The scaffold material used was HA(Hydroxyapatite) nano powder. HA is a type of calcium phosphate ceramic with similar characteristic to human inorganic bone component. The bone scaffold made by HA is expected, in the near future, to be an efficient therapy for bone defect.