ICR 마우스를 이용한 麻黃潤肺湯의 진해, 거담, 및 항염 효과 평가

정영은,김종대 대한한방내과학회 2022 大韓韓方內科學會誌 Vol.43 No.4

Objectives: The antitussive, expectorant, and anti-inflammatory effects of Mahwangyounpae-tang (MHYPT) aqueous extracts were observed in appropriate animal models of various respiratory disorders. Methods: MHYPT aqueous extracts were orally administered once a day for 11 days at dose levels of 400, 200, and 100 mg/kg. The effect of MHYPT was determined by comparing its antitussive effect with theobromine (TB), its expectorant effect with ambroxol (AM), and its anti-inflammatory effect with dexamethasone (DEXA). Results: MHYPT aqueous extracts (400 mg/kg) showed favorable antitussive effects comparable to those of TB (50 mg/kg) in the NH4OH-exposure coughing mouse model and expectorant effects comparable to those of AM (250 mg/kg) in the phenol red-secretion mouse model, but MHYPT (400 mg/kg) showed less anti-inflammatory activity compared to DEXA (1 mg/kg) in the xylene-induced acute inflammatory mouse ear model under the experimental conditions used. Conclusion: MHYPT aqueous extracts administered at dosage levels of 400, 200, and 100 mg/kg induced dose-dependent and favorable antitussive, expectorant, and anti-inflammatory activities that occurred by simultaneous modulation of the activity of mast cells and respiratory mucous production under the experimental conditions used in this study.

Vanadium oxide-based extruded honeycomb monolith catalyst for abatement of NOx with NH₃

정영은,하헌필,이관영,( Danh Thi Huong ),( Pullur Anil Kumar ),최현 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1

Vanadium based monolith type catalyst was carried out for the selective catalytic reduction(SCR) of NO_x by NH₃. The monolith catalyst can be adjusted to reduce the simulate exhaust gas of marine engine at wide temperature (150~500°C). The characteristics of the monolith catalysts were thoroughly characterized by surface area, temperature programmed desorption (TPD) of NO, SO₂ and NH₃, X-ray Fluorescence (XRF) spectrometer and scanning electron microscope (SEM). The Vanadum based monolith catalyst showed higher activity at low temperature about 200C under SO₂ and H₂O condition than commercial catalyst.

신기능 장애를 동반한 급성 알코올성 간염 환자 치험 1예

정영은,김승모,강석봉,김종대 한방비만학회 2016 한방비만학회지 Vol.16 No.2

The purpose of this study is to report the clinical effectiveness of Korean medicine, especially Galhwahajung-tang and Yijintang-gamibang on patient with acute alcoholic hepatitis and renal dysfunction. The patient in this case had suffered from pantalgia and dizziness with nausea. He was diagnosed as acute alcoholic hepatitis. Based on related symptoms and blood-test, we could diagnose acute alcoholic hepatitis. We treated him with Korean medicine, involving herbal decoction, acupuncture, moxibustion and cupping. We used visual analogue scale and blood-test for assessment. After 31 days of treatment, the pantalgia and dizziness with nausea were disappeared and liver function test was in the normal range. According to this study, Korean medicine, including Galhwahajung-tang and Yijintang-gamibang are an effective treatment for the cure of acute alcoholic hepatitis with renal dysfunction which occurs on crapulence.

Dobutamine-Induced Perioperative Anaphylaxis in a Dog

정영은,장윤설,문창환,정재민,노윤호,이해범,정성목 한국임상수의학회 2020 한국임상수의학회지 Vol.37 No.3

A 9-years old spayed female Maltese was referred for the treatment of mass on the right 1st mammary gland and acute weight bearing lameness of right hindlimb. It was diagnosed as malignant mammary tumor and cranial cruciate ligament rupture of right stifle joint. Right upper regional mastectomy followed by cranial closing wedge osteotomy (CCWO) of the right tibia were planned for the present problems. Preanesthetic work-up did not show any remarkable abnormalities. Forty-five minutes after induction of anesthesia dobutamine was administered at a rate of 5 μg/kg/min by constant rate infusion due to gradual decrease of blood pressure below MAP 60 mmHg during surgical procedure. Despite of the increase of dobutamine infusion rate up to 20 μg/kg/min, blood pressure didn’t recover. At the end of regional mastectomy generalized skin redness and eyelid edema were identified. Anesthesia was stopped and CCWO procedure was cancelled. To recover from the anaphylactic reactions dexamethasone and diphenhydramine were administered. After about one hour, the patient completely recovered from hypotension and anaphylactic reactions. After 4 weeks, intradermal skin test (IDST) was performed for all the drugs used during anesthesia. Only dobutamine showed positive reaction in IDST. Therefore, dobutamine was considered as the causative agent of anaphylaxis in this patient during the anesthesia. In case of perioperative anaphylactic reaction, postoperative investigation should be performed to identify causative agent and to provide safe recommendations for future anesthetic procedure.

한국형 양극성 장애 약물치료 알고리듬 2018 : 노인

정영은,김문두,박원명,윤보현,전덕인,서정석,김원,이정구,우영섭,정종현,손인기,심세훈,송후림,민경준 대한우울조울병학회 2018 우울조울병 Vol.16 No.3

Objectives : The fourth revision of Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP) was performed to provide more proper guidelines for clinicians. In this study, we evaluated treatment strategies of elderly patients with bipolar disorders of KMAP-BP 2018. Methods : Sixty-one psychiatrists of the review committee with vast clinical experiences in treating bipolar disorders, completed the survey. An expert consensus was obtained, on pharmacological treatment strategies for elderly patients with bipolar disorder. The executive committee analyzed results, and discussed the results to produce the final algorithm. Results : In elderly patients with bipolar disorder, first-line treatment option for acute manic episode is monotherapy, with atypical antipsychotics or mood stabilizer, and a combination of mood stabilizer and atypical antipsychotics. First-line treatment option for acute depressive episode, was a combination of mood stabilizer and atypical antipsychotics, monotherapy with atypical antipsychotic or mood stabilizer, and atypical antipsychotics with lamotrigine. Conclusion : In KMAP-BP 2018, the recommendation for treatment option in elderly patients with bipolar disorder, was newly introduced. We expect this algorithm may provide valuable information, and facilitate treatment of elderly patients with bipolar disorder.

啓示에 있어서의 幻視와 預言의 意味에 관한 舊約聖書的 考察

鄭泳漢(정영한) 광주가톨릭대학교 신학연구소 1994 神學展望 Vol.- No.104

Investigation of neural network-based cathode potential monitoring to support nuclear safeguards of electrorefining in pyroprocessing

정영은,안성규,임만성 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.2

During the pyroprocessing operation, various signals can be collected by process monitoring (PM). Thesesignals are utilized to diagnose process states. In this study, feasibility of using PM for nuclear safeguardsof electrorefining operation was examined based on the use of machine learning for detecting off-normaloperations. The off-normal operation, in this study, is defined as co-deposition of key elements throughreduction on cathode. The monitored process signal selected for PM was cathode potential. The necessary data were produced through electrodeposition experiments in a laboratory molten salt system. Model-based cathodic surface area data were also generated and used to support model development. Computer models for classification were developed using a series of recurrent neural network architectures. The concept of transfer learning was also employed by combining pre-training and fine-tuningto minimize data requirement for training. The resulting models were found to classify the normal andthe off-normal operation states with a 95% accuracy. With the availability of more process data, theapproach is expected to have higher reliability

아동기 외상 경험이 대학생의 우울 증상에 미치는 영향 : 긍정심리자원의 조절 효과를 중심으로

정영은,양현주,유정원,김문두 대한우울조울병학회 2018 우울조울병 Vol.16 No.3

Objectives : The purpose of this study was to examine effects of traumatic experiences in childhood, on depressive symptoms of college students, and to determine how depression depended on positive psychological resources. Methods : A total of 430 students were recruited, from two universities in Jeju area. All participants completed self-report questionnaires, that included demographic variables, Adverse Childhood Experience (ACE) Scale, Patient Health Questionnaire-9, and Positive Resources Test (POREST). Results : Prevalence of depression was 47.9%, and a total of 133 (30.9%) college students reported traumatic experiences in childhood. Students with depressive symptoms, were likely to report more traumatic experiences in childhood, and less positive psychological resources. Results from regression analyses indicated that, while controlling for a range of demographic variables, positive psychological resources moderated the association, between traumatic experiences in childhood and depression. Conclusion : Based on results, professionals must consider positive psychological and social resources, for treatment to reduce depressive symptoms in patients with history of childhood adversity.

첫 조증 삽화로 입원한 양극성 장애 환자에서 비정형 항정신병약물과 기분조절제 병합치료에 따른 1년 재입원율: 예비 연구

정영은,송후림,왕희령,전태연,박원명 대한정신약물학회 2010 대한정신약물학회지 Vol.21 No.3

본 연구는 첫 번째 조증 삽화로 I형 양극성 장애를 진단받고 첫 입원한 환자를 대상으로 1년간의 의무기록을 조사하여 비정형 항정신병약물(olanzapine, quetiapine, risperidone)과 기분조절제의 병합 치료에 따른 1년 재입원율을알아보고자 하였다. 본 연구에 포함된 환자는 총 92명이었으며, risperidone 군은 34명, olanzapine 군은 26명, quetiapine 군은 32명이었다. 조사 결과 퇴원 후 1년 이내에 재입원한 환자는 총 21명(22.8%)이었다. 비정형 항정신병 약물에따라서는 risperidone 군 10명(29.4%), olanzapine 군 6명(23.1%), quetiapine 군 5명(15.6%)이며, Kaplan-Meier 공식에 의한 생존분석 결과 세 군 간에 통계적으로 유의한 차이는 없었다. 추가적으로 시행한 Cox 회귀 모델에 의한 분석결과 첫 조증 삽화 후 재입원에 유의하게 영향을 미치는 위험요인은 정신병적 증상이 있는 경우, 첫 조증 삽화 이전 우울삽화를 경험한 경우, 입원 기간이 짧은 경우 그리고 퇴원시GAF 점수가 낮은 경우였다. 본 연구는 대상자수가 적어 그의미를 일반화하기 어려우나, 국내의 자연적 임상 상황에서첫 조증 삽화를 보인 양극성 장애 환자를 대상으로 비정형 항정신병약물 사용에 따른 경과를 비교 관찰하였다는 점에서 의의가 있다. Objective We compared the one-year rehospitalization rates of first-episode bipolar manic patients who were discharged while being treated with atypical antipsychotics in combination with mood stabilizers. Methods We monitored the rehospitalization status of the first-episode bipolar manic patients who were discharged between 1 January 2003 and 31 December 2008 while they were taking risperidone (n=34), olanzapine (n=26) or quetiapine (n=32) in combination with mood stabilizers. Rehospitalizations were tracked over a 1-year period using the Kaplan-Meier method and Cox regression model was used to analyze covariates thought to affect time to rehospitalization. Results The rehospitalization rates during the 1-year follow-up period for patients taking atypical antipsychotics plus mood stabilizers were 22.8% (n=21). There were no significant differences in rehospitalization estimated using the Kaplan-Meier formula among the patients treated with risperidone (29.4%), olanzapine (23.1%) or quetiapine (15.6%). The psychotic symptoms, previous depressive episodes, lower Global Assessment of Functioning (GAF) score at discharge and less length of first hospitalization contributed to the risk of rehospitalization. Conclusion The 1-year rehospitalization rates of first-episode bipolar manic patients taking risperidone, olanzapine, or quetiapine do not differ and the psychotic symptoms and previous depressive episodes affect time to rehospitalization.

양극성 조증 입원 환자에서 과체중, 비만과 연관 인자 : 예비 연구

정영은,서호준,송후림,왕희령,전태연,박원명,Jung, Young-Eun,Seo, Ho-Jun,Song, Hoo-Rim,Wang, Hee-Ryung,Jun, Tae-Youn,Bahk, Won-Myong 대한불안의학회 2010 대한불안의학회지 Vol.6 No.2

Objective : Being overweight or obesity impairs quality of life and often causes treatment noncompliance in patients with bipolar disorder. This preliminary study evaluated the prevalence of overweight and obesity in inpatients with bipolar mania. Methods : Inpatients with bipolar mania, who were treated with adequate medications at least 4 weeks were included in a retrospective study. The body weight of each patient was measured and the body mass index (BMI) was calculated. Results : Of the 80 patients, 16.4% (N=13) were overweight, and 35.0% (N=28) were obese at discharge. Female patients had higher prevalence rates of overweight and obesity. Being overweight or obesity was associated with the number of previous episodes of depression and combination treatment with atypical antipsychotics and mood stabilizers. Conclusions : Being overweight or obesity is highly prevalent in patients with bipolar mania. Clinicians should pay more attention to weight gain and obesity when prescribing combination therapies. More research is required to identify the impact of specific risk factors for overweight and obesity in patients with bipolar mania.